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ES2586283T3 - Emulsiones autoconservadas - Google Patents

Emulsiones autoconservadas Download PDF

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Publication number
ES2586283T3
ES2586283T3 ES09767290.1T ES09767290T ES2586283T3 ES 2586283 T3 ES2586283 T3 ES 2586283T3 ES 09767290 T ES09767290 T ES 09767290T ES 2586283 T3 ES2586283 T3 ES 2586283T3
Authority
ES
Spain
Prior art keywords
formula
alkyl
alkenyl
equal
self
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES09767290.1T
Other languages
English (en)
Inventor
Masood A. Chowhan
Malay Ghosh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of ES2586283T3 publication Critical patent/ES2586283T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Ophthalmology & Optometry (AREA)
  • Otolaryngology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Una emulsión adecuada para administración ocular, nasal u ótica que comprende agua, un agente de regulación, un aceite, un emulsificador, un ajustador de pH, un compuesto sintético multifuncional de la fórmula I, **Fórmula** en donde: x es 1 a 3 o mezclas de los mismos; x+y es igual a 3; a es 0 a 2; z es igual a x; B es O- u OM; A es un anión; M es un catión; Y se selecciona del grupo que consiste de OH, O-alquilo C1-C10 y O-alquenilo C1-C10; y R1, R2 y R3 son los mismos o diferentes y son alquilo, alquilo sustituido, grupos alquilo arilo o alquenilo, opcionalmente interrumpidos por -NHC(>=O)-, de hasta 16 átomos de carbono con la condición de que los átomos de carbono totales en R1+R2+R3 está entre 10 y 24, y opcionalmente un agente terapéutico, en donde la cantidad de el compuesto de la fórmula I es desde 0.05 hasta 0.2%.

Description

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ES09767290.1T 2008-05-28 2009-05-27 Emulsiones autoconservadas Active ES2586283T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5667508P 2008-05-28 2008-05-28
US56675P 2008-05-28
PCT/US2009/045282 WO2009154978A2 (en) 2008-05-28 2009-05-27 Self-preserved emulsions

Publications (1)

Publication Number Publication Date
ES2586283T3 true ES2586283T3 (es) 2016-10-13

Family

ID=41203940

Family Applications (1)

Application Number Title Priority Date Filing Date
ES09767290.1T Active ES2586283T3 (es) 2008-05-28 2009-05-27 Emulsiones autoconservadas

Country Status (9)

Country Link
US (1) US20090298956A1 (es)
EP (1) EP2278953B1 (es)
JP (1) JP2011521957A (es)
KR (2) KR20110010788A (es)
AU (1) AU2009260572B2 (es)
BR (1) BRPI0912302A2 (es)
CA (1) CA2725523C (es)
ES (1) ES2586283T3 (es)
WO (1) WO2009154978A2 (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE412400T1 (de) * 2004-11-09 2008-11-15 Novagali Pharma Sa Öl-in-wasser-emulsion mit niedriger konzentration des kationischen mittels und positivem zetapotential
EP2228058A1 (en) 2009-03-04 2010-09-15 Novagali Pharma S.A. Anionic oil-in-water emulsion containing prostaglandins and uses thereof
EP2389939A1 (en) 2010-05-28 2011-11-30 Novagali Pharma S.A. Use of prostaglandins F2alpha and analogues for the healing of corneal and conjunctival lesions
JP5673278B2 (ja) * 2011-03-24 2015-02-18 日油株式会社 ホスホリルコリン類似構造を有する化合物および化粧料
JP5782847B2 (ja) * 2011-06-13 2015-09-24 日油株式会社 ホスホリルコリン類似構造を有する化合物および化粧料
JP5782846B2 (ja) * 2011-06-13 2015-09-24 日油株式会社 ホスホリルコリン類似構造を有する化合物および化粧料
PL2887923T3 (pl) * 2012-08-24 2023-08-14 Sun Pharmaceutical Industries Limited Preparat okulistyczny polioksylipidu lub polioksylowego kwasu tłuszczowego i leczenie chorób oczu
JP2018532809A (ja) 2015-11-10 2018-11-08 サン ファーマ グローバル エフジーイー 局所製剤およびその使用
DK3423076T3 (da) 2016-02-29 2024-07-08 Sun Pharmaceutical Ind Ltd Topisk cyclosporinholdige formuleringer og anvendelser deraf
ITUA20162425A1 (it) * 2016-04-08 2017-10-08 Medivis S R L Composizione oftalmica che comprende PVP-I
CN108201526A (zh) * 2018-03-13 2018-06-26 云南云龙制药股份有限公司 一种治疗鼻炎的凝胶及其制备方法和应用
JP2023505409A (ja) * 2019-08-18 2023-02-09 アイビュー セラピューティクス（ズーハイ）カンパニー リミテッド 持続型の眼用薬物送達システムとしてシクロスポリンミセルを含むｉｎ－ｓｉｔｕゲル
AR124568A1 (es) * 2021-01-16 2023-04-12 Godrej Industries Ltd Agentes antifúngicos, mezcla de los mismos y composiciones de limpieza para el cuidado personal que los contienen
CN115463088A (zh) * 2021-06-11 2022-12-13 温士顿医药股份有限公司 含前列腺素衍生物的眼用纳米乳剂组合物

