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ES521121A0 - Un procedimiento para la preparacion de derivados de benzotia-zolsulfonamida. - Google Patents

Un procedimiento para la preparacion de derivados de benzotia-zolsulfonamida.

Info

Publication number
ES521121A0
ES521121A0 ES521121A ES521121A ES521121A0 ES 521121 A0 ES521121 A0 ES 521121A0 ES 521121 A ES521121 A ES 521121A ES 521121 A ES521121 A ES 521121A ES 521121 A0 ES521121 A0 ES 521121A0
Authority
ES
Spain
Prior art keywords
zolsulfonamide
benzotia
derivatives
procedure
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES521121A
Other languages
English (en)
Other versions
ES8405387A1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES8405387A1 publication Critical patent/ES8405387A1/es
Publication of ES521121A0 publication Critical patent/ES521121A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/70—Sulfur atoms
    • C07D277/76—Sulfur atoms attached to a second hetero atom
    • C07D277/80—Sulfur atoms attached to a second hetero atom to a nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
ES521121A 1982-04-02 1983-03-30 Un procedimiento para la preparacion de derivados de benzotia-zolsulfonamida. Granted ES521121A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/364,953 US4426388A (en) 1982-04-02 1982-04-02 5-Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure

Publications (2)

Publication Number Publication Date
ES8405387A1 ES8405387A1 (es) 1984-06-01
ES521121A0 true ES521121A0 (es) 1984-06-01

Family

ID=23436843

Family Applications (1)

Application Number Title Priority Date Filing Date
ES521121A Granted ES521121A0 (es) 1982-04-02 1983-03-30 Un procedimiento para la preparacion de derivados de benzotia-zolsulfonamida.

Country Status (5)

