ES451375A1 - 2,4-diamino-5-benzylpyrimidines - Google Patents
2,4-diamino-5-benzylpyrimidinesInfo
- Publication number
- ES451375A1 ES451375A1 ES451375A ES451375A ES451375A1 ES 451375 A1 ES451375 A1 ES 451375A1 ES 451375 A ES451375 A ES 451375A ES 451375 A ES451375 A ES 451375A ES 451375 A1 ES451375 A1 ES 451375A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- image
- benzylpyrimidines
- diamino
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- XHPZVBGIPQQTQW-UHFFFAOYSA-N 5-benzylpyrimidine-2,4-diamine Chemical class NC1=NC(N)=NC=C1CC1=CC=CC=C1 XHPZVBGIPQQTQW-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 abstract 2
- RORTUEWWZUJHTM-UHFFFAOYSA-N 3-aminoprop-2-enenitrile Chemical compound NC=CC#N RORTUEWWZUJHTM-UHFFFAOYSA-N 0.000 abstract 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002490 anilino group Chemical group [H]N(*)C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000000973 chemotherapeutic effect Effects 0.000 abstract 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
- C07D239/49—Two nitrogen atoms with an aralkyl radical, or substituted aralkyl radical, attached in position 5, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
2,4-Diamino-5-benzylpyrimidines of the formula (I) < IMAGE > in which R is an alkyl group with 1-4 carbon atoms or a halogen atom are prepared by reacting an appropriate beta -aminoacrylonitrile of the formula (V) < IMAGE > in which R' is an anilino group which is optionally substituted, or a morpholino group, with guanidine to give a compound of the formula (VI) < IMAGE > and converting the latter by elimination of the methoxymethyl radical into the compound of the formula (I). The compounds (I) can be obtained as acid addition salts and be used for chemotherapeutic purposes.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2546667A DE2546667C3 (en) | 1975-10-17 | 1975-10-17 | 2,4-DiamuH »-5- (3-methoxy-4-hydroxy-5-halobenzyl) -pyrimidines, and medicinal products containing these compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES451375A1 true ES451375A1 (en) | 1981-10-16 |
Family
ID=5959437
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES451375A Expired ES451375A1 (en) | 1975-10-17 | 1976-09-09 | 2,4-diamino-5-benzylpyrimidines |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS5251376A (en) |
| AR (1) | AR210905A1 (en) |
| AT (1) | AT352735B (en) |
| AU (1) | AU1724576A (en) |
| BE (1) | BE846397A (en) |
| CA (1) | CA1055498A (en) |
| CH (1) | CH623313A5 (en) |
| DE (1) | DE2546667C3 (en) |
| ES (1) | ES451375A1 (en) |
| FR (1) | FR2327786A1 (en) |
| GB (1) | GB1522537A (en) |
| GR (1) | GR60352B (en) |
| HU (1) | HU174155B (en) |
| IL (1) | IL50430A0 (en) |
| MX (1) | MX4485E (en) |
| NL (1) | NL7609652A (en) |
| PT (1) | PT65482B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2720771C3 (en) | 1977-05-09 | 1979-11-29 | Ludwig Heumann & Co Gmbh, 8500 Nuernberg | 2,4-Diamino-5- (33-dimethoxy-4thioalkyl-benzyD-pyrimidines, process for their preparation and pharmaceuticals containing these compounds |
| NO791699L (en) * | 1978-05-24 | 1979-11-27 | Wellcome Found | BENZYLPYRIMIDINE COMPOUNDS AND PROCEDURES FOR THEIR PREPARATION |
| HU188588B (en) * | 1982-08-13 | 1986-04-28 | Egyt Gyogyszervegyeszeti Gyar | Process for the production of 2,4-diamino-5-benzyl-pyrimidine-derivatives |
-
1975
- 1975-10-17 DE DE2546667A patent/DE2546667C3/en not_active Expired
-
1976
- 1976-07-28 CH CH962676A patent/CH623313A5/en not_active IP Right Cessation
- 1976-08-03 GR GR51404A patent/GR60352B/en unknown
- 1976-08-17 PT PT65482A patent/PT65482B/en unknown
- 1976-08-27 AU AU17245/76A patent/AU1724576A/en not_active Expired
- 1976-08-31 NL NL7609652A patent/NL7609652A/en not_active Application Discontinuation
- 1976-09-01 AT AT649276A patent/AT352735B/en not_active IP Right Cessation
- 1976-09-08 IL IL50430A patent/IL50430A0/en unknown
- 1976-09-09 ES ES451375A patent/ES451375A1/en not_active Expired
- 1976-09-16 FR FR7627872A patent/FR2327786A1/en active Granted
- 1976-09-21 BE BE170783A patent/BE846397A/en unknown
- 1976-09-22 AR AR264813A patent/AR210905A1/en active
- 1976-09-27 CA CA262,152A patent/CA1055498A/en not_active Expired
- 1976-10-01 HU HU76HE722A patent/HU174155B/en unknown
- 1976-10-01 GB GB40800/76A patent/GB1522537A/en not_active Expired
- 1976-10-01 JP JP51118916A patent/JPS5251376A/en active Pending
- 1976-10-01 MX MX764949U patent/MX4485E/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL7609652A (en) | 1977-04-19 |
| ATA649276A (en) | 1979-03-15 |
| GB1522537A (en) | 1978-08-23 |
| FR2327786B1 (en) | 1980-04-18 |
| BE846397A (en) | 1977-01-17 |
| CA1055498A (en) | 1979-05-29 |
| AT352735B (en) | 1979-10-10 |
| PT65482A (en) | 1976-09-01 |
| DE2546667B2 (en) | 1978-02-09 |
| PT65482B (en) | 1978-02-13 |
| DE2546667C3 (en) | 1978-10-12 |
| IL50430A0 (en) | 1976-11-30 |
| MX4485E (en) | 1982-05-21 |
| CH623313A5 (en) | 1981-05-29 |
| DE2546667A1 (en) | 1977-04-28 |
| JPS5251376A (en) | 1977-04-25 |
| AU1724576A (en) | 1978-03-02 |
| HU174155B (en) | 1979-11-28 |
| FR2327786A1 (en) | 1977-05-13 |
| GR60352B (en) | 1978-05-18 |
| AR210905A1 (en) | 1977-09-30 |
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