ES2636673T3 - Dispositivo para la administración de medicamentos contra la artritis reumatoide - Google Patents
Dispositivo para la administración de medicamentos contra la artritis reumatoide Download PDFInfo
- Publication number
- ES2636673T3 ES2636673T3 ES11774518.2T ES11774518T ES2636673T3 ES 2636673 T3 ES2636673 T3 ES 2636673T3 ES 11774518 T ES11774518 T ES 11774518T ES 2636673 T3 ES2636673 T3 ES 2636673T3
- Authority
- ES
- Spain
- Prior art keywords
- rheumatoid arthritis
- administration
- silicon
- arthritis medications
- nanostructures
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229940079593 drug Drugs 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 3
- 206010039073 rheumatoid arthritis Diseases 0.000 title abstract 3
- 238000002483 medication Methods 0.000 title 1
- 239000002086 nanomaterial Substances 0.000 abstract 2
- 230000004888 barrier function Effects 0.000 abstract 1
- 230000002500 effect on skin Effects 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 230000000717 retained effect Effects 0.000 abstract 1
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 9
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 6
- 229910052710 silicon Inorganic materials 0.000 description 6
- 239000010703 silicon Substances 0.000 description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- -1 Polyethylene Polymers 0.000 description 2
- 238000000609 electron-beam lithography Methods 0.000 description 2
- 238000005530 etching Methods 0.000 description 2
- 238000007654 immersion Methods 0.000 description 2
- PGMYKACGEOXYJE-UHFFFAOYSA-N pentyl acetate Chemical group CCCCCOC(C)=O PGMYKACGEOXYJE-UHFFFAOYSA-N 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 235000012239 silicon dioxide Nutrition 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 239000004904 UV filter Substances 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 238000005229 chemical vapour deposition Methods 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000009477 glass transition Effects 0.000 description 1
- 239000002120 nanofilm Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 238000000206 photolithography Methods 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000003507 refrigerant Substances 0.000 description 1
- 230000007261 regionalization Effects 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 238000001878 scanning electron micrograph Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 229910052814 silicon oxide Inorganic materials 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Dermatology (AREA)
- Medical Informatics (AREA)
- Vascular Medicine (AREA)
- Epidemiology (AREA)
- Surgery (AREA)
- Rheumatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicinal Preparation (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Moulds For Moulding Plastics Or The Like (AREA)
Abstract
Dispositivo (10) para la administración de un fármaco contra la artritis reumatoide a través de una barrera dérmica, comprendiendo el dispositivo: una matriz de microagujas (116) y una pluralidad de nanoestructuras (104) conformadas sobre una superficie de, como mínimo, una de las microagujas (12; 22; 120; 330; 230), estando las nanoestructuras (104) dispuestas en un patrón predeterminado; y caracterizado por que comprende adicionalmente: un depósito (112; 206; 306) que está en comunicación fluida con la matriz de microagujas (116); y un fármaco contra la artritis reumatoide retenido dentro del depósito (112; 206; 306).
Description
5
10
15
20
25
30
35
40
45
50
55
Ejemplo 1
Se prepararon varios moldes diferentes utilizando técnicas de fotolitografía similares a las empleadas en el diseño y conformación de circuitos eléctricos. Las etapas individuales del proceso se conocen de forma general en la técnica y han sido descritas.
Inicialmente, los sustratos de silicio se prepararon mediante lavado con acetona, metanol y alcohol isopropilíco, y posteriormente se recubrieron con una capa de 258 nanómetros (nm) de dióxido de silicio según un proceso de deposición química en fase vapor.
A continuación, se conformó un patrón sobre cada sustrato a través de un proceso de formación de patrones por litografía de haz de electrones, tal como se conoce en la técnica, utilizando un sistema JEOL JBX-9300FS EBL. Las condiciones de procesamiento fueron las siguientes:
Corriente del haz = 11 nA Tensión de aceleración = 100 kV Periodo de tiro = 14 nm Dosis = 260 µC/cm2 Resina fotosensible = ZEP520A, ~330 nm de espesor Revelador = acetato de n-amilo Revelado = 2 min de inmersión, seguido de enjuague de 30 s con alcohol isopropílico.
A continuación, se llevó a cabo un grabado de dióxido de silicio con un STS Advanced Oxide Etch (AOE). El tiempo de grabado fue de 50 segundos utilizando 55 centímetros cúbicos estándar por minuto (sccm) de He, 22 sccm de CF4, 20 sccm de C4F8 a 4 mTorr, bobina de 400 W, RIE de 200 W y un DC Bias de 404-411 V.
A continuación, se realizó un grabado con silicio con un grabado con óxido de silicio STS (SOE). El tiempo de grabado fue de 2 minutos utilizando 20 sccm de Cl2 y 5 sccm de Ar a 5 mTorr, bobina de 600 W, RIE de 50 W y un DC Bias de 96-102 V. La profundidad de grabado de silicio fue de 500 nanómetros.
Se utilizó una solución de grabado de óxido tamponada (BOE) para la eliminación del óxido restante, que consistió en una inmersión de BOE de tres minutos seguida por un enjuague con agua desionizada.
Se utilizó una nanoimpresora Obducat NIL-Eitre® 6 para formar patrones nanométricos sobre una variedad de sustratos poliméricos. Se utilizó agua externa como refrigerante. El módulo UV utilizó una sola lámpara pulsada a una longitud de onda comprendida entre 200 y 1.000 nanómetros a 1,8 W/cm2. Se utilizó un filtro UV de 250-400 nanómetros. El área de exposición fue de 6 pulgadas con una temperatura máxima de 200°C y a 80 bar. La nanoimpresora incluía una unidad de separación semiautomática y desmoldeo controlado automático.
Para facilitar la liberación de las películas nanoimpresas desde los moldes, los moldes se trataron con trideca-(1,1,2,2 tetrahidro)octactriclorosilano (F13-TCS). Para tratar un molde, el molde de silicio se limpió primero con un lavado de acetona, metanol y alcohol isopropílico, y se secó con nitrógeno gaseoso. Se colocó una placa de Petri sobre una placa caliente en una atmósfera de nitrógeno y se añadieron 1-5 ml de F13-TCS a la placa de Petri. Se colocó un molde de silicio en la placa de Petri y se cubrió durante 10-15 minutos para permitir que el vapor de F13-TCS humedeciera el molde de silicio antes de retirar el molde.
Se utilizaron cinco polímeros diferentes, según se indican en la siguiente tabla 1, para formar diversos diseños de nanotopografía.
