ES285846A1 - Procedure for the obtaining of new derivatives of antranilic acid (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the obtaining of new derivatives of antranilic acid (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES285846A1 ES285846A1 ES285846A ES285846A ES285846A1 ES 285846 A1 ES285846 A1 ES 285846A1 ES 285846 A ES285846 A ES 285846A ES 285846 A ES285846 A ES 285846A ES 285846 A1 ES285846 A1 ES 285846A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- free
- compounds
- acid
- salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical class NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 150000001408 amides Chemical class 0.000 abstract 3
- 150000002148 esters Chemical class 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 239000005711 Benzoic acid Substances 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- 125000000565 sulfonamide group Chemical group 0.000 abstract 2
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- -1 amino, mercapto groups Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
"Process for obtaining new derivatives of the antralitic acid" of the general formula R1 is an amino group substituted by aliphatic hydrocarbon radicals, which may also be substituted by hetero atoms, such as oxygen, nitrogen or sulfur atoms and/or substituted by functional groups, such as oxy, amino, mercapto groups or halogen atoms, R 2 means a phenylaminic group, its esters and amides and, if appropriate, the salts of these compounds, characterized in that a 2-X-5- (R 1) acid -sulfonyl) -benzoic acid, corresponding where R1 has the indicated meaning and X is a dissociable moiety or an ester or an amide thereof, is reacted with a corresponding phenylamine, or in a 1-Y-2-R2-5- ( R 1 -sulfonyl) -benzole, where R 1 and R 2 have the indicated meanings and Y is a moiety that can be transformed into a free, esterified or amidized carboxyl group, and is converted into a free, esterified or amidated carboxylic group, or a 2-R2-5-Z-benzoic acid corresponding, where R2 have the indicated meaning and Z means a residue that allows the formation of a N, N-bisubstituted sulfonamide group, or esters or amides thereof, the sulfonamide group N is formed , N-bituted and, if desired, substituents are introduced into the obtained compounds, modified or dissociated and/or the optionally obtained salts are converted into the free compounds or the free compounds into their salts. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH285262A CH433378A (en) | 1962-03-09 | 1962-03-09 | Process for the production of new anthranilic acid derivatives |
| CH660362A CH452542A (en) | 1962-03-09 | 1962-05-30 | Process for the production of new anthranilic acid derivatives |
| CH66363 | 1963-01-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES285846A1 true ES285846A1 (en) | 1963-10-16 |
Family
ID=27172288
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES285846A Expired ES285846A1 (en) | 1962-03-09 | 1963-03-08 | Procedure for the obtaining of new derivatives of antranilic acid (Machine-translation by Google Translate, not legally binding) |
Country Status (4)
| Country | Link |
|---|---|
| DE (1) | DE1493513C3 (en) |
| ES (1) | ES285846A1 (en) |
| FR (1) | FR2598M (en) |
| GB (1) | GB997176A (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH590260A5 (en) * | 1973-07-10 | 1977-07-29 | Ciba Geigy Ag | |
| US5470882A (en) * | 1994-06-02 | 1995-11-28 | Smithkline Beecham Corp. | Anti-inflammatory compounds |
| US5545669A (en) * | 1994-06-02 | 1996-08-13 | Adams; Jerry L. | Anti-inflammatory compounds |
-
1963
- 1963-03-02 DE DE1493513A patent/DE1493513C3/en not_active Expired
- 1963-03-08 ES ES285846A patent/ES285846A1/en not_active Expired
- 1963-03-11 GB GB9620/63A patent/GB997176A/en not_active Expired
- 1963-05-24 FR FR935806A patent/FR2598M/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE1493513A1 (en) | 1969-05-14 |
| FR2598M (en) | 1964-06-15 |
| DE1493513B2 (en) | 1975-01-30 |
| GB997176A (en) | 1965-07-07 |
| DE1493513C3 (en) | 1975-09-11 |
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