ES485801A1 - Un procedimiento de preparacion de ciclo-1,3,2-oxazafosfo- ril-derivados - Google Patents
Un procedimiento de preparacion de ciclo-1,3,2-oxazafosfo- ril-derivadosInfo
- Publication number
- ES485801A1 ES485801A1 ES485801A ES485801A ES485801A1 ES 485801 A1 ES485801 A1 ES 485801A1 ES 485801 A ES485801 A ES 485801A ES 485801 A ES485801 A ES 485801A ES 485801 A1 ES485801 A1 ES 485801A1
- Authority
- ES
- Spain
- Prior art keywords
- oxazaphosphoryl
- derivatives
- formula
- group
- image
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Un procedimiento de preparación de ciclo-1,3,2-oxazafosforil- derivados de fórmula (II) **(Fórmula 01)** donde R2 y R3 son respectivamente un grupo alquilo inferior que puede contener uno o más átomos de halógeno o uno o más grupos (alcano inferior) sulfoniloxi como sustituyentes y n es un número entero igual a 2 a 6; cuyo procedimiento consiste en escindir por la acción de un ácido el enlace N-R1 de los 3-(alfa-arilalquil)- ciclo-1,3,2-oxazafosforil-derivados representados por la fórmula (I) **(Fórmula 02)** donde R1 es un grupo alfa-arilalquilo y R2, R3 y n son los definidos anteriormente.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP53137685A JPS5826919B2 (ja) | 1978-11-07 | 1978-11-07 | シクロ↓−１，３，２↓−オキサアザホスホル誘導体の製造法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES485801A1 true ES485801A1 (es) | 1980-07-01 |
Family
ID=15204405
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES485801A Expired ES485801A1 (es) | 1978-11-07 | 1979-11-07 | Un procedimiento de preparacion de ciclo-1,3,2-oxazafosfo- ril-derivados |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4238423A (es) |
| JP (1) | JPS5826919B2 (es) |
| AU (1) | AU515571B2 (es) |
| CA (1) | CA1125781A (es) |
| CH (1) | CH641186A5 (es) |
| DE (1) | DE2944106C2 (es) |
| ES (1) | ES485801A1 (es) |
| FR (1) | FR2440953A1 (es) |
| GB (1) | GB2034714B (es) |
| IT (1) | IT1119426B (es) |
| NL (1) | NL181433C (es) |
| SE (1) | SE439636B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3111428A1 (de) | 1981-03-24 | 1982-10-07 | Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld | Oxazaphosphorin-4-thio-alkansulfonsaeuren und deren neutrale salze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen |
| US5258538A (en) * | 1985-08-26 | 1993-11-02 | Applied Biosystems, Inc. | 2,3-disubstituted-1,3,2-oxazaphosphacycloalkanes as nucleic acid linking agents |
| DE19739159C1 (de) * | 1997-09-06 | 1999-01-28 | Asta Medica Ag | Verfahren zur Herstellung von Oxazaphosphorin-2-aminen |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL100390B1 (pl) * | 1975-10-06 | 1978-09-30 | Sposob wytwarzania 2-tlenku-2-/bis/2-chloroetylo/-amino/-1-/okso-3-aza-2-fosfacykloheksanu/cyklofosfamidu/o czynnosci optycznej |
-
1978
- 1978-11-07 JP JP53137685A patent/JPS5826919B2/ja not_active Expired
-
1979
- 1979-10-31 CA CA338,856A patent/CA1125781A/en not_active Expired
- 1979-10-31 DE DE2944106A patent/DE2944106C2/de not_active Expired
- 1979-11-02 AU AU52468/79A patent/AU515571B2/en not_active Ceased
- 1979-11-06 IT IT69163/79A patent/IT1119426B/it active
- 1979-11-06 GB GB7938360A patent/GB2034714B/en not_active Expired
- 1979-11-06 CH CH992779A patent/CH641186A5/de not_active IP Right Cessation
- 1979-11-06 NL NLAANVRAGE7908116,A patent/NL181433C/xx not_active IP Right Cessation
- 1979-11-06 SE SE7909157A patent/SE439636B/sv not_active IP Right Cessation
- 1979-11-06 US US06/091,786 patent/US4238423A/en not_active Expired - Lifetime
- 1979-11-07 ES ES485801A patent/ES485801A1/es not_active Expired
- 1979-11-07 FR FR7927426A patent/FR2440953A1/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| CH641186A5 (de) | 1984-02-15 |
| GB2034714B (en) | 1983-04-13 |
| FR2440953A1 (fr) | 1980-06-06 |
| NL7908116A (nl) | 1980-05-09 |
| JPS5826919B2 (ja) | 1983-06-06 |
| US4238423A (en) | 1980-12-09 |
| GB2034714A (en) | 1980-06-11 |
| IT7969163A0 (it) | 1979-11-06 |
| NL181433B (nl) | 1987-03-16 |
| DE2944106A1 (de) | 1980-05-08 |
| IT1119426B (it) | 1986-03-10 |
| FR2440953B1 (es) | 1984-09-14 |
| SE439636B (sv) | 1985-06-24 |
| AU515571B2 (en) | 1981-04-09 |
| SE7909157L (sv) | 1980-05-08 |
| DE2944106C2 (de) | 1983-05-05 |
| CA1125781A (en) | 1982-06-15 |
| AU5246879A (en) | 1980-05-15 |
| JPS5564594A (en) | 1980-05-15 |
| NL181433C (nl) | 1987-08-17 |
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