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ES2531480T3 - Péptidos derivados de la proteína bplp humana, polinucleótidos que codifican dichos péptidos y anticuerpos dirigidos contra dichos péptidos - Google Patents

Péptidos derivados de la proteína bplp humana, polinucleótidos que codifican dichos péptidos y anticuerpos dirigidos contra dichos péptidos Download PDF

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Publication number
ES2531480T3
ES2531480T3 ES05708768.6T ES05708768T ES2531480T3 ES 2531480 T3 ES2531480 T3 ES 2531480T3 ES 05708768 T ES05708768 T ES 05708768T ES 2531480 T3 ES2531480 T3 ES 2531480T3
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Prior art keywords
peptides
peptide
arg
directed against
polynucleotides encoding
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Inventor
Catherine Rougeot
Jean-François HUAULME
Marie-Noëlle UNGEHEUER
Anne Wisner
Evelyne Dufour
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Institut Pasteur
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Institut Pasteur
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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Abstract

Péptido que es un producto de maduración de la proteína lacrimal rica en prolina básica (BPLP) o un derivado peptídico de dicho producto de maduración, en el que: (i) el péptido o derivado peptídico presenta una propiedad moduladora, especialmente inhibidora, contra una metaloectopeptidasa; (ii) el péptido o derivado peptídico tiene, como máximo, aminoácidos de longitud; (iii) el péptido comprende la secuencia X1-X2-Arg-Phe-Ser-Arg, en la que: - X1 representa un átomo de H o un aminoácido Tyr o un aminoácido Cys, - X2 representa Gln o Glp cuando X1 es H, o X2 representa Gln cuando X1 es Tyr o Cys, en el que dicha secuencia X1-X2-Arg-Phe-Ser-Arg es la parte del extremo C de dicho péptido; y (iv) el derivado peptídico deriva de dicho péptido mediante una a dos sustituciones de aminoácidos.

Description

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Claims (1)

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ES05708768.6T 2004-03-19 2005-03-18 Péptidos derivados de la proteína bplp humana, polinucleótidos que codifican dichos péptidos y anticuerpos dirigidos contra dichos péptidos Expired - Lifetime ES2531480T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04290754 2004-03-19
EP04290754A EP1577320B1 (en) 2004-03-19 2004-03-19 Peptides derived from human BPLP protein, polynucleotides coding for said peptides and antibodies directed against said peptides
PCT/IB2005/000700 WO2005090386A1 (en) 2004-03-19 2005-03-18 Peptides derived from human bplp protein, polynucleotides coding for said peptides and antibodies directed against said peptides

Publications (1)

Publication Number Publication Date
ES2531480T3 true ES2531480T3 (es) 2015-03-16

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Application Number Title Priority Date Filing Date
ES04290754T Expired - Lifetime ES2390075T3 (es) 2004-03-19 2004-03-19 Péptidos derivados de la proteína BPLP humana, polinucleótidos que codifican dichos péptidos y anticuerpos dirigidos contra dichos péptidos
ES05708768.6T Expired - Lifetime ES2531480T3 (es) 2004-03-19 2005-03-18 Péptidos derivados de la proteína bplp humana, polinucleótidos que codifican dichos péptidos y anticuerpos dirigidos contra dichos péptidos
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DK1577320T3 (da) 2004-03-19 2012-10-15 Pasteur Institut Peptider afledt fra humant BPLP-protein, polynukleotider kodende for nævnte peptider og antistoffer rettet mod nævnte peptider
US20100062052A1 (en) 2007-02-02 2010-03-11 Greenpharma Peptide-based compounds as new inhibitors of metalloectopeptidases, compositions comprising said compounds and their pharmaceutical and cosmetic uses
WO2009090265A1 (en) * 2008-01-18 2009-07-23 Institut Pasteur Method for identifying bplp and opiorphin agonists or antagonists
US8889827B2 (en) 2008-04-07 2014-11-18 Institut Pasteur Opiorphin peptide derivatives as potent inhibitors of enkephalin-degrading ectopeptidases
FR2931362B1 (fr) * 2008-05-26 2017-08-18 Pasteur Institut L'opiorphine pour une utilisation en tant que psychostimulant.
WO2010028671A1 (en) * 2008-09-09 2010-03-18 Mondobiotech Laboratories Ag Use of opiorphin as a therapeutic agent
US20110174064A1 (en) * 2008-10-02 2011-07-21 Ramot At Tel-Aviv University Ltd. Method and system for emitting light
CA2645452A1 (en) * 2008-11-28 2010-05-28 Institut Pasteur Use of basic prolin-rich lacrimal gene products, such as opiorphin, as a biomarker
FR2968560A1 (fr) * 2010-12-13 2012-06-15 Oreal Utilisation de l'ide comme biomarqueur d'un etat du cuir chevelu
PH12019500306B1 (en) * 2016-08-16 2024-02-21 Aist Malignant tumor target peptide
CN113284553B (zh) * 2021-05-28 2023-01-10 南昌大学 一种用于治疗药物成瘾的药物靶点结合能力测试方法

