ES406044A1 - 17-hydroxy-7-/lower alkoxy/carbonyl-3-oxo-17alpha-pregn-4-ene-21- carboxylic acid ypsilon-lactones and congeners - Google Patents
17-hydroxy-7-/lower alkoxy/carbonyl-3-oxo-17alpha-pregn-4-ene-21- carboxylic acid ypsilon-lactones and congenersInfo
- Publication number
- ES406044A1 ES406044A1 ES406044A ES406044A ES406044A1 ES 406044 A1 ES406044 A1 ES 406044A1 ES 406044 A ES406044 A ES 406044A ES 406044 A ES406044 A ES 406044A ES 406044 A1 ES406044 A1 ES 406044A1
- Authority
- ES
- Spain
- Prior art keywords
- hydroxy
- oxo
- carbonyl
- pregn
- lactones
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000003545 alkoxy group Chemical group 0.000 title 1
- 239000000039 congener Substances 0.000 title 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000001340 alkali metals Chemical class 0.000 abstract 2
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 2
- 150000001342 alkaline earth metals Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- -1 alkali metal alkoxide Chemical class 0.000 abstract 1
- 150000003863 ammonium salts Chemical class 0.000 abstract 1
- 125000000457 gamma-lactone group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 238000002955 isolation Methods 0.000 abstract 1
- 150000002596 lactones Chemical class 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/001—Lactones
- C07J21/003—Lactones at position 17
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Procedure for obtaining γ -lactones of 17-hydroxy-7- (lower alkyl) carbonyl-3-oxo-17α-pregn-4-ene-2l-carboxylic acids, of general formula: **(See formula)** and the corresponding compounds in which lactone is in the form of the corresponding 17-hydroxy-21-carboxylic acids and the alkali metal, alkaline earth metal/2 and ammonium salts of 17-hydroxy-21-carboxylic acids ; wherein Z is selected from the group consisting of hydrogen, alkali metal, alkaline earth metal/2, ammonium, and alkyl; the dotted line indicates that bond Δ 1 is selected from the group consisting of saturated and unsaturated bonds; the wavy line indicates that the configuration at position -7 is selected from the α and β configurations; characterized in that 4α, 7α-carbonyl-5-cyano-17-hydroxy-3-oxo-5β, 17α-pregnano-21-carboxylic acid-lactone is contacted with an alkali metal alkoxide metal, to provide a mixture of the corresponding 7α and 7β compounds of formula (Ia) in which Z is alkyl and the 1,2 bond is saturated, followed by isolation of the desired isomer. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17492271A | 1971-08-25 | 1971-08-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES406044A1 true ES406044A1 (en) | 1976-01-16 |
Family
ID=22638078
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES406044A Expired ES406044A1 (en) | 1971-08-25 | 1972-08-23 | 17-hydroxy-7-/lower alkoxy/carbonyl-3-oxo-17alpha-pregn-4-ene-21- carboxylic acid ypsilon-lactones and congeners |
| ES435189A Expired ES435189A1 (en) | 1971-08-25 | 1975-02-28 | 17-hydroxy-7-/lower alkoxy/carbonyl-3-oxo-17alpha-pregn-4-ene-21- carboxylic acid ypsilon-lactones and congeners |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES435189A Expired ES435189A1 (en) | 1971-08-25 | 1975-02-28 | 17-hydroxy-7-/lower alkoxy/carbonyl-3-oxo-17alpha-pregn-4-ene-21- carboxylic acid ypsilon-lactones and congeners |
Country Status (21)
| Country | Link |
|---|---|
| JP (2) | JPS5839840B2 (en) |
