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ES2580173T3 - Combinaciones sinérgicas de carotenoides y polifenoles - Google Patents

Combinaciones sinérgicas de carotenoides y polifenoles Download PDF

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Publication number
ES2580173T3
ES2580173T3 ES10731120.1T ES10731120T ES2580173T3 ES 2580173 T3 ES2580173 T3 ES 2580173T3 ES 10731120 T ES10731120 T ES 10731120T ES 2580173 T3 ES2580173 T3 ES 2580173T3
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Spain
Prior art keywords
therapeutic composition
lutein
pge2
peritonitis
lycopene
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ES10731120.1T
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English (en)
Inventor
Morris Zelkha
Rachel Levy
Esther Paran
Yoav Sharoni
Joseph Levy
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Lycored Ltd
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Lycored Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/01—Hydrocarbons
    • A61K31/015—Hydrocarbons carbocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/225—Polycarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Abstract

Una composición terapéutica para su uso en el tratamiento de afecciones inflamatorias en el que los iones superóxido, el NO, el TNF-alfa y/o la PGE2 actúan como modulador o mediador de dicha afección mediante la inhibición o la reducción de la producción de iones superóxido, NO, TNF-alfa y/o PGE2 en un sujeto humano, en donde la afección que se va a tratar se selecciona entre el grupo que consiste en artritis reumatoide, síndrome de insuficiencia respiratoria en el adulto (ARDS), asma, rinitis, fibrosis pulmonar idiopática, peritonitis, inflamación cardiovascular, isquemia miocárdica, lesión por reperfusión, ateroesclerosis, septicemia, traumatismo, diabetes tipo II, retinopatía, psoriasis, inflamación gastrointestinal, cirrosis, peritonitis y enfermedad inflamatoria intestinal, y enfermedades neurodegenerativas, incluyendo la enfermedad de Alzheimer; comprendiendo dicha composición terapéutica ácido carnósico y dos o más carotenoides seleccionados entre el grupo que consiste en luteína, licopeno y beta-caroteno, en donde la zeaxantina comprende hasta el 15 % del contenido de luteína, y en donde dichos componentes están presentes en los siguientes intervalos de peso: licopeno : luteína : beta-caroteno : ácido carnósico : 0,1-1,0 : 0,1-1,0 : 0,1-1,0 : 0,1-1,0 y en donde cada uno de los agentes activos en dicha composición terapéutica se ha de administrar en una cantidad diaria en el intervalo de 1 a 5 mg.

Description

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Claims (1)

  1. imagen1
ES10731120.1T 2009-01-19 2010-01-19 Combinaciones sinérgicas de carotenoides y polifenoles Active ES2580173T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US145593P 1999-07-26
US14559309P 2009-01-19 2009-01-19
US26651709P 2009-12-04 2009-12-04
US266517P 2009-12-04
PCT/IL2010/000045 WO2010082205A1 (en) 2009-01-19 2010-01-19 Synergistic combinations of carotenoids and polyphenols

Publications (1)

Publication Number Publication Date
ES2580173T3 true ES2580173T3 (es) 2016-08-19

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ID=42339496

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10731120.1T Active ES2580173T3 (es) 2009-01-19 2010-01-19 Combinaciones sinérgicas de carotenoides y polifenoles

Country Status (11)

Country Link
US (3) US20120071550A1 (es)
EP (2) EP3085365A3 (es)
JP (2) JP5778584B2 (es)
CN (2) CN102355894B (es)
AU (1) AU2010205367B2 (es)
BR (1) BRPI1005154A2 (es)
CA (1) CA2749202C (es)
ES (1) ES2580173T3 (es)
PL (1) PL2381935T3 (es)
RU (1) RU2563991C2 (es)
WO (1) WO2010082205A1 (es)

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JP7492222B2 (ja) * 2018-04-18 2024-05-29 国立大学法人京都大学 アディポネクチン受容体作動薬及びその使用、並びにアディポネクチン受容体作動用食品組成物及びその使用
JP2022500487A (ja) * 2018-04-19 2022-01-04 エフエフエフ バイオワークス エルエルピー 相乗的な肝保護組成物
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CA2749202A1 (en) 2010-07-22
CN102355894B (zh) 2016-06-15
EP2381935B1 (en) 2016-06-01
US20220079901A1 (en) 2022-03-17
AU2010205367A1 (en) 2011-08-11
WO2010082205A1 (en) 2010-07-22
CA2749202C (en) 2019-11-26
BRPI1005154A2 (pt) 2018-02-06
JP2015205882A (ja) 2015-11-19
CN102355894A (zh) 2012-02-15
EP2381935A1 (en) 2011-11-02
RU2563991C2 (ru) 2015-09-27
JP2012515198A (ja) 2012-07-05
RU2011134652A (ru) 2013-02-27
JP5778584B2 (ja) 2015-09-16
AU2010205367B2 (en) 2015-06-18
EP3085365A3 (en) 2017-01-04
US20170035713A1 (en) 2017-02-09
US20120071550A1 (en) 2012-03-22
CN105193777A (zh) 2015-12-30
CN105193777B (zh) 2019-06-28
PL2381935T3 (pl) 2016-11-30
EP2381935A4 (en) 2013-03-13

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