ES414415A1 - Procedure for preparation of benzodiazepine derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for preparation of benzodiazepine derivatives. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES414415A1 ES414415A1 ES414415A ES414415A ES414415A1 ES 414415 A1 ES414415 A1 ES 414415A1 ES 414415 A ES414415 A ES 414415A ES 414415 A ES414415 A ES 414415A ES 414415 A1 ES414415 A1 ES 414415A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- hydrogen
- lower alcohol
- alcohol
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 title abstract 2
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- -1 nitro, amino Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 125000003158 alcohol group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 108010007979 Glycocholic Acid Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- HGCIXCUEYOPUTN-UHFFFAOYSA-N cis-cyclohexene Natural products C1CCC=CC1 HGCIXCUEYOPUTN-UHFFFAOYSA-N 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 230000002140 halogenating effect Effects 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Landscapes
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Preparation procedure for benzodiazepine derivatives of formula: **(See formula)** wherein R1 represents Hydrogen or a hydroxy, lower alcohol, lower alkoxy, lower alkoxy-carbonyl or acyloxy group; and which may be identical or different, each represents a hydrogen or halogen atom, or a lower alcohol, lower alkoxy, trifluoromethyl, nitro, amino, mono- or di-lower alcohol-amino, lower alkanoyl-thio group, lower alcohol sulphonyl, lower alcohol-sulfinyl, carboxy, lower acyloxy-carbonyl, lower acyloxy, cyano or carbamyl; R4- represents a phenyl radical optionally substituted by at least one halogen atom or a lower alcohol group, a cyclohexane radical optionally substituted by at least one alcohol group, or a cyclohexene radical and R5 is a hydrogen or halogen atom; its N-oxides and its addition salts with acids, characterized in that ethyl glycocholate is reacted with a compound of the formula: **(See formula)** thus obtaining a compound of the formula: **(See formula)** which is cyclized by the action of heat, which provides a derivative of formula (I) in which R5 is hydrogen and, if desired, the latter derivative is reacted with a halogenating agent to obtain the derivative of formula (I) where R5 is a halogen. (Machine-translation by Google Translate, not legally binding)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES414415A ES414415A1 (en) | 1973-05-04 | 1973-05-04 | Procedure for preparation of benzodiazepine derivatives. (Machine-translation by Google Translate, not legally binding) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES414415A ES414415A1 (en) | 1973-05-04 | 1973-05-04 | Procedure for preparation of benzodiazepine derivatives. (Machine-translation by Google Translate, not legally binding) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES414415A1 true ES414415A1 (en) | 1976-02-01 |
Family
ID=8464049
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES414415A Expired ES414415A1 (en) | 1973-05-04 | 1973-05-04 | Procedure for preparation of benzodiazepine derivatives. (Machine-translation by Google Translate, not legally binding) |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES414415A1 (en) |
-
1973
- 1973-05-04 ES ES414415A patent/ES414415A1/en not_active Expired
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