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ES2569327T3 - Promotores de la apoptosis que contienen N-acilsulfonamida - Google Patents

Promotores de la apoptosis que contienen N-acilsulfonamida Download PDF

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Publication number
ES2569327T3
ES2569327T3 ES04810896.3T ES04810896T ES2569327T3 ES 2569327 T3 ES2569327 T3 ES 2569327T3 ES 04810896 T ES04810896 T ES 04810896T ES 2569327 T3 ES2569327 T3 ES 2569327T3
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Prior art keywords
methyl
phenylsulfanyl
amino
piperazin
propylamino
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Expired - Lifetime
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ES04810896.3T
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English (en)
Inventor
Milan Bruncko
Hong Ding
Steven Elmore
Aaron R. Kunzer
Christopher L. Lynch
William Mcclellan
Cheol-Min Park
Andrew Petros
Xiaohong Song
Xilu Wang
Noah Tu
Michael D. Wendt
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AbbVie Bahamas Ltd
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AbbVie Bahamas Ltd
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    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D277/70—Sulfur atoms
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Abstract

Una compuesto que tiene la fórmula (I)**Fórmula** o una sal terapéuticamente aceptable del mismo, donde A1 es C(A2); A2 es H, F, CN, C(O)OH, C(O)NH2 o C(O)OCH3; B1 es R1, OR1, NHR1, N(R1)2 o NR1C(O)N(R1)2; D1 es H, F, Cl o CF3; E1 es H, F o Cl; Y1 es H, CN, NO2, F, Cl, CF3, OCF3, NH2, C(O)NH2, o B1 e Y1, junto con los átomos a los que están unidos, son imidazol o triazol; R1 es fenilo, pirrolilo, ciclopentilo, ciclohexilo, piperidinilo, tetrahidrofuranoílo, tetrahidropiranilo, tetrahidrotiopiranilo o R5; R5 es alquilo C1, alquilo C2, alquilo C3, alquilo C4, alquilo C5 o alquilo C6, cada uno de los cuales está sin sustituir o sustituido con uno o dos o tres sustituyentes espiroalquilo C4, espiroalquilo C5, R7, OR7, SR7, SO2R7, NHR1, N(R7)2, C(O)R7, C(O)NH2, C(O)NHR7, NHC(O)R7, NHSO2Rc, NHC(O)OR7, NHC(O)NH2, NHC(O)CH(CH3) NHC(O)CH(CH3)NH2, OH, C(O)OH o NH2 independientemente seleccionados; R7 es fenilo, furanilo, imidazolilo, piridinilo, tetrazolilo, tiazolilo, tienilo, 1,3-benzoxazolilo, 1,3-benzodioxolilo, 1,3-benzotiazol, ciclopropilo, ciclobutilo, ciclohexilo, azetidinilo, morfolinilo, piperazinilo, piperidinilo, tiomorfolinilo, tiomorfolinilsulfona-7-azabiciclo[2.2.1]heptanilo, 8-azabiciclo[3.2.1]octanilo, 4,5-dihidro-1Himidazolil 2-oxa-5-azabiciclo [2.2.1] heptanilo, 1,4,5,6-tetrahidropirimidinilo o R11; R11 es alquilo C1, alquilo C2, alquilo C3 o alquilo C4, cada uno de los cuales está sin sustituir o sustituido con uno o dos o tres sustituyentes R12, OR12, N(R12)2, C(O)N(R12)2, OH, C(O)OH, NH2, CF3, F, Cl, Br o I independientemente seleccionados; R12 es 1,3-benzodioxolilo, piridinilo, morfolinilo o alquilo C1; Z1 es fenilo o piridinilo, cada uno de los cuales está sustituido con ciclohexenilo, piperazinilo, piperidinilo, 1,2,3,6-tetrahidropiridinilo o octahidropirrolo[3,4-c]pirrolilo, cada uno de los cuales está sustituido con CH2R37, C (espiroalquil C2)(R37) o C(O)R37; R37 es fenilo, naftil imidazolilo, pirazolilo, piridinilo, ciclopentenilo, ciclohexanol, cicloheptenilo, ciclooctenilo o 3,6-dihidro-2H-piranilo, cada uno de los cuales está sustituido con R41, NHR41, N(R41)2, NHC(O)OR41 o SR41; R41 es fenilo, naftilo, ciclohexilo, morfolinilo, piperidinilo, tienilo, piridinilo, quinolinilo, benzofuranilo, 1,3- benzodioxolilo, isoindolinilo, 1,3-oxazolidin-2-onilo o R45; R45 es alquilo C1, alquilo C2, alquilo C3 o alquilo C4, cada uno de los cuales está sustituido con fenilo; donde los restos representados por B1 e Y1 juntos están sustituidos con alquilo C2, alquilo C3 o alquilo C4, cada uno de los cuales está sustituido con uno o dos sustituyentes SR55 o N(R55)2 independientemente seleccionados, donde R55 se selecciona independientemente entre fenilo o alquilo C1; los restos representados por R1 están sin sustituir o sustituidos con uno o dos sustituyentes R50, OR50, SR50, SO2R50, CO(O)R50 o OCF3 independientemente seleccionados, donde R50 es fenilo, alquilo C1, alquilo C2, alquilo C3 o alquilo C4; los restos representados por R7 están sin sustituir o sustituidos con uno o dos sustituyentes R50, OR50, C(O)NHSO2R50, CO(O)R50, C(O)R50, C(O)OH, C(O)NHOH, OH, NH2, F, Cl, Br o I independientemente seleccionados, donde R50 es fenilo, tetrazolilo o R54, donde R54 es alquilo C1, alquilo C2 o alquilo C3, cada uno de los cuales está sin sustituir o sustituido con fenilo: los restos fenilo y piridinilo de Z1 están adicionalmente sin sustituir o sustituidos con uno o dos sustituyentes F, Br, Cl o I independientemente seleccionados; los restos ciclohexenilo, piperazinilo, piperidinilo, 1,2,3,6-tetrahidropiridinilo y octahidropirrolo[3,4-c]pirrolilo de Z1 están adicionalmente sin sustituir o sustituidos con OR54, donde R54 es alquilo C1 o alquilo C2, cada uno de los cuales está sin sustituir o sustituido con N(alquil C1)2, morfolinilo, piperidinilo o piperidinilo, los restos representados por R37 están sin sustituir o sustituidos adicionalmente con uno o dos sustituyentes alquilo C1, F, Br, Cl o I independientemente seleccionados; y los restos representados por R41 están sin sustituir o sustituidos con uno o dos sustituyentes R50, OR50, SR50, N(R50)2, SO2R50, CN, CF3, F, Cl, Br o I independientemente seleccionados, donde R50 es fenilo o R54, donde R54 es alquilo C1, alquilo C2 o alquilo C3, cada uno de los cuales está sin sustituir o sustituido con N(alquil C1)2 o morfolinilo.

