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ES2597877T3 - Promotor mejorado y método para la producción de L-lisina mediante el uso del mismo - Google Patents

Promotor mejorado y método para la producción de L-lisina mediante el uso del mismo Download PDF

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Publication number
ES2597877T3
ES2597877T3 ES09705987.7T ES09705987T ES2597877T3 ES 2597877 T3 ES2597877 T3 ES 2597877T3 ES 09705987 T ES09705987 T ES 09705987T ES 2597877 T3 ES2597877 T3 ES 2597877T3
Authority
ES
Spain
Prior art keywords
lysine
production
improved promoter
promoter
improved
Prior art date
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Active
Application number
ES09705987.7T
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English (en)
Inventor
Chul Ha Kim
Jong Soo Choi
Sang Jo Lim
Hyoung Joon Kim
So Yeon Rah
Gey Hang Jeon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CJ CheilJedang Corp
Original Assignee
CJ CheilJedang Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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Application filed by CJ CheilJedang Corp filed Critical CJ CheilJedang Corp
Application granted granted Critical
Publication of ES2597877T3 publication Critical patent/ES2597877T3/es
Active legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/77—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Corynebacterium; for Brevibacterium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine

Landscapes

  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fodder In General (AREA)

Abstract

Una molécula de ácido nucleico, que tiene una secuencia de nucleótidos de la SEQ ID NO. 2, que está unida operativamente a un gen que codifica la diaminopimelato deshidrogenasa.

Description

imagen1
imagen2
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imagen4
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Claims (1)

  1. imagen1
ES09705987.7T 2008-01-31 2009-01-23 Promotor mejorado y método para la producción de L-lisina mediante el uso del mismo Active ES2597877T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR20080010073 2008-01-31
KR1020080010073A KR100987281B1 (ko) 2008-01-31 2008-01-31 개량된 프로모터 및 이를 이용한 ｌ-라이신의 생산 방법
PCT/KR2009/000382 WO2009096690A2 (ko) 2008-01-31 2009-01-23 개량된 프로모터 및 이를 이용한 ｌ-라이신의 생산 방법

Publications (1)

Publication Number Publication Date
ES2597877T3 true ES2597877T3 (es) 2017-01-23

Family

ID=40913400

Family Applications (2)

Application Number Title Priority Date Filing Date
ES15184909T Active ES2743422T3 (es) 2008-01-31 2009-01-23 Promotor mejorado y un procedimiento de producción de L-lisina mediante el uso del mismo
ES09705987.7T Active ES2597877T3 (es) 2008-01-31 2009-01-23 Promotor mejorado y método para la producción de L-lisina mediante el uso del mismo

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES15184909T Active ES2743422T3 (es) 2008-01-31 2009-01-23 Promotor mejorado y un procedimiento de producción de L-lisina mediante el uso del mismo

Country Status (13)

Country Link
US (1) US8535915B2 (es)
EP (3) EP2993233B1 (es)
JP (1) JP5400065B2 (es)
KR (1) KR100987281B1 (es)
CN (2) CN101939432B (es)
BR (1) BRPI0906584B1 (es)
DK (2) DK2993233T3 (es)
ES (2) ES2743422T3 (es)
HR (1) HRP20161224T1 (es)
HU (2) HUE044749T2 (es)
LT (1) LT2236610T (es)
PL (2) PL2236610T3 (es)
WO (1) WO2009096690A2 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100987281B1 (ko) * 2008-01-31 2010-10-12 씨제이제일제당 (주) 개량된 프로모터 및 이를 이용한 ｌ-라이신의 생산 방법
KR101226384B1 (ko) 2010-03-05 2013-01-25 씨제이제일제당 (주) 개량된 프로모터 및 이를 이용한 ｌ-라이신의 생산 방법
DE102010019059A1 (de) * 2010-05-03 2011-11-03 Forschungszentrum Jülich GmbH Sensoren zur intrazellulären Metabolit-Detektion
KR101335853B1 (ko) 2011-12-01 2013-12-02 씨제이제일제당 (주) Ｌ-아미노산 및 리보플라빈을 동시에 생산하는 미생물 및 이를 이용한 ｌ-아미노산 및 리보플라빈을 생산하는 방법
CA2860252C (en) 2011-12-21 2019-07-23 Cj Cheiljedang Corporation Method for producing l-lysine using microorganisms having ability to produce l-lysine
KR20140066553A (ko) 2012-11-23 2014-06-02 삼성전자주식회사 코리네박테리움 속 균주의 신규 프로모터
KR101793328B1 (ko) * 2015-07-03 2017-11-03 씨제이제일제당 (주) Ｌ-라이신 생산능을 갖는 미생물 및 이를 이용한 ｌ-라이신 생산 방법
CN106190997B (zh) * 2016-07-20 2024-09-17 清华大学 一种nadh依赖性的二氨基庚二酸脱氢酶及其应用
WO2018043856A1 (ko) * 2016-08-31 2018-03-08 씨제이제일제당 (주) 신규 프로모터 및 이의 용도
KR101925930B1 (ko) * 2017-07-24 2019-02-26 씨제이제일제당 주식회사 Ｌ-라이신을 생산하는 미생물 및 이를 이용한 ｌ-라이신의 생산 방법
CN113201536B (zh) * 2020-08-19 2022-09-13 中国科学院天津工业生物技术研究所 具有启动子活性的多核苷酸及其在生产氨基酸中的应用
WO2022265130A1 (ko) * 2021-06-15 2022-12-22 씨제이제일제당 (주) 신규 프로모터 및 이의 용도

