ES443935A1 - Substituted indoles and precursors therefor - Google Patents
Substituted indoles and precursors thereforInfo
- Publication number
- ES443935A1 ES443935A1 ES443935A ES443935A ES443935A1 ES 443935 A1 ES443935 A1 ES 443935A1 ES 443935 A ES443935 A ES 443935A ES 443935 A ES443935 A ES 443935A ES 443935 A1 ES443935 A1 ES 443935A1
- Authority
- ES
- Spain
- Prior art keywords
- substituted indoles
- group
- formula
- image
- precursors therefor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002475 indoles Chemical class 0.000 title abstract 3
- 239000002243 precursor Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 sulphonyl group Chemical group 0.000 abstract 2
- 125000004149 thio group Chemical group *S* 0.000 abstract 2
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Novel substituted indoles containing a thio group, of the formula I < IMAGE > or of the formula I' < IMAGE > are prepared by introducing the heterocyclic groups indicated into the corresponding amines by substitution on the nitrogen atom. In the substituted indoles of the formulae I and I', the substituents have the meaning given in Patent Claim 1 and the thio group of these compounds can be converted into the sulphonyl group or sulphinyl group by oxidation. All these novel compounds have the effect of decreasing the heart rate.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53761274A | 1974-12-30 | 1974-12-30 | |
| US63179875A | 1975-11-13 | 1975-11-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES443935A1 true ES443935A1 (en) | 1977-08-16 |
Family
ID=27065555
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES443935A Expired ES443935A1 (en) | 1974-12-30 | 1975-12-29 | Substituted indoles and precursors therefor |
Country Status (27)
| Country | Link |
|---|---|
| JP (1) | JPS51131872A (en) |
| AR (1) | AR219052A1 (en) |
| AT (1) | AT356648B (en) |
| AU (1) | AU505215B2 (en) |
| CA (1) | CA1065874A (en) |
| CH (1) | CH622516A5 (en) |
| DD (1) | DD125781A5 (en) |
| DE (1) | DE2559211A1 (en) |
| DK (1) | DK580175A (en) |
| ES (1) | ES443935A1 (en) |
| FI (1) | FI64590C (en) |
| FR (2) | FR2296413A1 (en) |
| GB (1) | GB1527510A (en) |
| HU (2) | HU174948B (en) |
| IE (1) | IE42390B1 (en) |
| IL (1) | IL48756A (en) |
| IN (1) | IN142735B (en) |
| IT (1) | IT1052654B (en) |
| NL (1) | NL7515100A (en) |
| NO (1) | NO145383C (en) |
| NZ (1) | NZ179580A (en) |
| PH (1) | PH12328A (en) |
| PL (1) | PL99353B1 (en) |
| RO (1) | RO69196A (en) |
| SE (1) | SE422210B (en) |
| SU (1) | SU667132A3 (en) |
| YU (1) | YU332275A (en) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1595056A (en) * | 1976-10-12 | 1981-08-05 | Wellcome Found | Pharmaceutical combination |
| FR2540109B1 (en) * | 1983-01-28 | 1985-08-30 | Logeais Labor Jacques | IMINO-2 PYRROLIDINES, THEIR PREPARATION PROCESS AND THEIR THERAPEUTIC APPLICATIONS |
| US4558048A (en) * | 1984-04-06 | 1985-12-10 | Pfizer Inc. | Method of treating diarrhoea using indole compounds |
| WO2001023350A1 (en) * | 1999-09-28 | 2001-04-05 | Nihon Nohyaku Co., Ltd. | Thioalkylamine derivatives and process for the preparation thereof |
| UA79504C2 (en) * | 2002-11-07 | 2007-06-25 | Organon Nv | Indols for treating diseases associated with androgen receptors |
| HRP20050396A2 (en) | 2002-11-07 | 2005-06-30 | Akzo Nobel N.V. | Indoles useful in the treatment of androgen-receptor related diseases |
| TW200602317A (en) | 2004-04-23 | 2006-01-16 | Akzo Nobel Nv | Novel androgens |
| WO2007020653A1 (en) * | 2005-08-12 | 2007-02-22 | Suven Life Sciences Limited | Thioether derivatives as functional 5-ht6 ligands |
-
1975
- 1975-12-17 IN IN2354/CAL/75A patent/IN142735B/en unknown
- 1975-12-17 NZ NZ179580A patent/NZ179580A/en unknown
- 1975-12-18 NO NO754313A patent/NO145383C/en unknown
- 1975-12-19 SE SE7514458A patent/SE422210B/en unknown
- 1975-12-19 DK DK580175A patent/DK580175A/en not_active Application Discontinuation
- 1975-12-24 CH CH1679775A patent/CH622516A5/en not_active IP Right Cessation
- 1975-12-24 NL NL7515100A patent/NL7515100A/en not_active Application Discontinuation
- 1975-12-26 JP JP50155154A patent/JPS51131872A/en active Pending
- 1975-12-29 PH PH7517930A patent/PH12328A/en unknown
- 1975-12-29 AT AT986075A patent/AT356648B/en not_active IP Right Cessation
- 1975-12-29 ES ES443935A patent/ES443935A1/en not_active Expired
- 1975-12-29 RO RO7584353A patent/RO69196A/en unknown
- 1975-12-29 FI FI753669A patent/FI64590C/en not_active IP Right Cessation
- 1975-12-29 IL IL48756A patent/IL48756A/en unknown
- 1975-12-29 DD DD190619A patent/DD125781A5/xx unknown
- 1975-12-29 YU YU03322/75A patent/YU332275A/en unknown
- 1975-12-29 CA CA242,669A patent/CA1065874A/en not_active Expired
- 1975-12-29 IT IT7552899A patent/IT1052654B/en active
- 1975-12-29 GB GB53024/75A patent/GB1527510A/en not_active Expired
- 1975-12-30 FR FR7540132A patent/FR2296413A1/en active Granted
- 1975-12-30 DE DE19752559211 patent/DE2559211A1/en not_active Ceased
- 1975-12-30 AR AR261797A patent/AR219052A1/en active
- 1975-12-30 AU AU87916/75A patent/AU505215B2/en not_active Expired
- 1975-12-30 PL PL1975186097A patent/PL99353B1/en unknown
- 1975-12-30 HU HU75ME1936A patent/HU174948B/en unknown
- 1975-12-30 IE IE2830/75A patent/IE42390B1/en unknown
- 1975-12-30 HU HU75ME2020A patent/HU174949B/en unknown
- 1975-12-30 SU SU752307502A patent/SU667132A3/en active
-
1976
- 1976-08-30 FR FR7626153A patent/FR2315921A1/en active Granted
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19980202 |