Description

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1-il)etoxi))piperidin-1-il)fenil-carbonilo, 4-(4-((2-(fenil)piridin-3-il)metil)piperazin-1-il)fenilcarbonilo, 4-(4-((1-fenil-1Hpirazol-5-il)metil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(piperidin-1-il)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2(pirid-3-il)fenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(quinolin-3-ilfenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4(4-(2-(quinolin-8-ilfenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(tien-2-il) fenilmetil)-4-metoxipiperazin-1
5 il)fenilcarbonilo, 4-(4-(2-(tien-2-il)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(4trifluorometoxifenil)fenilmetil)piperazin-1-il)fenilcarbonilo o 4-(4-(2-(4-trifluorometil-fenil)fenilmetil)piperazin-1il)fenilcarbonilo.
Aún otra realización pertenece a compuestos que tienen la fórmula (I), o sales terapéuticamente aceptables, profármacos o sales de profármacos de los mismos, donde A1 es C(A2); A2 es H, F, CN, C(O)OH, C(O)OCH3 o C(O)NH2; B1 es (1R)-3-(4-(hidroxiaminocarbonil)piperidin-1-il)-1-((fenilsulfanil)metil) propilamino, (1R)-3-(2-hidroxi-2metilpropil)amino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-(4-hidroxipiperidin-1-il)-1-((fenilsulfanil)metil)propilamino, (3R)-3-(3-hidroxipirrolidin-1-il)-1-((fenilsulfanil)metil) propilamino, isopropilamino, (1R)-3-(isopropilamino)-1((fenilsulfanil)metil)propilamino, (1R)-3-(1H-imidazol-1-il)-1-((fenilsulfanil)metil)propilamino, (1R)-315 (isopropil(metil)amino)-1-((fenilsulfanil)metil)-propilamino, (4-metoxiciclohex-1-il)metil)amino, (1R)-3-(4(metoxiimino)piperidin-1-il)-1-((fenilsulfanil)metil)-propilamino, (1R)-3-(N-metil-N-carboximetil)amino)-1((fenilsulfanil)metil)propilamino, (metil)(ciclohexil)amino, (metil)(ciclohexilmetil)amino, (1R)-3-(2-metil-4,5-dihidro-1Himidazol-1-il)-1-((fenilsulfanil)metil)propilamino, (3R)-3-(N-metil-N-(dimetilcarbonilmetil))-1((fenilsulfanil)metil)propilamino, (1R)-3-(N-metil-N-(1,1-dimetiletil)amino)-1-((fenilsulfanil)metil)propilamino, (N-metilN-(1,2-difenil)amino)carbonil)-N-metilamino, (N-metil-N-((difenilmetil)amino)carbonil)-N-metilamino, (2-metilfuran-3il)sulfanil)(1,1-espirobutil)etilamino, (1R)-3-(N-metil-N-(2-hidroxietil))amino)-1-((fenilsulfanil)metil)propilamino, (1R)-3(N-metil-N-isopropilamino)-1-((fenilsulfanil)metil)propilamino, (N-metil-N-(4-metoxifenil)amino)carbonil)-N-metilamino, 1-metil-4-(fenilsulfanil)pirrolidin-3-ilamino, (N-metil-N-(4-metil-fenil)amino)carbonil)-N-metilamino, (N-metil-N-(2metilfenil)amino)carbonil)-N-metilamino, (1R)-3-(4-metilpiperazin-1-il)-1-((fenilsulfanil)metil)propilamino, 125 metilpiperidin-4-iloxi, (N-metil-N-((S)-1-feniletil)amino)carbonil)-N-metilamino, (N-metil-N-(1-fenil-2-(4-metilpiperazin4-il))amino)carbonil)-N-metilamino, (N-metil-N-(1-fenil-2-(morfolin-1-il))amino)carbonil)-N-metilamino, (N-metil-N-(1fenil-2-(N,N-dimetilamino)amino)carbonil)-N-metilamino, (1R)-1-metil-2-((fenilsulfanil)metil)etilamino, (1S)-1-metil-2((fenilsulfanil)metil)etilamino, (1R)-4-(4-metilpiperazin-1-il)-1-((fenilsulfanil)metil)butilamino, (1R)-3-(metil(piridin-4il)amino)-1-((fenilsulfanil)metil)propilamino, (1R)-5-((metilsulfonilamino)-1-((fenilsulfanil)metil)pentilamino, (1R)-3-(4(metilsulfonilaminocarbonil)piperidin-1-il)-1-((fenilsulfanil)metil)-propilamino, 