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ES435812A1 - 2-substituted thio-1,4-benzodiazepine derivatives - Google Patents

2-substituted thio-1,4-benzodiazepine derivatives

Info

Publication number
ES435812A1
ES435812A1 ES435812A ES435812A ES435812A1 ES 435812 A1 ES435812 A1 ES 435812A1 ES 435812 A ES435812 A ES 435812A ES 435812 A ES435812 A ES 435812A ES 435812 A1 ES435812 A1 ES 435812A1
Authority
ES
Spain
Prior art keywords
alcoholic
benzodiazepine
group
hydrogen atom
individually represent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES435812A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of ES435812A1 publication Critical patent/ES435812A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/22—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

A process for preparing a thio-1,4-benzodiazepine derivative substituted in position 2 of the general formula (III) ** formula ** wherein R1 and R2 individually represent a hydrogen atom or a halogen atom or a grouponitre, amino, cyano, alcohol, haloalhohyl, alkoxy, alcoholylthio, alkanesulfinyl, alkanesulfenyl, alkylamino, or dialkoxylamino, R3 represents an alcoholic group and R4 and R5 individually represent a hydrogen atom or an alcoholic group and when R4 and R5 are both alcoholic groups, said alcohol groups may together form a ring with or without an oxygen atom or an imino group, said ring optionally having a substituent or substituents and its pharmaceutically acceptable non-toxic salt, comprising reacting a 1,4-benzodiazepine-2 derivative -tiona (Machine-translation by Google Translate, not legally binding)
ES435812A 1974-03-20 1975-03-20 2-substituted thio-1,4-benzodiazepine derivatives Expired ES435812A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP49031905A JPS5919099B2 (en) 1974-03-20 1974-03-20 Method for producing 2-substituted thio-1,4-benzodiazepine derivatives

Publications (1)

Publication Number Publication Date
ES435812A1 true ES435812A1 (en) 1976-12-01

Family

ID=12344003

Family Applications (1)

Application Number Title Priority Date Filing Date
ES435812A Expired ES435812A1 (en) 1974-03-20 1975-03-20 2-substituted thio-1,4-benzodiazepine derivatives

Country Status (15)

Country Link
JP (1) JPS5919099B2 (en)
AU (1) AU7929875A (en)
BE (1) BE826817A (en)
CA (1) CA1064029A (en)
DE (1) DE2511898A1 (en)
DK (1) DK114175A (en)
ES (1) ES435812A1 (en)
FI (1) FI750816A7 (en)
FR (1) FR2264545B1 (en)
GB (1) GB1467763A (en)
HU (1) HU170141B (en)
NL (1) NL7503269A (en)
NO (1) NO750943L (en)
SE (1) SE7503164L (en)
ZA (1) ZA751715B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4094870A (en) * 1974-03-20 1978-06-13 Fujisawa Pharmaceutical Co., Ltd. 2-Substituted thio-1,4-benzodiazepine derivatives
HU224435B1 (en) * 1995-02-09 2005-10-28 EGIS Gyógyszergyár Rt. Benzodiazepine derivatives, process for producing them, their use and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
HU170141B (en) 1977-04-28
CA1064029A (en) 1979-10-09
AU7929875A (en) 1976-09-23
DE2511898A1 (en) 1975-09-25
SE7503164L (en) 1975-09-22
BE826817A (en) 1975-09-18
NO750943L (en) 1975-09-23
FI750816A7 (en) 1975-09-21
NL7503269A (en) 1975-09-23
JPS5919099B2 (en) 1984-05-02
ZA751715B (en) 1976-02-25
JPS50131980A (en) 1975-10-18
FR2264545A1 (en) 1975-10-17
FR2264545B1 (en) 1978-08-04
GB1467763A (en) 1977-03-23
DK114175A (en) 1975-09-21

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