Tabla 1
- Polímero
- Temperatura de transición vítrea Tg (K) Módulo de tracción (MPa) Tensión superficial (mN/m) a 20oC
- Polietileno
- 140-170 100-300 30
- Polipropileno
- 280 1.389 21
- PMMA
- 322 3.100 41
- Poliestireno
- 373 3.300 40
- Policarbonato
- 423 2.340 43
Se formaron diferentes patrones de nanotopografía, cuyas representaciones esquemáticas se ilustran en las figuras 24A-24D. El patrón de nanotopografía ilustrado en la figura 12E era una superficie de un sustrato plano adquirido a NTT Advanced Technology, de Tokio, Japón. Los patrones se designaron DN1 (figura 24A), DN2 (figura 24B), DN3 (figura 24C), DN4 (figura 24D) y NTTAT2 (figura 24E). Las imágenes de SEM de los moldes se muestran en las figuras 24A, 24B, y 24C, y las imágenes de las películas se muestran en las figuras 24D y 24E. La figura 8 ilustra una película nanoestructurada formada mediante la utilización del molde de la figura 24A (DN1). En esta película en
21
Claims (1)
-
imagen1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US435973P | 2002-12-20 | ||
| US32872310P | 2010-04-28 | 2010-04-28 | |
| US328723P | 2010-04-28 | ||
| US41110110P | 2010-11-08 | 2010-11-08 | |
| US411101P | 2010-11-08 | ||
| US201161435973P | 2011-01-25 | 2011-01-25 | |
| PCT/IB2011/051861 WO2011135530A2 (en) | 2010-04-28 | 2011-04-27 | Device for delivery of rheumatoid arthritis medication |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2636673T3 true ES2636673T3 (es) | 2017-10-06 |
Family
ID=44861972
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES11774518.2T Active ES2636673T3 (es) | 2010-04-28 | 2011-04-27 | Dispositivo para la administración de medicamentos contra la artritis reumatoide |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US9522263B2 (es) |
| EP (1) | EP2563450B1 (es) |
| JP (1) | JP5860032B2 (es) |
| KR (1) | KR101799612B1 (es) |
| CN (1) | CN102971037B (es) |
| AU (1) | AU2011246879C1 (es) |
| CA (1) | CA2797204C (es) |
| DK (1) | DK2563450T3 (es) |
| ES (1) | ES2636673T3 (es) |
| MX (1) | MX345837B (es) |
| PT (1) | PT2563450T (es) |
| RU (1) | RU2585159C2 (es) |
| WO (1) | WO2011135530A2 (es) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102105108B (zh) | 2008-05-21 | 2013-12-04 | 谢拉杰克特股份有限公司 | 制作固体溶液穿孔器贴剂的方法及其使用 |
| RU2585138C2 (ru) | 2010-04-28 | 2016-05-27 | Кимберли-Кларк Ворлдвайд, Инк. | Медицинские устройства для доставки кирнк |
| US10245421B2 (en) | 2010-04-28 | 2019-04-02 | Sorrento Therapeutics, Inc. | Nanopatterned medical device with enhanced cellular interaction |
| PT2563450T (pt) * | 2010-04-28 | 2017-08-28 | Kimberly Clark Co | Dispositivo para entrega de medicação para a artrite reumatóide |
| CA2796965C (en) | 2010-04-28 | 2019-04-16 | Kimberly-Clark Worldwide, Inc. | Method for increasing permeability of an epithelial barrier |
| CN102631243B (zh) * | 2011-02-15 | 2014-09-17 | 成功大学 | 电磁热疗法的治疗器具 |
| US8696637B2 (en) | 2011-02-28 | 2014-04-15 | Kimberly-Clark Worldwide | Transdermal patch containing microneedles |
| US8636696B2 (en) | 2011-06-10 | 2014-01-28 | Kimberly-Clark Worldwide, Inc. | Transdermal device containing microneedles |
| EP3542851B1 (en) | 2011-10-27 | 2021-12-15 | Sorrento Therapeutics, Inc. | Implantable devices for delivery of bioactive agents |
| CN104039382B (zh) | 2011-10-27 | 2018-01-12 | 金伯利-克拉克环球有限公司 | 高粘度生物活性剂的经皮递送 |
| US20170246439A9 (en) | 2011-10-27 | 2017-08-31 | Kimberly-Clark Worldwide, Inc. | Increased Bioavailability of Transdermally Delivered Agents |
| JP6249591B2 (ja) * | 2012-02-24 | 2017-12-20 | 凸版印刷株式会社 | マイクロニードル |
| JP6023752B2 (ja) * | 2014-06-10 | 2016-11-09 | 日本写真印刷株式会社 | マイクロニードルシート及び経皮投与用貼付剤 |
| WO2016006409A1 (ja) * | 2014-07-09 | 2016-01-14 | 凸版印刷株式会社 | 液剤注入装置 |
| GB201420946D0 (en) * | 2014-11-25 | 2015-01-07 | Kirby Andrew J And Xobaderm Ltd | Flexible device incorporating microperforators |
| KR20170118698A (ko) * | 2014-12-10 | 2017-10-25 | 더 차레스 스타크 드레이퍼 래보레이토리, 인코포레이티드 | 폴리머 마이크로웨지 및 그 제조방법 |
| CN107949418B (zh) * | 2015-07-24 | 2024-07-02 | 索伦托治疗有限公司 | 用于活性剂的淋巴递送的方法 |
| PL3325080T3 (pl) | 2015-07-24 | 2022-01-24 | Sorrento Therapeutics, Inc. | Sposoby lepszego dostarczania środków czynnych do guzów |
| JP6606939B2 (ja) * | 2015-09-17 | 2019-11-20 | 凸版印刷株式会社 | 経皮投与デバイス、および、経皮投与デバイスの製造方法 |
| EP3351287A4 (en) * | 2015-09-17 | 2019-10-09 | AOF Pte. Ltd. | MICRO NEEDLE |
| GB201517373D0 (en) * | 2015-10-01 | 2015-11-18 | Ge Healthcare Uk Ltd | Micro-Needle Sampling Device And Use Thereof |
| EP3365096A4 (en) * | 2015-10-20 | 2019-12-04 | National Research Council of Canada | POLYMERMERMBRANE WITH OPEN PIPE HOLES AND METHOD FOR THE PRODUCTION THEREOF |
| KR101719319B1 (ko) * | 2016-04-05 | 2017-03-23 | 주식회사 엘지생활건강 | 효율적인 피부 천공을 위한 마이크로니들 구조 |
| CN113198101B (zh) | 2016-04-29 | 2023-06-09 | 索伦托治疗有限公司 | 微针阵列组件、药物递送装置和用于大面积低压输注液体的方法 |
| CN106063971A (zh) * | 2016-05-24 | 2016-11-02 | 中山大学 | 基于金属多孔微针阵列的经皮电渗给药装置及给药方法 |
| WO2018132430A1 (en) | 2017-01-10 | 2018-07-19 | A.T. Still Universiy | Fluid infusion system |
| AU2018222745B2 (en) | 2017-02-17 | 2021-02-18 | Allergan, Inc. | Microneedle array with active ingredient |
| CA3053362C (en) * | 2017-04-04 | 2022-11-29 | F. Hoffmann-La Roche Ag | Body-wearable medical device |
| US12042284B2 (en) * | 2018-01-23 | 2024-07-23 | Medtronic Minimed, Inc. | Implantable polymer surfaces exhibiting reduced in vivo inflammatory responses |