2-((4-metil-1,3-tiazol-2il)sulfanil)etilamino, (N-metil-N-(4-trifluorometoxifenil)amino)carbonil)-N-metilamino, (1R)-3-(morfolin-4-ilamino)-1((fenilsulfanil)metil)propilamino, (1R)-3-((2-(morfolin-4-il)etil)amino)-1-((fenilsulfanil)metil)propilamino, (1R)-3(morfolin-4-il)-3-oxo-1-((2-tienilsulfanil)metil)-propilamino, (1R)-3-(morfolin-4-il)-1-((1,3-tiazol-2ilsulfanil)metil)propilamino, (1R)-3-(morfolin-4-il)-7-((tien-2-ilsulfanil)metil)propilamino, (1R)-3-(morfolin-4-il)-135 ((fenilsulfanil)metil) propilamino, (1R)-3-(morfolin-4-il)-1-(((4-(metoxi)fenil)sulfanil)metil)propilamino, (1R)-3-(morfolin4-il)-1-(((4-(metil)fenil)sulfanil)metil)propilamino, (1R)-3-(morfolin-4-il)-1-((fenilsulfonil)metil)propilamino, (1R)-3(morfolin-4-il)-1-((4-(trifluorometoxi)fenil)sulfanil)metil)propilamino; D1 es H, F, Cl o CF3; E1 es H, F o Cl; Y1 es H, CN, NO2, F, Cl, CF3, OCF3, NH2 o C(O)NH2; y Z1 es 4-(4-(2-(1,3-benzodioxol-5-il) fenilmetil)piperazin-1-il)fenilcarbonilo, 4(4-(2-(benzofuran-2-ilfenil)fenilmetil)piperazin-1-il)fenil-carbonilo, 4-(2-bromociclohex-1-en-1-ilmetil)piperazin-1il)fenilcarbonilo, 4-(2-bromociclopent-1-en-1-ilmetil)piperazin-1-il)fenilcarbonilo, 4-(2-(4bromofenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(4-clorofenil)ciclohept-1-en-1-ilmetil)piperazin-1il)fenilcarbonilo, 4-(1-(2-(4-clorofenil)ciclohex-1-en-1-ilmetil)-1,2,3,6-tetrahidropiridin-4-il)fenilcarbonilo, 4-(4-(2-(4clorofenil)ciclohex-1-en-1-ilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(4-clorofenil)ciclopent-1-en-1-ilmetil)piperazin-1il)fenilcarbonilo, 4-(4-(2-(4-clorofenil)ciclooct-1-en-1-ilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-((4-(4-clorofenil)-5,6-di
45 hidro-2H-piran-3-il)metil)piperazin-1-il)fenilcarbonilo, 4-(4-((4-(4-clorofenil)-5,6-dihidro-2H-piran-3-il) metil)piperazin-1il)fenilcarbonilo, 4-(1-((2-(4-clorofenil)-5,5-dimetil-1-ciclohex-1-en-1-il)metil)-1,2,3,6-tetrahidropiridin-4-il)fenilmetilo, 4(4-(2-(4-clorofenil)naft-3-ilmetil)piperazin-1-il)-fenilcarbonilo, 4-(4-(2-(4-clorofenil)piridin-3-ilmetil)piperazin-1il)fenilcarbonilo, 4-(4-(3-(4-clorofenil)piridin-4-ilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-((4-(4-clorofenil)piridin-5il)metil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(4-clorofenil)fenilcarbonil)piperazin-1-il)fenilcarbonilo, 4-(1-(2-(4clorofenil)fenilcicloprop-1-il)piperazin-1-il)fenilcarbonilo o 4-(4-(2-(4-clorofenil)fenilmetil)ciclohex-1-en-1il)fenilcarbonilo.
Aún otra realización pertenece a compuestos que tienen la fórmula (I), o sales terapéuticamente aceptables, profármacos o sales de profármacos de los mismos, donde A1 es C(A2); A2 es H, F, CN, C(O)OH, C(O)OCH3 o 55 C(O)NH2; B1 es (1R)-3-(4-(hidroxiaminocarbonil)piperidin-1-il)-1-((fenilsulfanil)metil) propilamino, (1R)-3-(2-hidroxi-2metilpropil)amino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-(4-hidroxi-piperidin-1-il)-1-((fenilsulfanil)metil)propilamino, (3R)-3-(3-hidroxipirrolidin-1-il)-1-((fenilsulfanil)metil) propilamino, isopropilamino, (1R)-3-(isopropilamino)-1((fenilsulfanil)metil)propilamino, (1R)-3-(1H-imidazol-1-il)-1-((fenilsulfanil)metil)propilamino, (1R)-3(isopropil(metil)amino)-1-((fenilsulfanil)metil)-propilamino, (4-metoxiciclohex-1-il)metil)amino, (1R)-3-(4(metoxiimino)piperidin-1-il)-1-((fenilsulfanil)metil)-propilamino, (1R)-3-(N-metil-N-carboximetil)amino)-1((fenilsulfanil)metil)propilamino, (metil)(ciclohexil)amino, (metil)(ciclohexilmetil)amino, (1R)-3-(2-metil-4,5-dihidro-1Himidazol-1-il)-1-((fenilsulfanil)metil)propilamino, (1R)-3-(N-metil-N-(dimetilcarbonilmetil))-1((fenilsulfanil)metil)propilamino, (1R)-3-(N-metil-N-(2,1-dimetiletil)amino)-1-((fenilsulfanil)metil)propilamino, (N-metilN-(1,2-difenil) amino)carbonil)-N-metilamino, (N-metil-N-((difenilmetil)amino)carbonil)-N-metilamino, (2-metilfuran-365 il)sulfanil)-(1,1-espirobutil)etilamino, (1R)-3-(N-metil-N-(2-hidroxietil))amino)-1-((fenilsulfanil)metil) propilamino, (1R)3-(N-metil-N-isopropilamino)-1-((fenilsulfanil)metil)propilamino, (N-metil-N-(4-metoxifenil)amino)carbonil)-N
