ES2850278B2 - COMPLEJO DE ETINIL ESTRADIOL-ß-CICLODEXTRINA Y PROCEDIMIENTO PARA SU PREPARACION - Google Patents

COMPLEJO DE ETINIL ESTRADIOL-ß-CICLODEXTRINA Y PROCEDIMIENTO PARA SU PREPARACION Download PDF

Info

Publication number: ES2850278B2
Authority: ES; Spain
Prior art keywords: ethinyl estradiol; cyclodextrin; amorphous; complex; tetrahydrofolic acid
Prior art date: 2018-12-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

ES202190031A

Other languages

English (en)

Spanish (es)

Other versions

ES2850278R1 (es

ES2850278A2 (es

Inventor

Ortega María Dolores Moya

Andreza Maria Ribeiro

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Laboratorios Leon Farma SA

Original Assignee

Laboratorios Leon Farma SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2018-12-13

Filing date

2019-12-11

Publication date

2023-09-15

2019-12-11 Application filed by Laboratorios Leon Farma SA filed Critical Laboratorios Leon Farma SA

2021-08-26 Publication of ES2850278A2 publication Critical patent/ES2850278A2/es

2022-12-02 Publication of ES2850278R1 publication Critical patent/ES2850278R1/es

2023-09-15 Application granted granted Critical

2023-09-15 Publication of ES2850278B2 publication Critical patent/ES2850278B2/es

Status Active legal-status Critical Current

2039-12-11 Anticipated expiration legal-status Critical

Links

239000001116 FEMA 4028 Substances 0.000 title claims description 56
229960004853 betadex Drugs 0.000 title claims description 56
238000000034 method Methods 0.000 title claims description 31
238000002360 preparation method Methods 0.000 title description 5
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XEHVFKKSDRMODV-UHFFFAOYSA-N ethynyl Chemical class C#[C] XEHVFKKSDRMODV-UHFFFAOYSA-N 0.000 title description 2
VOXZDWNPVJITMN-WKUFJEKOSA-N oestradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-WKUFJEKOSA-N 0.000 title 1
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BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 claims description 68
BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 claims description 68
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AZFLJNIPTRTECV-FUMNGEBKSA-N dienogest Chemical compound C1CC(=O)C=C2CC[C@@H]([C@H]3[C@@](C)([C@](CC3)(O)CC#N)CC3)C3=C21 AZFLJNIPTRTECV-FUMNGEBKSA-N 0.000 claims description 3
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230000004580 weight loss Effects 0.000 description 1
238000005550 wet granulation Methods 0.000 description 1
239000000811 xylitol Substances 0.000 description 1
235000010447 xylitol Nutrition 0.000 description 1
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
229960002675 xylitol Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/40—Cyclodextrins; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
- A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Reproductive Health (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Endocrinology (AREA)
Gynecology & Obstetrics (AREA)
Inorganic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Steroid Compounds (AREA)

ES202190031A 2018-12-13 2019-12-11 COMPLEJO DE ETINIL ESTRADIOL-ß-CICLODEXTRINA Y PROCEDIMIENTO PARA SU PREPARACION Active ES2850278B2 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP18382921.7A EP3666260A1 (fr)	2018-12-13	2018-12-13	Complexe d'éthinyl estradiol-beta-cyclodextrine et son procédé de preparation
PCT/EP2019/084591 WO2020120548A1 (fr)	2018-12-13	2019-12-11	COMPLEXE D'ÉTHINYLESTRADIOL-β-CYCLODEXTRINE ET SON PROCÉDÉ DE PRÉPARATION

Publications (3)

Publication Number	Publication Date
ES2850278A2 ES2850278A2 (es)	2021-08-26
ES2850278R1 ES2850278R1 (es)	2022-12-02
ES2850278B2 true ES2850278B2 (es)	2023-09-15

Family

ID=65003157

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES202190031A Active ES2850278B2 (es)	2018-12-13	2019-12-11	COMPLEJO DE ETINIL ESTRADIOL-ß-CICLODEXTRINA Y PROCEDIMIENTO PARA SU PREPARACION

Country Status (5)

Country	Link
US (1)	US12318395B2 (fr)
EP (1)	EP3666260A1 (fr)
JP (1)	JP7499252B2 (fr)
ES (1)	ES2850278B2 (fr)
WO (1)	WO2020120548A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US12318395B2 (en)	2018-12-13	2025-06-03	Laboratorios Leon Farma, S.A.	Ethinyl estradiol-β-cyclodextrin complex and process for preparing thereof

