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ES2667346T3 - Estrategias de secuenciación de región genómica 3-D de interés - Google Patents

Estrategias de secuenciación de región genómica 3-D de interés Download PDF

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Publication number
ES2667346T3
ES2667346T3 ES11736190.7T ES11736190T ES2667346T3 ES 2667346 T3 ES2667346 T3 ES 2667346T3 ES 11736190 T ES11736190 T ES 11736190T ES 2667346 T3 ES2667346 T3 ES 2667346T3
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dna
fragments
interest
sequence
genomic region
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Spanish (es)
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ES2667346T9 (es
Inventor
Max Jan Van Min
Wouter Leonard De Laat
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Cergentis BV
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Cergentis BV
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6853Nucleic acid amplification reactions using modified primers or templates
    • C12Q1/6855Ligating adaptors
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00Reaction characterised by the enzymatic activity
    • C12Q2521/30Phosphoric diester hydrolysing, i.e. nuclease
    • C12Q2521/301Endonuclease
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00Reaction characterised by the enzymatic activity
    • C12Q2521/50Other enzymatic activities
    • C12Q2521/501Ligase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00Reactions characterised by treatment of reaction samples
    • C12Q2523/10Characterised by chemical treatment
    • C12Q2523/101Crosslinking agents, e.g. psoralen
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00Reactions characterised by treatment of reaction samples
    • C12Q2523/10Characterised by chemical treatment
    • C12Q2523/107Chemical cleaving agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/30Oligonucleotides characterised by their secondary structure
    • C12Q2525/307Circular oligonucleotides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • General Chemical & Material Sciences (AREA)
ES11736190.7T 2010-07-09 2011-07-08 Estrategias de secuenciación de región genómica 3-D de interés Active ES2667346T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36277810P 2010-07-09 2010-07-09
US362778P 2010-07-09
PCT/NL2011/050504 WO2012005595A2 (fr) 2010-07-09 2011-07-08 Stratégies de séquençage de la région génomique d'intérêt v3-d

Publications (2)

Publication Number Publication Date
ES2667346T3 true ES2667346T3 (es) 2018-05-10
ES2667346T9 ES2667346T9 (es) 2018-06-11

Family

ID=44629077

Family Applications (2)

Application Number Title Priority Date Filing Date
ES11736190.7T Active ES2667346T3 (es) 2010-07-09 2011-07-08 Estrategias de secuenciación de región genómica 3-D de interés
ES18163123T Active ES2916339T3 (es) 2010-07-09 2011-07-08 Estrategias de secuenciación de región genómica de interés 3D

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES18163123T Active ES2916339T3 (es) 2010-07-09 2011-07-08 Estrategias de secuenciación de región genómica de interés 3D

Country Status (26)

