ES2853350A1 - METHOD FOR THE PREPARATION OF THERAPEUTIC VACCINES BY WARMING AUTOLOGOUS BLOOD SERUM (Machine-translation by Google Translate, not legally binding) - Google Patents
METHOD FOR THE PREPARATION OF THERAPEUTIC VACCINES BY WARMING AUTOLOGOUS BLOOD SERUM (Machine-translation by Google Translate, not legally binding) Download PDFInfo
- Publication number
- ES2853350A1 ES2853350A1 ES202000028A ES202000028A ES2853350A1 ES 2853350 A1 ES2853350 A1 ES 2853350A1 ES 202000028 A ES202000028 A ES 202000028A ES 202000028 A ES202000028 A ES 202000028A ES 2853350 A1 ES2853350 A1 ES 2853350A1
- Authority
- ES
- Spain
- Prior art keywords
- serum
- heating
- tray
- blood serum
- containers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 210000002966 serum Anatomy 0.000 title claims abstract description 56
- 238000000034 method Methods 0.000 title claims abstract description 19
- 229940021747 therapeutic vaccine Drugs 0.000 title claims abstract description 8
- 238000002360 preparation method Methods 0.000 title claims description 6
- 238000010438 heat treatment Methods 0.000 claims abstract description 26
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 16
- 244000052769 pathogen Species 0.000 claims abstract description 16
- 201000011510 cancer Diseases 0.000 claims abstract description 11
- 230000009471 action Effects 0.000 claims abstract description 6
- 230000006378 damage Effects 0.000 claims abstract description 4
- 230000028993 immune response Effects 0.000 claims abstract 3
- 238000013019 agitation Methods 0.000 claims description 10
- 230000008569 process Effects 0.000 claims description 6
- 241001465754 Metazoa Species 0.000 claims description 2
- 230000005540 biological transmission Effects 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 230000002779 inactivation Effects 0.000 abstract description 5
- 238000003756 stirring Methods 0.000 abstract description 3
- 230000007850 degeneration Effects 0.000 abstract description 2
- 238000011161 development Methods 0.000 abstract description 2
- 244000000010 microbial pathogen Species 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 description 11
- 229960005486 vaccine Drugs 0.000 description 8
- 210000000987 immune system Anatomy 0.000 description 5
- 239000000427 antigen Substances 0.000 description 4
- 102000036639 antigens Human genes 0.000 description 4
- 108091007433 antigens Proteins 0.000 description 4
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000001717 pathogenic effect Effects 0.000 description 3
- 230000003449 preventive effect Effects 0.000 description 3
- 230000036425 denaturation Effects 0.000 description 2
- 238000004925 denaturation Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000007614 genetic variation Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 206010070834 Sensitisation Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 229940037642 autologous vaccine Drugs 0.000 description 1
- 238000001574 biopsy Methods 0.000 description 1
- 238000009529 body temperature measurement Methods 0.000 description 1
- 231100000357 carcinogen Toxicity 0.000 description 1
- 239000003183 carcinogenic agent Substances 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 230000000899 immune system response Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/16—Blood plasma; Blood serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
- H05B6/00—Heating by electric, magnetic or electromagnetic fields
- H05B6/64—Heating using microwaves
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05B—ELECTRIC HEATING; ELECTRIC LIGHT SOURCES NOT OTHERWISE PROVIDED FOR; CIRCUIT ARRANGEMENTS FOR ELECTRIC LIGHT SOURCES, IN GENERAL
- H05B6/00—Heating by electric, magnetic or electromagnetic fields
- H05B6/64—Heating using microwaves
- H05B6/78—Arrangements for continuous movement of material
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Electromagnetism (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Zoology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
DESCRIPCIÓNDESCRIPTION
Método para la elaboración de vacunas terapéuticas mediante el calentamiento de suero sanguíneo autólogoMethod for the development of therapeutic vaccines by heating autologous blood serum
Objeto de la invenciónObject of the invention
La presente invención se refiere a un método para la elaboración de vacunas terapéuticas mediante el calentamiento de suero sanguíneo autólogo, extraído del propio enfermo, basado en la atenuación, modificación o inactivación de agentes patógenos y/o cancerígenos presentes en el suero, que se produce durante el calentamiento de dicho suero, que una vez administrado al paciente, deja al sistema inmunitario en condiciones de efectuar una respuesta rápida y correcta, mediante la creación de anticuerpos específicos, para la eliminación del resto de elementos patógenos que se encuentran en el cuerpo del sujeto enfermo y que son iguales o similares a los que se han inactivado en el suero calentado.The present invention refers to a method for the preparation of therapeutic vaccines by heating autologous blood serum, extracted from the patient himself, based on the attenuation, modification or inactivation of pathogens and / or carcinogens present in the serum, which is produced During the heating of said serum, which once administered to the patient, leaves the immune system in a position to carry out a rapid and correct response, through the creation of specific antibodies, for the elimination of the rest of the pathogenic elements found in the body of the patient. diseased subject and that are the same or similar to those that have been inactivated in the heated serum.