| US11926091B2 (en) | 2018-03-27 | 2024-03-12 | UNITED STATES OF AMERICA has certain rights in the invention from DOE Grant No. DE-SC0008581 | In situ partially degradable separation interface for fabrication of complex near net shape objects by pressure assisted sintering |
| JP7476119B2 (ja) * | 2018-06-29 | 2024-04-30 | ジョンソン アンド ジョンソン コンシューマー インコーポレイテッド | 活性物質の送達のための三次元マイクロ流体デバイス |
| JP2021533901A (ja) * | 2018-08-15 | 2021-12-09 | アラーガン、インコーポレイテッドAllergan, Incorporated | 有効成分を含むマイクロニードルアレイ |
| CN109528695B (zh) * | 2019-01-12 | 2022-04-19 | 蚌埠医学院 | 一种治疗类风湿性关节炎的微针透皮给药贴片及其制备方法 |
| US12434427B2 (en) | 2019-08-20 | 2025-10-07 | Solventum Intellectual Properties Company | Microstructured surface with increased microorganism removal when cleaned, articles and methods |
| US11766822B2 (en) | 2019-08-20 | 2023-09-26 | 3M Innovative Properties Company | Microstructured surface with increased microorganism removal when cleaned, articles and methods |
| US11638545B2 (en) * | 2019-10-16 | 2023-05-02 | Medtronic Minimed, Inc. | Reducing sensor foreign body response via high surface area metal structures |
| KR20220110273A (ko) | 2019-12-05 | 2022-08-05 | 소렌토 쎄라퓨틱스, 인코포레이티드 | 항-pd-1 또는 항-pd-l1 치료제를 림프 전달 장치를 통해 투여하여 암을 치료하는 방법 |
| CN111420264B (zh) * | 2020-04-23 | 2022-01-18 | 西安交通大学医学院第一附属医院 | 一种类风湿关节炎多部位辅助治疗器械 |
| CN115734798A (zh) | 2020-04-28 | 2023-03-03 | 提克纳有限责任公司 | 微针组件 |
| US12280540B2 (en) | 2020-09-27 | 2025-04-22 | San Diego State University Research Foundation | In situ partially degradable separation interface for fabrication of complex near net shape objects by pressure assisted sintering |
| CN117813128A (zh) | 2021-01-22 | 2024-04-02 | 索伦托药业有限公司 | 用于微升级淋巴递送冠状病毒疫苗的装置 |
| WO2022192594A2 (en) | 2021-03-11 | 2022-09-15 | Sorrento Therapeutics, Inc. | Nucleic acid molecules and vaccines comprising same for the prevention and treatment of coronavirus infections and disease |
| CA3221925A1 (en) | 2021-06-09 | 2022-12-15 | Sorrento Therapeutics, Inc. | Method of treating cancer by administration of an anti-pd-1 or anti-pd-l1 therapeutic agent via a lymphatic microneedle delivery device |
| US20250120905A1 (en) | 2021-08-18 | 2025-04-17 | Vivasor, Inc | Therapeutic agents targeting the lymphatic system |
| JP2023037488A (ja) * | 2021-09-03 | 2023-03-15 | 地方独立行政法人神奈川県立産業技術総合研究所 | 薬剤送達デバイスおよびその製造方法 |
| KR20230063270A (ko) * | 2021-11-01 | 2023-05-09 | 신신제약 주식회사 | 마이크로니들을 포함하는 약물 전달 장치 |
| CN116585606A (zh) * | 2023-06-15 | 2023-08-15 | 徕兄健康科技(威海)有限责任公司 | 一种可自调节的局部麻醉用微针贴片 |
| WO2025129128A1 (en) | 2023-12-15 | 2025-06-19 | Vivasor, Inc. | Compositions and methods for non-viral delivery of therapeutic compounds |
Family Cites Families (199)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3797494A (en) | 1969-04-01 | 1974-03-19 | Alza Corp | Bandage for the administration of drug by controlled metering through microporous materials |
| US3964482A (en) | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
| US4031894A (en) | 1975-12-08 | 1977-06-28 | Alza Corporation | Bandage for transdermally administering scopolamine to prevent nausea |
| US4436741A (en) | 1975-12-08 | 1984-03-13 | Alza Corporation | Method for administering scopolamine transdermally |
| US4051840A (en) | 1976-01-05 | 1977-10-04 | Sinai Hospital Of Detroit | Dynamic aortic patch |
| US4201211A (en) | 1977-07-12 | 1980-05-06 | Alza Corporation | Therapeutic system for administering clonidine transdermally |
| US4379454A (en) | 1981-02-17 | 1983-04-12 | Alza Corporation | Dosage for coadministering drug and percutaneous absorption enhancer |
| US4725272A (en) | 1981-06-29 | 1988-02-16 | Alza Corporation | Novel bandage for administering beneficial drug |
| US4661105A (en) | 1981-06-29 | 1987-04-28 | Alza Corporation | Medical bandage for administering vasodilator drug |
| US5310559A (en) | 1982-09-01 | 1994-05-10 | Hercon Laboratories Corporation | Device for controlled release and delivery to mammalian tissue of pharmacologically active agents incorporating a rate controlling member which comprises an alkylene-alkyl acrylate copolymer |
| US4588580B2 (en) | 1984-07-23 | 1999-02-16 | Alaz Corp | Transdermal administration of fentanyl and device therefor |
| US4615699A (en) | 1985-05-03 | 1986-10-07 | Alza Corporation | Transdermal delivery system for delivering nitroglycerin at high transdermal fluxes |
| US4681584A (en) | 1985-05-03 | 1987-07-21 | Alza Corporation | Transdermal delivery system for delivering nitroglycerin at high transdermal fluxes |
| US4698062A (en) | 1985-10-30 | 1987-10-06 | Alza Corporation | Medical device for pulsatile transdermal delivery of biologically active agents |
| US4880633A (en) | 1986-03-12 | 1989-11-14 | Merck & Co., Inc. | Transdermal drug delivery system |
| US5344656A (en) | 1986-09-12 | 1994-09-06 | Alza Corporation | Subsaturated transdermal therapeutic system having improved release characteristics |
| US4908027A (en) | 1986-09-12 | 1990-03-13 | Alza Corporation | Subsaturated transdermal therapeutic system having improved release characteristics |
| US4832953A (en) | 1987-08-13 | 1989-05-23 | Alza Corporation | Method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a monaqueous matrix |
| US5364630A (en) | 1988-06-14 | 1994-11-15 | Alza Corporation | Subsaturated nicotine transdermal therapeutic system |
| US5004610A (en) | 1988-06-14 | 1991-04-02 | Alza Corporation | Subsaturated nicotine transdermal therapeutic system |
| US5328470A (en) | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