Country Link
US (2) US12006538B2 (fr)
EP (3) EP2591125B1 (fr)
JP (1) JP5977234B2 (fr)
KR (1) KR101862756B1 (fr)
CN (1) CN103180459B (fr)
AU (1) AU2011274642B2 (fr)
BR (1) BR112013000552B8 (fr)
CA (1) CA2804450C (fr)
CY (1) CY1121702T1 (fr)
DK (2) DK3360975T3 (fr)
ES (2) ES2667346T3 (fr)
HR (1) HRP20180593T1 (fr)
HU (1) HUE037359T2 (fr)
IL (2) IL224127B (fr)
LT (1) LT2591125T (fr)
NO (1) NO2591125T3 (fr)
NZ (1) NZ606228A (fr)
PL (2) PL2591125T3 (fr)
PT (2) PT3360975T (fr)
RS (1) RS57295B1 (fr)
RU (1) RU2603082C2 (fr)
SG (1) SG186954A1 (fr)
SI (1) SI2591125T1 (fr)
SM (1) SMT201800213T1 (fr)
WO (1) WO2012005595A2 (fr)
ZA (1) ZA201300375B (fr)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2760439A1 (fr) 2009-04-30 2010-11-04 Good Start Genetics, Inc. Procedes et compositions d'evaluation de marqueurs genetiques
US12129514B2 (en) 2009-04-30 2024-10-29 Molecular Loop Biosolutions, Llc Methods and compositions for evaluating genetic markers
HRP20180593T1 (hr) 2010-07-09 2018-07-27 Cergentis B.V. Strategije 3-d sekvenciranja genomskog područja od interesa
US9163281B2 (en) 2010-12-23 2015-10-20 Good Start Genetics, Inc. Methods for maintaining the integrity and identification of a nucleic acid template in a multiplex sequencing reaction
EP2753715A4 (fr) 2011-09-09 2015-05-20 Univ Leland Stanford Junior Procédés permettant d'obtenir une séquence
EP2766498B1 (fr) 2011-10-14 2019-06-19 President and Fellows of Harvard College Séquençage par assemblage structurel
US9228233B2 (en) 2011-10-17 2016-01-05 Good Start Genetics, Inc. Analysis methods
EP4249605B1 (fr) 2011-12-22 2024-08-28 President And Fellows Of Harvard College Procédés de détection d'analyte
ES2991004T3 (es) 2011-12-22 2024-12-02 Harvard College Métodos para la detección de analitos
US8209130B1 (en) 2012-04-04 2012-06-26 Good Start Genetics, Inc. Sequence assembly
US10227635B2 (en) 2012-04-16 2019-03-12 Molecular Loop Biosolutions, Llc Capture reactions
WO2013184754A2 (fr) 2012-06-05 2013-12-12 President And Fellows Of Harvard College Séquençage spatial d'acides nucléiques à l'aide de sondes d'origami d'adn
US9411930B2 (en) 2013-02-01 2016-08-09 The Regents Of The University Of California Methods for genome assembly and haplotype phasing
CN108624668B (zh) 2013-02-01 2022-12-02 加利福尼亚大学董事会 用于基因组组装及单体型定相的方法
WO2014129894A1 (fr) * 2013-02-19 2014-08-28 Cergentis B.V. Stratégies de séquençage pour régions génomiques d'intérêt
US10138509B2 (en) 2013-03-12 2018-11-27 President And Fellows Of Harvard College Method for generating a three-dimensional nucleic acid containing matrix
US8778609B1 (en) 2013-03-14 2014-07-15 Good Start Genetics, Inc. Methods for analyzing nucleic acids
US11618923B2 (en) 2013-03-15 2023-04-04 The Broad Institute, Inc. Methods of determining multiple interactions between nucleic acids in a cell