9
metilamino, 1-metil-4-(fenilsulfanil)pirrolidin-3-ilamino, (N-metil-N-(4-metil-fenil)amino)carbonil)-N-metilamino, (Nmetil-N-(2-metilfenil)amino)carbonil)-N-metilamino, (1R)-3-(4-metilpiperazin-1-il)-1-((fenilsulfanil)metil)propilamino, 1metilpiperidin-4-iloxi, (N-metil-N-((S)-1-feniletil)amino)carbonil)-N-metilamino, (N-metil-N-(1-fenil-2-(4-metilpiperazin4-il))amino)carbonil)-N-metilamino, (N-metil-N-(1-fenil-2-(morfolin-1-il))amino)carbonil)-N-metilamino, (N-metil-N-(15 fenil-2-(N,N-dimetilamino))amino)carbonil)-N-metilamino, (1R)-1-metil-2-((fenilsulfanil)metil)etilamino, (1S)-1-metil-2((fenilsulfanil)metil)etilamino, (1R)-4-(4-metilpiperazin-1-il)-1-((fenilsulfanil)metil) butilamino, (1R)-3-(metil(piridin-4il)amino)-1-((fenilsulfanil)metil)propilamino, (1R)-5-((metilsulfonilamino)-1-((fenilsulfanil)metil)pentilamino, (1R)-3-(4(metilsulfonilaminocarbonil)piperidin-1-il)-1-((fenilsulfanil)metil)-propilamino, 2-((4-metil-1,3-tiazol-2il)sulfanil)etilamino, (N-metil-N-(4-trifluorometoxifenil)amino)carbonil)-N-metilamino, (1R)-3-(morfolin-4-ilamino)-1((fenilsulfanil)metil)propilamino, (1R)-3-((2-(morfolin-4-il)etil)amino)-1-((fenilsulfanil)metil)propilamino, (1R)-3(morfolin-4-il)-3-oxo-1-((2-tienilsulfanil)metil)-propilamino, (1R)-3-(morfolin-4-il)-1-((1,3-tiazol-2ilsulfanil)metil)propilamino, (1R)-3-(morfolin-4-il)-1-((tien-2-ilsulfanil)metil)propilamino, (1R)-3-(morfolin-4-il)-1((fenilsulfanil)metil)propilamino, (1R)-3-(morfolin-4-il)-1-(((4-(metoxi)fenil)sulfanil)metil)propilamino, (1R)-3-(morfolin-4il)-1-(((4-(metil)fenil)sulfanil)metil)propilamino, (1R)-3-(morfolin-4-il)-1-((fenilsulfonil)-metil)propilamino, (1R)-315 (morfolin-4-il)-1-(((4-(trifluorometoxi)fenil)sulfanil)metil)propilamino; D1 es H, F, Cl o CF3; E1 es H, F o Cl; Y1 es H, CN, NO2, F, Cl, CF3, OCF3, NH2 o C(O)NH2; y Z1 es 4-(5-(2-(4-clorofenil)fenilmetil) hexahidropirrolo[3,4-c]pirrol-2(1H)il)fenilcarbonilo, 4-(4-(2-(4-clorofenil)fenilmetil)-piperazin-1-il)fenilcarbonilo, 4-(4-(2-(4-clorofenil)fenilmetil)-4metoxipiperidin-1-il)fenilcarbonilo, 4-(4-(2-(4-clorofenil)fenilmetil)piperazin-1-il)-3,5-difluorofenilcarbonilo, 4-(4-(2-(4clorofenil)fenilmetil)piperazin-1-il)-2-fluorofenilcarbonilo, 4-(4-(2-(4-clorofenil)fenilmetil)piperazin-1-il)-3fluorofenilcarbonilo, 2-(4-(2-(4-clorofenil)fenilmetil)piperazin-1-il)piridin-5-ilcarbonilo, 4-(1-(2-(4clorofenil)fenilmetil)piperidin-4-il)fenilcarbonilo, 5-(4-(2-(4-clorofenil)fenilmetil)piperazin-1-il)piridin-2-ilcarbonilo, 4-(1(2-(4-clorofenil)fenilmetil)-1,2,3,6-tetrahidropiridin-4-il)fenilcarbonilo, 4-(4-(2-(ciclohex-1-ilamino)fenilmetil)piperazin-1il)fenilcarbonil4-(4-(2-ciclohex-1-ilfenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(3-cianofenil)fenilmetil)piperazin-1il)fenilcarbonilo, 4-(4-(2-(2,4-diclorofenil)fenilmetil)piperazin-1-il)fenil-carbonilo, 4-(4-(2-(3,4
25 diclorofenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(2,4-difluorofenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(2(1,3-dihidro-2H-isoindol-2-il)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(3-(1,1dimetiletoxicarbonilamino)fenil)piperazin-1-il)fenilcarbonilo, 4-(2-(4-(2-(dimetil-amino)etoxi)fenil)fenilmetil)piperazin-1il)fenilcarbonilo o 4-(4-(3-(dimetilamino)fenil)piperazin-1-il) fenilcarbonilo.
