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ES471868A1 - Procedimiento para la obtencion de tioeteres basicos - Google Patents

Procedimiento para la obtencion de tioeteres basicos

Info

Publication number
ES471868A1
ES471868A1 ES471868A ES471868A ES471868A1 ES 471868 A1 ES471868 A1 ES 471868A1 ES 471868 A ES471868 A ES 471868A ES 471868 A ES471868 A ES 471868A ES 471868 A1 ES471868 A1 ES 471868A1
Authority
ES
Spain
Prior art keywords
carbon atoms
alkyl
phenyl
chr3
chr4
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES471868A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of ES471868A1 publication Critical patent/ES471868A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/76—Dibenzothiophenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Procedimiento para la obtención de tioéteres básicos de fórmula general I R-A-(CH2)n-Z donde R significa p-R5-S-fenilo o 2-dibenzotienilo, A significa -CHR3-CHR4-, -CR-(OH)-CHR4, -CHR3-CR4(OH)- o -CR3=CR4-, Z significa -NR1R2, l-imidazolilo o 1,2,4-triazol-l-ilo, n representa 1,2 o 3, R1 y R2 (iguales o diferentes) significan en cada caso H, alquilo con 1 - 4 átomos de carbono o juntos alquileno con 4 - 7 átomos de carbono o 3-oxapentametileno, R3 y R4 (iguales o diferentes) significan en cada caso H, alquilo con 1 - 4 átomos de carbono o fenilo, R5 significa un grupo fenilo, o bencilo insustituido, o sustituido una o dos veces por halógeno, nitro, amino, y/o alcoxi con 1-4 átomos de carbono, alquilo con 1-6 átomos de carbono o cicloalquilo con 3-7 átomos e carbono, donde, sin embargo R5 significa un grupo alquilo con 1 - 6 átomos e carbono o cicloalquilo con 3-7 átomos de carbono si A significa simultáneamente un grupo -CHR3-CH2 y Z significa un grupo imidazolilo, así como sus sales de adición de ácido fisiológicamente compatibles.
ES471868A 1977-07-20 1978-07-19 Procedimiento para la obtencion de tioeteres basicos Expired ES471868A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19772732750 DE2732750A1 (de) 1977-07-20 1977-07-20 Basische thioaether und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
ES471868A1 true ES471868A1 (es) 1979-10-01

Family

ID=6014381

Family Applications (3)

Application Number Title Priority Date Filing Date
ES471868A Expired ES471868A1 (es) 1977-07-20 1978-07-19 Procedimiento para la obtencion de tioeteres basicos
ES479057A Expired ES479057A1 (es) 1977-07-20 1979-03-29 Procedimiento para la obtencion de tioeteres basicos.
ES479056A Expired ES479056A1 (es) 1977-07-20 1979-03-29 Procedimiento para la obtencion de tioeteres basicos.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES479057A Expired ES479057A1 (es) 1977-07-20 1979-03-29 Procedimiento para la obtencion de tioeteres basicos.
ES479056A Expired ES479056A1 (es) 1977-07-20 1979-03-29 Procedimiento para la obtencion de tioeteres basicos.

Country Status (18)