EP2984182B1 (fr) 2013-04-11 2019-12-11 Sahlén, Pelin Capture de conformation de chromosome ciblé
MY197877A (en) 2013-06-04 2023-07-22 Harvard College Rna-guided transcriptional regulation
EP3022320B2 (fr) 2013-07-19 2024-09-25 Ludwig Institute for Cancer Research Ltd Reconstruction d'haplotype ciblée et au niveau du génome intégral
GB2517936B (en) * 2013-09-05 2016-10-19 Babraham Inst Chromosome conformation capture method including selection and enrichment steps
WO2015048595A1 (fr) * 2013-09-27 2015-04-02 Jay Shendure Procédés et systèmes d'échafaudage à grande échelle d'assemblages de génomes
US10851414B2 (en) 2013-10-18 2020-12-01 Good Start Genetics, Inc. Methods for determining carrier status
GB201320351D0 (en) * 2013-11-18 2014-01-01 Erasmus Universiteit Medisch Ct Method
WO2015175530A1 (fr) 2014-05-12 2015-11-19 Gore Athurva Procédés pour la détection d'aneuploïdie
EP2960818A1 (fr) * 2014-06-24 2015-12-30 Institut Pasteur Procédé, dispositif et programme informatique permettant d'assembler des pièces de chromosomes à partir d'un ou de plusieurs organismes
US10179932B2 (en) 2014-07-11 2019-01-15 President And Fellows Of Harvard College Methods for high-throughput labelling and detection of biological features in situ using microscopy
WO2016019360A1 (fr) 2014-08-01 2016-02-04 Dovetail Genomics Llc Marquage d'acides nucléiques pour l'assemblage de séquences
US20160048608A1 (en) 2014-08-15 2016-02-18 Good Start Genetics, Inc. Systems and methods for genetic analysis
US11408024B2 (en) 2014-09-10 2022-08-09 Molecular Loop Biosciences, Inc. Methods for selectively suppressing non-target sequences
WO2016048829A1 (fr) 2014-09-24 2016-03-31 Good Start Genetics, Inc. Commande de procédé pour accroître la robustesse de tests génétiques
WO2016089920A1 (fr) 2014-12-01 2016-06-09 The Broad Institute, Inc. Procédé de détermination in situ de proximité d'acide nucléique
US10066259B2 (en) 2015-01-06 2018-09-04 Good Start Genetics, Inc. Screening for structural variants
JP6777966B2 (ja) 2015-02-17 2020-10-28 ダブテイル ゲノミクス エルエルシー 核酸配列アセンブリ
GB2554572B (en) 2015-03-26 2021-06-23 Dovetail Genomics Llc Physical linkage preservation in DNA storage
US10395759B2 (en) * 2015-05-18 2019-08-27 Regeneron Pharmaceuticals, Inc. Methods and systems for copy number variant detection
WO2017004612A1 (fr) 2015-07-02 2017-01-05 Arima Genomics, Inc. Déconvolution moléculaire précise de mélanges échantillons
US20180282799A1 (en) * 2015-10-05 2018-10-04 Koninklijke Nederlandse Akademie Van Wetenschappen Targeted locus amplification using cloning strategies
JP7300831B2 (ja) 2015-10-19 2023-06-30 ダブテイル ゲノミクス エルエルシー ゲノムアセンブリ、ハプロタイプフェージング、および標的に依存しない核酸検出のための方法
EP3366818B1 (fr) * 2015-10-19 2021-04-14 Zhejiang Annoroad Bio-Technology Co., Ltd. Procédé de construction d'une bibliothèque hi-c à cellules uniques de haute résolution présentant un lot d'informations