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN114225050B (zh) *	2022-01-29	2022-12-13	国家卫生健康委科学技术研究所	炔雌醇环糊精复合物的制备及应用
CN116617157B (zh) *	2023-05-25	2025-02-18	国家卫生健康委科学技术研究所	一种制备pH响应性炔雌醇复合水凝胶的方法

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4727064A (en) *	1984-04-25	1988-02-23	The United States Of America As Represented By The Department Of Health And Human Services	Pharmaceutical preparations containing cyclodextrin derivatives
DE4426709A1 (de)	1994-07-20	1996-01-25	Schering Ag	Steroidale Sexualhormone enthaltende feste Arzneiformen
IT1304190B1 (it)	1998-12-18	2001-03-08	Euphar Group Srl	Clatrati di deidroepiandrosterone e relative composizionifarmaceutiche
CH693905A5 (de)	1999-04-15	2004-04-15	Eprova Ag	Stabile kristalline Salze von 5-Methyltetrahydrofolsäure.
EP1216713A1 (fr) *	2000-12-20	2002-06-26	Schering Aktiengesellschaft	Compositions de complexes de estrogen-cyclodextrine
WO2014056035A1 (fr)	2012-10-10	2014-04-17	The University Of Queensland	Encapsulation de gaz dans des cyclodextrines
EP2781214A1 (fr)	2013-03-22	2014-09-24	Chemo Research, S.L.	Formulation de calcium amorphe L-5-méthyltétrahydrofolate (L-5-MTHF-Ca)
WO2016097025A1 (fr)	2014-12-19	2016-06-23	Synthon B.V.	Composition pharmaceutique comprenant de la lénalidomide amorphe
EP3666260A1 (fr)	2018-12-13	2020-06-17	Laboratorios Leon Farma SA	Complexe d'éthinyl estradiol-beta-cyclodextrine et son procédé de preparation

2018
- 2018-12-13 EP EP18382921.7A patent/EP3666260A1/fr not_active Withdrawn
2019
- 2019-12-11 ES ES202190031A patent/ES2850278B2/es active Active
- 2019-12-11 WO PCT/EP2019/084591 patent/WO2020120548A1/fr not_active Ceased
- 2019-12-11 JP JP2021534321A patent/JP7499252B2/ja active Active
- 2019-12-11 US US17/413,692 patent/US12318395B2/en active Active

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US12318395B2 (en)	2018-12-13	2025-06-03	Laboratorios Leon Farma, S.A.	Ethinyl estradiol-β-cyclodextrin complex and process for preparing thereof

Also Published As

Publication number	Publication date
EP3666260A1 (fr)	2020-06-17
US20220040200A1 (en)	2022-02-10
ES2850278R1 (es)	2022-12-02
JP7499252B2 (ja)	2024-06-13
WO2020120548A1 (fr)	2020-06-18
ES2850278A2 (es)	2021-08-26
JP2022513237A (ja)	2022-02-07
US12318395B2 (en)	2025-06-03

Publication	Publication Date	Title
AU2024201228B2 (en)	2025-04-24	Orodispersible dosage unit containing an estetrol component
ES2639537T3 (es)	2017-10-27	Composiciones que comprenden drospirenona y un complejo entre etinilestradiol y una ciclodextrina
KR102265150B1 (ko)	2021-06-16	에스테트롤 성분을 함유하는 구강 붕해성 고체 투여 단위
EP3310346B1 (fr)	2021-03-24	Comprimé orodispersible comprenant estetrol
ES3019912T3 (en)	2025-05-21	Anticancer compositions
ES2850278B2 (es)	2023-09-15	COMPLEJO DE ETINIL ESTRADIOL-ß-CICLODEXTRINA Y PROCEDIMIENTO PARA SU PREPARACION
US20160045440A1 (en)	2016-02-18	FORMULATION OF AMORPHOUS CALCIUM L-5-METHYLTETRAHYDROFOLATE (L-5-MTHF-Ca)
JPWO2016175230A1 (ja)	2018-02-22	経口投与用医薬組成物
HK1254650B (en)	2021-03-12	Orodispersible dosage unit containing an estetrol component

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ES2850278B2 - COMPLEJO DE ETINIL ESTRADIOL-ß-CICLODEXTRINA Y PROCEDIMIENTO PARA SU PREPARACION - Google Patents

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Applications Claiming Priority (2)

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ID=65003157

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