ES426427A1 - A PROCEDURE FOR THE PREPARATION OF NEW DENITROCARBOSTIRILE DERIVATIVES. - Google Patents
A PROCEDURE FOR THE PREPARATION OF NEW DENITROCARBOSTIRILE DERIVATIVES.Info
- Publication number
- ES426427A1 ES426427A1 ES426427A ES426427A ES426427A1 ES 426427 A1 ES426427 A1 ES 426427A1 ES 426427 A ES426427 A ES 426427A ES 426427 A ES426427 A ES 426427A ES 426427 A1 ES426427 A1 ES 426427A1
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- formula
- nitro
- derivatives
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- -1 aralkoxy Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 238000006396 nitration reaction Methods 0.000 abstract 1
- 150000002828 nitro derivatives Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/10—Aza-phenanthrenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A procedure for the preparation of new nitrocarboestyril derivatives of formula (I) or a pharmaceutically acceptable salt thereof: **(See formula)** where R1, R2, R3 and R4 represent hydrogen or an alkyl, alkoxy, aryloxy, aralkoxy, aryl, aralkyl, heterocyclic, hydroxy, nitro or halogen group or any two of the R1, R2, R3 and R4 groups together with the atoms of carbon to which they are attached complete a carbocyclic ring, substituted or unsubstituted, and R5 represents hydrogen or an alkyl, aryl or aralkyl group, provided that: a) R1, R2, R3, R4 and R5 are not all hydrogen; b) R2 is not a nitro group when R1, R3, R4 and R5 are all hydrogen and e) R2 and R4 are not both a nitro group when R1, R3 and R5 are all hydrogen, whose process comprises the nitration of a compound of formula (II) **(See formula)** where R1, R2, R3, R4 and R5 are those defined by referring to formula (I) and, if desired, salification of the resulting nitro compound. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2400073A GB1453863A (en) | 1973-05-19 | 1973-05-19 | Pharmaceutical compositions comprising nitrocarbostyrils for the treatment of allergic and immunological hypersensitivity |
| GB2431773 | 1973-05-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES426427A1 true ES426427A1 (en) | 1976-09-16 |
Family
ID=26256830
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES426427A Expired ES426427A1 (en) | 1973-05-19 | 1974-05-17 | A PROCEDURE FOR THE PREPARATION OF NEW DENITROCARBOSTIRILE DERIVATIVES. |
Country Status (21)
| Country | Link |
|---|---|
| JP (1) | JPS5030884A (en) |
| AR (1) | AR201506A1 (en) |
| AT (1) | AT334373B (en) |
| CA (1) | CA1030539A (en) |
| CH (1) | CH601243A5 (en) |
| DD (1) | DD112126A5 (en) |
| DE (1) | DE2424076A1 (en) |
| DK (1) | DK137043B (en) |
| ES (1) | ES426427A1 (en) |
| FI (1) | FI153174A7 (en) |
| FR (1) | FR2229414B1 (en) |
| GB (1) | GB1453863A (en) |
| HU (1) | HU168001B (en) |
| IE (1) | IE39269B1 (en) |
| IL (1) | IL44849A (en) |
| IN (1) | IN139603B (en) |
| NL (1) | NL7406711A (en) |
| PH (1) | PH10621A (en) |
| SE (1) | SE7406631L (en) |
| SU (1) | SU578869A3 (en) |
| ZM (1) | ZM7974A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4065457A (en) * | 1973-05-19 | 1977-12-27 | Beecham Group Limited | 4-Hydroxy-3-nitro-carbostyril compounds |
| US4192876A (en) * | 1975-07-23 | 1980-03-11 | Sandoz, Inc. | 4-Hydroxy-3-nitro-quinoline-2(1H)-ones |
| DE2631317A1 (en) * | 1975-07-23 | 1977-02-17 | Sandoz Ag | ORGANIC COMPOUNDS, THEIR USE AND MANUFACTURING |
| JPS5919095B2 (en) * | 1977-06-22 | 1984-05-02 | 大塚製薬株式会社 | Quinoline derivatives and their production method |
| JPH0681744B2 (en) * | 1986-10-06 | 1994-10-19 | 三菱化成株式会社 | Method for producing 2,4-dioxyquinoline derivative |
| US5622965A (en) * | 1993-03-12 | 1997-04-22 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon, Eugene Oregon | 4-hydroxy-3-nitro-1,2-dihydroquinolin-2-ones and the use thereof as excitatory amino acid and glycine receptor antagonists |
-
1973
- 1973-05-19 GB GB2400073A patent/GB1453863A/en not_active Expired
-
1974
- 1974-05-15 IE IE1039/74A patent/IE39269B1/en unknown
- 1974-05-17 DK DK273074AA patent/DK137043B/en unknown
- 1974-05-17 IL IL44849A patent/IL44849A/en unknown
- 1974-05-17 DE DE2424076A patent/DE2424076A1/en active Pending
- 1974-05-17 NL NL7406711A patent/NL7406711A/xx not_active Application Discontinuation
- 1974-05-17 FI FI1531/74A patent/FI153174A7/fi unknown
- 1974-05-17 FR FR7417170A patent/FR2229414B1/fr not_active Expired
- 1974-05-17 SE SE7406631A patent/SE7406631L/xx unknown
- 1974-05-17 ES ES426427A patent/ES426427A1/en not_active Expired
- 1974-05-17 CA CA200,335A patent/CA1030539A/en not_active Expired
- 1974-05-17 AT AT409674A patent/AT334373B/en not_active IP Right Cessation
- 1974-05-17 SU SU7402031653A patent/SU578869A3/en active
- 1974-05-17 HU HUBE1198A patent/HU168001B/hu unknown
- 1974-05-17 CH CH683674A patent/CH601243A5/xx not_active IP Right Cessation
- 1974-05-20 JP JP49056448A patent/JPS5030884A/ja active Pending
- 1974-05-20 PH PH15854A patent/PH10621A/en unknown
- 1974-05-20 DD DD178631A patent/DD112126A5/xx unknown
- 1974-05-20 ZM ZM79/74A patent/ZM7974A1/en unknown
- 1974-05-20 AR AR253837A patent/AR201506A1/en active
- 1974-06-18 IN IN1344/CAL/74A patent/IN139603B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE39269L (en) | 1974-11-19 |
| DE2424076A1 (en) | 1974-12-05 |
| SU578869A3 (en) | 1977-10-30 |
| ZM7974A1 (en) | 1974-12-20 |
| ATA409674A (en) | 1976-05-15 |
| DK137043B (en) | 1978-01-09 |
| IL44849A0 (en) | 1974-07-31 |
| IL44849A (en) | 1978-04-30 |
| JPS5030884A (en) | 1975-03-27 |
| DD112126A5 (en) | 1975-03-20 |
| AU6915874A (en) | 1975-11-20 |
| AT334373B (en) | 1976-01-10 |
| IE39269B1 (en) | 1978-08-30 |
| AR201506A1 (en) | 1975-03-21 |
| CA1030539A (en) | 1978-05-02 |
| PH10621A (en) | 1977-07-19 |
| FR2229414B1 (en) | 1977-11-10 |
| FI153174A7 (en) | 1974-11-20 |
| SE7406631L (en) | 1974-11-20 |
| HU168001B (en) | 1976-02-28 |
| FR2229414A1 (en) | 1974-12-13 |
| IN139603B (en) | 1976-07-10 |
| DK137043C (en) | 1978-06-05 |
| CH601243A5 (en) | 1978-06-30 |
| NL7406711A (en) | 1974-11-21 |
| GB1453863A (en) | 1976-10-27 |
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