ES2741050T3 - Método para crear un clasificador indicativo de una presencia de una condición médica - Google Patents
Método para crear un clasificador indicativo de una presencia de una condición médica Download PDFInfo
- Publication number
- ES2741050T3 ES2741050T3 ES16704919T ES16704919T ES2741050T3 ES 2741050 T3 ES2741050 T3 ES 2741050T3 ES 16704919 T ES16704919 T ES 16704919T ES 16704919 T ES16704919 T ES 16704919T ES 2741050 T3 ES2741050 T3 ES 2741050T3
- Authority
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- Spain
- Prior art keywords
- chromatogram data
- chromatogram
- medical condition
- data
- indicative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 title claims abstract description 69
- 235000009413 Ratibida columnifera Nutrition 0.000 claims abstract description 8
- 241000510442 Ratibida peduncularis Species 0.000 claims abstract description 8
- 239000012855 volatile organic compound Substances 0.000 claims abstract 3
- 238000006073 displacement reaction Methods 0.000 claims description 10
- 238000004422 calculation algorithm Methods 0.000 claims description 8
- 238000012706 support-vector machine Methods 0.000 claims description 8
- 230000009466 transformation Effects 0.000 claims description 8
- 238000007637 random forest analysis Methods 0.000 claims description 7
- 238000010200 validation analysis Methods 0.000 claims description 7
- 238000004458 analytical method Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims 1
- 230000001131 transforming effect Effects 0.000 claims 1
- 239000000523 sample Substances 0.000 description 38
- 208000002551 irritable bowel syndrome Diseases 0.000 description 15
- 238000005070 sampling Methods 0.000 description 14
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 11
- 206010060862 Prostate cancer Diseases 0.000 description 8
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 8
- 206010028980 Neoplasm Diseases 0.000 description 7
- 201000011510 cancer Diseases 0.000 description 7
- 239000011159 matrix material Substances 0.000 description 7
- 206010005003 Bladder cancer Diseases 0.000 description 6
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 6
- 238000002790 cross-validation Methods 0.000 description 6
- 201000005112 urinary bladder cancer Diseases 0.000 description 6
- 238000001514 detection method Methods 0.000 description 5
- 229910044991 metal oxide Inorganic materials 0.000 description 4
- 150000004706 metal oxides Chemical class 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 238000004891 communication Methods 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 241000193163 Clostridioides difficile Species 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 239000000090 biomarker Substances 0.000 description 2
- 238000003066 decision tree Methods 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 210000003608 fece Anatomy 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 244000045947 parasite Species 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 239000013074 reference sample Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- 230000001594 aberrant effect Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000002574 cystoscopy Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 208000010643 digestive system disease Diseases 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 208000018685 gastrointestinal system disease Diseases 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 208000006750 hematuria Diseases 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 238000002705 metabolomic analysis Methods 0.000 description 1
- 230000001431 metabolomic effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000007781 pre-processing Methods 0.000 description 1
- 210000002307 prostate Anatomy 0.000 description 1
- 208000026455 prostate symptom Diseases 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/86—Signal analysis
- G01N30/8675—Evaluation, i.e. decoding of the signal into analytical information
- G01N30/8686—Fingerprinting, e.g. without prior knowledge of the sample components