Country Link
US (1) US4426388A (es)
EP (1) EP0091367B1 (es)
JP (1) JPS58183679A (es)
DE (1) DE3364150D1 (es)
ES (1) ES521121A0 (es)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4456599A (en) * 1983-04-22 1984-06-26 Merck & Co., Inc. Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure
US4788192A (en) * 1983-06-20 1988-11-29 Merck & Co., Inc. 2-Sulfamoylbenzo(b)thiophene derivatives pharmaceutical compositions and use
NZ208444A (en) * 1983-06-20 1987-08-31 Merck & Co Inc 2-thiophene derivatives and pharmaceutical compositions
US4585787A (en) * 1983-06-20 1986-04-29 Merck & Co., Inc. 5-[2(Or 3)-hydroxyphenylsulfonyl]thiophene-2-sulfonamides for the topical treatment of elevated intraocular pressure
US4668697A (en) * 1983-10-31 1987-05-26 Merck & Co., Inc. Elevated intraocular pressure lowering benzo-[b]-thiophene-2-sulfonamide derivatives, compositions, and method of use therefor
US4544667A (en) * 1984-02-09 1985-10-01 Merck & Co., Inc. 2-Sulfamoylbenzo[b]furan derivatives for the treatment of elevated intraocular pressure
US4840963A (en) * 1984-03-14 1989-06-20 Merck & Co., Inc. 2-Sulfamoyl-1H-indole derivatives for the treatment of elevated intraocular pressure
US4863922A (en) * 1984-12-12 1989-09-05 Merck & Co., Inc. Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use
US4929637A (en) * 1985-12-24 1990-05-29 Merck & Co., Inc. Substituted thiophene-2-sulfonamide antiglaucoma agents
US5075453A (en) * 1987-02-18 1991-12-24 Nippon Soda Co., Ltd. Process for producing aryloxy-substituted phosphazene derivatives
US4914111A (en) * 1987-03-23 1990-04-03 Merck & Co., Inc. 4-Benzylthiophene (or furan)-2-sulfonamides as antiglaucoma agents
US4847289A (en) * 1987-06-08 1989-07-11 Merck & Co., Inc. Thiophene sulfonamide antiglaucoma agents
US4929549A (en) * 1989-02-08 1990-05-29 Merck & Co., Inc. 5-carbamoylthieno[2,3-b]thiophene-2-sulfon-amides as topically active carbonic anhydrase inhibitors
US5059613A (en) * 1990-03-19 1991-10-22 Research Corporation Technologies, Inc. Topically active ocular benzothiazole sulfonamide carbonic anhydrase inhibitors
US5091409A (en) * 1990-05-17 1992-02-25 Merck & Co., Inc. 4-alkylamino-6-(C3-5 -hydrocarbyl)thieno[2,3-B]thiopyran-2-sulfonamide-7,7-dioxides
US5216020A (en) * 1990-10-12 1993-06-01 Merck & Co., Inc. Substituted 4,5-dihydrothieno(2,3-b)thiophene-2-sulfonamides and 6,6-dioxides thereof
SG84487A1 (en) 1991-04-17 2001-11-20 Merck & Co Inc Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a b-adrenergic antagonist
US5300499A (en) * 1992-09-02 1994-04-05 Allergan, Inc. 5-substituted 3-thiophene sulfonamides as antiglaucoma agents
US5519040A (en) * 1994-04-29 1996-05-21 Allergan Substituted thiazole sulfonamides as antiglaucoma agents
US6316443B1 (en) 1994-08-04 2001-11-13 Merck & Co., Inc. Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a β-adrenergic antagonist
US5789435A (en) * 1995-05-22 1998-08-04 Advanced Research And Technology Institute Method to increase retinal and optical nerve head blood flow velocity in order to preserve sight
US6156785A (en) * 1998-01-23 2000-12-05 Merck Sharp & Dohme B.V. Method for increasing oxygen tension in the optic nerve and retina
US6548535B2 (en) 2000-01-18 2003-04-15 Merck & Co., Inc. Method for treating ocular hypertension
DE60135972D1 (de) 2000-01-18 2008-11-13 Merck & Co Inc Orhthalmologische zusammenstellungen zur behandlung von ocularer hypertension
US20040254230A1 (en) * 2001-12-03 2004-12-16 Ogidigben Miller J. Method for treating ocular hypertension
US7387868B2 (en) * 2002-03-04 2008-06-17 Tokyo Electron Limited Treatment of a dielectric layer using supercritical CO2
WO2003077845A2 (en) * 2002-03-15 2003-09-25 Merck & Co., Inc. Compositions and methods for treating glaucoma and ocular hypertension
AU2003233731A1 (en) * 2002-06-06 2003-12-22 Xavier Billot 1,5-disubstituted imidazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of eye and bone diseases
JP2005532363A (ja) * 2002-06-14 2005-10-27 メルク　エンド　カムパニー　インコーポレーテッド 高眼圧を治療するための眼用組成物
CA2488884A1 (en) * 2002-06-17 2003-12-24 Merck & Co., Inc. Novel maxi-k channel blockers, methods of use and process for making the same
AU2003245565B2 (en) * 2002-06-17 2008-01-03 Banyu Pharmaceutical Co., Ltd. Ophthalmic compositions for treating ocular hypertension
AU2003247533B2 (en) * 2002-06-17 2008-09-18 Merck & Co., Inc. Novel maxi-k channel blockers, methods of use and process for making the same
EP1545517A1 (en) * 2002-08-28 2005-06-29 Merck Frosst Canada & Co. Oxazolidin-2-one and thiazolidin-2-one derivatives for use as ep4 receptor agonists in the treatment of glaucoma
CA2502914A1 (en) * 2002-10-25 2004-05-06 Merck Frosst Canada & Co. 2-pyrrolidones as ep4 receptor agonists
EP1610776A4 (en) * 2003-03-27 2007-03-28 Merck & Co Inc OPHTHALMIC COMPOSITIONS FOR THE TREATMENT OF OCCULAR HYPERTONIA
US7186093B2 (en) * 2004-10-05 2007-03-06 Tokyo Electron Limited Method and apparatus for cooling motor bearings of a high pressure pump
US20060102282A1 (en) * 2004-11-15 2006-05-18 Supercritical Systems, Inc. Method and apparatus for selectively filtering residue from a processing chamber
US7767145B2 (en) * 2005-03-28 2010-08-03 Toyko Electron Limited High pressure fourier transform infrared cell
US7380984B2 (en) * 2005-03-28 2008-06-03 Tokyo Electron Limited Process flow thermocouple
US20060225772A1 (en) * 2005-03-29 2006-10-12 Jones William D Controlled pressure differential in a high-pressure processing chamber
US20060226117A1 (en) * 2005-03-29 2006-10-12 Bertram Ronald T Phase change based heating element system and method
US7494107B2 (en) * 2005-03-30 2009-02-24 Supercritical Systems, Inc. Gate valve for plus-atmospheric pressure semiconductor process vessels
US8332007B2 (en) * 2009-01-12 2012-12-11 The Board Of Trustees Of The University Of Illinois Quantitative three-dimensional mapping of oxygen tension

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2595334A (en) 1950-04-08 1952-05-06 American Cyanamid Co Benzothiazolesulfonamides and method of preparing the same
US2868800A (en) 1954-10-13 1959-01-13 Upjohn Co 6-ethoxybenzothiazole-2-sulfonamide

Also Published As

Publication number Publication date
US4426388A (en) 1984-01-17
EP0091367B1 (en) 1986-06-18
JPS58183679A (ja) 1983-10-26
EP0091367A3 (en) 1984-05-23
ES8405387A1 (es) 1984-06-01
EP0091367A2 (en) 1983-10-12
DE3364150D1 (en) 1986-07-24

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970519