| US5344565A (en) | 1993-07-26 | 1994-09-06 | Pall Corporation | Method of treating a clogged porous medium |
| DE19525607A1 (de) * | 1995-07-14 | 1997-01-16 | Boehringer Ingelheim Kg | Transcorneales Arzneimittelfreigabesystem |
| AU8681098A (en) | 1997-08-01 | 1999-03-08 | Massachusetts Institute Of Technology | Three-dimensional polymer matrices |
| KR100576583B1 (ko) | 1997-12-22 | 2006-05-04 | 알자 코포레이션 | 서방성 약물 송달 장치용 속도 조절막 |
| GB9805214D0 (en) | 1998-03-11 | 1998-05-06 | Univ Glasgow | Cell adhesion |
| US6503231B1 (en) | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
| WO1999064580A1 (en) * | 1998-06-10 | 1999-12-16 | Georgia Tech Research Corporation | Microneedle devices and methods of manufacture and use thereof |
| GB9815819D0 (en) | 1998-07-22 | 1998-09-16 | Secr Defence | Transferring materials into cells and a microneedle array |
| US7048723B1 (en) | 1998-09-18 | 2006-05-23 | The University Of Utah Research Foundation | Surface micromachined microneedles |
| TW480759B (en) | 1999-03-18 | 2002-03-21 | Seiko Epson Corp | Electronic machine, charged electronic machine and control method of electronic machine |
| US6611707B1 (en) | 1999-06-04 | 2003-08-26 | Georgia Tech Research Corporation | Microneedle drug delivery device |
| US6743211B1 (en) | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
| US6312612B1 (en) | 1999-06-09 | 2001-11-06 | The Procter & Gamble Company | Apparatus and method for manufacturing an intracutaneous microneedle array |
| US6256533B1 (en) | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
| US6835184B1 (en) | 1999-09-24 | 2004-12-28 | Becton, Dickinson And Company | Method and device for abrading skin |
| US6569143B2 (en) | 1999-10-14 | 2003-05-27 | Becton, Dickinson And Company | Method of intradermally injecting substances |
| US20020095134A1 (en) | 1999-10-14 | 2002-07-18 | Pettis Ronald J. | Method for altering drug pharmacokinetics based on medical delivery platform |
| CN1390148A (zh) * | 1999-11-15 | 2003-01-08 | 维尔克鲁工业公司 | 皮肤附着件 |
| IL134997A0 (en) | 2000-03-09 | 2001-05-20 | Yehoshua Yeshurun | Health care system based on micro device |
| EP1309726B2 (en) | 2000-03-30 | 2018-10-03 | Whitehead Institute For Biomedical Research | Rna sequence-specific mediators of rna interference |
| US7473244B2 (en) | 2000-06-02 | 2009-01-06 | The University Of Utah Research Foundation | Active needle devices with integrated functionality |
| US6440096B1 (en) | 2000-07-14 | 2002-08-27 | Becton, Dickinson And Co. | Microdevice and method of manufacturing a microdevice |
| US6656147B1 (en) | 2000-07-17 | 2003-12-02 | Becton, Dickinson And Company | Method and delivery device for the transdermal administration of a substance |
| AU2002210881A1 (en) | 2000-10-12 | 2002-04-22 | Ink Jet Technology Ltd. | Transdermal method |
| RU2275871C2 (ru) * | 2000-10-13 | 2006-05-10 | Алза Корпорейшн | Устройство и способ для прокалывания кожи микровыступами |
| US7108681B2 (en) | 2000-10-16 | 2006-09-19 | Corium International, Inc. | Microstructures for delivering a composition cutaneously to skin |
| US7131987B2 (en) | 2000-10-16 | 2006-11-07 | Corium International, Inc. | Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation |
| US7828827B2 (en) * | 2002-05-24 | 2010-11-09 | Corium International, Inc. | Method of exfoliation of skin using closely-packed microstructures |
| US6979347B1 (en) | 2000-10-23 | 2005-12-27 | Advanced Cardiovascular Systems, Inc. | Implantable drug delivery prosthesis |
| NL1016779C2 (nl) * | 2000-12-02 | 2002-06-04 | Cornelis Johannes Maria V Rijn | Matrijs, werkwijze voor het vervaardigen van precisieproducten met behulp van een matrijs, alsmede precisieproducten, in het bijzonder microzeven en membraanfilters, vervaardigd met een dergelijke matrijs. |
| EP1342075B1 (en) | 2000-12-11 | 2008-09-10 | President And Fellows Of Harvard College | Device contaning nanosensors for detecting an analyte and its method of manufacture |
| WO2002064193A2 (en) | 2000-12-14 | 2002-08-22 | Georgia Tech Research Corporation | Microneedle devices and production thereof |
| CA2451882A1 (en) | 2001-03-14 | 2002-09-19 | University Of Massachusetts | Nanofabrication |
| US6663820B2 (en) | 2001-03-14 | 2003-12-16 | The Procter & Gamble Company | Method of manufacturing microneedle structures using soft lithography and photolithography |
| US6591124B2 (en) | 2001-05-11 | 2003-07-08 | The Procter & Gamble Company | Portable interstitial fluid monitoring system |
| US6767341B2 (en) | 2001-06-13 | 2004-07-27 | Abbott Laboratories | Microneedles for minimally invasive drug delivery |
| SE0102736D0 (sv) | 2001-08-14 | 2001-08-14 | Patrick Griss | Side opened out-of-plane microneedles for microfluidic transdermal interfacing and fabrication process of side opened out-of-plane microneedles |
| US6881203B2 (en) | 2001-09-05 | 2005-04-19 | 3M Innovative Properties Company | Microneedle arrays and methods of manufacturing the same |
| JP4383168B2 (ja) | 2001-09-12 | 2009-12-16 | ベクトン・ディキンソン・アンド・カンパニー | マイクロ針投与デバイスおよび薬物投与デバイス |
| US20040087992A1 (en) | 2002-08-09 | 2004-05-06 | Vladimir Gartstein | Microstructures for delivering a composition cutaneously to skin using rotatable structures |
| EP1471953B1 (en) | 2001-09-21 | 2011-02-16 | Valeritas, Inc. | Gas pressure actuated microneedle arrays, and systems and methods relating to same |
| US6746825B2 (en) | 2001-10-05 | 2004-06-08 | Wisconsin Alumni Research Foundation | Guided self-assembly of block copolymer films on interferometrically nanopatterned substrates |