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/86—Signal analysis
- G01N30/8675—Evaluation, i.e. decoding of the signal into analytical information
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
- G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
- G16C20/20—Identification of molecular entities, parts thereof or of chemical compositions
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/20—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for computer-aided diagnosis, e.g. based on medical expert systems
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/70—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
- G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
- G16C20/70—Machine learning, data mining or chemometrics
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medical Informatics (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Data Mining & Analysis (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Library & Information Science (AREA)
- Databases & Information Systems (AREA)
- Primary Health Care (AREA)
- Epidemiology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Computing Systems (AREA)
- Theoretical Computer Science (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB201502447A GB201502447D0 (en) | 2015-02-13 | 2015-02-13 | Method and apparatus for sample analysis |
| PCT/GB2016/050344 WO2016128764A1 (en) | 2015-02-13 | 2016-02-12 | Method and apparatus for creating a classifier indicative of a presence of a medical condition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2741050T3 true ES2741050T3 (es) | 2020-02-07 |
Family
ID=52781579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES16704919T Active ES2741050T3 (es) | 2015-02-13 | 2016-02-12 | Método para crear un clasificador indicativo de una presencia de una condición médica |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11635414B2 (da) |
| EP (1) | EP3256848B1 (da) |
| CN (1) | CN107223248B (da) |
| CA (1) | CA2975352A1 (da) |
| DK (1) | DK3256848T3 (da) |
| ES (1) | ES2741050T3 (da) |
| GB (1) | GB201502447D0 (da) |
| WO (1) | WO2016128764A1 (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109085282A (zh) * | 2018-06-22 | 2018-12-25 | 东南大学 | 一种基于小波变换和随机森林模型的色谱重叠峰解析方法 |
| WO2020188471A1 (en) * | 2019-03-19 | 2020-09-24 | Optina Diagnostics, Inc. | Method and system for identifying subjects who are potentially impacted by a medical condition |
| GB201909709D0 (en) | 2019-07-05 | 2019-08-21 | Univ Liverpool | Biomarkers for irritable bowel syndrome |
| CN116685259A (zh) * | 2020-10-19 | 2023-09-01 | 本-古里安大学B.G.内盖夫技术和应用公司 | 尿细菌对抗生素的敏感性的快速直接鉴定和确定 |
| CN116522252B (zh) * | 2023-04-26 | 2024-01-05 | 中国气象局公共气象服务中心(国家预警信息发布中心) | 太阳辐射校准方法、装置、电子设备及存储介质 |
| CN118918971B (zh) * | 2024-07-08 | 2025-05-30 | 长春大学 | 气体识别方法、装置、设备、存储介质和程序产品 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1064712C (zh) * | 1991-12-23 | 2001-04-18 | 华中理工大学 | 临床常规难检验病原菌自动检验网络系统及方法 |
| US5995868A (en) | 1996-01-23 | 1999-11-30 | University Of Kansas | System for the prediction, rapid detection, warning, prevention, or control of changes in activity states in the brain of a subject |
| US5885841A (en) * | 1996-09-11 | 1999-03-23 | Eli Lilly And Company | System and methods for qualitatively and quantitatively comparing complex admixtures using single ion chromatograms derived from spectroscopic analysis of such admixtures |
| CA2688795C (en) | 2000-06-01 | 2014-07-08 | Science Application International Corporation | Systems and methods for monitoring health and delivering drugs transdermally |
| GB0216650D0 (en) | 2002-07-18 | 2002-08-28 | Univ Bristol | Detection of disease by analysis of emissions |
| US7519488B2 (en) * | 2004-05-28 | 2009-04-14 | Lawrence Livermore National Security, Llc | Signal processing method and system for noise removal and signal extraction |
| US20070055151A1 (en) * | 2005-01-20 | 2007-03-08 | Shertukde Hemchandra M | Apparatus and methods for acoustic diagnosis |