Aún otra realización pertenece a compuestos que tienen la fórmula (I), o sales terapéuticamente aceptables, profármacos o sales de profármacos de los mismos, en la que A1 es C(A2); A2 es H, F, CN, C(O)OH, C(O)OCH3 o C(O)NH2; B1 es (1R)-3-(4-(hidroxiaminocarbonil)piperidin-1-il)-1-((fenilsulfanil)metil)propilamino, (1R)-3-(2-hidroxi-2metilpropil)amino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-(4-hidroxipiperidin-1-il)-1-((fenilsulfanil)metil)propilamino, (3R)-3-(3-hidroxipirrolidin-1-il)-1-((fenilsulfanil)metil)propilamino, isopropilamino, (1R)-3-(isopropilamino)-135 ((fenilsulfanil)metil)propilamino, (1R)-3-(1H-imidazol-1-il)-1-((fenilsulfanil)metil)propilamino, (1R)-3(isopropil(metil)amino)-1-((fenilsulfanil)metil)propilamino, (4-metoxiciclohex-1-il)metil)amino, (1R)-3-(4(metoxiimino)piperidin-1-il)-1-((fenilsulfanil)metil)propilamino, (1R)-3-(N-metil-N-carboximetil)amino)-1((fenilsulfanil)metil)propilamino, (metil)(ciclohexil)amino, (metil)(ciclohexilmetil)amino, (1R)-3-(2-metil-4,5-dihidro-1Himidazol-1-il)-1-((fenilsulfanil)metil)propilamino, (3R)-3-(N-metil-N-(dimetilcarbonilmetil))-1((fenilsulfanil)metil)propilamino, (1R)-3-(N-metil-N-(1,1-dimetiletil)amino)-1-((fenilsulfanil)metil)propilamino, (N-metilN-(1,2-difenil)amino)carbonil)-N-metilamino, (N-metil-N-((difenilmetil)amino)carbonil)-N-metilamino, (2-metilfuran-3il)sulfanil)-(1,1-espirobutil)etilamino, (1R)-3-(N-metil-N-(2-hidroxietil))amino)-1-((fenilsulfanil)metil)propilamino, (1R)-3(N-metil-N-isopropilamino)-1-((fenilsulfanil)metil)propilamino, (N-metil-N-(4-metoxifenil)amino)carbonil)-N-metilamino, 1-metil-4-(fenilsulfanil)pirrolidin-3-ilamino, (N-metil-N-(4-metilfenil)amino)carbonil)-N-metilamino, (N-metil-N-(245 metilfenil)amino)carbonil)-N-metilamino, (1R)-3-(4-metilpiperazin-1-il)-1-((fenilsulfanil)metil)propilamino, 1metilpiperidin-4-iloxi, (N-metil-N-((S)-1-feniletil)amino)carbonil)-N-metilamino, (N-metil-N-(1-fenil-2-(4-metilpiperazin4-il))amino)carbonil)-N-metilamino, (N-metil-N-(1-fenil-2-(morfolin-1-il))amino)carbonil)-N-metilamino, (N-metil-N-(1fenil-2-(N,N-dimetilamino))amino)carbonil)-N-metilamino, (1R)-1-metil-2-((fenilsulfanil)metil)etilamino, (1S)-1-metil-2((fenilsulfanil)metil)etilamino, (1R)-4-(4-metilpiperazin-1-il)-1-((fenilsulfanil)metil)butilamino, (1R)-3-(metil(piridin-4il)amino)-1-((fenilsulfanil)metil)propilamino, (1R)-5-((metilsulfonilamino)-1-((fenilsulfanil)metil)pentilamino, (1R)-3-(4(metilsulfonilaminocarbonil)piperidin-1-il)-1-((fenilsulfanil)metil)propilamino, 2-((4-metil-1,3-tiazol-2-il)sulfanil)etilamino, (N-metil-N-(4-trifluorometoxifenil)amino)carbonil)-N-metilamino, (1R)-3-(morfolin-4-ilamino)-1((fenilsulfanil)metil)propilamino, (1R)-3-((2-(morfolin-4-il)etil)amino)-1-((fenilsulfanil)metil)propilamino, (1R)-3(morfolin-4-il)-3-oxo-1-((2-tienilsulfanil)metil)propilamino, (1R)-3-(morfolin-4-il)-1-((1,3-tiazol-255 ilsulfanil)metil)propilamino, (1R)-3-(morfolin-4-il)-1-((tien-2-ilsulfanil)metil)propilamino, (1R)-3-(morfolin-4-il)-1((fenilsulfanil)metil)propilamino, (1R)-3-(morfolin-4-il)-1-(((4-(metoxi)fenil)sulfanil)metil)propilamino, (1R)-3-(morfolin-4il)-1-(((4-(metil)fenil)sulfanil)metil)propilamino, (1R)-3-(morfolin-4-il)-1-((fenilsulfonil)metil)propilamino, (1R)-3(morfolin-4-il)-1-(((4-(trifluorometoxi)fenil)sulfanil)metil)propilamino; D1 es H, F, Cl o CF3; E1 es H, F o Cl; Y1 es H, CN, NO2, F, Cl, CF3, OCF3, NH2 o C(O)NH2; y Z1 es 4-(2-(4-(dimetilamino)fenil)fenilcarbonil)piperazin-1il)fenilcarbonilo, 4-(4-(2-(4-(dimetilamino)fenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-((2-(4(dimetilamino)fenil)piridin-3-il)metil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(5,5-dimetil-2-oxo-1,3-oxazolidin-3il)fenilmetil)-piperazin-1-il)fenilcarbonilo, 4-(4-(2-(4-fluorofenil)ciclopent-1-en-1-ilmetil)piperazin-1-il)fenilcarbonilo, 4(4-(2-(4-fluorofenil)-3-fluorofenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(4-fluorofenil)fenilmetil)piperazin-1il)fenilcarbonilo, 4-(4-((2-(4-fluorofenil)piridin-3-il)metil)piperazin-1-il)fenilcarbonilo, 4-(2-(isopropilamino)fenilmetil)65 piperazin-1-il)fenilcarbonilo, 4-(4-(2-(4-(isopropilsulfanil)fenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(4metoxifenil)ciclopent-1-en-1-ilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(3-metoxifenil)fenilmetil)piperazin-1
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il)fenilcarbonilo, 4-(4-(2-(4-metoxifenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-((2-(4-metoxifenil)piridin-3il)metil)piperazin-1-il)fenilcarbonilo, 4-(4-metoxi-4-(2-(piridin-3-il)fenilmetil)piperidin-1-il)fenilcarbonilo, 4-(4-(2-(2-metil4-diclorofenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(2-metilfenil)fenilmetil)-piperazin-1-il)fenilcarbonilo, 4-(4(2-(4-(metilsulfonil)-fenil)metil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(4-metilsulfonilfenil)fenilmetil)piperazin-1
5 il)fenilcarbonilo o 4-(4-((2-(4-metilsulfonilfenil)piridin-3-il)metil)piperazin-1-il)fenilcarbonilo.