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3608073A (en) * 1968-07-16 1971-09-21 Barnes Hind Pharm Inc Emulsion of pilocarpine for ophthalmic use
US4215064A (en) * 1978-11-30 1980-07-29 Johnson & Johnson Phosphobetaines
US4209449A (en) * 1978-11-30 1980-06-24 Mona Industries Phosphate quaternary compounds
US4503002A (en) * 1978-11-30 1985-03-05 Mona Industries, Inc. Phosphate quaternary compounds
US4407791A (en) * 1981-09-28 1983-10-04 Alcon Laboratories, Inc. Ophthalmic solutions
ES2153365T3 (es) * 1991-10-28 2001-03-01 Dennis L Fost Composiciones fosfolipidas antimicrobianas.
US5286719A (en) * 1991-10-28 1994-02-15 Mona Industries, Inc. Phospholipid virucidal compositions
US5648348A (en) * 1991-10-28 1997-07-15 Mona Industries, Inc. Phospholipid antimicrobial compositions
US5505953A (en) * 1992-05-06 1996-04-09 Alcon Laboratories, Inc. Use of borate-polyol complexes in ophthalmic compositions
EP0724622A1 (en) * 1993-07-01 1996-08-07 Allergan, Inc. Contact lens cleaning solution based on quaternary ammonium phosphate esters
CA2166722A1 (en) * 1994-05-06 1995-11-16 Manoj L. Maniar Use of vitamin e tocopheryl derivatives in ophthalmic compositions
ES2094688B1 (es) * 1994-08-08 1997-08-01 Cusi Lab Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion.
US5827835A (en) * 1994-08-30 1998-10-27 Alcon Laboratories, Inc. Thermally-gelling emulsions
US5874469A (en) * 1996-01-05 1999-02-23 Alcon Laboratories, Inc. Fluoroalkyl hydrocarbons for administering water insoluble or unstable drugs
WO1998006381A1 (en) * 1996-08-09 1998-02-19 Alcon Laboratories, Inc. Preservative systems for pharmaceutical compositions containing cyclodextrins
AU9281698A (en) * 1997-10-01 1999-04-23 Wakamoto Pharmaceutical Co., Ltd. O/w emulsion compositions
US6120758A (en) * 1998-07-16 2000-09-19 Shaklee Corporation Preservative system for topically applied products
CA2340225A1 (en) * 1998-10-27 2000-05-04 Wesley Wehsin Han Preservative system for topically administrable pharmaceutical compositions containing a fatty acid/amino acid soap
US6750250B1 (en) * 2001-07-12 2004-06-15 Alcon, Inc. 11,12-oxidoarachidonic acid derivatives and methods of their use in treating dry eye disorders
US6451775B1 (en) * 2001-08-29 2002-09-17 Colonial Chemical Inc. Castor amidopropyl dimethyl phospholipids as emulsifiers
US6585961B1 (en) * 2001-11-30 2003-07-01 Richard F. Stockel Antimicrobial compositions
WO2003086332A1 (en) * 2002-04-11 2003-10-23 Dvm Pharmaceuticals, Inc. Antimicrobial wash and carrier solutions, and uses thereof
US20060141059A1 (en) * 2004-12-27 2006-06-29 Alcon, Inc. Self-preserved ophthalmic pharmaceutical compositions containing tobramycin
US20070297990A1 (en) * 2006-06-27 2007-12-27 Shah Mandar V Self-preserving composition
WO2008035246A2 (en) * 2006-07-28 2008-03-27 Novagali Pharma Sa Compositions containing quaternary ammonium compounds
US20080026013A1 (en) * 2006-07-28 2008-01-31 Laura Rabinovich-Guilatt Compositions containing quaternary ammonium compounds
TW200904485A (en) * 2007-05-18 2009-02-01 Alcon Res Ltd Phospholipid compositions for contact lens care and preservation of pharmaceutical compositions

Also Published As

Publication number Publication date
WO2009154978A3 (en) 2010-04-22
KR20160123400A (ko) 2016-10-25
CA2725523C (en) 2017-01-10
WO2009154978A2 (en) 2009-12-23
CA2725523A1 (en) 2009-12-23
EP2278953A2 (en) 2011-02-02
BRPI0912302A2 (pt) 2015-10-20
US20090298956A1 (en) 2009-12-03
AU2009260572B2 (en) 2015-07-23
EP2278953B1 (en) 2016-05-04
KR20110010788A (ko) 2011-02-07
AU2009260572A1 (en) 2009-12-23
JP2011521957A (ja) 2011-07-28

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