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3036912B2 (ja) * 1991-09-02 2000-04-24 協和醗酵工業株式会社 遺伝子発現調節ｄｎａ
JPH07155184A (ja) 1993-12-08 1995-06-20 Ajinomoto Co Inc 発酵法によるｌ−リジンの製造法
DE4440118C1 (de) * 1994-11-11 1995-11-09 Forschungszentrum Juelich Gmbh Die Genexpression in coryneformen Bakterien regulierende DNA
KR0159812B1 (ko) 1995-12-20 1998-11-16 손경식 코리네박테리움 글루타미컴 씨에이치 77 및 이 균주를 이용한 l-라이신의 제조 방법
JP4075087B2 (ja) 1996-12-05 2008-04-16 味の素株式会社 Ｌ−リジンの製造法
US20020086371A1 (en) * 1999-07-07 2002-07-04 Degussa-Huls Aktiengesellschaft L-lysine-producing corynebacteria and process for the preparation of L-lysine
WO2001009306A2 (en) * 1999-08-02 2001-02-08 Archer-Daniels-Midland Company Mutant bacterial strains l-lysine production
JP4623825B2 (ja) 1999-12-16 2011-02-02 協和発酵バイオ株式会社 新規ポリヌクレオチド
US6927046B1 (en) * 1999-12-30 2005-08-09 Archer-Daniels-Midland Company Increased lysine production by gene amplification using coryneform bacteria
CN1452659A (zh) 2000-03-09 2003-10-29 Basf公司 编码代谢途径蛋白的谷氨酸棒杆菌基因
US7141388B2 (en) 2000-11-15 2006-11-28 Archer-Daniels-Midland Company Nucleotide sequences for transcriptional regulation in corynebacterium glutamicum
KR100397322B1 (ko) 2000-12-30 2003-09-06 씨제이 주식회사 엘-라이신의 제조방법
AU2002325923A1 (en) * 2001-08-06 2003-05-19 Degussa Ag Production of l-lysine by genetically modified corynebacterium glutamicum strains
KR100620092B1 (ko) 2004-12-16 2006-09-08 씨제이 주식회사 코리네박테리움 속 세포로부터 유래된 신규한 프로모터서열, 그를 포함하는 발현 카세트 및 벡터, 상기 벡터를포함하는 숙주 세포 및 그를 이용하여 유전자를 발현하는방법
KR100653742B1 (ko) 2004-12-30 2006-12-05 씨제이 주식회사 신규한 ｌ-라이신-유도성 프로모터
CN101573438B (zh) * 2006-09-15 2013-01-02 Cj第一制糖株式会社 具有增加的l-赖氨酸生产力的棒状杆菌和使用其生产l-赖氨酸的方法
KR100987281B1 (ko) * 2008-01-31 2010-10-12 씨제이제일제당 (주) 개량된 프로모터 및 이를 이용한 ｌ-라이신의 생산 방법

Also Published As

Publication number Publication date
DK2993233T3 (da) 2019-08-19
WO2009096690A2 (ko) 2009-08-06
ES2743422T3 (es) 2020-02-19
EP2993233B1 (en) 2019-06-19
CN101939432B (zh) 2013-02-13
BRPI0906584B1 (pt) 2020-12-01
HUE030771T2 (en) 2017-05-29
PL2993233T3 (pl) 2019-11-29
PL2236610T3 (pl) 2017-01-31
KR20090084099A (ko) 2009-08-05
JP2011510651A (ja) 2011-04-07
DK2236610T3 (en) 2016-11-14
US20110076731A1 (en) 2011-03-31
CN103555721B (zh) 2025-04-08
BRPI0906584A2 (pt) 2019-10-01
LT2236610T (lt) 2016-10-25
EP2993233A1 (en) 2016-03-09
EP2236610A2 (en) 2010-10-06
WO2009096690A3 (ko) 2009-10-29
JP5400065B2 (ja) 2014-01-29
CN103555721A (zh) 2014-02-05
EP2990488A1 (en) 2016-03-02
US8535915B2 (en) 2013-09-17
HUE044749T2 (hu) 2019-11-28
HRP20161224T1 (hr) 2016-12-02
KR100987281B1 (ko) 2010-10-12
CN101939432A (zh) 2011-01-05
EP2236610B1 (en) 2016-07-20
EP2236610A4 (en) 2011-03-16

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