Aún otra realización pertenece a compuestos que tienen la fórmula (I), o sales terapéuticamente aceptables, profármacos o sales de profármacos de los mismos, en la que A1 es C(A2); A2 es H, F, CN, C(O)OH, C(O)OCH3 o C(O)NH2; B1 es (1R)-3-(4-(hidroxiaminocarbonil)piperidin-1-il)-1-((fenilsulfanil)metil)propilamino, (1R)-3-(2-hidroxi-2metilpropil)amino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-(4-hidroxipiperidin-1-il)-1-((fenilsulfanil)metil)propilamino, (3R)-3-(3-hidroxipirrolidin-1-il)-1-((fenilsulfanil)metil)propilamino, isopropilamino, (1R)-3-(isopropilamino)-1((fenilsulfanil)metil)propilamino, (1R)-3-(1H-imidazol-1-il)-1-((fenilsulfanil)metil)propilamino, (1R)-3(isopropil(metil)amino)-1-((fenilsulfanil)metil)propilamino, (4-metoxiciclohex-1-il)metil)amino, (1R)-3-(4(metoxiimino)piperidin-1-il)-1-((fenilsulfanil)metil)propilamino, (1R)-3-(N-metil-N-carboximetil)amino)-115 ((fenilsulfanil)metil)propilamino, (metil)(ciclohexil)amino, (metil)(ciclohexilmetil)amino, (1R)-3-(2-metil-4,5-dihidro-1Himidazol-1-il)-1-((fenilsulfanil)metil)propilamino, (3R)-3-(N-metil-N-(dimetilcarbonilmetil))-1((fenilsulfanil)metil)propilamino, (1R)-3-(N-metil-N-(1,1-dimetiletil)amino)-1-((fenilsulfanil)metil)propilamino, (N-metilN-(1,2-difenil)amino)carbonil)-N-metilamino, (N-metil-N-((difenilmetil)amino)carbonil)-N-metilamino, (2-metilfuran-3il)sulfanil)-(1,1-espirobutil)etilamino, (1R)-3-(N-metil-N-(2-hidroxietil))amino)-1-((fenilsulfanil)metil)propilamino, (1R)-3(N-metil-N-isopropilamino)-1-((fenilsulfanil)metil)propilamino, (N-metil-N-(4-metoxifenil)amino)carbonil)-N-metilamino, 1-metil-4-(fenilsulfanil)pirrolidin-3-ilamino, (N-metil-N-(4-metilfenil)amino)carbonil)-N-metilamino, (N-metil-N-(2metilfenil)amino)carbonil)-N-metilamino, (1R)-3-(4-metilpiperazin-1-il)-1-((fenilsulfanil)metil)propilamino, 1metilpiperidin-4-iloxi, (N-metil-N-((S)-1-feniletil)amino)carbonil)-N-metilamino, (N-metil-N-(1-fenil-2-(4-metilpiperazin4-il))amino)carbonil)-N-metilamino, (N-metil-N-(1-fenil-2-(morfolin-1-il))amino)carbonil)-N-metilamino, (N-metil-N-(125 fenil-2-(N,N-dimetilamino))amino)carbonil)-N-metilamino, (1R)-1-metil-2-((fenilsulfanil)metil)etilamino, (1S)-1-metil-2((fenilsulfanil)metil)etilamino, (1R)-4-(4-metilpiperazin-1-il)-1-((fenilsulfanil)metil)butilamino, (1R)-3-(metil(piridin-4il)amino)-1-((fenilsulfanil)metil)propilamino, (1R)-5-((metilsulfonilamino)-1-((fenilsulfanil)metil)pentilamino, (1R)-3-(4(metilsulfonilaminocarbonil)piperidin-1-il)-1-((fenilsulfanil)metil)propilamino, 2-((4-metil-1,3-tiazol-2-il)sulfanil)etilamino, (N-metil-N-(4-trifluorometoxifenil)amino)carbonil)-N-metilamino, (1R)-3-(morfolin-4-ilamino)-1((fenilsulfanil)metil)propilamino, (1R)-3-((2-(morfolin-4-il)etil)amino)-1-((fenilsulfanil)metil)propilamino, (1R)-3(morfolin-4-il)-3-oxo-1-((2-tienilsulfanil)metil)propilamino, (1R)-3-(morfolin-4-il)-1-((1,3-tiazol-2ilsulfanil)metil)propilamino, (1R)-3-(morfolin-4-il)-1-((tien-2-ilsulfanil)metil)propilamino, (1R)-3-(morfolin-4-il)-1((fenilsulfanil)metil)propilamino, (1R)-3-(morfolin-4-il)-1-(((4-(metoxi)fenil)sulfanil)metil)propilamino, (1R)-3-(morfolin-4il)-1-(((4-(metil)fenil)sulfanil)metilpropilamino, (1R)-3-(morfolin-4-il)-1-((fenilsulfonil)metil)propilamino, (1R)-3-(morfolin35 4-il)-1-(((4-(trifluorometoxi)fenil)sulfanil)metil)propilamino; D1 es H, F, Cl o CF3; E1 es H, F o Cl; Y1 es H, CN, NO2, F, Cl, CF3, OCF3, NH2 o C(O)NH2; y Z1 es 4-(4-(2-(5-metiltien-2-il)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(4metilsulfanilfenil)ciclohex-1-en-1-ilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(4-metilsulfanilfenil)fenilcarbonil)piperazin1-il)fenilcarbonilo, 4-(4-((2-(4-metilsulfanilfenil)piridin-3-il)metil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(4metilsulfanilfenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(4-(2-(morfolin-1-il)etoxi)fenil)fenilmetil)piperazin-1il)fenilcarbonilo, 4-(4-(2-(morfolin-1-il)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(naft-1-il)fenilmetil)piperazin-1il)fenilcarbonilo, 4-(4-(2-(naft-2-il)fenilmetil)piperazin-1-il)fenilcarbonilo o 4-(4-(2-(4-fenoxifenil)fenilmetil)piperazin-1il)fenilcarbonilo, 4-(4-((1-fenil-1H-imidazol-2-il)metil)piperazin-1-il) fenilcarbonilo, 4-(4-((1-fenil-1H-imidazol-5il)metil)piperazin-1-il)fenilcarbonilo, 4-(2-((fenilmetil)amino)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2(fenil)fenilmetil)-4-(2-(dimetilamino)etoxi))piperidin-1-il)fenilcarbonilo, 4-((2-(fenil)fenilmetil)-4-metoxipiperidin-1
45 il)fenilcarbonilo, 4-(4-(2-(fenil)fenilmetil)-4-(2-(morfolin-1-il)etoxi))piperidin-1-il)fenilcarbonilo, 4-(4-(2(fenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(3-(fenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(4(fenil)fenil)fenilmetil)piperazin-1-il)fenilcarbonilo o 4-(4-(2-(fenil)fenilmetil)-4-(2-(piperidin-1-il)etoxi))piperidin-1il)fenilcarbonilo.