| US7429258B2 (en) | 2001-10-26 | 2008-09-30 | Massachusetts Institute Of Technology | Microneedle transport device |
| US6908453B2 (en) | 2002-01-15 | 2005-06-21 | 3M Innovative Properties Company | Microneedle devices and methods of manufacture |
| EP1490147A2 (en) | 2002-03-04 | 2004-12-29 | Nano Pass Technologies Ltd. | Devices and methods for transporting fluid across a biological barrier |
| US7115108B2 (en) | 2002-04-02 | 2006-10-03 | Becton, Dickinson And Company | Method and device for intradermally delivering a substance |
| WO2003092785A1 (en) | 2002-04-30 | 2003-11-13 | Morteza Shirkhanzadeh | Arrays of microneedles comprising porous calcium phosphate coating and bioactive agents |
| WO2004032990A2 (en) | 2002-07-22 | 2004-04-22 | Becton, Dickinson And Company | Patch-like infusion device |
| US7185663B2 (en) | 2002-07-24 | 2007-03-06 | Koch Kenneth W | Methods and compositions for on-line gas turbine cleaning |
| US20040063100A1 (en) | 2002-09-30 | 2004-04-01 | Wang Chung Lin | Nanoneedle chips and the production thereof |
| EP1590034B1 (en) | 2002-10-07 | 2014-05-14 | Biovalve Technologies, Inc. | Microneedle array patch |
| IL152271A (en) * | 2002-10-13 | 2006-04-10 | Meir Hefetz | Structures of micro needles and manufacturing methods |
| IL152912A0 (en) * | 2002-11-18 | 2003-06-24 | Nanopass Ltd | Micro needle systems |
| US6995336B2 (en) | 2003-01-29 | 2006-02-07 | The Regents Of The University Of Michigan | Method for forming nanoscale features |
| WO2005029179A2 (en) * | 2003-02-13 | 2005-03-31 | The Regents Of The University Of Michigan | Combined nanoimprinting and photolithography for micro and nano devices fabrication |
| US7578954B2 (en) | 2003-02-24 | 2009-08-25 | Corium International, Inc. | Method for manufacturing microstructures having multiple microelements with through-holes |
| US7972616B2 (en) | 2003-04-17 | 2011-07-05 | Nanosys, Inc. | Medical device applications of nanostructured surfaces |
| JP2006524120A (ja) | 2003-04-21 | 2006-10-26 | ストラテージェント ライフ サイエンシズ | マイクロジェットで反復的に薬物を搬送する装置および方法 |
| US7803574B2 (en) | 2003-05-05 | 2010-09-28 | Nanosys, Inc. | Medical device applications of nanostructured surfaces |
| US7572405B2 (en) | 2003-06-02 | 2009-08-11 | Corium International Inc. | Method for manufacturing microstructures having hollow microelements using fluidic jets during a molding operation |
| US7563451B2 (en) | 2003-07-22 | 2009-07-21 | Iowa State University Research Foundation, Inc. | Capped mesoporous silicates |
| EP1660162B1 (en) | 2003-08-01 | 2019-05-15 | Kanag Baska | Laryngeal mask |
| EP1668117A4 (en) | 2003-08-18 | 2006-12-13 | Gen Hospital Corp | NANOTOPOGRAPHIC COMPOSITIONS AND METHOD FOR CELLULAR ORGANIZATION IN TISSUE CONSTRUCTION STRUCTURES |
| EP1660172A1 (en) | 2003-08-26 | 2006-05-31 | Alza Corporation | Device and method for intradermal cell implantation |
| US7544770B2 (en) | 2003-08-29 | 2009-06-09 | Louisiana Tech Foundation, Inc. | Multilayer films, coatings, and microcapsules comprising polypeptides |
| DE10353629A1 (de) | 2003-11-17 | 2005-06-16 | Lts Lohmann Therapie-Systeme Ag | Vorrichtung zur transdermalen Verabreichung von Wirkstoffen |
| US7753888B2 (en) | 2003-11-21 | 2010-07-13 | The Regents Of The University Of California | Method and/or apparatus for puncturing a surface for extraction, in situ analysis, and/or substance delivery using microneedles |
| JP2007518468A (ja) | 2003-11-21 | 2007-07-12 | アルザ・コーポレーシヨン | 超音波支援経皮ワクチン送達方法およびシステム |
| US20050119723A1 (en) | 2003-11-28 | 2005-06-02 | Medlogics Device Corporation | Medical device with porous surface containing bioerodable bioactive composites and related methods |
| GB0402131D0 (en) | 2004-01-30 | 2004-03-03 | Isis Innovation | Delivery method |
| JP4832082B2 (ja) | 2004-02-03 | 2011-12-07 | 久光製薬株式会社 | 経皮薬物投与装置用インタフェース |
| WO2005082593A1 (en) | 2004-02-17 | 2005-09-09 | Avery Dennison Corporation | Method of making microneedles |
| US20070191761A1 (en) | 2004-02-23 | 2007-08-16 | 3M Innovative Properties Company | Method of molding for microneedle arrays |
| US8915957B2 (en) | 2004-03-11 | 2014-12-23 | Alcatel Lucent | Drug delivery stent |
| US7611481B2 (en) | 2004-03-24 | 2009-11-03 | Corium International, Inc. | Transdermal delivery device |
| EP1753292A4 (en) | 2004-05-12 | 2007-09-26 | Kamel Khalili | COMPOSITIONS AND METHODS FOR INHIBITING ARNIC GENES OF PRIMATE POLYOMA VIRUS |
| US7315758B2 (en) | 2004-06-03 | 2008-01-01 | Lynntech, Inc. | Transdermal delivery of therapeutic agent |
| US20060025848A1 (en) | 2004-07-29 | 2006-02-02 | Jan Weber | Medical device having a coating layer with structural elements therein and method of making the same |
| WO2006015299A2 (en) | 2004-07-30 | 2006-02-09 | Microchips, Inc. | Multi-reservoir device for transdermal drug delivery and sensing |
| US8696619B2 (en) | 2004-08-10 | 2014-04-15 | Robert P. Schnall | Drug delivery devices |
| EP1790375A4 (en) | 2004-08-12 | 2009-06-17 | Hisamitsu Pharmaceutical Co | TRANSDERMAL MEDICINE ADMINISTRATION WITH MICRONADEL |
| US7316665B2 (en) | 2004-08-25 | 2008-01-08 | Becton, Dickinson And Company | Method and device for the delivery of a substance including a covering |
| DE102004041813A1 (de) | 2004-08-26 | 2006-03-02 | Siemens Ag | Oberfläche mit einer haftungsvermindernden Mikrostruktur und Verfahren zu deren Herstellung |
