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ES2593261B1 - PRODUCT IN CREAM OF TOPICAL USE FOR THE TREATMENT OF SKIN DISEASES AND PROCEDURE OF OBTAINING - Google Patents

PRODUCT IN CREAM OF TOPICAL USE FOR THE TREATMENT OF SKIN DISEASES AND PROCEDURE OF OBTAINING Download PDF

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Publication number
ES2593261B1
ES2593261B1 ES201631278A ES201631278A ES2593261B1 ES 2593261 B1 ES2593261 B1 ES 2593261B1 ES 201631278 A ES201631278 A ES 201631278A ES 201631278 A ES201631278 A ES 201631278A ES 2593261 B1 ES2593261 B1 ES 2593261B1
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product
treatment
enoxolone
vitamin
cream product
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ES2593261A1 (en
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Jose Ramos Prieto
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/60Salicylic acid; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/01Hydrocarbons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07Retinol compounds, e.g. vitamin A
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • A61K35/64Insects, e.g. bees, wasps or fleas
    • A61K35/644Beeswax; Propolis; Royal jelly; Honey
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Insects & Arthropods (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medical Informatics (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Birds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Producto en crema de uso tópico para el tratamiento de enfermedades de la piel que comprende vaselina filante, ácido salicílico, aceite de rosa mosqueta, vitamina A (retinol) y enoxolona, donde, además comprende miel de romero y violeta genciana. Es también objeto de la presente solicitud el procedimiento de obtención del producto en crema de uso tópico anterior.Topical cream product for the treatment of skin diseases that includes petroleum jelly, salicylic acid, rosehip oil, vitamin A (retinol) and enoxolone, where it also includes rosemary honey and gentian violet. The procedure for obtaining the above topical cream product is also the subject of the present application.

Description

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PRODUCTO EN CREMA DE USO TOPICO PARA EL TRATAMIENTO DE ENFERMEDADES DE LA PIEL Y PROCEDIMIENTO DE OBTENCIONPRODUCT IN TOPICAL USE CREAM FOR THE TREATMENT OF SKIN DISEASES AND PROCEDURE OF OBTAINING

DESCRIPCIONDESCRIPTION

CAMPO TECNICO DE LA INVENCIONTECHNICAL FIELD OF THE INVENTION

El campo de aplicacion de la presente invencion se enmarca dentro del sector de la industria dedicada a la fabrication de productos cosmeticos y farmaceuticos, y mas concretamente, en el campo de la elaboration de preparados para el tratamiento de enfermedades de la piel humana.The field of application of the present invention is part of the industry sector dedicated to the manufacture of cosmetic and pharmaceutical products, and more specifically, in the field of preparation of preparations for the treatment of human skin diseases.

En particular, la presente invencion tiene por objeto un producto para el tratamiento de enfermedades de la piel, tales como, psoriasis, dermatitis, acnes, herpes, hongos u otras enfermedades de la piel mediante su uso en crema por aplicacion directa sobre la zona afectada.In particular, the present invention aims at a product for the treatment of skin diseases, such as psoriasis, dermatitis, acnes, herpes, fungi or other skin diseases by use in cream by direct application on the affected area .

Es tambien objeto de la presente invencion el procedimiento de obtencion de dicho producto.The method of obtaining said product is also object of the present invention.

ANTECEDENTES DE LA INVENCIONBACKGROUND OF THE INVENTION

En la actualidad, se conocen diferentes remedios para el tratamiento de las multiples afecciones de la piel.At present, different remedies are known for the treatment of multiple skin conditions.

Por ejemplo, el documento de patente ES 2551281, publicado el 17 de noviembre de 2015, muestra un producto en crema de uso topico para enfermedades de la piel, el cual, comprende entre sus ingredientes vaselina filante, acido acetico, aceite de mosqueta, vitamina A, enoxolona, agua destilada, glicerina y colorante.For example, patent document ES 2551281, published on November 17, 2015, shows a topical use cream product for skin diseases, which includes among its ingredients filament petrolatum, acetic acid, mustard oil, vitamin A, enoxolone, distilled water, glycerin and dye.

Este producto en crema influye positivamente en la curacion de enfermedades de la piel, tales como, dermatitis, acnes, herpes, hongos, etc., incluida la psoriasis; sin embargo, requiere su aplicacion en las zonas de la piel afectadas por dichas enfermedades durante un periodo de tiempo no menor a 15 dias, lo cual, hace engorroso su tratamiento.This cream product positively influences the healing of skin diseases, such as dermatitis, acnes, herpes, fungi, etc., including psoriasis; However, it requires its application in the areas of the skin affected by these diseases for a period of time not less than 15 days, which makes its treatment cumbersome.

