ES359830A1 - Procedure for the obtaining of sulfonilureas. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the obtaining of sulfonilureas. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES359830A1 ES359830A1 ES359830A ES359830A ES359830A1 ES 359830 A1 ES359830 A1 ES 359830A1 ES 359830 A ES359830 A ES 359830A ES 359830 A ES359830 A ES 359830A ES 359830 A1 ES359830 A1 ES 359830A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- radicals
- radical
- hydrogen
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 4
- -1 alkyl radicals Chemical class 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 229940100389 Sulfonylurea Drugs 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000004421 aryl sulphonamide group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
- 150000001602 bicycloalkyls Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 238000010494 dissociation reaction Methods 0.000 abstract 1
- 230000005593 dissociations Effects 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 239000012948 isocyanate Substances 0.000 abstract 1
- 150000002513 isocyanates Chemical class 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000005359 phenoxyalkyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229940124530 sulfonamide Drugs 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Process for the preparation of sulfonylureas containing heterocyclic acylamino radicals, characterized in that arylsulfonamides of the general formula ** (see formula) ** Wherein r, means hydrogen or an alkyl moiety, r'and r "signify hydrogen, halogen atoms, alkyl radicals or aryl, aralkyl or cycloalkyl radicals, optionally substituted by halogen, alkyl, alkoxy or trifluoroethyl radicals, and further x means an oxygen atom, a sulfur atom, a nitrogen atom substituted by hydrogen, an alkyl radical, an aryl or aralkyl radical, optionally substituted by halogen, alkyl, alkoxy or trifluoromethyl radicals, y means a direct bond, a straight or branched alkylene radical having 1 to 8 carbon atoms and n represents a number of 0 to 4, the substituents on the benzene ring are ortho or meta, preferably, however, in the para position, as such or in the form of their alkali metal salts are reacted with an amine derivative of general formula b co nr'''r'''', wherein r''' and r " mean hydrogen, alkyl, hydroxyalkyl, alkoxyalqu ilo, phenoxyalkyl, cycloalkyl, cycloalkylalkyl, bicycloalkyl, bicycloalkylalkyl, triecycloalkyl, tricycloalkyl, alkyl, tetracycloalkyl, tetracycloalkalkyl, optionally alkyl-substituted, aryl or aralkyl radicals, optionally substituted by halogen, alkyl, alkoxy or trifluoroethyl radicals, or also, together with the nitrogen atom bonded thereto, a monocyclic or polycyclic radical, containing one or more heteroatoms, optionally substituted by alkyl radicals, or, if r'''denotes hydrogen, with an isocyanate o = c = N-r "''', where b denotes a radical which in the course of the reaction reacts with a hydrogen atom of the sulphonamide radical or the N-alkaline atom of the corresponding alkaline sulfonanidic salt by dissociation of hb or nb, meaning here b, for example, halogen, an azido, alkoxy, aryloxy, alkylmercapto, arylmercapto, amino, cyclic amino or acylamino radical, optionally substituted. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19671670945 DE1670945C3 (en) | 1967-11-02 | 1967-11-02 | Arylsulfonylureas, process for their preparation and oral anti-diabetic drug |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES359830A1 true ES359830A1 (en) | 1970-06-16 |
Family
ID=5686349
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES359830A Expired ES359830A1 (en) | 1967-11-02 | 1968-11-02 | Procedure for the obtaining of sulfonilureas. (Machine-translation by Google Translate, not legally binding) |
| ES363815A Expired ES363815A1 (en) | 1967-11-02 | 1969-02-19 | Procedure for the obtaining of sulfonilureas. (Machine-translation by Google Translate, not legally binding) |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES363815A Expired ES363815A1 (en) | 1967-11-02 | 1969-02-19 | Procedure for the obtaining of sulfonilureas. (Machine-translation by Google Translate, not legally binding) |
Country Status (10)
| Country | Link |
|---|---|
| AT (1) | AT287733B (en) |
| BR (1) | BR6803649D0 (en) |
| CA (1) | CA932728A (en) |
| CS (2) | CS158230B2 (en) |
| ES (2) | ES359830A1 (en) |
| FI (1) | FI50414C (en) |
| IE (1) | IE32534B1 (en) |
| IL (1) | IL30928A (en) |
| NO (1) | NO128111B (en) |
| YU (1) | YU33288B (en) |
-
1968
- 1968-10-22 IL IL6830928A patent/IL30928A/en unknown
- 1968-10-29 CA CA033815A patent/CA932728A/en not_active Expired
- 1968-10-30 YU YU253868A patent/YU33288B/en unknown
- 1968-10-30 IE IE130468A patent/IE32534B1/en unknown
- 1968-10-31 BR BR20364968A patent/BR6803649D0/en unknown
- 1968-11-01 NO NO434268A patent/NO128111B/no unknown
- 1968-11-01 CS CS100873A patent/CS158230B2/cs unknown
- 1968-11-01 CS CS747168A patent/CS158229B2/cs unknown
- 1968-11-02 ES ES359830A patent/ES359830A1/en not_active Expired
- 1968-11-04 FI FI314568A patent/FI50414C/en active
- 1968-11-04 AT AT1069368A patent/AT287733B/en not_active IP Right Cessation
-
1969
- 1969-02-19 ES ES363815A patent/ES363815A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FI50414B (en) | 1975-12-01 |
| NO128111B (en) | 1973-10-01 |
| IL30928A0 (en) | 1968-12-26 |
| IE32534L (en) | 1969-05-02 |
| ES363815A1 (en) | 1970-12-16 |
| CS158229B2 (en) | 1974-10-15 |
| YU253868A (en) | 1976-03-31 |
| CA932728A (en) | 1973-08-28 |
| IE32534B1 (en) | 1973-09-05 |
| CS158230B2 (en) | 1974-10-15 |
| IL30928A (en) | 1972-12-29 |
| BR6803649D0 (en) | 1973-02-13 |
| FI50414C (en) | 1976-03-10 |
| AT287733B (en) | 1971-02-10 |
| YU33288B (en) | 1976-08-31 |
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