GB201518843D0 (en) 2015-10-23 2015-12-09 Isis Innovation Method of analysing DNA sequences
EP3371329A4 (fr) 2015-11-03 2019-06-19 President and Fellows of Harvard College Procédé et appareil pour imagerie volumétrique d'une matrice tridimensionnelle contenant des acides nucléiques
ES2926495T3 (es) 2015-12-04 2022-10-26 10X Genomics Inc Métodos y composiciones para el análisis de ácidos nucleicos
KR102744506B1 (ko) * 2016-02-23 2024-12-18 더브테일 제노믹스 엘엘씨 게놈 어셈블리를 위한 페이징된 판독 세트의 생성 및 반수체형 페이징
CN109415761B (zh) 2016-04-25 2022-09-20 哈佛学院董事及会员团体 用于原位分子检测的杂交链反应方法
GB201608000D0 (en) * 2016-05-06 2016-06-22 Oxford Biodynamics Ltd Chromosome detection
CN105839196B (zh) * 2016-05-11 2018-04-17 北京百迈客生物科技有限公司 一种真核生物DNA的Hi‑C高通量测序建库方法
SG11201810088SA (en) 2016-05-13 2018-12-28 Dovetail Genomics Llc Recovering long-range linkage information from preserved samples
KR101915701B1 (ko) 2016-06-16 2018-11-07 한국한의학연구원 돌연변이 발생률의 측정 방법
CN109983125B (zh) 2016-08-31 2024-06-04 哈佛学院董事及会员团体 生成用于通过荧光原位测序检测的核酸序列文库的方法
JP7057348B2 (ja) 2016-08-31 2022-04-19 プレジデント アンド フェローズ オブ ハーバード カレッジ 蛍光in situ配列決定を用いた単一アッセイに生体分子の検出を組み合わせる方法
KR102481242B1 (ko) * 2016-12-01 2022-12-23 옥스포드 바이오다이나믹스 피엘씨 암 진단에서 후생적 염색체 상호 작용의 적용
EP3448396A4 (fr) 2017-04-14 2020-01-22 President and Fellows of Harvard College Procédés de génération d'un réseau de microfilaments dérivés de cellules
CN107119120A (zh) * 2017-05-04 2017-09-01 河海大学常州校区 一种基于染色质3d构象技术的关键作用分子检测方法
CN111655848A (zh) 2017-11-21 2020-09-11 阿瑞玛基因组学公司 在核酸模板中保留空间邻位邻接性和分子邻接性
US12378592B2 (en) 2018-01-31 2025-08-05 Dovetail Genomics, Llc. Sample prep for DNA linkage recovery
JP7502787B2 (ja) 2018-04-09 2024-06-19 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー インサイチュ遺伝子配列決定の方法
WO2020028194A1 (fr) 2018-07-30 2020-02-06 Readcoor, Inc. Procédés et systèmes de traitement ou d'analyse d'échantillons
WO2020076976A1 (fr) 2018-10-10 2020-04-16 Readcoor, Inc. Indexation moléculaire spatiale tridimensionnelle
US20220251640A1 (en) * 2019-05-17 2022-08-11 The Broad Institute, Inc. Methods of determination of genome architecture and epigenetic profile
WO2021224233A1 (fr) 2020-05-04 2021-11-11 Cergentis B.V. Procédé
GB202006546D0 (en) 2020-05-04 2020-06-17 Cergentis B V Method
WO2021224225A1 (fr) 2020-05-04 2021-11-11 Cergentis B.V. Procédé
GB202006550D0 (en) 2020-05-04 2020-06-17 Cergentis B V Method
US20220049303A1 (en) 2020-08-17 2022-02-17 Readcoor, Llc Methods and systems for spatial mapping of genetic variants
WO2022114957A1 (fr) 2020-11-26 2022-06-02 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Marqueurs tumoraux personnalisés
EP4352254A4 (fr) * 2021-05-21 2025-04-16 The Board Of Trustees Of The Leland Stanford Junior University Séquençage in situ volumétrique de prochaine génération
GB202111194D0 (en) 2021-08-03 2021-09-15 Cergentis B V Method