| SE0402100D0 (sv) | 2004-08-30 | 2004-08-30 | Bonsens Ab | Molded micro-needles |
| US8137697B1 (en) | 2004-10-05 | 2012-03-20 | Gp Medical, Inc. | Nanoparticles for protein/peptide delivery and delivery means thereof |
| US7449200B2 (en) | 2006-04-17 | 2008-11-11 | Gp Medical, Inc. | Nanoparticles for protein/peptide delivery and delivery means |
| US7627938B2 (en) | 2004-10-15 | 2009-12-08 | Board Of Regents, The Univeristy Of Texas System | Tapered hollow metallic microneedle array assembly and method of making and using the same |
| US8057842B2 (en) | 2004-11-18 | 2011-11-15 | 3M Innovative Properties Company | Method of contact coating a microneedle array |
| CA2587216C (en) | 2004-11-18 | 2014-11-18 | Nanopass Technologies Ltd. | System and method for delivering fluid into flexible biological barrier |
| CA2588080C (en) * | 2004-11-18 | 2013-01-08 | 3M Innovative Properties Company | Masking method for coating a microneedle array |
| CA2589733C (en) | 2004-12-07 | 2014-02-11 | 3M Innovative Properties Company | Method of molding a microneedle |
| EP1819393B1 (en) | 2004-12-10 | 2010-10-06 | 3M Innovative Properties Company | Medical device |
| WO2006075689A1 (ja) | 2005-01-14 | 2006-07-20 | Fujikura Ltd. | 医薬物運搬用器具とその製造方法 |
| US20070112548A1 (en) | 2005-02-18 | 2007-05-17 | Georgia Tech Research Corporation | Methods for fabricating micro-to-nanoscale devices via biologically-induced solid formation on biologically-derived templates, and micro-to-nanoscale structures and micro-to-nanoscale devices made thereby |
| US20080269666A1 (en) | 2005-05-25 | 2008-10-30 | Georgia Tech Research Corporation | Microneedles and Methods for Microinfusion |
| WO2007002523A2 (en) | 2005-06-24 | 2007-01-04 | 3M Innovative Properties Company | Collapsible patch with microneedle array |
| ATE477833T1 (de) | 2005-06-27 | 2010-09-15 | 3M Innovative Properties Co | Mikronadelkartuschenanordnung |
| CA2614927A1 (en) * | 2005-07-25 | 2007-02-01 | Nanotechnology Victoria Pty Ltd | Microarray device |
| US8118753B2 (en) | 2005-08-18 | 2012-02-21 | Seoul National University Industry Foundation | Barb-wired micro needle made of single crystalline silicon and biopsy method and medicine injecting method using the same |
| CN101242869B (zh) | 2005-09-02 | 2010-05-26 | Iomai公司 | 经皮递送疫苗和透皮递送药物的装置及其应用 |
| US7659252B2 (en) | 2005-09-15 | 2010-02-09 | Novomed Technologies, Inc. (Shanghai) | Transdermal delivery peptides and method of use thereof |
| US20070066934A1 (en) | 2005-09-19 | 2007-03-22 | Transport Pharmaceuticals, Inc. | Electrokinetic delivery system and methods therefor |
| JP2007089792A (ja) * | 2005-09-28 | 2007-04-12 | Nano Device & System Research Inc | 経皮投与装置 |
| JP2009509634A (ja) | 2005-09-30 | 2009-03-12 | Ｔｔｉ・エルビュー株式会社 | 官能基化マイクロニードル経皮薬剤送達システム、装置及び方法 |
| KR20080066712A (ko) | 2005-09-30 | 2008-07-16 | 티티아이 엘뷰 가부시키가이샤 | 관능화된 미세바늘 경피 약물 전달 시스템, 장치 및 방법 |
| US20070112309A1 (en) | 2005-11-17 | 2007-05-17 | Jerry Zucker | Withdrawal syringe |
| US20080262416A1 (en) | 2005-11-18 | 2008-10-23 | Duan Daniel C | Microneedle Arrays and Methods of Preparing Same |
| WO2007070004A2 (en) * | 2005-12-14 | 2007-06-21 | Silex Microsystems Ab | Methods for making micro needles and applications thereof |
| US8944804B2 (en) | 2006-01-04 | 2015-02-03 | Liquidia Technologies, Inc. | Nanostructured surfaces for biomedical/biomaterial applications and processes thereof |
| US7658728B2 (en) | 2006-01-10 | 2010-02-09 | Yuzhakov Vadim V | Microneedle array, patch, and applicator for transdermal drug delivery |
| JPWO2007091608A1 (ja) | 2006-02-10 | 2009-07-02 | 久光製薬株式会社 | マイクロニードル付き経皮薬物投与装置 |
| US20070224235A1 (en) | 2006-03-24 | 2007-09-27 | Barron Tenney | Medical devices having nanoporous coatings for controlled therapeutic agent delivery |
| WO2007112309A2 (en) | 2006-03-24 | 2007-10-04 | 3M Innovative Properties Company | Process for making microneedles, microneedle arrays, masters, and replication tools |
| WO2007116959A1 (ja) | 2006-04-07 | 2007-10-18 | Hisamitsu Pharmaceutical Co., Inc. | マイクロニードルデバイスおよびマイクロニードル付き経皮薬物投与装置 |
| CN1830496A (zh) | 2006-04-10 | 2006-09-13 | 清华大学 | “－”字形结构三维微型实心、空心硅针或刀 |
| WO2007124411A1 (en) | 2006-04-20 | 2007-11-01 | 3M Innovative Properties Company | Device for applying a microneedle array |
| US7918814B2 (en) | 2006-05-02 | 2011-04-05 | Georgia Tech Research Corporation | Method for drug delivery to ocular tissue using microneedle |
| WO2008024141A2 (en) * | 2006-05-09 | 2008-02-28 | Apogee Technology, Inc. | Nanofiber structures on asperities for sequestering, carrying and transferring substances |
| JP5290962B2 (ja) | 2006-05-17 | 2013-09-18 | デビオテック ソシエテ アノニム | 異方性ナノ多孔質被膜 |
| US20070276318A1 (en) | 2006-05-26 | 2007-11-29 | Mit, Llp | Iontosonic-microneedle applicator apparatus and methods |
| DE102006031506A1 (de) | 2006-07-07 | 2008-01-17 | Robert Bosch Gmbh | Verfahren zur Herstellung von Mikronadeln in einem Si-Halbleitersubstrat |
| MX2009001248A (es) * | 2006-08-03 | 2009-02-11 | Nitec Pharma Ag | Tratamiento con glucocorticoide de liberacion prolongada de enfermedad reumatoide. |
| WO2008020632A1 (en) | 2006-08-18 | 2008-02-21 | Toppan Printing Co., Ltd. | Microneedle and microneedle patch |
| DE102006040642A1 (de) | 2006-08-30 | 2008-03-13 | Robert Bosch Gmbh | Mikronadeln zur Platzierung in der Haut zwecks transdermaler Applikation von Pharmazeutika |
| ES2360538T3 (es) | 2006-09-08 | 2011-06-06 | Johns Hopkins University | Composiciones para aumentar el transporte a través de moco. |