| WO2007009229A1 (en) | 2005-07-15 | 2007-01-25 | Angiochem Inc. | Use of aprotinin polypeptides as carriers in pharmaceutical conjugates |
| US7873196B2 (en) | 2006-03-22 | 2011-01-18 | Cornell Research Foundation, Inc. | Medical imaging visibility index system and method for cancer lesions |
| US7736905B2 (en) * | 2006-03-31 | 2010-06-15 | Biodesix, Inc. | Method and system for determining whether a drug will be effective on a patient with a disease |
| KR20100084528A (ko) * | 2007-10-02 | 2010-07-26 | 안나-카린 올린 | 호기 입자의 수집 및 측정 |
| JP5643650B2 (ja) | 2007-11-21 | 2014-12-17 | コスモシド・インコーポレーテッド | ゲノム同定システム |
| EP2229459B1 (en) | 2007-12-13 | 2014-08-27 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for prevention or treatment of RSV infection |
| CN102006824B (zh) | 2008-04-16 | 2015-02-04 | 皇家飞利浦电子股份有限公司 | 用于睡眠/清醒状况估计的方法和系统 |
| US8580231B2 (en) | 2008-05-23 | 2013-11-12 | Northwestern University | Compositions and methods comprising magnetic resonance contrast agents |
| EP2369989A4 (en) * | 2008-12-01 | 2013-05-15 | Tricorntech Corp | ATTA ANALYSIS SYSTEM AND ASSAYS FOR THE DIAGNOSIS AND TREATMENT OF ASTHMA, TUBERCULOSIS AND LUNG CANCER |
| CN101929989A (zh) | 2009-06-24 | 2010-12-29 | 陈喆 | 一种代谢谱峰位置分辨与对齐的方法 |
| US8999245B2 (en) * | 2009-07-07 | 2015-04-07 | Tricorn Tech Corporation | Cascaded gas chromatographs (CGCs) with individual temperature control and gas analysis systems using same |
| WO2011034539A1 (en) * | 2009-09-18 | 2011-03-24 | The Regents Of The University Of California | Methods for detecting autodigestion |
| GB0920315D0 (en) * | 2009-11-20 | 2010-01-06 | Univ Bristol | A diagnostic apparatus |
| GB0922505D0 (en) | 2009-12-23 | 2010-02-10 | Plant Bioscience Ltd | Use |
| WO2011083473A1 (en) | 2010-01-07 | 2011-07-14 | Technion Research And Development Foundation Ltd. | Volatile organic compounds as diagnostic markers for various types of cancer |
| EP2542577A1 (en) | 2010-03-01 | 2013-01-09 | Lostam Biopharmaceuticals Ltd | Improved therapeutic antibodies against flagellated pseudomonas aeruginosa |
| BR112013020220B1 (pt) | 2011-02-09 | 2020-03-17 | Natera, Inc. | Método para determinar o estado de ploidia de um cromossomo em um feto em gestação |
| DK2694095T3 (da) | 2011-04-05 | 2018-05-28 | Longevity Biotech Inc | Sammensætninger omfattende glucagon-analoger og fremgangsmåder til fremstilling og anvendelse af samme |
| JP6024025B2 (ja) | 2011-05-02 | 2016-11-09 | イミューノメディクス、インコーポレイテッドＩｍｍｕｎｏｍｅｄｉｃｓ， Ｉｎｃ． | 少容量投与用のアロタイプ選択抗体の限外濾過濃縮 |
| GB201110344D0 (en) | 2011-06-20 | 2011-08-03 | Univ Bristol | Apparatus for collecting a sample |
| PE20190907A1 (es) | 2012-01-27 | 2019-06-26 | AbbVie Deutschland GmbH and Co KG | Composicion y metodo para el diagnostico y el tratamiento de las enfermedades asociadas a la degeneracion de las neuritas |
| US8765725B2 (en) | 2012-05-08 | 2014-07-01 | Aciex Therapeutics, Inc. | Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof |
| KR20130134901A (ko) | 2012-05-31 | 2013-12-10 | 서울대학교산학협력단 | 비선형적 연관성 탐색 모델을 이용한 천연물 미지 시료의 생물학적 활성을 예측하는 방법 |
| CN107250788B (zh) * | 2015-02-16 | 2019-06-07 | 株式会社岛津制作所 | 噪声水平估计方法和测定数据处理装置 |
-
2015
- 2015-02-13 GB GB201502447A patent/GB201502447D0/en not_active Ceased
-
2016
- 2016-02-12 CN CN201680009486.2A patent/CN107223248B/zh active Active
- 2016-02-12 ES ES16704919T patent/ES2741050T3/es active Active
- 2016-02-12 EP EP16704919.6A patent/EP3256848B1/en active Active
- 2016-02-12 DK DK16704919.6T patent/DK3256848T3/da active
- 2016-02-12 CA CA2975352A patent/CA2975352A1/en not_active Abandoned
- 2016-02-12 US US15/550,734 patent/US11635414B2/en active Active
- 2016-02-12 WO PCT/GB2016/050344 patent/WO2016128764A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| US11635414B2 (en) | 2023-04-25 |
| CN107223248B (zh) | 2021-11-02 |
| GB201502447D0 (en) | 2015-04-01 |
| US20180038839A1 (en) | 2018-02-08 |
| EP3256848A1 (en) | 2017-12-20 |
| CA2975352A1 (en) | 2016-08-18 |
| WO2016128764A1 (en) | 2016-08-18 |
| CN107223248A (zh) | 2017-09-29 |
| EP3256848B1 (en) | 2019-05-15 |
| DK3256848T3 (da) | 2019-08-19 |
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