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5077204A (en) * 1984-06-21 1991-12-31 Chiron Corporation Yeast endopeptidase for basic amino-acid site cleavage, preparation and use
US9328391B1 (en) * 1984-08-22 2016-05-03 The United States Of America As Represented By The Secretary, Department Of Health And Human Services Cloning and expression of HIV-1 DNA
JPS6226300A (ja) * 1984-10-10 1987-02-04 セントコ−・インコ−ポレ−テツド Htlv−3dnaのクロ−ニングおよび発現
US5221518A (en) * 1984-12-14 1993-06-22 Mills Randell L DNA sequencing apparatus
US5258507A (en) * 1990-11-08 1993-11-02 Amoco Corporation Labeling reagents useful for the chemical attachment of nitrophenyl derivative ligands to DNA probes
US6060644A (en) * 1994-03-24 2000-05-09 Iowa State University Research Foundation, Inc. Isolation and use of cuticular lipid genes
EP1736554B1 (fr) * 1996-05-29 2013-10-09 Cornell Research Foundation, Inc. Detection de differences dans des sequences d'acides nucleiques utilisant une combinaison de la detection par ligase et de reactions d'amplification en chaine par polymerase
EP0960123A4 (fr) * 1996-11-07 2004-05-19 Univ Leland Stanford Junior Proteine ramifiee et sequence codante
US6261804B1 (en) * 1997-01-21 2001-07-17 The General Hospital Corporation Selection of proteins using RNA-protein fusions
ATE273381T1 (de) * 1997-02-12 2004-08-15 Eugene Y Chan Verfahren zur analyse von polymeren
EP1044264A2 (fr) * 1997-12-02 2000-10-18 E.I. Du Pont De Nemours And Company Enzymes biosynthetiques a acides amines ramifies
US6455692B1 (en) * 1998-08-04 2002-09-24 Transgenomic, Inc. Method of concentrating polynucleotides using MIPC
US6291168B1 (en) * 1998-10-27 2001-09-18 Auburn University Nucleic acid sequences diagnostic for pathogenic E.coli O157:H7, methods of identification and kit therefore
US20050232900A1 (en) * 1999-05-18 2005-10-20 Crucell Holland B.V. Serotype of adenovirus and uses thereof
AU1824101A (en) * 1999-06-18 2001-01-09 Elitra Pharmaceuticals, Inc. Nucleotide sequences of moraxella catarrhalis genome
US7470507B2 (en) * 1999-09-01 2008-12-30 Whitehead Institute For Biomedical Research Genome-wide location and function of DNA binding proteins
US20040014195A1 (en) * 1999-12-29 2004-01-22 Diversa Corporation Nitrilases, nucleic acids encoding them and methods for making and using them
EP1425579A2 (fr) * 2000-08-14 2004-06-09 TransGenetics Incorporated Decouverte de gene cible de facteur de transcription
US6709861B2 (en) * 2000-11-17 2004-03-23 Lucigen Corp. Cloning vectors and vector components
US20030054347A1 (en) * 2001-04-27 2003-03-20 The Regents Of The University Of Michigan Latrophilin Polynucleotides
US20030013863A1 (en) * 2001-07-16 2003-01-16 Buchholz Wallace G. High resolution DNA size standards
US20030157705A1 (en) * 2001-08-10 2003-08-21 Fodor William L. Engineered recombinant molecule that regulates humoral and cellular effector functions of the immune system
AUPR823601A0 (en) * 2001-10-12 2001-11-08 University Of Queensland, The Automated genotyping
AU2003237312A1 (en) * 2002-05-29 2003-12-19 University Of Washington Mutants of gad65 and ian5 relating to diabetes
EP1923464A1 (fr) * 2002-08-30 2008-05-21 Japan Science and Technology Agency Ligase de bactérie hyperthermostable et puce utilisant une telle ligase
ES2315397T3 (es) * 2002-09-30 2009-04-01 F. Hoffmann-La Roche Ag Oligonucleotidos para obtener el genotipo del gen de timidilato sintasa.
US7575865B2 (en) * 2003-01-29 2009-08-18 454 Life Sciences Corporation Methods of amplifying and sequencing nucleic acids
CA2517899A1 (fr) * 2003-03-06 2004-09-16 Children's Hospital, Inc. Genes d'un isolat de l'otite moyenne de haemophilus influenzae non typable
FR2852317B1 (fr) * 2003-03-13 2006-08-04 Biopuces a sondes et leurs methodes d'utilisation
EP1670505B1 (fr) * 2003-09-18 2012-11-14 GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Promoteurs d'adn et vaccins contre l'anthrax
US20060150283A1 (en) * 2004-02-13 2006-07-06 Nickolai Alexandrov Sequence-determined DNA fragments and corresponding polypeptides encoded thereby
US20060107345A1 (en) * 2003-09-30 2006-05-18 Nickolai Alexandrov Sequence-determined DNA fragments and corresponding polypeptides encoded thereby
US20050221341A1 (en) * 2003-10-22 2005-10-06 Shimkets Richard A Sequence-based karyotyping
