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ES2683846T3 - ROS quinasa mutante y de translocación en el carcinoma pulmonar no microcítico humano - Google Patents

ROS quinasa mutante y de translocación en el carcinoma pulmonar no microcítico humano Download PDF

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Publication number
ES2683846T3
ES2683846T3 ES13176525.7T ES13176525T ES2683846T3 ES 2683846 T3 ES2683846 T3 ES 2683846T3 ES 13176525 T ES13176525 T ES 13176525T ES 2683846 T3 ES2683846 T3 ES 2683846T3
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Spain
Prior art keywords
ros
translocation
mutant
kinase
small cell
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Active
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English (en)
Inventor
Ailan Guo
Anthony Possemato
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Cell Signaling Technology Inc
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Cell Signaling Technology Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38288244&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2683846(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cell Signaling Technology Inc filed Critical Cell Signaling Technology Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)

Abstract

Un método para caracterizar un cáncer de pulmón que comprende detectar la presencia de una mutación de ROS en una muestra biológica procedente de un cáncer de pulmón humano.
ES13176525.7T 2006-01-20 2007-01-19 ROS quinasa mutante y de translocación en el carcinoma pulmonar no microcítico humano Active ES2683846T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76063406P 2006-01-20 2006-01-20
US760634P 2006-01-20

Publications (1)

Publication Number Publication Date
ES2683846T3 true ES2683846T3 (es) 2018-09-28

Family

ID=38288244

Family Applications (2)

Application Number Title Priority Date Filing Date
ES13176525.7T Active ES2683846T3 (es) 2006-01-20 2007-01-19 ROS quinasa mutante y de translocación en el carcinoma pulmonar no microcítico humano
ES07718104.8T Active ES2539830T3 (es) 2006-01-20 2007-01-19 ROS quinasa mutante y de translocación en el carcinoma pulmonar no microcítico humano

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES07718104.8T Active ES2539830T3 (es) 2006-01-20 2007-01-19 ROS quinasa mutante y de translocación en el carcinoma pulmonar no microcítico humano

Country Status (10)

Country Link
EP (4) EP3936621A1 (es)
JP (7) JP5554925B2 (es)
CN (2) CN103981198B (es)
DK (2) DK2671954T3 (es)
ES (2) ES2683846T3 (es)
HK (1) HK1256305A1 (es)
HU (1) HUE039085T2 (es)
PT (1) PT2671954T (es)
SI (1) SI2671954T1 (es)
WO (1) WO2007084631A2 (es)

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EP3936621A1 (en) * 2006-01-20 2022-01-12 Cell Signaling Technology, Inc. Translocation and mutant ros kinase in human non-small cell lung carcinoma
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US20120208824A1 (en) 2006-01-20 2012-08-16 Cell Signaling Technology, Inc. ROS Kinase in Lung Cancer
JP5769968B2 (ja) * 2007-10-18 2015-08-26 セル・シグナリング・テクノロジー・インコーポレイテツド ヒト非小細胞肺癌における転座および変異ｒｏｓキナーゼ
AU2010213578B2 (en) 2009-02-12 2015-01-29 Cell Signaling Technology, Inc. Mutant ROS expression in human cancer
US9109259B2 (en) 2010-06-22 2015-08-18 Japanese Foundation For Cancer Research Detection method for novel ROS1 fusions
MX2014001354A (es) 2011-08-02 2014-10-14 Pfizer Crizotinib para uso en el tratamiento de cancer.
JP2015508644A (ja) * 2012-02-08 2015-03-23 インサイト ジェネティクス インコーポレイテッド 癌の診断および治療のためのｒｏｓ１の融合体に関する方法および組成物
EP3071706B1 (en) * 2013-11-21 2018-04-25 Assistance Publique-Hôpitaux de Paris Method for detecting chromosomal rearrangements
CN107236818A (zh) * 2017-07-19 2017-10-10 臻悦生物科技江苏有限公司 肺癌临床用药突变基因检测试剂盒
CN111094582A (zh) * 2017-08-09 2020-05-01 帕姆基因有限公司 预测非小细胞肺癌患者对药物的反应的方法
CN108148912B (zh) 2018-03-08 2021-10-08 四川大学 肿瘤的生物标志物、应用和肿瘤检测试剂盒
US20220227889A1 (en) * 2019-04-30 2022-07-21 Encodia, Inc. Methods and reagents for cleavage of the n-terminal amino acid from a polypeptide
CN110655080B (zh) * 2019-10-25 2022-08-05 山东大学 一种具有选择性杀灭癌细胞功能的无氧化Ti3C2量子点及其制备方法与应用
WO2025028453A1 (ja) * 2023-07-31 2025-02-06 国立大学法人大阪大学 肺がんバイオマーカー

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Also Published As

Publication number Publication date
EP1973946A2 (en) 2008-10-01
EP2671954B1 (en) 2018-05-16
ES2539830T3 (es) 2015-07-06
EP3360965A1 (en) 2018-08-15
HUE039085T2 (hu) 2018-12-28
JP2014140371A (ja) 2014-08-07
JP2023039988A (ja) 2023-03-22
CN103981198A (zh) 2014-08-13
DK1973946T3 (da) 2015-06-22
JP6259320B2 (ja) 2018-01-10
CN103981198B (zh) 2020-09-01
SI2671954T1 (sl) 2018-11-30
JP2009523446A (ja) 2009-06-25
JP2021006039A (ja) 2021-01-21
EP1973946B1 (en) 2015-03-25
JP6521928B2 (ja) 2019-05-29
EP2671954A3 (en) 2014-02-12
WO2007084631A2 (en) 2007-07-26
HK1256305A1 (en) 2019-09-20
EP2671954A2 (en) 2013-12-11
DK2671954T3 (en) 2018-08-13
EP3936621A1 (en) 2022-01-12
JP2017070286A (ja) 2017-04-13
JP2019141060A (ja) 2019-08-29
CN101528921B (zh) 2013-11-20
EP1973946A4 (en) 2010-08-11
JP5554925B2 (ja) 2014-07-23
PT2671954T (pt) 2018-10-08
CN101528921A (zh) 2009-09-09
JP2019068816A (ja) 2019-05-09
WO2007084631A3 (en) 2008-12-31
HK1120272A1 (en) 2009-03-27
JP6957546B2 (ja) 2021-11-02
JP7262214B2 (ja) 2023-04-21

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