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ES2529369A1 - Use of the compound 2,5-calcium dihydroxybenzenesulfonate (calcium dobesilate) for the preparation of a medicine for the treatment of achondroplasia - Google Patents

Use of the compound 2,5-calcium dihydroxybenzenesulfonate (calcium dobesilate) for the preparation of a medicine for the treatment of achondroplasia Download PDF

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Publication number
ES2529369A1
ES2529369A1 ES201300662A ES201300662A ES2529369A1 ES 2529369 A1 ES2529369 A1 ES 2529369A1 ES 201300662 A ES201300662 A ES 201300662A ES 201300662 A ES201300662 A ES 201300662A ES 2529369 A1 ES2529369 A1 ES 2529369A1
Authority
ES
Spain
Prior art keywords
calcium
dihydroxybenzenesulfonate
achondroplasia
dobesilate
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES201300662A
Other languages
Spanish (es)
Other versions
ES2529369B2 (en
Inventor
Ana CASTRO BUGARÍN
Ana Isabel GUZMÁN ARÁNGUEZ
María J. PÉREZ DE LARA
Patricia LOMA LOZANO
Alba MARTÍN GIL
Jesús Jerónimo PINTOR JUST
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ocupharm Diagnostics SL
Original Assignee
Ocupharm Diagnostics SL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ocupharm Diagnostics SL filed Critical Ocupharm Diagnostics SL
Priority to ES201300662A priority Critical patent/ES2529369B2/en
Publication of ES2529369A1 publication Critical patent/ES2529369A1/en
Application granted granted Critical
Publication of ES2529369B2 publication Critical patent/ES2529369B2/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención describe la aplicación del 2,5-dihidroxibencenosulfonato de calcio (calcio dobesilato) para el tratamiento de la acondroplasia (enanismo). La aplicación del 2,5-dihidroxibencenosulfonato de calcio (calcio dobesilato) es capaz de reducir el nivel de fosforilación de las proteínas ERK1/2 que están anormalmente elevadas en la acondroplasia y causa los efectos característicos del enanismo. El efecto del 2,5-dihidroxibencenosulfonato de calcio (calcio dobesilato) reduciendo la fosforilación de ERK1/2 está relacionado con la disminución de los efectos patológicos asociados a esta enfermedad.The present invention describes the application of calcium 2,5-dihydroxybenzenesulfonate (calcium dobesilate) for the treatment of achondroplasia (dwarfism). The application of calcium 2,5-dihydroxybenzenesulfonate (calcium dobesilate) is able to reduce the level of phosphorylation of ERK1/2 proteins that are abnormally elevated in achondroplasia and cause the characteristic effects of dwarfism. The effect of calcium 2,5-dihydroxybenzenesulfonate (calcium dobesilate) reducing ERK1/2 phosphorylation is related to the reduction of the pathological effects associated with this disease.

Description

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Claims (1)

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ES201300662A 2013-07-09 2013-07-09 Use of the compound 2,5-calcium dihydroxybenzenesulfonate (calcium dobesilate) for the preparation of a medicine for the treatment of achondroplasia Expired - Fee Related ES2529369B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES201300662A ES2529369B2 (en) 2013-07-09 2013-07-09 Use of the compound 2,5-calcium dihydroxybenzenesulfonate (calcium dobesilate) for the preparation of a medicine for the treatment of achondroplasia

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES201300662A ES2529369B2 (en) 2013-07-09 2013-07-09 Use of the compound 2,5-calcium dihydroxybenzenesulfonate (calcium dobesilate) for the preparation of a medicine for the treatment of achondroplasia

Publications (2)

Publication Number Publication Date
ES2529369A1 true ES2529369A1 (en) 2015-02-19
ES2529369B2 ES2529369B2 (en) 2015-10-14

Family

ID=52469462

Family Applications (1)

Application Number Title Priority Date Filing Date
ES201300662A Expired - Fee Related ES2529369B2 (en) 2013-07-09 2013-07-09 Use of the compound 2,5-calcium dihydroxybenzenesulfonate (calcium dobesilate) for the preparation of a medicine for the treatment of achondroplasia

Country Status (1)

Country Link
ES (1) ES2529369B2 (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030068313A1 (en) * 2001-09-28 2003-04-10 Kazuwa Nakao Therapeutic agents for achondroplasia
ES2286933B1 (en) * 2006-01-11 2009-10-02 Fundacion Lopez Hidalgo TREATMENT OF ACONDROPLASIA THROUGH THE ADMINISTRATION OF PIRIDOXAL AND ITS DERIVATIVES.
ES2315117B1 (en) * 2006-08-16 2009-12-30 Action Medicines, S.L. USE OF 2,5-DIHYDROXIBENCENIC DERIVATIVES IN THE PREPARATION OF USEFUL MEDICATIONS IN THE TREATMENT OF ASTHMA.
US20120015912A1 (en) * 2006-08-16 2012-01-19 Action Medicines Use of 2,5-dihydroxybenzene for the treatment of ocular diseases

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030068313A1 (en) * 2001-09-28 2003-04-10 Kazuwa Nakao Therapeutic agents for achondroplasia
ES2286933B1 (en) * 2006-01-11 2009-10-02 Fundacion Lopez Hidalgo TREATMENT OF ACONDROPLASIA THROUGH THE ADMINISTRATION OF PIRIDOXAL AND ITS DERIVATIVES.
ES2315117B1 (en) * 2006-08-16 2009-12-30 Action Medicines, S.L. USE OF 2,5-DIHYDROXIBENCENIC DERIVATIVES IN THE PREPARATION OF USEFUL MEDICATIONS IN THE TREATMENT OF ASTHMA.
US20120015912A1 (en) * 2006-08-16 2012-01-19 Action Medicines Use of 2,5-dihydroxybenzene for the treatment of ocular diseases

Also Published As

Publication number Publication date
ES2529369B2 (en) 2015-10-14

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