WO2005047521A2 (fr) * 2003-11-10 2005-05-26 Investigen, Inc. Procedes de preparation d'acides nucleiques en vue de leur detection
CN101072882A (zh) * 2004-09-10 2007-11-14 塞昆纳姆股份有限公司 用于核酸长程序列分析的方法
US20070048748A1 (en) * 2004-09-24 2007-03-01 Li-Cor, Inc. Mutant polymerases for sequencing and genotyping
US20060223073A1 (en) * 2005-03-31 2006-10-05 Boyes Barry E Methods of using a DNase I-like enzyme
US7601499B2 (en) * 2005-06-06 2009-10-13 454 Life Sciences Corporation Paired end sequencing
US8407013B2 (en) * 2005-06-07 2013-03-26 Peter K. Rogan AB initio generation of single copy genomic probes
EP3492602A1 (fr) * 2005-06-15 2019-06-05 Complete Genomics, Inc. Réseaux de molécules simples pour l'analyse génétique et chimique
US20090142758A1 (en) * 2005-06-23 2009-06-04 Keygene N V Strategies for sequencing complex genomes using high throughput sequencing technologies
CN105039313B (zh) * 2005-06-23 2018-10-23 科因股份有限公司 用于多态性的高通量鉴定和检测的策略
NZ564262A (en) * 2005-07-04 2010-02-26 Univ Erasmus Medical Ct Chromosome conformation capture-on-chip (4C) assay
US20090143240A1 (en) * 2005-08-25 2009-06-04 Harbison Christopher T Novel Methods for Genome-Wide Location Analysis
WO2007030678A2 (fr) * 2005-09-07 2007-03-15 Whitehead Institute For Biomedical Research Procedes d'analyse de localisation sur tout le genome dans des cellules souches
US8071310B2 (en) * 2005-11-14 2011-12-06 Keygene Nv Method for the high throughput screening of transposon tagging populations and massive parallel sequence identification of insertion sites
JP5285431B2 (ja) * 2005-12-28 2013-09-11 ザ ユーエイビー リサーチ ファウンデイション 肺炎球菌血清型
GB0603251D0 (en) * 2006-02-17 2006-03-29 Isis Innovation DNA conformation
US20080015494A1 (en) 2006-07-11 2008-01-17 Microchips, Inc. Multi-reservoir pump device for dialysis, biosensing, or delivery of substances
US9328378B2 (en) * 2006-07-31 2016-05-03 Illumina Cambridge Limited Method of library preparation avoiding the formation of adaptor dimers
DE112007002823T5 (de) * 2006-11-27 2009-09-10 Dsm Ip Assets B.V. Fermentative Herstellung von Hydroxytyrosol
WO2008076406A2 (fr) * 2006-12-14 2008-06-26 Ion Torrent Systems Incorporated Procédés et appareil permettant de mesurer des analytes en utilisant des matrices de tec à grande échelle
ES2634266T3 (es) * 2007-01-11 2017-09-27 Erasmus University Medical Center Captura de conformación cromosómica circular (4C)
ATE521948T1 (de) * 2007-01-26 2011-09-15 Illumina Inc System und verfahren zur nukleinsäuresequenzierung
US20100120036A1 (en) * 2007-03-07 2010-05-13 Kunio Shiota Method for amplifying dna fragment
US20080248958A1 (en) * 2007-04-05 2008-10-09 Hollenbach Andrew D System for pulling out regulatory elements in vitro
US7932030B2 (en) * 2007-04-05 2011-04-26 The Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College System for pulling out regulatory elements using yeast
CN101720359A (zh) * 2007-06-01 2010-06-02 454生命科学公司 从多重混合物中识别个别样本的系统和方法
EP2053132A1 (fr) * 2007-10-23 2009-04-29 Roche Diagnostics GmbH Enrichissement et analyse de séquence de régions génomiques
US8518640B2 (en) * 2007-10-29 2013-08-27 Complete Genomics, Inc. Nucleic acid sequencing and process
US8263367B2 (en) * 2008-01-25 2012-09-11 Agency For Science, Technology And Research Nucleic acid interaction analysis
US8296075B2 (en) * 2008-05-21 2012-10-23 Mito Tech, LLC Computer system and computer-facilitated method for nucleic acid sequence alignment and analysis
WO2009143499A1 (fr) * 2008-05-23 2009-11-26 Life Technologies Corporation Procédés et kits pour l’extraction d’adn
FR2945545B1 (fr) * 2009-05-14 2011-08-05 Univ Aix Marseille Ii Methode de detection d'adn procaryote extrait d'un echantillon de selles
US9493822B2 (en) * 2009-09-01 2016-11-15 Koninklijke Philips Electronics N.V. Devices and methods for microarray selection
EP2354243A1 (fr) 2010-02-03 2011-08-10 Lexogen GmbH Procédé de réduction de la complexité
JP5901046B2 (ja) * 2010-02-19 2016-04-06 国立大学法人 千葉大学 OATP1B3mRNAの新規な選択的スプライシングバリアント
HRP20180593T1 (hr) 2010-07-09 2018-07-27 Cergentis B.V. Strategije 3-d sekvenciranja genomskog područja od interesa
WO2018044831A1 (fr) * 2016-08-30 2018-03-08 Integrated Dna Technologies, Inc. Amorces clivables en épingle à cheveux

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