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ES479134A1 - Un procedimiento para la preparacion de un derivado de car- boestirilo. - Google Patents

Un procedimiento para la preparacion de un derivado de car- boestirilo.

Info

Publication number
ES479134A1
ES479134A1 ES479134A ES479134A ES479134A1 ES 479134 A1 ES479134 A1 ES 479134A1 ES 479134 A ES479134 A ES 479134A ES 479134 A ES479134 A ES 479134A ES 479134 A1 ES479134 A1 ES 479134A1
Authority
ES
Spain
Prior art keywords
group
carbon atoms
integer
hydrogen atom
carbon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES479134A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of ES479134A1 publication Critical patent/ES479134A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C07D215/28—Alcohols; Ethers thereof with halogen atoms or nitro radicals in positions 5, 6 or 7

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Anesthesiology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1. Un procedimiento para la preparación de un derivado de carboestirilo, representado por la fórmula general: **(Fórmula)** en donde R1 es un átomo de hidrógeno, un grupo alquilo que tiene de 1 a 6 átomos de carbono, un grupo alquenilo que tiene de 2 a 4 átomos de carbono, un grupo alquinilo que tiene de 2 a 4 átomos de carbono o un grupo fenilalquilo que tiene un grupo alquileno de 1 a 4 átomos de carbono o un grupo fenilo; R4 es un átomo de hidrógeno, o un grupo alquilo que tiene de 1 a 4 átomos de carbono; R5 es un grupo cicloalquilo que tiene de 3 a 8 átomos de carbono, un grupo fenilo que puede tener de 1 a 3 grupos sustituyentes seleccionados del grupo formado por átomos de halógeno, grupos alquilo de 1 a 4 átomos de carbono y grupos alcoxi de 1 a 4 átomos de carbono, un grupo alquilo sustituido que tiene de 1 a 4 átomos de carbono, siendo el sustituyente un grupo hidroxilo, un grupo fenilo o un grupo alcanoiloxi de 1 a 4 átomos de carbono, un grupo alcanoilo que tiene de 1 a 4 átomosde carbono o un grupo benzoilo; R6 es un átomo de hidrógeno, un grupo hidroxi o un grupo alquilo de 1 a 4 átomos de carbono, o un grupo -OR7, donde R7 es un grupo alcanoiloxi de 1 a 4 átomos de carbono, o un grupo 3,4,5 trimetoxibenzoilo; q es un número entero de 2 ó 3; l y m son respectivamente 0 ó un número entero de 1 a 6, pero la suma de l y m no debe ser superior a 6; X es un átomo de halógeno; n es 0 o un número entero de 1 ó 2; el enlace carbono- carbono entre las posiciones 3- y 4- del esqueleto de carboestirilo es un enlace sencillo o doble.
ES479134A 1978-03-30 1979-03-30 Un procedimiento para la preparacion de un derivado de car- boestirilo. Expired ES479134A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3778378A JPS54130587A (en) 1978-03-30 1978-03-30 Carbostyryl derivative

Publications (1)

Publication Number Publication Date
ES479134A1 true ES479134A1 (es) 1980-06-16

Family

ID=12507080

Family Applications (4)

Application Number Title Priority Date Filing Date
ES479134A Expired ES479134A1 (es) 1978-03-30 1979-03-30 Un procedimiento para la preparacion de un derivado de car- boestirilo.
ES486990A Expired ES486990A1 (es) 1978-03-30 1979-12-17 Un procedimiento para la preparacion de un derivado de car- boestirilo
ES486992A Expired ES486992A1 (es) 1978-03-30 1979-12-17 Un procedimiento para la preparacion de un derivado de car- boestirilo
ES486991A Expired ES486991A1 (es) 1978-03-30 1979-12-17 Un procedimiento para la preparacion de un derivado de car- boestirilo

Family Applications After (3)

Application Number Title Priority Date Filing Date
ES486990A Expired ES486990A1 (es) 1978-03-30 1979-12-17 Un procedimiento para la preparacion de un derivado de car- boestirilo
ES486992A Expired ES486992A1 (es) 1978-03-30 1979-12-17 Un procedimiento para la preparacion de un derivado de car- boestirilo
ES486991A Expired ES486991A1 (es) 1978-03-30 1979-12-17 Un procedimiento para la preparacion de un derivado de car- boestirilo

Country Status (21)

Country Link
US (2) US4734416A (es)
JP (1) JPS54130587A (es)
AT (1) AT376432B (es)
AU (1) AU515531B2 (es)
BE (1) BE875174A (es)
CA (1) CA1117110A (es)
CH (2) CH641455A5 (es)
DE (2) DE2953723C2 (es)
DK (1) DK158225C (es)
ES (4) ES479134A1 (es)
FI (1) FI70704C (es)
FR (1) FR2421174A1 (es)
GB (1) GB2017701B (es)
IT (1) IT1119284B (es)
MX (1) MX5862E (es)
NL (1) NL183189C (es)
NO (1) NO151321C (es)
PT (1) PT69422A (es)
SE (1) SE434945B (es)
SU (2) SU1140687A3 (es)
ZA (1) ZA791516B (es)

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Also Published As

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BE875174A (fr) 1979-10-01
PT69422A (en) 1979-04-01
US4734416A (en) 1988-03-29
ES486990A1 (es) 1980-10-01
AU4548079A (en) 1979-10-04
NO151321B (no) 1984-12-10
CH641455A5 (de) 1984-02-29
SE7902794L (sv) 1979-10-01
DK128679A (da) 1979-10-26
FR2421174B1 (es) 1982-11-19
FI70704C (fi) 1986-10-06
FI70704B (fi) 1986-06-26
ES486992A1 (es) 1980-10-01
SU1232144A3 (ru) 1986-05-15
ATA235179A (de) 1984-04-15
AU515531B2 (en) 1981-04-09
ZA791516B (en) 1980-04-30
NL183189C (nl) 1988-08-16
DK158225C (da) 1990-09-17
JPS6223750B2 (es) 1987-05-25
CH641350A5 (de) 1984-02-29
NO151321C (no) 1985-03-20
GB2017701A (en) 1979-10-10
US4824840A (en) 1989-04-25
ES486991A1 (es) 1980-10-01
JPS54130587A (en) 1979-10-09
SU1140687A3 (ru) 1985-02-15
IT7967674A0 (it) 1979-03-30
DE2953723C2 (de) 1989-01-12
NL7902514A (nl) 1979-10-02
NO791049L (no) 1979-10-02
MX5862E (es) 1984-08-13
AT376432B (de) 1984-11-26
DK158225B (da) 1990-04-16
IT1119284B (it) 1986-03-10
GB2017701B (en) 1983-03-16
SE434945B (sv) 1984-08-27
FR2421174A1 (fr) 1979-10-26
FI791034A7 (fi) 1979-10-01
CA1117110A (en) 1982-01-26
DE2912105C2 (de) 1985-08-29
DE2912105A1 (de) 1979-10-11

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