| US20080097352A1 (en) * | 2006-09-12 | 2008-04-24 | Beck Patricia A | Methods of fabricating microneedles with bio-sensory functionality |
| GB0620617D0 (en) | 2006-10-17 | 2006-11-29 | Glaxo Group Ltd | Novel device |
| US20080091226A1 (en) | 2006-10-17 | 2008-04-17 | Nanopass Technologies Ltd. | Microneedle device |
| WO2008115290A2 (en) | 2006-10-25 | 2008-09-25 | Revalesio Corporation | Methods of wound care and treatment |
| US7785301B2 (en) | 2006-11-28 | 2010-08-31 | Vadim V Yuzhakov | Tissue conforming microneedle array and patch for transdermal drug delivery or biological fluid collection |
| US8238995B2 (en) | 2006-12-08 | 2012-08-07 | General Electric Company | Self-adhering electrodes and methods of making the same |
| WO2008078319A1 (en) | 2006-12-22 | 2008-07-03 | Medingo Ltd. | Fluid delivery with in vivo electrochemical analyte sensing |
| US8560059B2 (en) | 2007-03-09 | 2013-10-15 | Covidien Lp | System and methods for optical sensing and drug delivery using microneedles |
| US9775932B2 (en) | 2007-03-16 | 2017-10-03 | The Regents Of The University Of California | Nanostructure surface coated medical implants and methods of using the same |
| JP2008237673A (ja) * | 2007-03-28 | 2008-10-09 | Toppan Printing Co Ltd | 針状体およびその製造方法 |
| US9114238B2 (en) | 2007-04-16 | 2015-08-25 | Corium International, Inc. | Solvent-cast microprotrusion arrays containing active ingredient |
| US20080311172A1 (en) | 2007-04-25 | 2008-12-18 | Schapira Jay N | Programmed-release, nanostructured biological construct |
| US8366677B2 (en) | 2007-08-06 | 2013-02-05 | Transderm, Inc. | Microneedle arrays formed from polymer films |
| US20100121307A1 (en) | 2007-08-24 | 2010-05-13 | Microfabrica Inc. | Microneedles, Microneedle Arrays, Methods for Making, and Transdermal and/or Intradermal Applications |
| US20090093879A1 (en) | 2007-10-04 | 2009-04-09 | Debra Wawro | Micro- and nano-patterned surface features to reduce implant fouling and regulate wound healing |
| US20090093871A1 (en) | 2007-10-08 | 2009-04-09 | Medtronic Vascular, Inc. | Medical Implant With Internal Drug Delivery System |
| US20090099427A1 (en) | 2007-10-12 | 2009-04-16 | Arkal Medical, Inc. | Microneedle array with diverse needle configurations |
| CN101970030B (zh) | 2007-12-17 | 2014-04-16 | 新世界药品有限公司 | 整合的真皮内递送、诊断和通讯系统 |
| WO2009079712A1 (en) | 2007-12-24 | 2009-07-02 | The University Of Queensland | Coating method |
| JP2009207733A (ja) * | 2008-03-05 | 2009-09-17 | Toppan Printing Co Ltd | 針状体 |
| EP2100850A1 (en) * | 2008-03-11 | 2009-09-16 | Stichting Voor De Technische Wetenschappen | Microneedle array and a method for manufacturing microneedles |
| WO2009114719A2 (en) | 2008-03-13 | 2009-09-17 | Richmond Chemical Corporation | Apparatus and method of retaining and releasing molecules from nanostructures by an external stimulus |
| CA2760680A1 (en) | 2008-05-23 | 2009-11-26 | The University Of Queensland | Analyte detection by microneedle patch with analyte selective reagents |
| US20100004733A1 (en) | 2008-07-02 | 2010-01-07 | Boston Scientific Scimed, Inc. | Implants Including Fractal Structures |
| US20100028604A1 (en) | 2008-08-01 | 2010-02-04 | The Ohio State University | Hierarchical structures for superhydrophobic surfaces and methods of making |
| CN101347652B (zh) | 2008-09-09 | 2011-01-12 | 南京大学 | 一种空心微针阵列注射器的制备方法 |
| CA2702604C (en) | 2008-09-22 | 2013-12-03 | Biochemics, Inc. | Transdermal drug delivery using an osmolyte and vasoactive agent |
| US20110021996A1 (en) | 2008-12-18 | 2011-01-27 | Miti Systems Inc. | Structure of micro-needle with side channel and manufacturing method thereof |
| KR101039078B1 (ko) | 2009-08-04 | 2011-06-07 | (주)마이티시스템 | 이동되는 약물 저장 캡슐이 있는 미세바늘 약물 전달 시스템 |
| US9358375B2 (en) | 2008-12-19 | 2016-06-07 | Janisys Limited | Fluid transfer device and an active substance cartridge for the fluid transfer device, and a method for controlling the pressure at which an active substance is delivered to a subject from a fluid transfer device |
| KR101087088B1 (ko) | 2008-12-29 | 2011-11-25 | 한국과학기술연구원 | 나노 구조 패턴을 갖는 약물 방출용 스텐트의 제조방법 및 이로부터 제조된 약물 방출용 스텐트 |
| KR101033513B1 (ko) | 2009-01-20 | 2011-05-09 | (주)마이티시스템 | 미세바늘을 이용한 유용성분 피부전달용 용기 |
| EP2381972A2 (en) | 2009-01-27 | 2011-11-02 | California Institute Of Technology | Drug delivery and substance transfer facilitated by nano-enhanced device having aligned carbon nanotubes protruding from device surface |
| JP5717653B2 (ja) | 2009-02-12 | 2015-05-13 | タフツ ユニバーシティー／トラスティーズ オブ タフツ カレッジ | 生物医学的用途およびバイオフォトニック用途のための絹フィブロイン構造体のナノインプリンティングの方法 |
| SG10201401744QA (en) | 2009-04-23 | 2014-08-28 | Univ Singapore | An apparatus that includes nano-sized projections and a method for manufacture thereof |
| WO2010126174A1 (en) | 2009-05-01 | 2010-11-04 | Nanbu Plastics Co., Ltd. | Transdermal administration device |
| US8389205B2 (en) * | 2009-06-11 | 2013-03-05 | International Business Machines Corporation | Patterning nano-scale patterns on a film comprising unzipping polymer chains |
| DE102009035795A1 (de) | 2009-07-31 | 2011-02-03 | Leibniz-Institut Für Neue Materialien Gemeinnützige Gmbh | Struktuierte Oberflächen für Implantate |
| US20110144591A1 (en) | 2009-12-11 | 2011-06-16 | Ross Russell F | Transdermal Delivery Device |
| US20110306853A1 (en) | 2010-03-19 | 2011-12-15 | Michael Darryl Black | Body fluid sampling/fluid delivery device |