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Por tal razon, se requiere obtener un producto en crema de uso topico que permita regenerar la piel de forma mas rapida, para asi, reducir el tiempo de aplicacion del producto, con vistas a que el tratamiento sea mas llevadero para el paciente.For this reason, it is required to obtain a topical cream product that allows the skin to regenerate more quickly, in order to reduce the time of application of the product, with a view to making the treatment more bearable for the patient.

DESCRIPCION DE LA INVENCIONDESCRIPTION OF THE INVENTION

La presente invention queda establecida y caracterizada en las reivindicaciones independientes, mientras que las reivindicaciones dependientes describen otras caracteristicas de la misma.The present invention is established and characterized in the independent claims, while the dependent claims describe other features thereof.

El objeto de la invencion es un producto en crema de uso topico para el tratamiento de enfermedades de la piel, asi como, su procedimiento de obtencion. El problema tecnico a resolver es como reducir el tiempo de aplicacion del producto.The object of the invention is a topical cream product for the treatment of skin diseases, as well as its method of obtaining. The technical problem to solve is how to reduce the time of application of the product.

La presente invencion tiene, pues, como objetivo principal el desarrollo de un producto que, aplicado a las zonas afectadas por una enfermedad de la piel, ya sea, dermatitis, acnes, herpes, hongos, etc., incluida la psoriasis, permita la curacion o alivio de dicha enfermedad despues de un corto periodo de tiempo de aplicacion del mismo, asi como, la elimination de los smtomas de picazon o escamado que generalmente llevan asociado dichas enfermedades, para lo cual dicho producto, configurado a modo de crema, es de uso topico.The present invention thus has as its main objective the development of a product that, applied to the areas affected by a skin disease, be it dermatitis, acnes, herpes, fungi, etc., including psoriasis, allows healing or relief of said disease after a short period of application thereof, as well as the elimination of the itching or scaly symptoms that are generally associated with said diseases, for which said product, configured as a cream, is of Topical use.

El producto comprende entre sus ingredientes miel de romero y violeta genciana, ademas de vaselina filante, acido salicflico, aceite de rosa mosqueta, vitamina A (retinol) y enoxolona.The product includes among its ingredients rosemary honey and gentian violet, in addition to petroleum jelly, salicylic acid, rosehip oil, vitamin A (retinol) and enoxolone.

Por su parte, el procedimiento de preparation del mismo se basa en la realization de una mezcla de los ingredientes que lo componen mediante una serie de combinaciones llevadas a cabo en un determinado orden y en unas condiciones.For its part, the procedure for preparing it is based on the realization of a mixture of the ingredients that compose it through a series of combinations carried out in a certain order and under certain conditions.

Con el producto en crema de uso topico obtenido se consigue mejorar la formula del producto conocido, sustituyendo el agua destilada y la glicerina por miel de romero y violeta genciana, consiguiendo que la piel regenere mucho mejor y mas rapido, con lo cual, es mas eficaz el tratamiento de patologias de la piel, tal como la psoriasis, dermatitis, acnes, herpes, hongos, etc., igualmente, se logra tratar eficazmente la rosacea.With the topical cream product obtained, the formula of the known product is improved, replacing the distilled water and glycerin with rosemary honey and gentian violet, getting the skin to regenerate much better and faster, which is more Effective treatment of skin pathologies, such as psoriasis, dermatitis, acnes, herpes, fungi, etc., also, Rosacea can be treated effectively.

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Asi mismo, se logra reducir el tiempo de aplicacion del tratamiento a 9 o 10 dias, notandose mejoria de la zona afectada de la piel desde la primera aplicacion respecto al producto conocido.Likewise, it is possible to reduce the time of application of the treatment to 9 or 10 days, showing improvement of the affected area of the skin from the first application with respect to the known product.

EXPOSICION DETALLADA DE LA INVENCIONDETAILED EXHIBITION OF THE INVENTION

La presente invencion es un producto en crema de uso topico, el cual, es eficaz en el tratamiento de enfermedades de la piel, tales como, la psoriasis, dermatitis, acnes, herpes, hongos, etc. Es tambien objeto de la presente invencion el procedimiento de obtencion de dicho producto.The present invention is a topical cream product, which is effective in the treatment of skin diseases, such as psoriasis, dermatitis, acnes, herpes, fungi, etc. The method of obtaining said product is also object of the present invention.