Aún otra realización pertenece a compuestos que tienen la fórmula (I), o sales terapéuticamente aceptables, profármacos o sales de profármacos de los mismos, en la que A1 es C(A2); A2 es H, F, CN, C(O)OH, C(O)OCH3 o C(O)NH2; B1 es (1R)-3-(4-(hidroxiaminocarbonil)piperidin-1-il)-1-((fenilsulfanil)metil)propilamino, (1R)-3-(2-hidroxi-2metilpropil)amino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-(4-hidroxipiperidin-1-il)-1-((fenilsulfanil)metil)propilamino, (3R)-3-(3-hidroxipirrolidin-1-il)-1-((fenilsulfanil)metil)propilamino, isopropilamino, (1R)-3-(isopropilamino)-155 ((fenilsulfanil)metil)propilamino, (1R)-3-(1H-imidazol-1-il)-1-((fenilsulfanil)metil)propilamino, (1R)-3(isopropil(metil)amino)-1-((fenilsulfanil)metil)-propilamino, (4-metoxiciclohex-1-il)metil)amino, (1R)-3-(4(metoxiimino)piperidin-1-il)-1-((fenilsulfanil)metil)propilamino, (1R)-3-(N-metil-N-carboximetil)amino)-1((fenilsulfanil)metil)propilamino, (metil)(ciclohexil)amino, (metil)(ciclohexilmetil)amino, (1R)-3-(2-metil-4,5-dihidro-1Himidazol-1-il)-1-((fenilsulfanil)metil)propilamino, (3R)-3-(N-metil-N-(dimetilcarbonilmetil))-1((fenilsulfanil)metil)propilamino, (1R)-3-(N-metil-N-(1,1-dimetiletil)amino)-1-((fenilsulfanil)metil)propilamino, (N-metilN-(1,2-difenil)amino)carbonil)-N-metilamino, (N-metil-N-((difenilmetil)amino)carbonil)-N-metilamino, (2-metilfuran-3il)sulfanil)-(1,1-espirobutil)etilamino, (1R)-3-(N-metil-N-(2-hidroxietil))amino)-1-((fenilsulfanil)metil)propilamino, (1R)-3(N-metil-N-isopropilamino)-1-((fenilsulfanil)metil)propilamino, (N-metil-N-(4-metoxifenil)amino)carbonil)-N-metilamino, 1-metil-4-(fenilsulfanil)pirrolidin-3-ilamino, (N-metil-N-(4-metilfenil)amino)carbonil)-N-metilamino, (N-metil-N-(265 metilfenil)amino)carbonil)-N-metilamino, (1R)-3-(4-metilpiperazin-1-il)-1-((fenilsulfanil)metil)propilamino, 1metilpiperidin-4-iloxi, (N-metil-N-((S)-1-feniletil)amino)carbonil)-N-metilamino, (N-metil-N-(1-fenil-2-(4-metilpiperazin
11
4-il))amino)carbonil)-N-metilamino, (N-metil-N-(1-fenil-2-(morfolin-1-il))amino)carbonil)-N-metilamino, (N-metil-N-(1fenil-2-(N,N-dimetilamino))amino)carbonil)-N-metilamino, (1R)-1-metil-2-((fenilsulfanil)metil)etilamino, (1S)-1-metil-2((fenilsulfanil)metil)etilamino, (1R)-4-(4-metilpiperazin-1-il)-1-((fenilsulfanil)metil)butilamino, (1R)-3-(metil(piridin-4il)amino)-1-((fenilsulfanil)metil)propilamino, (1R)-5-((metilsulfonilamino)-1-((fenilsulfanil)metil)pentilamino, (1R)-3-(45 (metilsulfonilaminocarbonil)piperidin-1-il)-1-((fenilsulfanil)metil)propilamino, 2-((4-metil-1,3-tiazol-2-il)sulfanil)etilamino, (N-metil-N-(4-trifluorometoxifenil)amino)carbonil)-N-metilamino, (1R)-3-(morfolin-4-ilamino)-1((fenilsulfanil)metil)propilamino, (1R)-3-((2-(morfolin-4-il)etil)amino)-1-((fenilsulfanil)metil)propilamino, (1R)-3(morfolin-4-il)-3-oxo-1-((2-tienilsulfanil)metil)propilamino, (1R)-3-(morfolin-4-il)-1-((1,3-tiazol-2ilsulfanil)metil)propilamino, (1R)-3-(morfolin-4-il)-1-((tien-2-ilsulfanil)metil)propilamino, (1R)-3-(morfolin-4-il)-1((fenilsulfanil)metil)propilamino, (1R)-3-(morfolin-4-il)-1-(((4-(metoxi)fenil)sulfanil)metil)propilamino, (1R)-3-(morfolin-4il)-1-(((4-(metil)fenil)sulfanil)metil)propilamino, (1R)-3-(morfolin-4-il)-1-((fenilsulfonil)metil)propilamino, (1R)-3(morfolin-4-il)-1-(((4-(trifluorometoxi)fenil)sulfanil)metil)propilamino; D1 es H, F, Cl o CF3; E1 es H, F o Cl; Y1 es H, CN, NO2, F, Cl, CF3, OCF3, NH2 o C(O)NH2; y Z1 es 4-(4-(2-(fenil)fenilmetil)-4-(2-(pirrolidin-1-il)etoxi))piperidin-1il)fenilcarbonilo, 4-(4-((2-(fenil)piridin-3-il)metil)piperazin-1-il)fenilcarbonilo, 4-(4-((1-fenil-1H-pirazol-5
15 il)metil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(piperidin-1-il)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(pirid-3il)fenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(quinolin-3-ilfenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2(quinolin-8-ilfenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(tien-2-il)fenilmetil)-4-metoxipiperazin-1il)fenilcarbonilo, 4-(4-(2-(tien-2-il)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(4trifluorometoxifenil)fenilmetil)piperazin-1-il)fenilcarbonilo o 4-(4-(2-(4-trifluorometilfenil)fenilmetil)piperazin-1il)fenilcarbonilo.