A diferencia de las vacunas preventivas, la vacuna terapéutica mediante el calentamiento de suero sanguíneo autólogo se utiliza de forma curativa frente a aquellas enfermedades susceptibles de ser combatidas por el sistema inmunitario.Unlike preventive vaccines, the therapeutic vaccine by heating autologous blood serum is used curatively against those diseases that can be fought by the immune system.
La invención concierne también a un dispositivo para la puesta en práctica del citado método.The invention also concerns a device for putting the aforementioned method into practice.
Antecedentes de la invenciónBackground of the invention
Bajo el concepto de vacuna se comprende la sensibilización preventiva del sistema inmunitario frente a los patógenos de los que se desea proteger.The concept of a vaccine includes the preventive sensitization of the immune system against the pathogens from which it is desired to protect.
Las vacunas se elaboran en laboratorios básicamente mediante un proceso de inactivación o atenuación de varias cepas de patógenos, y son únicamente eficaces frente a aquellas cepas que son idénticas a las que se han utilizado para la elaboración de la mismas, de manera que una vez inactivados o atenuados, estos patógenos se presentan en forma de vacunas que se administran a personas o animales de forma preventiva. Dentro del organismo, estos patógenos son fagocitados, procesados, presentados y reconocidos por determinadas células inmunitarias, obteniéndose así una información que el sistema inmunitario memoriza, quedando de esta manera preparado para combatir con rapidez y eficacia a estos patógenos en caso de que se presenten posteriormente.Vaccines are made in laboratories basically by means of a process of inactivation or attenuation of various strains of pathogens, and are only effective against those strains that are identical to those that have been used to make them, so that once inactivated or attenuated, these pathogens come in the form of vaccines that are administered to people or animals preventively. Within the body, these pathogens are phagocytosed, processed, presented and recognized by certain immune cells, thus obtaining information that the immune system memorizes, thus being prepared to fight these pathogens quickly and effectively if they appear later. .
Como se ha dicho, las vacunas no son eficaces frente a patógenos genéticamente diferentes. Del mismo modo, las vacunas son ineficaces en los casos en los que la enfermedad ya se ha producido, aunque se trate de patógenos idénticos a los que se han utilizado en la elaboración de las mismas.As mentioned, vaccines are not effective against genetically different pathogens. In the same way, vaccines are ineffective in cases in which the disease has already occurred, even if they are pathogens identical to those used in their preparation.
También es conocido el uso de vacunas autólogas para el tratamiento de tumores. Este tipo de vacunas se elaboran a partir de células cancerígenas extraídas del tumor del propio paciente, por medio de biopsia o cirugía, y actúan contra células cancerígenas que poseen los mismos antígenos específicos del tumor. Sin embargo, presentan el inconveniente de que no siempre es posible acceder al tumor en toda su extensión. Además, protegen únicamente contra células cancerígenas que tienen los mismos antígenos que los extraídos de la zona del tumor, pero no contra aquellas que presentan variaciones genéticas del mismo.The use of autologous vaccines for the treatment of tumors is also known. These types of vaccines are made from cancer cells extracted from the patient's own tumor, through biopsy or surgery, and act against cancer cells that have the same tumor-specific antigens. However, they have the drawback that it is not always possible to access the tumor in its entirety. In addition, they protect only against cancer cells that have the same antigens as those extracted from the tumor area, but not against those that present genetic variations thereof.
Por otro lado, el calentamiento de suero sanguíneo, in vitro a 60°C durante 30 minutos, es utilizado en el laboratorio para inactivar a posibles microorganismos altamente infecciosos que pueden infectar a las personas que manipulan muestras para el diagnóstico y seguimiento de enfermedades.On the other hand, the heating of blood serum, in vitro at 60 ° C for 30 minutes, is used in the laboratory to inactivate possible highly infectious microorganisms that they can infect people who handle samples for disease diagnosis and monitoring.
