ES457563A1 - Dipeptide derivatives - Google Patents
Dipeptide derivativesInfo
- Publication number
- ES457563A1 ES457563A1 ES457563A ES457563A ES457563A1 ES 457563 A1 ES457563 A1 ES 457563A1 ES 457563 A ES457563 A ES 457563A ES 457563 A ES457563 A ES 457563A ES 457563 A1 ES457563 A1 ES 457563A1
- Authority
- ES
- Spain
- Prior art keywords
- radicals
- dipeptide derivatives
- case
- benzyl radical
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 108010016626 Dipeptides Proteins 0.000 title abstract 2
- SLRMQYXOBQWXCR-UHFFFAOYSA-N 2154-56-5 Chemical compound [CH2]C1=CC=CC=C1 SLRMQYXOBQWXCR-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 150000003254 radicals Chemical class 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- -1 cycloalkyl radicals Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Procedimiento para la obtención derivados de dipéptidos de la fórmula general I: *** en la que R1 y R2 pueden ser iguales o distintos (con la condición de que los dos radicales R1 y R2 no signigfiquen a un mismo tiemo hidrógeno), y representar hidrógeno o radicales alcohilo ocicloalcohilo con hasta 6 átomos de carbono, en cada caso, o bien el radical bencilo de carbono, en cada caso, o bien el radical bencilo, o ¿junto con el átomo de hidrógeno que sustenta estos radicales- formar un anillo heterocíclico con 5 a 7 eslabones.Procedure for obtaining dipeptide derivatives of the general formula I: *** in which R1 and R2 can be the same or different (with the condition that the two radicals R1 and R2 do not mean hydrogen at the same time), and represent hydrogen or alkyl or cycloalkyl radicals with up to 6 carbon atoms, in each case, or the carbon benzyl radical, in each case, or the benzyl radical, or together with the hydrogen atom that supports these radicals - form a ring heterocyclic with 5 to 7 links.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2615455A DE2615455C2 (en) | 1976-04-09 | 1976-04-09 | N-acyl-L-histidyl-L-proline (N-substituted) amides, processes for their preparation and pharmaceutical preparations containing these compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES457563A1 true ES457563A1 (en) | 1978-03-16 |
Family
ID=5974903
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES457563A Expired ES457563A1 (en) | 1976-04-09 | 1977-04-05 | Dipeptide derivatives |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS52125166A (en) |
| AT (1) | AT352921B (en) |
| AU (1) | AU2322677A (en) |
| BE (1) | BE853444A (en) |
| CA (1) | CA1088520A (en) |
| CH (1) | CH632737A5 (en) |
| DE (1) | DE2615455C2 (en) |
| DK (1) | DK148902C (en) |
| ES (1) | ES457563A1 (en) |
| FR (1) | FR2347338A1 (en) |
| GB (1) | GB1564078A (en) |
| IE (1) | IE44485B1 (en) |
| NL (1) | NL7703789A (en) |
| PT (1) | PT66283B (en) |
| SE (1) | SE427835B (en) |
| YU (1) | YU85977A (en) |
| ZA (1) | ZA771097B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE58849B1 (en) * | 1984-12-18 | 1993-11-17 | Gruenenthal Chemie | Use of dipeptide derivatives for the manufacture of medicaments for the treatment of patients with amyotrophic lateral sclerosis |
| DE3502041A1 (en) | 1985-01-23 | 1986-07-24 | Grünenthal GmbH, 5190 Stolberg | USE OF DIPEPTIDE DERIVATIVES FOR THE TREATMENT OF POSTTRAUMATIC NERVOUS DAMAGE |
| JPS63316724A (en) * | 1987-06-19 | 1988-12-26 | Nippon Shinyaku Co Ltd | Anticonvulsant |
| US5151497A (en) * | 1989-02-21 | 1992-09-29 | Japan Tobacco Inc. | Histidyl peptide derivatives |
| US6039956A (en) * | 1994-09-12 | 2000-03-21 | Pennsylvania, Trustees Of The University Of, The | Corticotropin release inhibiting factor and methods of using same for treating behavioral symptoms in an anxiety disorder |
| AU704838B2 (en) * | 1994-09-12 | 1999-05-06 | Trustees Of The University Of Pennsylvania, The | Corticotropin release inhibiting factor and methods of using same |
-
1976
- 1976-04-09 DE DE2615455A patent/DE2615455C2/en not_active Expired
-
1977
- 1977-02-21 AT AT113977A patent/AT352921B/en not_active IP Right Cessation
- 1977-02-23 ZA ZA00771097A patent/ZA771097B/en unknown
- 1977-03-09 PT PT66283A patent/PT66283B/en unknown
- 1977-03-15 AU AU23226/77A patent/AU2322677A/en not_active Expired
- 1977-03-15 GB GB10831/77A patent/GB1564078A/en not_active Expired
- 1977-03-16 CA CA274,078A patent/CA1088520A/en not_active Expired
- 1977-03-21 IE IE593/77A patent/IE44485B1/en unknown
- 1977-03-31 YU YU00859/77A patent/YU85977A/en unknown
- 1977-04-05 ES ES457563A patent/ES457563A1/en not_active Expired
- 1977-04-06 NL NL7703789A patent/NL7703789A/en not_active Application Discontinuation
- 1977-04-06 SE SE7704088A patent/SE427835B/en not_active IP Right Cessation
- 1977-04-06 DK DK157077A patent/DK148902C/en not_active IP Right Cessation
- 1977-04-06 CH CH437277A patent/CH632737A5/en not_active IP Right Cessation
- 1977-04-08 JP JP3962977A patent/JPS52125166A/en active Granted
- 1977-04-08 FR FR7710825A patent/FR2347338A1/en active Granted
- 1977-04-08 BE BE176590A patent/BE853444A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK148902B (en) | 1985-11-11 |
| SE7704088L (en) | 1977-10-10 |
| DK148902C (en) | 1986-06-09 |
| JPS52125166A (en) | 1977-10-20 |
| JPS6110479B2 (en) | 1986-03-29 |
| PT66283B (en) | 1978-08-09 |
| SE427835B (en) | 1983-05-09 |
| GB1564078A (en) | 1980-04-02 |
| FR2347338A1 (en) | 1977-11-04 |
| ZA771097B (en) | 1978-01-25 |
| DE2615455A1 (en) | 1977-10-20 |
| NL7703789A (en) | 1977-10-11 |
| CH632737A5 (en) | 1982-10-29 |
| AU2322677A (en) | 1978-09-21 |
| IE44485L (en) | 1977-10-09 |
| AT352921B (en) | 1979-10-10 |
| CA1088520A (en) | 1980-10-28 |
| BE853444A (en) | 1977-08-01 |
| YU85977A (en) | 1982-10-31 |
| IE44485B1 (en) | 1981-12-16 |
| PT66283A (en) | 1977-04-01 |
| DE2615455C2 (en) | 1985-06-20 |
| DK157077A (en) | 1977-10-10 |
| ATA113977A (en) | 1979-03-15 |
| FR2347338B1 (en) | 1980-07-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19990405 |