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ES2531751T3 - Montaje de microvesícula rellena de gas con componente activo para imagenología de contraste - Google Patents

Montaje de microvesícula rellena de gas con componente activo para imagenología de contraste Download PDF

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Publication number
ES2531751T3
ES2531751T3 ES04806412.5T ES04806412T ES2531751T3 ES 2531751 T3 ES2531751 T3 ES 2531751T3 ES 04806412 T ES04806412 T ES 04806412T ES 2531751 T3 ES2531751 T3 ES 2531751T3
Authority
ES
Spain
Prior art keywords
assembly
gas filled
active component
contrast imaging
filled microvesicle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES04806412.5T
Other languages
English (en)
Inventor
Michel Schneider
Philippe Bussat
Feng Yan
Anne Senente
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bracco Suisse SA
Original Assignee
Bracco Suisse SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Suisse SA filed Critical Bracco Suisse SA
Application granted granted Critical
Publication of ES2531751T3 publication Critical patent/ES2531751T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0028—Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6925—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a microcapsule, nanocapsule, microbubble or nanobubble
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/225—Microparticles, microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Acoustics & Sound (AREA)
  • Nanotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

Un montaje que comprende una microvesícula rellena de gas que tiene una primera carga neta global y un componente asociado a dicha microvesícula en donde dicho componente es una estructura supramolecular formada por la asociación de una pluralidad de moléculas, tiene una segunda carga neta global opuesta en signo a dicha primera carga neta y comprende un ligando de direccionamiento, un agente diagnóstico o cualquier combinación de los mismos, y un agente tensioactivo anfifílico biocompatible.
ES04806412.5T 2003-12-22 2004-12-21 Montaje de microvesícula rellena de gas con componente activo para imagenología de contraste Expired - Lifetime ES2531751T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03079014 2003-12-22
EP03079014 2003-12-22
PCT/IB2004/004233 WO2005063306A1 (en) 2003-12-22 2004-12-21 Assembly of gas-filled microvesicle with active component for contrast imaging

Publications (1)

Publication Number Publication Date
ES2531751T3 true ES2531751T3 (es) 2015-03-18

Family

ID=34717205

Family Applications (1)

Application Number Title Priority Date Filing Date
ES04806412.5T Expired - Lifetime ES2531751T3 (es) 2003-12-22 2004-12-21 Montaje de microvesícula rellena de gas con componente activo para imagenología de contraste

Country Status (9)

Country Link
US (2) US20070081946A1 (es)
EP (1) EP1696965B1 (es)
JP (1) JP2007515471A (es)
CN (1) CN1897978B (es)
AU (1) AU2004308757B2 (es)
CA (1) CA2545362C (es)
ES (1) ES2531751T3 (es)
NO (1) NO338317B1 (es)
WO (1) WO2005063306A1 (es)