Descripción de la invenciónDescription of the invention
El método para la elaboración de vacunas terapéuticas mediante el calentamiento de suero sanguíneo autólogo que la invención propone, ha sido concebido para desnaturalizar las proteínas del propio suero del enfermo, es decir, con esta desnaturalización, se pretende inactivar a agentes patógenos o degenerar a células cancerígenas en suficientes cantidades como para que las células presentadoras dispongan de suficiente antígeno, de manera que se proporcionan al sistema inmunitario elementos diferenciados, necesarios para que éste pueda distinguir al antígeno de las células sanas y en consecuencia destruir al patógeno o a las células cancerígenas sin dañar a las células sanas.The method for the preparation of therapeutic vaccines by heating autologous blood serum that the invention proposes, has been conceived to denature the proteins of the patient's own serum, that is, with this denaturation, it is intended to inactivate pathogens or degenerate cells cancer cells in sufficient quantities so that the presenting cells have sufficient antigen, so that differentiated elements are provided to the immune system, necessary for it to be able to distinguish the antigen from healthy cells and consequently destroy the pathogen or cancer cells without damaging healthy cells.
De forma más concreta, el método que se preconiza se inicia con el calentamiento de una muestra de suero contenida en un recipiente hasta alcanzar una temperatura suficiente que, mantenida durante el tiempo necesario, produce la inactivación de diferentes patógenos, temperatura que para degenerar o destruir a células cancerígenas es del orden de 42°C a 45°C y para inactivar a diferentes virus puede ser del orden de 60°C, habiéndose previsto para ello la utilización de ondas electromagnéticas (microondas), láser, transmisión capacitiva o cualquier otro método apropiado. Durante su calentamiento el suero es permanentemente sometido, mediante vibración y/o golpeteo, a un proceso de agitación. Este proceso es imprescindible, puesto que sin la agitación durante su calentamiento, el suero se gelifica y/o endurece y se hace inservible. Bajo los efectos del calor, en el suero se produce la desnaturalización de las proteínas y la inactivación de cualquier posible patógeno y/o degeneración de células cancerígenas. Una vez terminado el proceso de calentamiento, el suero se enfría hasta alcanzar una temperatura del orden de 37°C, y a continuación, por vía subcutánea, se inyecta al mismo organismo del sujeto del que fue extraído, en el que en consecuencia, se produce una respuesta del sistema inmunitario idéntica a la que se produce en el caso de las vacunas preventivas.More specifically, the recommended method begins with the heating of a serum sample contained in a container until it reaches a sufficient temperature that, maintained for the necessary time, produces the inactivation of different pathogens, a temperature that to degenerate or destroy cancer cells is of the order of 42 ° C to 45 ° C and to inactivate different viruses it can be of the order of 60 ° C, having provided for this the use of electromagnetic waves (microwaves), laser, capacitive transmission or any other method appropriate. During its heating, the serum is permanently subjected, by means of vibration and / or knocking, to a stirring process. This process is essential, since without stirring during heating, the serum gels and / or hardens and becomes unusable. Under the effects of heat, in the serum the denaturation of proteins occurs and the inactivation of any possible pathogen and / or degeneration of cancer cells. Once the heating process is finished, the serum is cooled to a temperature of the order of 37 ° C, and then, subcutaneously, it is injected into the same organism of the subject from which it was extracted, in which, consequently, it is produced an immune system response identical to that produced in preventive vaccines.
Con el fin de inactivar a todas las diferentes cepas o variaciones genéticas de los patógenos que se encuentran en el organismo infectado, se repite el proceso con posteriores muestras de suero del paciente, pudiéndose reducir los tiempos de calentamiento con arreglo a la mejora del estado clínico y analítico del paciente.In order to inactivate all the different strains or genetic variations of the pathogens found in the infected organism, the process is repeated with subsequent serum samples from the patient, being able to reduce the heating times according to the improvement of the clinical state and analytical of the patient.
