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ES2529865B8 - USE OF COMPOUNDS DERIVED FROM SIRES OF PIRIDAZINO [1 ', 6': 1,2] PIRIDO [3,4-b] INDOLINIO AS ANTI-INFLAMMATORY AGENTS - Google Patents

USE OF COMPOUNDS DERIVED FROM SIRES OF PIRIDAZINO [1 ', 6': 1,2] PIRIDO [3,4-b] INDOLINIO AS ANTI-INFLAMMATORY AGENTS Download PDF

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Publication number
ES2529865B8
ES2529865B8 ES201331143A ES201331143A ES2529865B8 ES 2529865 B8 ES2529865 B8 ES 2529865B8 ES 201331143 A ES201331143 A ES 201331143A ES 201331143 A ES201331143 A ES 201331143A ES 2529865 B8 ES2529865 B8 ES 2529865B8
Authority
ES
Spain
Prior art keywords
inflammatory agents
inflammatory
compounds derived
indolinio
piridazino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES201331143A
Other languages
Spanish (es)
Other versions
ES2529865A1 (en
ES2529865B1 (en
Inventor
Rafael SELGAS GUTIÉRREZ
Teresa BELLÓN HEREDIA
Aranzazu Isabel RODRÍGUEZ SANZ
Juan José Vaquero López
Ramón ALAJARÍN FERRÁNDEZ
Julio ÁLVAREZ-BUILLA GÓMEZ
Patricia SÁNCHEZ ALONSO
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidad de Alcala de Henares UAH
Fundacion para la Investigacion Biomedica del Hospital Universitario La Paz
Original Assignee
Universidad de Alcala de Henares UAH
Fundacion para la Investigacion Biomedica del Hospital Universitario La Paz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidad de Alcala de Henares UAH, Fundacion para la Investigacion Biomedica del Hospital Universitario La Paz filed Critical Universidad de Alcala de Henares UAH
Priority to ES201331143A priority Critical patent/ES2529865B8/en
Priority to PCT/ES2014/070603 priority patent/WO2015011331A1/en
Publication of ES2529865A1 publication Critical patent/ES2529865A1/en
Application granted granted Critical
Publication of ES2529865B1 publication Critical patent/ES2529865B1/en
Publication of ES2529865B8 publication Critical patent/ES2529865B8/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Uso de compuestos derivados de sales de piridazino[1',6':1,2]pirido[3,4-b]indolinio como agentes antiinflamatorios.#La presente invención está relacionada con compuestos de las familias de sales de piridazinopiridoindolinio, con las composiciones farmacéuticas que los contienen y con el uso de los mismos como agentes antiinflamatorios a través de la inhibición de la producción del factor de necrosis tumoral alfa (TNF-{al}) por monocitos y macrófagos proinflamatorios en mamíferos y en todas las enfermedades y condiciones en las que este mediador presenta niveles elevados, tales como artritis reumatoide, osteoartritis, enfermedad de Crohn, colitis ulcerosa, asma, bronquitis, enfermedad obstructiva de las vías respiratorias crónica, psoriasis, rinitis alérgica, espondilitis anquilosante, hidradenitis supurativa, dermatitis y cualquier otro estado inflamatorio que curse con niveles altos de TNF-{al}.Use of compounds derived from pyridazine salts [1 ', 6': 1,2] pyrido [3,4-b] indolinium as anti-inflammatory agents. # The present invention relates to compounds of the families of pyridazinopyridoindolinium salts, with pharmaceutical compositions containing them and with the use thereof as anti-inflammatory agents through the inhibition of the production of tumor necrosis factor alpha (TNF-al) by monocytes and pro-inflammatory macrophages in mammals and in all diseases and conditions in which this mediator has high levels, such as rheumatoid arthritis, osteoarthritis, Crohn's disease, ulcerative colitis, asthma, bronchitis, chronic obstructive airways disease, psoriasis, allergic rhinitis, ankylosing spondylitis, suppurative hydradenitis, dermatitis and any other inflammatory state with high levels of TNF- {al}.

ES201331143A 2013-07-25 2013-07-25 USE OF COMPOUNDS DERIVED FROM SIRES OF PIRIDAZINO [1 ', 6': 1,2] PIRIDO [3,4-b] INDOLINIO AS ANTI-INFLAMMATORY AGENTS Expired - Fee Related ES2529865B8 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
ES201331143A ES2529865B8 (en) 2013-07-25 2013-07-25 USE OF COMPOUNDS DERIVED FROM SIRES OF PIRIDAZINO [1 ', 6': 1,2] PIRIDO [3,4-b] INDOLINIO AS ANTI-INFLAMMATORY AGENTS
PCT/ES2014/070603 WO2015011331A1 (en) 2013-07-25 2014-07-25 Use of compounds derived from pyridazino[1',6':1,2]pyrido[3,4-b]indole and pyridazino[3,2-b]benzimidazole salts as anti-inflammatory agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES201331143A ES2529865B8 (en) 2013-07-25 2013-07-25 USE OF COMPOUNDS DERIVED FROM SIRES OF PIRIDAZINO [1 ', 6': 1,2] PIRIDO [3,4-b] INDOLINIO AS ANTI-INFLAMMATORY AGENTS

Publications (3)

Publication Number Publication Date
ES2529865A1 ES2529865A1 (en) 2015-02-25
ES2529865B1 ES2529865B1 (en) 2015-12-09
ES2529865B8 true ES2529865B8 (en) 2016-01-22

Family

ID=52392780

Family Applications (1)

Application Number Title Priority Date Filing Date
ES201331143A Expired - Fee Related ES2529865B8 (en) 2013-07-25 2013-07-25 USE OF COMPOUNDS DERIVED FROM SIRES OF PIRIDAZINO [1 ', 6': 1,2] PIRIDO [3,4-b] INDOLINIO AS ANTI-INFLAMMATORY AGENTS

Country Status (2)

Country Link
ES (1) ES2529865B8 (en)
WO (1) WO2015011331A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA032314B1 (en) * 2015-03-18 2019-05-31 Бристол-Маерс Сквибб Компани Tricyclic heterocyclic compounds useful as inhibitors of tnf
JP2021503486A (en) 2017-11-20 2021-02-12 アイカーン スクール オブ メディシン アット マウント サイナイ Kinase Inhibitor Compounds and Compositions and Usage
AU2019205944A1 (en) 2018-01-05 2020-07-09 Icahn School Of Medicine At Mount Sinai Method of increasing proliferation of pancreatic beta cells, treatment method, and composition
AU2019240065A1 (en) * 2018-03-20 2020-09-24 Icahn School Of Medicine At Mount Sinai Kinase inhibitor compounds and compositions and methods of use
US20230107927A1 (en) 2020-02-28 2023-04-06 First Wave Bio, Inc. Methods of treating iatrogenic autoimmune colitis

Also Published As

Publication number Publication date
ES2529865A1 (en) 2015-02-25
ES2529865B1 (en) 2015-12-09
WO2015011331A1 (en) 2015-01-29

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