ES2637245T3 - Nuevas 4-(amino sustituido)-7H-pirrolo[2,3-d]pirimidinas como inhibidores de LRRK2 - Google Patents

Nuevas 4-(amino sustituido)-7H-pirrolo[2,3-d]pirimidinas como inhibidores de LRRK2 Download PDF

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Publication number: ES2637245T3
Authority: ES; Spain
Prior art keywords: pyrrolo; pyrimidin; procedure; morpholin; pyrimidine
Prior art date: 2012-06-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

ES13752678.6T

Other languages

English (en)

Spanish (es)

Inventor

Paul Galatsis

Matthew Merrill Hayward

Jaclyn HENDERSON

Bethany Lyn KORMOS

Ravi G KURUMBAIL

Antonia Friederike STEPAN

Patrick Robert Verhoest

Travis T. Wager

Lei Zhang

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pfizer Corp Belgium

Pfizer Corp SRL

Original Assignee

Pfizer Corp Belgium

Pfizer Corp SRL

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2012-06-29

Filing date

2013-06-19

Publication date

2017-10-11

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49029142&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2637245(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2013-06-19 Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium

2017-10-11 Application granted granted Critical

2017-10-11 Publication of ES2637245T3 publication Critical patent/ES2637245T3/es

Status Active legal-status Critical Current

2033-06-19 Anticipated expiration legal-status Critical

Links

-1 4- (substituted amino) -7H-pyrrolo [2,3-d] pyrimidines Chemical class 0.000 title abstract description 47
229940124786 LRRK2 inhibitor Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract description 80
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract description 23
125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract description 14
125000005842 heteroatom Chemical group 0.000 abstract description 13
229910052757 nitrogen Inorganic materials 0.000 abstract description 12
229910052760 oxygen Inorganic materials 0.000 abstract description 12
229910052717 sulfur Inorganic materials 0.000 abstract description 11
125000001072 heteroaryl group Chemical group 0.000 abstract description 7
125000000592 heterocycloalkyl group Chemical group 0.000 abstract description 7
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract description 6
239000001257 hydrogen Substances 0.000 abstract description 6
229910052739 hydrogen Inorganic materials 0.000 abstract description 6
125000000753 cycloalkyl group Chemical group 0.000 abstract description 5
125000005843 halogen group Chemical group 0.000 abstract description 4
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract description 4
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract description 3
150000003839 salts Chemical class 0.000 abstract description 3
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract description 2
125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract description 2
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract description 2
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UAOMVDZJSHZZME-UHFFFAOYSA-N diisopropylamine Chemical compound CC(C)NC(C)C UAOMVDZJSHZZME-UHFFFAOYSA-N 0.000 description 6
QNXXNOAXMRJFPK-UHFFFAOYSA-N formic acid 4-[5-(1H-pyrazol-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]morpholine Chemical compound OC=O.C1CN(CCO1)c1ncnc2[nH]cc(-c3cn[nH]c3)c12 QNXXNOAXMRJFPK-UHFFFAOYSA-N 0.000 description 6
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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ES13752678.6T 2012-06-29 2013-06-19 Nuevas 4-(amino sustituido)-7H-pirrolo[2,3-d]pirimidinas como inhibidores de LRRK2 Active ES2637245T3 (es)

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US201361820828P		2013-05-08
PCT/IB2013/055039 WO2014001973A1 (fr)	2012-06-29	2013-06-19	Nouvelles 7h-pyrrolo[2,3-d]pyrimidines substituées par un groupe amino en position 4, utilisées comme inhibiteurs de lrrk2

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UY (1)	UY34883A (fr)
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2013
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Publication number	Publication date
JP2017226684A (ja)	2017-12-28
AU2013282869A1 (en)	2015-01-15
US20140005183A1 (en)	2014-01-02
SG11201408044QA (en)	2015-01-29
TN2014000537A1 (fr)	2016-03-30
CO7160063A2 (es)	2015-01-15
CA2878054C (fr)	2018-09-11
CN104395315B (zh)	2016-08-17
GT201400301A (es)	2015-06-02
US9642855B2 (en)	2017-05-09
AU2013282869B2 (en)	2015-12-24
PE20150153A1 (es)	2015-02-05
AR091628A1 (es)	2015-02-18
CN104395315A (zh)	2015-03-04
IL236294A0 (en)	2015-02-26
CL2014003566A1 (es)	2015-04-10
JP2019073522A (ja)	2019-05-16
GEP201706620B (en)	2017-02-10
WO2014001973A1 (fr)	2014-01-03
DOP2014000303A (es)	2015-03-15
UY34883A (es)	2014-01-31
NZ702571A (en)	2017-02-24
PH12014502886B1 (en)	2015-02-23
US20150366874A1 (en)	2015-12-24
US9156845B2 (en)	2015-10-13
JP6189948B2 (ja)	2017-08-30
EP2867236B1 (fr)	2017-06-14
AP3902A (en)	2016-11-17
EP3255049A1 (fr)	2017-12-13
MD20140130A2 (ro)	2015-04-30
ZA201409136B (en)	2016-08-31
AP2014008147A0 (en)	2014-12-31
BR112014032913A2 (pt)	2017-06-27
MX2014015769A (es)	2015-04-10
JP2015522002A (ja)	2015-08-03
PH12014502886A1 (en)	2015-02-23
TW201414736A (zh)	2014-04-16
KR20150027267A (ko)	2015-03-11
CR20140566A (es)	2015-01-09
EP2867236A1 (fr)	2015-05-06
EA201492125A1 (ru)	2015-06-30
CN105732639A (zh)	2016-07-06
HK1204619A1 (en)	2015-11-27
IL236294A (en)	2016-09-29
JP6462795B2 (ja)	2019-01-30
NI201400151A (es)	2015-06-05
TWI482774B (zh)	2015-05-01
CA2878054A1 (fr)	2014-01-03
EA025186B1 (ru)	2016-11-30

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CA2932608A1 (fr)	2015-06-18	Composes biaryliques utiles pour le traitement de maladies humaines en oncologie, en neurologie et en immunologie
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