El dispositivo para la puesta en práctica del citado método está estructurado a partir de un bastidor o estructura fija que contiene una cavidad cerrada, a la que se accede a través de una abertura o ventana que permite introducir recipientes que contienen suero, de manera que en el interior de dicha cavidad son irradiadas ondas electromagnéticas a través de una abertura, guiaondas o antena, habiéndose provisto dentro de la cavidad un soporte o bandeja que alberga varios recipientes que contienen suero autólogo extraído del paciente, estando dicho suero sometido a una agitación producida por la acción de un motor encargado de hacer girar una masa excéntrica o contrapeso que, durante el movimiento giratorio, genera fuerzas centrifugas que producen una vibración de la bandeja y una agitación del suero contenido en los recipientes, de modo que durante el calentamiento del suero, que se produce por la acción de las ondas electromagnéticas, se consigue una agitación del mismo que impide su destrucción que se produciría por la elevación térmica. The device for the implementation of the aforementioned method is structured from a frame or fixed structure that contains a closed cavity, which is accessed through an opening or window that allows to introduce containers that contain serum, so that in Inside said cavity, electromagnetic waves are radiated through an opening, waveguide or antenna, having provided inside the cavity a support or tray that houses several containers containing autologous serum extracted from the patient, said serum being subjected to agitation produced by the action of a motor in charge of rotating an eccentric mass or counterweight that, during the rotating movement, generates centrifugal forces that produce a vibration of the tray and an agitation of the serum contained in the containers, so that during the heating of the serum, produced by the action of electromagnetic waves, agitation is achieved that prevents its destruction that would be produced by thermal elevation.
Descripción de los dibujosDescription of the drawings
Para completar la descripción que se está realizando y con objeto de ayudar a una mejor comprensión de las características del invento, se acompaña a la presente memoria descriptiva, como parte integrante de la misma, un juego de dibujos en donde con carácter ilustrativo y no limitativo, se ha representado lo siguiente:To complete the description that is being made and in order to help a better understanding of the characteristics of the invention, the present specification is attached, as an integral part thereof, to a set of drawings where with an illustrative and non-limiting character , the following has been represented:
La figura 1.- muestra una vista general en perspectiva del dispositivo para la puesta en práctica del método para la elaboración de vacunas terapéuticas mediante el calentamiento de suero sanguíneo autólogo, realizado de acuerdo con el objeto de la invención, con una parte seccionada en el bastidor, para dejar ver determinados elementos y componentes del dispositivo.Figure 1.- shows a general perspective view of the device for putting into practice the method for the preparation of therapeutic vaccines by heating autologous blood serum, carried out in accordance with the object of the invention, with a section sectioned in the frame, to reveal certain elements and components of the device.
La figura 2.- muestra en perspectiva otro ejemplo de un dispositivo que produce la agitación del suero durante su proceso de calentamiento.Figure 2.- shows in perspective another example of a device that produces the agitation of the serum during its heating process.
Realización preferente de la invenciónPreferred embodiment of the invention
A la vista de la figura 1, puede observarse cómo el dispositivo que se preconiza está estructurado a partir de un bastidor fijo (14), que contiene una cavidad (6), a la que se accede a través de una abertura o ventana (7), estando dotada dicha cavidad (6) de una abertura, guiaondas o antena (8), a través de la cual se dirigen ondas electromagnéticas (microondas) que calientan suero sanguíneo contenido en unos recipientes o tubos (5), colocados sobre un soporte o bandeja (4) que está unida, mediante un eje (3), a un motor (1), estando dicho eje (3) provisto de una masa excéntrica o contrapeso (2), de manera que cuando el motor (1) y la bandeja (4) giran, el contrapeso (2) se mueve alrededor del eje (3), generando fuerzas centrifugas que producen una vibración sobre la bandeja (4), y en consecuencia una agitación del suero contenido en los recipientes (5), de modo que durante el calentamiento del suero, generado por la acción de las ondas electromagnéticas, se produce una agitación de dicho suero que impide su destrucción por los efectos de la elevación térmica.In view of figure 1, it can be seen how the device that is advocated is structured from a fixed frame (14), which contains a cavity (6), which is accessed through an opening or window (7 ), said cavity (6) being provided with an opening, waveguide or antenna (8), through which electromagnetic waves (microwaves) are directed that heat blood serum contained in containers or tubes (5), placed on a support or tray (4) that is joined, by means of a shaft (3), to a motor (1), said shaft (3) being provided with an eccentric mass or counterweight (2), so that when the motor (1) and The tray (4) rotates, the counterweight (2) moves around the axis (3), generating centrifugal forces that produce a vibration on the tray (4), and consequently an agitation of the serum contained in the containers (5), so that during the heating of the serum, generated by the action of electromagnetic waves, there is an agitation of di This serum that prevents its destruction by the effects of thermal elevation.