| AT (1) | AT323907B (en) |
| AU (1) | AU475957B2 (en) |
| BE (1) | BE787940A (en) |
| CA (1) | CA970361A (en) |
| CH (2) | CH601350A5 (en) |
| DE (1) | DE2241680C2 (en) |
| DK (1) | DK133954B (en) |
| ES (2) | ES406044A1 (en) |
| FI (1) | FI50429C (en) |
| FR (1) | FR2150852B1 (en) |
| GB (1) | GB1368005A (en) |
| IE (1) | IE36653B1 (en) |
| IL (1) | IL40197A (en) |
| KE (1) | KE2813A (en) |
| MY (1) | MY7800121A (en) |
| NL (1) | NL176569C (en) |
| NO (1) | NO134990C (en) |
| PH (1) | PH9271A (en) |
| SE (2) | SE380533B (en) |
| ZA (1) | ZA725839B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4069219A (en) * | 1976-12-27 | 1978-01-17 | G. D. Searle & Co. | 7ξ-(Alkoxycarbonyl)-6ξ-alkyl/halo-17-hydroxy-3-oxo-17α-pregn-4-ene-21-carboxylic acid γ-lactones and corresponding 21-carboxylic acids, their salts, and esters |
| FR2496669A1 (en) * | 1980-12-23 | 1982-06-25 | Roussel Uclaf | NOVEL STEROID 3-KETO4 OR 1-4 SUBSTITUTED DERIVATIVES IN POSITION 7, PROCESS FOR PREPARING THEM AND THEIR APPLICATION AS MEDICAMENTS |
| DE3111951A1 (en) * | 1981-03-23 | 1982-09-30 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | 7 (ALPHA) -ALKOXYCARBONYL-15SS-METHYLENE-4-ANDROSTENE, METHOD FOR THE PRODUCTION AND USE THEREOF AS A MEDICINAL PRODUCT |
| JPS57169230A (en) * | 1981-04-10 | 1982-10-18 | Matsushita Electric Industrial Co Ltd | Oil-immersed plastic ilm capacitor |
| US5296318A (en) * | 1993-03-05 | 1994-03-22 | Bell Communications Research, Inc. | Rechargeable lithium intercalation battery with hybrid polymeric electrolyte |
| MX2007002846A (en) * | 2004-09-09 | 2007-04-30 | Pharmacia Corp | Process for preparing 7 -alkoxycarbonyl substituted steroids. |
-
0
- BE BE787940D patent/BE787940A/en not_active IP Right Cessation
-
1972
- 1972-08-21 AU AU45787/72A patent/AU475957B2/en not_active Expired
- 1972-08-23 ES ES406044A patent/ES406044A1/en not_active Expired
- 1972-08-24 NO NO3032/72A patent/NO134990C/no unknown
- 1972-08-24 DK DK420472AA patent/DK133954B/en not_active IP Right Cessation
- 1972-08-24 NL NLAANVRAGE7211559,A patent/NL176569C/en not_active IP Right Cessation
- 1972-08-24 GB GB3940172A patent/GB1368005A/en not_active Expired
- 1972-08-24 PH PH13830*UA patent/PH9271A/en unknown
- 1972-08-24 DE DE2241680A patent/DE2241680C2/en not_active Expired
- 1972-08-24 IE IE1160/72A patent/IE36653B1/en unknown
- 1972-08-24 ZA ZA725839A patent/ZA725839B/en unknown
- 1972-08-24 AT AT733172A patent/AT323907B/en not_active IP Right Cessation
- 1972-08-24 CA CA150,118A patent/CA970361A/en not_active Expired
- 1972-08-24 SE SE7210976A patent/SE380533B/en unknown
- 1972-08-24 FI FI722353A patent/FI50429C/en active
- 1972-08-24 FR FR7230235A patent/FR2150852B1/fr not_active Expired
- 1972-08-24 IL IL40197A patent/IL40197A/en unknown
- 1972-08-25 JP JP47085217A patent/JPS5839840B2/en not_active Expired
- 1972-08-25 CH CH1262572A patent/CH601350A5/xx not_active IP Right Cessation
-
1974
- 1974-12-04 SE SE7415187A patent/SE404024B/en unknown
-
1975
- 1975-02-28 ES ES435189A patent/ES435189A1/en not_active Expired
-
1977
- 1977-03-25 CH CH383477A patent/CH603689A5/xx not_active IP Right Cessation
-
1978
- 1978-01-19 KE KE2813A patent/KE2813A/en unknown
- 1978-12-30 MY MY121/78A patent/MY7800121A/en unknown
-
1982
- 1982-10-29 JP JP57190666A patent/JPS5890598A/en active Granted
Also Published As
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