El producto en crema de uso topico comprende vaselina filante, acido salicflico, aceite de rosa mosqueta, vitamina A (retinol) y enoxolona; comprendiendo adicionalmente miel de romero y violeta genciana.The topical cream product comprises petroleum jelly, salicylic acid, rosehip oil, vitamin A (retinol) and enoxolone; additionally comprising rosemary honey and gentian violet.

Por ejemplo, el producto en crema de uso topico podria comprender las siguientes proporciones de sus ingredientes:For example, the topical cream product could comprise the following proportions of its ingredients:

* entre 0,6 y 1,4 kg de vaselina filante,* between 0.6 and 1.4 kg of petroleum jelly,

* entre 0,69 y 0,77 g de acido salicflico,* between 0.69 and 0.77 g of salicylic acid,

* entre 0,31 y 0,39 g de aceite de rosa de mosqueta,* between 0.31 and 0.39 g of rosehip oil,

* entre 0,01 y 0,09 g de vitamina A (retinol),* between 0.01 and 0.09 g of vitamin A (retinol),

* entre 0,16 y 0,24 g de enoxolona,* between 0.16 and 0.24 g of enoxolone,

* entre 0,34 y 0,42 g de miel de romero, y* between 0.34 and 0.42 g of rosemary honey, and

* entre 0,01 y 0,04 g de violeta genciana.* between 0.01 and 0.04 g of gentian violet.

En un ejemplo de realization preferido, el producto en crema de uso topico comprende las siguientes proporciones de sus ingredientes:In an example of preferred realization, the topical cream product comprises the following proportions of its ingredients:

* 1 kg de vaselina filante,* 1 kg of petroleum jelly,

* 0,73 g de acido salicflico,* 0.73 g of salicylic acid,

* 0,36 g de aceite de rosa de mosqueta,* 0.36 g rosehip oil,

* 0,05 g de vitamina A (retinol),* 0.05 g of vitamin A (retinol),

* 0,20 g de enoxolona,* 0.20 g of enoxolone,

* 0,38 g de miel de romero, y* 0.38 g of rosemary honey, and

* 0,01 g de violeta genciana.* 0.01 g of gentian violet.

Por su parte, el producto de la composition anterior, se obtiene en base a un procedimiento que comprende los siguientes pasos:On the other hand, the product of the previous composition is obtained based on a procedure that includes the following steps:

5 En primer lugar, se mezclan la vaselina filante y la enoxolona durante entre 26 y 34 minutos, preferiblemente, durante media hora.5 First, the filament petrolatum and enoxolone are mixed for between 26 and 34 minutes, preferably, for half an hour.

Seguidamente, a la mezcla obtenida anteriormente, se anade vitamina A y se continua mezclando durante entre 6 y 14 minutos, preferiblemente, durante 10 minutos.Then, to the mixture obtained above, vitamin A is added and mixing is continued for 6 to 14 minutes, preferably for 10 minutes.

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Luego, se anade el aceite rosa de mosqueta a la ultima mezcla obtenida anteriormente y se continua mezclando durante entre 3 y 7 minutos, preferiblemente, durante 5 minutos.Then, the rosehip oil is added to the last mixture obtained above and mixing is continued for 3 to 7 minutes, preferably, for 5 minutes.

Finalmente, a la ultima mezcla obtenida anteriormente, se anaden el resto de ingredientes 15 del producto, es decir, la violeta genciana, el acido salicflico y la miel de romero y se continua mezclando durante entre 26 y 34 minutos, preferiblemente, durante media hora.Finally, to the last mixture obtained above, the rest of the ingredients 15 of the product are added, that is, the gentian violet, the salicylic acid and the rosemary honey and it is continued mixing for between 26 and 34 minutes, preferably, for half an hour .

Despues, la ultima mezcla obtenida anteriormente, se deja reposar durante entre 3 y 5 horas, preferiblemente, durante cuatro horas en un lugar refrigerado, por ejemplo, con una 20 temperatura no superior a 20 oC, antes de envasar.Then, the last mixture obtained above is allowed to stand for 3 to 5 hours, preferably, for four hours in a refrigerated place, for example, with a temperature not exceeding 20 oC, before packaging.