Además, el proceso de calentamiento del suero contenido en los recipientes (5), dispuestos en la bandeja (4) dentro de la cavidad (6), es controlado mediante una medida de temperatura, realizada por un termómetro o termógrafo de infrarrojos (10), u otro medio adecuado que permita la dosificación correcta de irradiación de ondas electromagnéticas, producidas por un generador no representado en la figura, de forma que la temperatura a la que se desea calentar el suero se puede ajustar con un mando (11), del mismo modo que el tiempo durante el que se pretende calentar el suero se puede ajustar con un mando (12), estando los valores de temperatura del suero y el tiempo de calentamiento visualizados en una pantalla (9) o en cualquier otro medio adecuado que informe de esos valores.In addition, the process of heating the serum contained in the containers (5), arranged in the tray (4) inside the cavity (6), is controlled by a temperature measurement, carried out by an infrared thermometer or thermograph (10) , or another suitable means that allows the correct dosage of irradiation of electromagnetic waves, produced by a generator not represented in the figure, so that the temperature to which the serum is to be heated can be adjusted with a knob (11), of the In the same way that the time for which the serum is to be heated can be adjusted with a knob (12), the serum temperature values and the heating time being displayed on a screen (9) or in any other suitable means that reports of those values.
En la figura 2 se observa una segunda posible realización de un ejemplo práctico del dispositivo que produce la agitación de suero sanguíneo contenido en uno o varios recipientes (18), de manera que un motor (16), situado en la bandeja o soporte (17), hace girar una masa excéntrica (15) que durante su movimiento circular produce una vibración o golpeteo que se transmite al suero sanguíneo contenido en los citados recipientes o tubos (18).Figure 2 shows a second possible embodiment of a practical example of the device that produces the agitation of blood serum contained in one or more containers (18), so that a motor (16), located on the tray or support (17 ), it rotates an eccentric mass (15) that during its circular movement produces a vibration or knocking that is transmitted to the blood serum contained in said containers or tubes (18).
No se considera necesario hacer más extensa esta descripción para que cualquier experto en la materia comprenda el alcance de la invención y las ventajas que de la misma se derivan. It is not considered necessary to make this description more extensive for any person skilled in the art to understand the scope of the invention and the advantages derived from it.
Los materiales, forma, tamaño y disposición de los elementos serán susceptibles de variación siempre y cuando ello no suponga una alteración de la esenciabilidad del invento. The materials, shape, size and arrangement of the elements will be susceptible to variation as long as this does not imply an alteration of the essence of the invention.
Los términos en los que se ha redactado esta memoria deberán ser tomados siempre en sentido amplio y no limitativo. The terms in which this report has been written should always be taken in a broad and non-limiting sense.
Claims (4)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES202000028A ES2853350A1 (en) | 2020-02-26 | 2020-02-26 | METHOD FOR THE PREPARATION OF THERAPEUTIC VACCINES BY WARMING AUTOLOGOUS BLOOD SERUM (Machine-translation by Google Translate, not legally binding) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES202000028A ES2853350A1 (en) | 2020-02-26 | 2020-02-26 | METHOD FOR THE PREPARATION OF THERAPEUTIC VACCINES BY WARMING AUTOLOGOUS BLOOD SERUM (Machine-translation by Google Translate, not legally binding) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2853350A1 true ES2853350A1 (en) | 2021-09-15 |
Family
ID=77663491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES202000028A Withdrawn ES2853350A1 (en) | 2020-02-26 | 2020-02-26 | METHOD FOR THE PREPARATION OF THERAPEUTIC VACCINES BY WARMING AUTOLOGOUS BLOOD SERUM (Machine-translation by Google Translate, not legally binding) |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2853350A1 (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4968483A (en) * | 1987-01-15 | 1990-11-06 | Quarzlampenfabrik Dr.-Ing. Felix W. Muller Gmbh & Co. Kg | Apparatus for the production of oxygenated blood |