| WO2011127207A2 (en) | 2010-04-07 | 2011-10-13 | California Institute Of Technology | Simple method for producing superhydrophobic carbon nanotube array |
| US10245421B2 (en) | 2010-04-28 | 2019-04-02 | Sorrento Therapeutics, Inc. | Nanopatterned medical device with enhanced cellular interaction |
| RU2585138C2 (ru) | 2010-04-28 | 2016-05-27 | Кимберли-Кларк Ворлдвайд, Инк. | Медицинские устройства для доставки кирнк |
| CA2796965C (en) | 2010-04-28 | 2019-04-16 | Kimberly-Clark Worldwide, Inc. | Method for increasing permeability of an epithelial barrier |
| PT2563450T (pt) * | 2010-04-28 | 2017-08-28 | Kimberly Clark Co | Dispositivo para entrega de medicação para a artrite reumatóide |
| WO2012006677A1 (en) | 2010-07-14 | 2012-01-19 | The University Of Queensland | Patch applying apparatus |
| WO2012058605A1 (en) * | 2010-10-28 | 2012-05-03 | 3M Innovative Properties Company | Engineered surfaces for reducing bacterial adhesion |
| US9017289B2 (en) | 2010-11-03 | 2015-04-28 | Covidien Lp | Transdermal fluid delivery device |
| CN103619384A (zh) | 2011-01-18 | 2014-03-05 | 麻省理工学院 | 装置和其用途 |
| US8696637B2 (en) | 2011-02-28 | 2014-04-15 | Kimberly-Clark Worldwide | Transdermal patch containing microneedles |
| EP3542851B1 (en) | 2011-10-27 | 2021-12-15 | Sorrento Therapeutics, Inc. | Implantable devices for delivery of bioactive agents |
| US20170246439A9 (en) | 2011-10-27 | 2017-08-31 | Kimberly-Clark Worldwide, Inc. | Increased Bioavailability of Transdermally Delivered Agents |
| CN104039382B (zh) * | 2011-10-27 | 2018-01-12 | 金伯利-克拉克环球有限公司 | 高粘度生物活性剂的经皮递送 |
-
2011
- 2011-04-27 PT PT117745182T patent/PT2563450T/pt unknown
- 2011-04-27 CA CA2797204A patent/CA2797204C/en active Active
- 2011-04-27 AU AU2011246879A patent/AU2011246879C1/en not_active Ceased
- 2011-04-27 DK DK11774518.2T patent/DK2563450T3/da active
- 2011-04-27 MX MX2012012437A patent/MX345837B/es active IP Right Grant
- 2011-04-27 JP JP2013506796A patent/JP5860032B2/ja not_active Expired - Fee Related
- 2011-04-27 WO PCT/IB2011/051861 patent/WO2011135530A2/en not_active Ceased
- 2011-04-27 US US13/641,501 patent/US9522263B2/en active Active
- 2011-04-27 CN CN201180032076.7A patent/CN102971037B/zh active Active
- 2011-04-27 EP EP11774518.2A patent/EP2563450B1/en active Active
- 2011-04-27 ES ES11774518.2T patent/ES2636673T3/es active Active
- 2011-04-27 RU RU2012150728/14A patent/RU2585159C2/ru not_active IP Right Cessation
- 2011-04-27 KR KR1020127030831A patent/KR101799612B1/ko not_active Expired - Fee Related
-
2016
- 2016-12-14 US US15/378,097 patent/US10029082B2/en active Active
-
2018
- 2018-07-20 US US16/040,714 patent/US10709884B2/en active Active
-
2020
- 2020-06-09 US US16/896,941 patent/US11565098B2/en active Active
-
2022
- 2022-12-29 US US18/148,025 patent/US20230137871A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2011246879C1 (en) | 2016-03-24 |
| US10029082B2 (en) | 2018-07-24 |
| CA2797204C (en) | 2018-06-12 |
| JP2013524985A (ja) | 2013-06-20 |
| EP2563450A4 (en) | 2013-10-23 |
| CA2797204A1 (en) | 2011-11-03 |
| PT2563450T (pt) | 2017-08-28 |
| US20170157380A1 (en) | 2017-06-08 |
| US9522263B2 (en) | 2016-12-20 |
| RU2585159C2 (ru) | 2016-05-27 |
| RU2012150728A (ru) | 2014-06-10 |
| CN102971037B (zh) | 2016-05-25 |
| KR20130058704A (ko) | 2013-06-04 |
| EP2563450A2 (en) | 2013-03-06 |
| MX2012012437A (es) | 2013-12-02 |
| WO2011135530A3 (en) | 2012-03-15 |
| KR101799612B1 (ko) | 2017-11-20 |
| US10709884B2 (en) | 2020-07-14 |
| MX345837B (es) | 2017-02-16 |
| EP2563450B1 (en) | 2017-07-26 |
| AU2011246879B2 (en) | 2015-09-17 |
| US20230137871A1 (en) | 2023-05-04 |
| JP5860032B2 (ja) | 2016-02-16 |
| US20130144257A1 (en) | 2013-06-06 |
| US11565098B2 (en) | 2023-01-31 |
| US20190209818A1 (en) | 2019-07-11 |
| US20200297986A1 (en) | 2020-09-24 |
| AU2011246879A1 (en) | 2012-11-08 |
| DK2563450T3 (da) | 2017-11-13 |
| WO2011135530A2 (en) | 2011-11-03 |
| CN102971037A (zh) | 2013-03-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2636673T3 (es) | Dispositivo para la administración de medicamentos contra la artritis reumatoide | |
| JP5977727B2 (ja) | 基板洗浄方法、基板洗浄システムおよび記憶媒体 | |
| JP5543633B2 (ja) | 基板洗浄システム、基板洗浄方法および記憶媒体 | |
| JP6765488B2 (ja) | 基板洗浄装置、基板洗浄方法および記憶媒体 | |
| JP2012533338A5 (ja) | 薬剤送達バルーンの形成方法及び同方法により生成された薬物送達バルーン | |
| JP6000822B2 (ja) | 基板洗浄方法および基板洗浄システム | |
| US20150342036A1 (en) | Method for fabricating a flexible electronic structure and a flexible electronic structure | |
| KR102233590B1 (ko) | 기판 처리 방법, 기판 처리 장치 및 기억 매체 | |
| JP5677603B2 (ja) | 基板洗浄システム、基板洗浄方法および記憶媒体 | |
| JP5937632B2 (ja) | 基板処理方法、前処理装置、後処理装置、基板処理システムおよび記憶媒体 | |
| KR20190038402A (ko) | 차광 재료를 구비한 나노임프린트 템플릿 및 제작 방법 | |
| JP2014170922A5 (es) | ||
| US20140100346A9 (en) | Nanoimprint lithography processes for forming nanoparticles | |
| TW201421537A (zh) | 基板處理方法、程式、電腦記憶媒體及基板處理系統 | |
| CN103887244A (zh) | 阵列基板及其制备方法、显示装置 | |
| JP5192016B2 (ja) | 半導体装置の製造方法及び半導体装置の製造装置 | |
| CN107991842B (zh) | 一种聚碳酸酯作为电子束光刻胶材料的应用 | |
| US8846305B2 (en) | Photolithography method including dual development process | |
| TWI645252B (zh) | 壓印用光硬化性組成物、圖案形成方法及元件製造方法 | |
| JP5703896B2 (ja) | パターン形成方法およびパターン形成体 | |
| TWI571920B (zh) | Substrate processing methods, programs, computer memory media and substrate processing systems | |
| KR20120122714A (ko) | 반도체 장치의 홀 패턴 제조 방법 | |
| CN105097426A (zh) | 一种消除湿法清洗中的图形损坏缺陷的方法 | |
| JP2012023242A (ja) | パターン製造方法およびパターン形成体 | |
| JP6357753B2 (ja) | ナノインプリントモールドの製造方法 |