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US20070003482A1 (en) * 2004-01-15 2007-01-04 Koninklijke Philips Electronic, N.V. Ultrasound contrast agents for molecular imaging
CN101005858A (zh) 2004-08-18 2007-07-25 伯拉考开发股份有限公司 用于反差成像的充气微泡组合物
EP1968550A2 (en) * 2005-12-16 2008-09-17 University Of Kansas Nanoclusters for delivery of therapeutics
JP5420410B2 (ja) 2006-09-05 2014-02-19 ブラッコ・シュイス・ソシエテ・アノニム ポリマー修飾脂質を含むガス封入微小胞
WO2008042855A2 (en) * 2006-09-29 2008-04-10 The Trustees Of The University Of Pennsylvania Use of ultrasound as an antivascular agent
US20090234231A1 (en) * 2008-03-13 2009-09-17 Knight Jon M Imaging Catheter With Integrated Contrast Agent Injector
GB0811856D0 (en) 2008-06-27 2008-07-30 Ucl Business Plc Magnetic microbubbles, methods of preparing them and their uses
JP5491511B2 (ja) 2008-10-07 2014-05-14 ブラッコ・シュイス・ソシエテ・アノニム 抗ポリマー抗体およびそれと結合するリポソームまたは微小胞を含むターゲッティング構築物
CN105152939A (zh) 2008-11-10 2015-12-16 阿尔尼拉姆医药品有限公司 用于递送治疗剂的脂质和组合物
CN106362171A (zh) * 2009-02-13 2017-02-01 华盛顿大学 用于磁共振成像的钆表现脂质纳米颗粒
EP2253308A1 (en) 2009-05-22 2010-11-24 Ludwig-Maximilians-Universität München Pharmaceutical composition comprising microbubbles for targeted tumor therapy
US20120328529A1 (en) * 2009-08-05 2012-12-27 The Trustees Of The University Of Pennsylvania Microfluidic-based generation of functionalized microbubbles for ultrasound imaging and therapy
US10058837B2 (en) 2009-08-28 2018-08-28 The Trustees Of Columbia University In The City Of New York Systems, methods, and devices for production of gas-filled microbubbles
WO2011035254A1 (en) * 2009-09-21 2011-03-24 Drexel University Stabilized ultrasound contrast agent
US8974818B2 (en) * 2010-01-20 2015-03-10 Henry Wu Custom-formulated phospholipid microbubbles and methods and uses thereof
US9265483B2 (en) 2010-08-06 2016-02-23 The Trustees Of Columbia University In The City Of New York Medical imaging contrast devices, methods, and systems
TW201208706A (en) 2010-08-17 2012-03-01 Univ Nat Yang Ming Ultrasonically-triggered drug vehicle with magnetic resonance imaging function
KR101292939B1 (ko) * 2010-12-31 2013-08-02 삼성전자주식회사 엠알유도 고강도집속초음파 치료 및 진단용 인지질 나노입자 및 이의 제조방법
WO2014096165A2 (en) 2012-12-21 2014-06-26 Bracco Suisse Sa Gas-filled microvesicles
CN105658243B (zh) * 2013-09-27 2019-11-08 菲尼克斯解决方案有限公司 超声介导的药物递送
JP6202563B2 (ja) * 2013-10-21 2017-09-27 ネッパジーン株式会社 負電荷バブルリポソーム及びカチオン性ペプチドからなる薬物送達キャリア
KR101595795B1 (ko) * 2014-03-19 2016-02-22 (주)아이엠지티 약물을 함유한 나노입자가 결합된 이중-목적 paｔ／초음파 조영제 및 이의 제조방법
US11752222B2 (en) * 2018-03-07 2023-09-12 Bracco Suisse Sa Preparation of size-controlled microvesicles
JP7539380B2 (ja) * 2018-12-21 2024-08-23 ブラッコ・スイス・ソシエテ・アノニム リガンドを含むガス充填微小胞
GB2595513B (en) * 2020-05-29 2023-03-29 Act Therapeutics Ltd Treatment of infections
CN117479962A (zh) * 2021-07-14 2024-01-30 博莱科瑞士股份有限公司 阳离子标准化尺寸充气微泡
WO2024059715A2 (en) * 2022-09-14 2024-03-21 Drexel University Microbubbles and methods of making same

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Also Published As

Publication number Publication date
AU2004308757B2 (en) 2010-06-17
CA2545362A1 (en) 2005-07-14
JP2007515471A (ja) 2007-06-14
CN1897978B (zh) 2011-11-23
CA2545362C (en) 2013-02-12
US20110150778A1 (en) 2011-06-23
EP1696965A1 (en) 2006-09-06
AU2004308757A1 (en) 2005-07-14
NO20063420L (no) 2006-09-22
NO338317B1 (no) 2016-08-08
WO2005063306A1 (en) 2005-07-14
US20070081946A1 (en) 2007-04-12
CN1897978A (zh) 2007-01-17
EP1696965B1 (en) 2014-12-10

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