| DE19726625A1 (en) * | 1997-06-17 | 1998-12-24 | Scheuermann & Co Gmbh | Microwave heating equipment for bags containing, blood, derivatives and organs |
| EP1124575A1 (en) * | 1998-10-28 | 2001-08-22 | Hans-Günter Sonntag | Method for the production of an antiviral agent |
| US20020168420A1 (en) * | 1992-02-07 | 2002-11-14 | Anthony E. Bolton | Endothelial lining effects and treatment of vasospastic disorders |
-
2020
- 2020-02-26 ES ES202000028A patent/ES2853350A1/en not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4968483A (en) * | 1987-01-15 | 1990-11-06 | Quarzlampenfabrik Dr.-Ing. Felix W. Muller Gmbh & Co. Kg | Apparatus for the production of oxygenated blood |
| US20020168420A1 (en) * | 1992-02-07 | 2002-11-14 | Anthony E. Bolton | Endothelial lining effects and treatment of vasospastic disorders |
| DE19726625A1 (en) * | 1997-06-17 | 1998-12-24 | Scheuermann & Co Gmbh | Microwave heating equipment for bags containing, blood, derivatives and organs |
| EP1124575A1 (en) * | 1998-10-28 | 2001-08-22 | Hans-Günter Sonntag | Method for the production of an antiviral agent |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Kinsey et al. | Thermal considerations in murine tumor killing using hematoporphyrin derivative phototherapy | |
| Jenne et al. | High-intensity focused ultrasound: principles, therapy guidance, simulations and applications | |
| Mouratidis et al. | Latest advances in the use of therapeutic focused ultrasound in the treatment of pancreatic cancer | |
| Teng et al. | Bio-mineralization of virus-like particles by metal–organic framework nanoparticles enhances the thermostability and immune responses of the vaccines | |
| ES2247162T3 (en) | APPARATUS FOR SELECTIVE DESTRUCTION OF CELLS IN A HUMAN ORGANISM. | |
| Moore et al. | Evaluation of high-intensity therapeutic ultrasound irradiation in the treatment of experimental hepatoma | |
| Marmor et al. | Treating spontaneous tumors in dogs and cats by ultrasound-induced hyperthermia | |
| JP2022188267A (en) | Device and method for controlling laser thermotherapy | |
| McCabe et al. | Application of high-intensity focused ultrasound to the study of mild traumatic brain injury | |
| ES2853350A1 (en) | METHOD FOR THE PREPARATION OF THERAPEUTIC VACCINES BY WARMING AUTOLOGOUS BLOOD SERUM (Machine-translation by Google Translate, not legally binding) | |
| Milne et al. | Development of stereotactically guided laser interstitial thermotherapy of breast cancer: In situ measurement and analysis of the temperature field in ex vivo and in vivo adipose tissue | |
| US20160230139A1 (en) | Self-Contained Device and System to Produce Ex-Vivo Autologous Whole Cell Tumor Vaccines | |
| Paulus et al. | Thermal ablation of canine prostate using interstitial temperature self-regulating seeds: new treatment for prostate cancer | |
| Tozburun et al. | A compact laparoscopic probe for optical stimulation of the prostate nerves | |
| RU2005127615A (en) | METHOD FOR OBTAINING THERAPEUTIC ANTITUMOR VACCINE, MODIFIED ANTITUMOR VACCINE, METHOD OF LASER VACCINATION OF PATIENTS WITH METASTATIC FORMS OF CANCER | |
| Schena et al. | Monitoring of temperature increase and tissue vaporization during laser interstitial thermotherapy of ex vivo swine liver by computed tomography | |
| CN109044403A (en) | The excitation of digital control type low-strength focusing ultrasonic wave and imaging system | |
| Shikunova et al. | Sapphire needle capillaries for laser medicine | |
| Ahuja et al. | Microparticles entrapping pneumococcal protein SP0845 show improved immunogenicity and temperature stability | |
| Mago et al. | Therapeutic applications of ultrasonography in dentistry | |
| Koole et al. | Treatment of the human retinoblastoma cell line Y-79 growing in the athymic mouse eye with fractionated hyperthermia and/or radiation | |
| RU2811948C1 (en) | Inactivated vaccine against brucellosis from brucella abortus 82 strain based on calcium biohydroxyapatite adjuvant for cattle | |
| Wu | High intensity focused ultrasound (HIFU) ablation | |
| Monesa et al. | The Decline of 20th Century High-Frequency Therapeutics | |
| KILIÇ et al. | Orthodontic Materials Interacting with Fifth Generation (5G) Electromagnetic Waves |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BA2A | Patent application published |
Ref document number: 2853350 Country of ref document: ES Kind code of ref document: A1 Effective date: 20210915 |
|
| FA2A | Application withdrawn |
Effective date: 20220111 |