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WO2009090265A1 (en) * 2008-01-18 2009-07-23 Institut Pasteur Method for identifying bplp and opiorphin agonists or antagonists
US8889827B2 (en) 2008-04-07 2014-11-18 Institut Pasteur Opiorphin peptide derivatives as potent inhibitors of enkephalin-degrading ectopeptidases
FR2931362B1 (fr) 2008-05-26 2017-08-18 Pasteur Institut L'opiorphine pour une utilisation en tant que psychostimulant.
CA2645452A1 (en) 2008-11-28 2010-05-28 Institut Pasteur Use of basic prolin-rich lacrimal gene products, such as opiorphin, as a biomarker

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SI1725579T1 (sl) 2015-04-30
SI2952521T1 (en) 2018-08-31
EP1725579A1 (en) 2006-11-29
TR201809994T4 (tr) 2018-08-27
CA2559215A1 (en) 2005-09-29
US20080206230A1 (en) 2008-08-28
PT2952521T (pt) 2018-07-30
CY1120424T1 (el) 2019-07-10
DK2952521T3 (en) 2018-08-06
CN103183726A (zh) 2013-07-03
CN103183726B (zh) 2016-04-06
DK1577320T3 (da) 2012-10-15
EP2952521B1 (en) 2018-04-25
LT2952521T (lt) 2018-07-25
JP2008507256A (ja) 2008-03-13
EP2952521A1 (en) 2015-12-09
JP5049776B2 (ja) 2012-10-17
CN1953988B (zh) 2013-02-13
US9714951B2 (en) 2017-07-25
US9403871B2 (en) 2016-08-02
JP5580347B2 (ja) 2014-08-27
JP2012120533A (ja) 2012-06-28
ES2390075T3 (es) 2012-11-06
EP1577320B1 (en) 2012-07-18
US8895251B2 (en) 2014-11-25
US20110244491A1 (en) 2011-10-06
ES2685268T3 (es) 2018-10-08
AU2005223492B2 (en) 2011-05-26
CY1116087T1 (el) 2017-02-08
EP1725579B1 (en) 2014-11-26
US8017571B2 (en) 2011-09-13
HUE016435T4 (en) 2017-01-30
US20160341744A1 (en) 2016-11-24
CN1953988A (zh) 2007-04-25
WO2005090386A1 (en) 2005-09-29
CA2559215C (en) 2017-06-13
PL2952521T3 (pl) 2018-09-28
US20140349946A1 (en) 2014-11-27
PT1577320E (pt) 2012-10-30
EP1577320A1 (en) 2005-09-21
JP2014176383A (ja) 2014-09-25
DK1725579T3 (en) 2015-02-23
PT1725579E (pt) 2015-03-02
PL1577320T3 (pl) 2012-12-31
PL1725579T3 (pl) 2015-04-30
AU2005223492A1 (en) 2005-09-29
HK1185894A1 (zh) 2014-02-28

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