Claims (4)

55 1010 15fifteen 20twenty 2525 3030 3535 REIVINDICACIONES 1. - Producto en crema de uso topico para el tratamiento de enfermedades de la piel que comprende vaselina filante, acido salicflico, aceite de rosa mosqueta, vitamina A (retinol), enoxolona, caracterizado por que comprende ademas miel de romero y violeta genciana.1. - Topical use cream product for the treatment of skin diseases that includes petroleum jelly, salicylic acid, rosehip oil, vitamin A (retinol), enoxolone, characterized in that it also includes rosemary honey and gentian violet. 2. - Producto en crema de uso topico segun la reivindicacion 1, en el que las proporciones de los ingredientes son:2. - Topical use cream product according to claim 1, wherein the proportions of the ingredients are: * entre 0,6 y 1,4 kg de vaselina filante,* between 0.6 and 1.4 kg of petroleum jelly, * entre 0,69 y 0,77 g de acido salicflico,* between 0.69 and 0.77 g of salicylic acid, * entre 0,31 y 0,39 g de aceite de rosa de mosqueta,* between 0.31 and 0.39 g of rosehip oil, * entre 0,01 y 0,09 g de vitamina A (retinol),* between 0.01 and 0.09 g of vitamin A (retinol), * entre 0,16 y 0,24 g de enoxolona,* between 0.16 and 0.24 g of enoxolone, * entre 0,34 y 0,42 g de miel de romero, y* between 0.34 and 0.42 g of rosemary honey, and * entre 0,01 y 0,04 g de violeta genciana.* between 0.01 and 0.04 g of gentian violet. 3. - Producto en crema de uso topico segun la reivindicacion 2, en el que las proporciones de sus ingredientes son:3. - Topical use cream product according to claim 2, wherein the proportions of its ingredients are: * 1 kg de vaselina filante,* 1 kg of petroleum jelly, * 0,73 g de acido salicflico,* 0.73 g of salicylic acid, * 0,36 g de aceite de rosa de mosqueta,* 0.36 g rosehip oil, * 0,05 g de vitamina A (retinol),* 0.05 g of vitamin A (retinol), * 0,20 g de enoxolona,* 0.20 g of enoxolone, * 0,38 g de miel de romero, y* 0.38 g of rosemary honey, and * 0,01 g de violeta genciana.* 0.01 g of gentian violet. 4. - Procedimiento de obtencion del producto en crema de uso topico de cualquiera de las reivindicaciones anteriores, que comprende los siguientes pasos:4. - Procedure for obtaining the topical cream product of any of the preceding claims, comprising the following steps: a) mezclar la vaselina filante y la enoxolona durante entre 26 y 34 minutos,a) mix the petroleum jelly and the enoxolone for between 26 and 34 minutes, b) anadir la vitamina A a la mezcla obtenida en el paso a) y mezclar durante entre 6 y 14 minutos,b) add vitamin A to the mixture obtained in step a) and mix for 6 to 14 minutes, c) anadir el aceite de rosa de mosqueta a la mezcla obtenida en el paso b) y mezclar durante entre 3 y 7 minutos,c) add the rosehip oil to the mixture obtained in step b) and mix for 3 to 7 minutes, d) anadir la violeta genciana, el acido salidlico y la miel de romero a la mezcla obtenida en el paso c) y mezclar durante entre 26 y 34 minutos,d) add gentian violet, salidic acid and rosemary honey to the mixture obtained in step c) and mix for between 26 and 34 minutes, e) dejar reposar la mezcla obtenida en el paso d) durante entre 3 y 5 horas en un lugar refrigerado, ye) let the mixture obtained in step d) stand for 3 to 5 hours in a refrigerated place, and 5 f) envasar la mezcla reposada en el paso e).5 f) pack the rest mixture in step e).
ES201631278A 2016-10-03 2016-10-03 PRODUCT IN CREAM OF TOPICAL USE FOR THE TREATMENT OF SKIN DISEASES AND PROCEDURE OF OBTAINING Expired - Fee Related ES2593261B1 (en)

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ES201631278A ES2593261B1 (en) 2016-10-03 2016-10-03 PRODUCT IN CREAM OF TOPICAL USE FOR THE TREATMENT OF SKIN DISEASES AND PROCEDURE OF OBTAINING

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES201631278A ES2593261B1 (en) 2016-10-03 2016-10-03 PRODUCT IN CREAM OF TOPICAL USE FOR THE TREATMENT OF SKIN DISEASES AND PROCEDURE OF OBTAINING

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ES2593261B1 true ES2593261B1 (en) 2017-07-10

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2315186B1 (en) * 2007-08-13 2010-01-08 Jose Ramos Prieto POMADA TO COMBAT AND TREAT SKIN DISEASES, AND PROCEDURE FOR PREPARATION OF SUCH POMADA.
ES2551281B1 (en) * 2014-05-14 2016-09-14 José RAMOS PRIETO Topical cream product for the treatment of skin diseases and obtaining procedure

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