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ES2621191R1 - Surgical support with immunomodulatory biological activity - Google Patents

Surgical support with immunomodulatory biological activity Download PDF

Info

Publication number
ES2621191R1
ES2621191R1 ES201500236A ES201500236A ES2621191R1 ES 2621191 R1 ES2621191 R1 ES 2621191R1 ES 201500236 A ES201500236 A ES 201500236A ES 201500236 A ES201500236 A ES 201500236A ES 2621191 R1 ES2621191 R1 ES 2621191R1
Authority
ES
Spain
Prior art keywords
biological activity
surgical
surgical support
coated
support
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES201500236A
Other languages
Spanish (es)
Other versions
ES2621191B1 (en
ES2621191A2 (en
Inventor
Rebeca BLÁZQUEZ DURÁN
Javier Garcia Casado
Verónica ÁLVAREZ PÉREZ
Francisco Miguel SÁNCHEZ MARGALLO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fundacion Centro de Cirugia de Minima Invasion Jesus Uson CCMIJU
Original Assignee
Fundacion Centro de Cirugia de Minima Invasion Jesus Uson CCMIJU
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fundacion Centro de Cirugia de Minima Invasion Jesus Uson CCMIJU filed Critical Fundacion Centro de Cirugia de Minima Invasion Jesus Uson CCMIJU
Priority to ES201500236A priority Critical patent/ES2621191B1/en
Publication of ES2621191A2 publication Critical patent/ES2621191A2/en
Publication of ES2621191R1 publication Critical patent/ES2621191R1/en
Application granted granted Critical
Publication of ES2621191B1 publication Critical patent/ES2621191B1/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Developmental Biology & Embryology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)

Abstract

Material quirúrgico consistente en un soporte quirúrgico convencional en forma de malla que ha sido modificado con una sustancia química y recubierto con células madre mesenquimales. Este soporte modificado se recubre con una suspensión de células madre mesenquimales o de cualquier otro tipo de célula madre que exprese al menos uno de los marcadores CD73, CD90, CD105 y posean capacidad de diferenciación osteogénica y/o adipogénica y/o condrogénica, de forma que le proporciona actividad biológica y puede ser conservado y almacenado para implantarse en el momento que sea necesario. Esta invención reducirá las complicaciones derivadas de la inflamación que se produce de manera frecuente al emplear los soportes quirúrgicos convencionales.Surgical material consisting of a conventional mesh-shaped surgical support that has been modified with a chemical substance and coated with mesenchymal stem cells. This modified support is coated with a suspension of mesenchymal stem cells or any other type of stem cell that expresses at least one of the markers CD73, CD90, CD105 and possesses osteogenic and / or adipogenic and / or chondrogenic differentiation capacity, so It provides biological activity and can be preserved and stored for implantation at the time it is necessary. This invention will reduce the complications derived from the inflammation that occurs frequently when using conventional surgical supports.

ES201500236A 2015-03-25 2015-03-25 Surgical support with immunomodulatory biological activity Expired - Fee Related ES2621191B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES201500236A ES2621191B1 (en) 2015-03-25 2015-03-25 Surgical support with immunomodulatory biological activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES201500236A ES2621191B1 (en) 2015-03-25 2015-03-25 Surgical support with immunomodulatory biological activity

Publications (3)

Publication Number Publication Date
ES2621191A2 ES2621191A2 (en) 2017-07-03
ES2621191R1 true ES2621191R1 (en) 2017-10-09
ES2621191B1 ES2621191B1 (en) 2018-10-10

Family

ID=59157293

Family Applications (1)

Application Number Title Priority Date Filing Date
ES201500236A Expired - Fee Related ES2621191B1 (en) 2015-03-25 2015-03-25 Surgical support with immunomodulatory biological activity

Country Status (1)

Country Link
ES (1) ES2621191B1 (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020009805A1 (en) * 1999-07-06 2002-01-24 Ramot University Authority For Applied Research & Industrial Development Ltd. Scaffold matrix and tissue maintaining systems
US20030054035A1 (en) * 2001-09-14 2003-03-20 Benjamin Chu Cell storage and delivery system
US20120003185A1 (en) * 2008-04-10 2012-01-05 Shai Meretzki Bone-like prosthetic implants
US20120165957A1 (en) * 2009-07-06 2012-06-28 Hanne Everland Biodegradable scaffold for soft tissue regeneration and use thereof
WO2012158169A1 (en) * 2011-05-18 2012-11-22 Affinergy, Inc. Methods and compositions for tissue repair

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020009805A1 (en) * 1999-07-06 2002-01-24 Ramot University Authority For Applied Research & Industrial Development Ltd. Scaffold matrix and tissue maintaining systems
US20030054035A1 (en) * 2001-09-14 2003-03-20 Benjamin Chu Cell storage and delivery system
US20120003185A1 (en) * 2008-04-10 2012-01-05 Shai Meretzki Bone-like prosthetic implants
US20120165957A1 (en) * 2009-07-06 2012-06-28 Hanne Everland Biodegradable scaffold for soft tissue regeneration and use thereof
WO2012158169A1 (en) * 2011-05-18 2012-11-22 Affinergy, Inc. Methods and compositions for tissue repair

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Lam M T et al. COMPARISON OF SEVERAL ATTACHMENT METHODS FOR HUMAN IPS, EMBRYONIC AND ADIPOSE-DERIVED STEM CELLS FOR TISSUE ENGINEERING. 30/11/2012, Vol. 6, Páginas s80-s86 ISSN 1932-6254 (print) ISSN 1932-7005 (electronic), (DOI: doi:10.1002/term.1499) página 2, último párrafo. *

Also Published As

Publication number Publication date
ES2621191B1 (en) 2018-10-10
ES2621191A2 (en) 2017-07-03

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