ES449069A1 - Procedure for the obtaining of 2-piperidinoalquil- (1- benzofuranos or 1,4-benzodioxanos). (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for obtaining 2-piperidinoalkyl- (1-benzofurans or 1,4-benzodioxanes) of general formula I **(See formula)** where Ph means a 1,2-phenylene residue, which is optionally substituted by 1 to 3 same or different substituents, selected from lower alkyl, hydroxy, mercapto, lower alkoxy, lower alkylenedioxy, benzyloxy, lower alkylthio, halogen, trifluoromethyl, nitro or amino, I means oxygen or sulfur, m is the integer 0 or 1 and n is 1 to 4, each of the symbols p and q represent an integer from 1 to 3, where (p + q) is the number 4, each of the symbols R1 and R2 means hydrogen, lower alkyl or HPh, R3 means hydrogen, hydroxy, lower alkoxy, lower or higher alkanoyloxy, R4 means lower alkyl, HPh-lower alkyl, HPh or naphthyl, which may be substituted as Ph, furyl, thienyl, pyridyl, benzofuryl, benzothienyl, quinolyl or isoquinolyl, the heterocyclic moieties of which are optionally substituted as Ph, the acid addition salts, especially the therapeutically usable acid addition salts of est compounds, characterized in that the compounds of general formulas III and IV are condensed where the symbol Y means a reactive esterified hydroxy group and the two symbols Z together mean the group (see formula) or Y means amino and each of the symbols Z means a reactive esterified hydroxy group, and if desired, a free compound obtained it is transformed into an acid addition salt or an acid addition salt obtained in the free compound or another acid addition salt, and/or, if desired, a mixture of isomers or racemates obtained is separated into the different isomers or racemates, and/or, if desired, the racemates obtained dissociate at the optical antipodes. (Machine-translation by Google Translate, not legally binding)