Country Link
US (1) US4285961A (es)
JP (1) JPS5422333A (es)
AT (1) ATA523978A (es)
AU (1) AU519568B2 (es)
BE (1) BE869163A (es)
CA (1) CA1118780A (es)
DE (1) DE2732750A1 (es)
ES (3) ES471868A1 (es)
FR (1) FR2398056A1 (es)
GB (1) GB1585036A (es)
GR (1) GR71673B (es)
HU (1) HU177353B (es)
IL (1) IL55150A (es)
IT (1) IT1106421B (es)
NL (1) NL7807789A (es)
PT (1) PT68272A (es)
SE (1) SE7807975L (es)
ZA (1) ZA784134B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4246274A (en) * 1978-05-10 1981-01-20 Bayer Aktiengesellschaft Antimycotic hydroxypropyl-imidazoles
CA1156661A (en) * 1980-02-25 1983-11-08 Hoffmann-La Roche Limited Phenoxy-aminopropanol derivatives
EP0158741A3 (en) * 1980-11-19 1986-02-12 Imperial Chemical Industries Plc Intermediates for fungicidal triazole and imidazole compounds
HU187399B (en) * 1980-12-24 1985-12-28 Sumitomo Chemical Co Process for preparing imidazolyl-propanol derivatives
JPS61223073A (ja) * 1985-03-29 1986-10-03 Toyo Ink Mfg Co Ltd 活性エネルギ−線硬化性被覆組成物
JP2538226B2 (ja) * 1987-02-10 1996-09-25 日本ペイント株式会社 架橋アクリル樹脂粒子分散組成物ならびにその製造方法
GB8726505D0 (en) * 1987-11-12 1987-12-16 Ici Plc Naphtho(2 1-b)furan derivatives
US5238959A (en) * 1988-04-08 1993-08-24 Eli Lilly And Company 3-phenyloxy-3-phenyl propanamines
IL89854A (en) * 1988-04-08 1994-02-27 Lilly Co Eli Phenoxypropanamines, the process for their preparation and medicinal preparations containing them
US4859693A (en) * 1988-08-10 1989-08-22 E. I. Du Pont De Nemours And Company Antiinflammatory carbinoloimidazoles
US5049570A (en) * 1990-01-23 1991-09-17 Du Pont Merck Pharmaceutical Company Pyridylphenyl nitrogen heterocycle-substituted carbinols and derivatives thereof with anti-inflammatory activity
TW248556B (es) * 1993-01-18 1995-06-01 Takeda Pharm Industry Co
DE4426245A1 (de) * 1994-07-23 1996-02-22 Gruenenthal Gmbh 1-Phenyl-3-dimethylamino-propanverbindungen mit pharmakologischer Wirkung
JP2007186422A (ja) * 2004-01-28 2007-07-26 Astellas Pharma Inc アリールスルフィド誘導体
WO2014157371A1 (ja) * 2013-03-28 2014-10-02 日本合成化学工業株式会社 新規イミダゾール化合物、電子デバイス用材料、発光素子、電子デバイス及びその製造方法
US20200029564A1 (en) 2016-09-29 2020-01-30 Bayer Cropscience Aktiengesellschaft Novel 5-substituted imidazolylmethyloxirane derivatives
MX2019003714A (es) 2016-09-29 2019-06-24 Bayer Cropscience Ag Novedosos derivados de imidazolilmetilo 5-sustituidos.
BR112019006450A2 (pt) 2016-09-29 2019-06-25 Bayer Cropscience Ag novos derivados de imidazolilmetila substituídos na posição 5
BR112019006441A2 (pt) 2016-09-29 2019-06-25 Bayer Ag derivados de 5-imidazol metil dioxolano substituídos como fungicidas
WO2018060075A1 (en) 2016-09-29 2018-04-05 Bayer Cropscience Aktiengesellschaft 1 -[2-(1 -chlorocyclopropyl)-2-hydroxy-3-(3-phenyl-1,2-oxazol-5-yl)propyl]-1h-imidazole-5-carbonitrile derivatives and related compounds as fungicides for crop protection
BR112019006451A2 (pt) 2016-09-29 2019-06-25 Bayer Ag derivados substituídos de 1,5 imidazóis como fungicidas para proteção de plantação.
CN109890795A (zh) 2016-09-29 2019-06-14 拜耳作物科学股份公司 新的5-取代的咪唑衍生物
JPWO2024005030A1 (es) * 2022-07-01 2024-01-04

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2742500A (en) * 1953-12-22 1956-04-17 Du Pont Resolution of phenylaminopropanediols and intermediates
NL6407943A (es) * 1964-07-11 1966-01-12
GB1321701A (en) * 1969-10-01 1973-06-27 Continental Pharma Amino-alcohols their salts and process for prepairing the same
IE40911B1 (en) * 1974-04-11 1979-09-12 Schering Ag Imidazole derivatives and process for their manufacture
IL48319A0 (en) * 1974-10-26 1975-12-31 Merck Patent Gmbh Araliphatic nitrogen compounds and a process for their preparation
US3997540A (en) * 1975-07-21 1976-12-14 Burroughs Wellcome Co. O [(O-piperazinocarbonyl-phenyl)-thio]-benzoates

Also Published As

Publication number Publication date
IT1106421B (it) 1985-11-11
US4285961A (en) 1981-08-25
PT68272A (de) 1978-08-01
GB1585036A (en) 1981-02-18
BE869163A (fr) 1979-01-22
IL55150A0 (en) 1978-09-29
FR2398056A1 (fr) 1979-02-16
DE2732750A1 (de) 1979-02-08
AU519568B2 (en) 1981-12-10
ES479057A1 (es) 1979-07-01
IL55150A (en) 1982-02-28
FR2398056B1 (es) 1981-01-30
ATA523978A (de) 1983-02-15
CA1118780A (en) 1982-02-23
AU3806678A (en) 1980-01-17
ZA784134B (en) 1979-07-25
IT7850354A0 (it) 1978-07-18
GR71673B (es) 1983-06-21
SE7807975L (sv) 1979-01-21
JPS5422333A (en) 1979-02-20
ES479056A1 (es) 1979-07-01
NL7807789A (nl) 1979-01-23
HU177353B (en) 1981-09-28

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