Aún otra realización pertenece a compuestos que tienen la fórmula (I), o sales terapéuticamente aceptables, profármacos o sales de profármacos de los mismos, en la que A1 es C(A2); A2 es H, F, CN, C(O)OH, C(O)OCH3 o C(O)NH2; B1 es (1R)-3-((1S,4S)-2-oxa-5-azabiciclo[2,2,1]hept-5-il)-1-((fenilsulfanil)metil)propilamino, (1R)-3-((1R,4R)25 2-oxa-5-azabiciclo[2,2,1]hept-5-il)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(azetidin-1-il)-1((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(ciclobutilamino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3(ciclopropilamino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(dimetilamino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(dimetilamino)-1-((fenilsulfonilmetil)metil)propilamino, (1R)-3-oxo-3-(dimetilamino)-1-((pirimidin-1ilsulfanil)metil)propilamino, (1R)-3-oxo-3-((1,1-dimetiletil)amino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3(diisopropilamino)-1-((fenilsulfanil)metil)-propilamino, (1R)-3-oxo-3-(1,1-dioxotiomorfolin-4-il)-1((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(N-metil-N-(1,1-dimetiletil)amino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(piperidin-1-il)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-amino-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(metilamino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(4-metilpiperazin-1-il)-1((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(morfolin-1-il)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(235 (morfolin-1-il)etil)-1-((fenilsulfanil)metil)propilamino, (2-fenoxietil)amino, 4-(1-(fenilmetil)piperidin-4-il)amino, 4-(1(fenilmetil)piperidin-4-il)metilamino, (4-fenil-1,3-tiazol-2-ilsulfanil)etilamino, (1R,2S)-2-(fenilsulfanil)ciclohex-1-ilamino, (1S,2R)-2-(fenilsulfanil)ciclohex-1-ilamino, 2-(fenilsulfanil)ciclopentilamino, 2-(fenilsulfanil)etoxi, 2(fenilsulfanil)etilamino, 2-(fenilsulfonil)etilamino, (1R)-1-((fenilsulfanil)metil)-3-(morfolin-4-il)propilamino, (1R)-1((fenilsulfanil)metil)-3-((2,2,2-trifluoroetil)amino)propilamino, 4-(fenilsulfonil)tetrahidrofurano-3-ilamino, 4(fenilsulfanil)tetrahidrofurano-3-ilamino, (1R)-1-((fenilsulfanil)metil)-3-((2,2,2-trifluoroetil)amino)propilamino, (1S)-1((fenilsulfanil)metil)propilamino, (1R)-1-((fenilsulfanil)metil)-3-(piridin-4-ilsulfanil)propilamino, (1R)-1((fenilsulfanil)metil)-3-(tiomorfolin-4-il)propilamino, (1R)-1-((fenilsulfanil)metil)-3-(piperazin-1-il)propilamino, (1R)-1((fenilsulfanil)metil)-3-((2-(piridin-2-il)etil)amino)propilamino, (1R)-1-((fenilsulfanil)metil)-3-((piridin-4ilmetil)amino)propilamino, (1R)-1-((fenilsulfanil)metil)-3-(piridin-3-ilamino)propilamino, (1R)-1-((fenilsulfanil)metil)-345 (pirrolidin-1-ilamino)propilamino), (1R)-1-((fenilsulfanil)metil)-3-(2H-tetrazol-5-il)propilamino, (1R)-1((fenilsulfanil)metil)-3-(pirrolidin-1-il)propilamino, (1R)-1-((fenilsulfanil)metil)3-((piridin-2-ilmetil)amino)propilamino, (1S)-2-(fenilsulfanil)-1-(piridin-3-ilmetil)etilamino, (3S,4R)-(fenilsulfanil)pirrolidin-4-ilamino, 2-(fenilsulfanil)-1,1espirobutiletilamino, 2-(fenilsulfanil)-1,1-espiroetiletilamino, 2-(fenilsulfanil)-1,1-espiropentiletilamino, piperidin-4-iloxi, (1-propilpiperidin-4-il)metilamino, piran-4-ilamino, 2-(piridin-4-ilsulfanil)etilamino, 2-(pirimidin-2-ilsulfanil)etilamino, 1,1espirobutil-2-(fenilsulfanil)etilo, 2-(tien-2-ilsulfanil)etilamino, sulfanilpiran-4-ilamino, (1R)-3-(2-(2H-tetrazol-3il)pirrolidin-1-il)-1-((fenilsulfanil)metil)propilamino, (1R)-3-(3-(2H-tetrazol-3-il)azetidin-1-il)-1((fenilsulfanil)metil)propilamino o 2-(1,3-tiazol-2-ilsulfanil)etilamino; D1 es H, F, Cl o CF3; E1 es H, F o Cl; Y1 es H, CN, NO2, F, Cl, CF3, OCF3, NH2 o C(O)NH2; y Z1 es 4-(4-(2-(1,3-benzodioxol-5-il)fenilmetil)piperazin-1-il)fenilcarbonilo, 4(4-(2-(benzofuran-2-ilfenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(2-bromociclohex-1-en-1-ilmetil)piperazin-155 il)fenilcarbonilo, 4-(2-bromociclopent-1-en-1-ilmetil)piperazin-1-il)fenilcarbonilo, 4-(2-(4bromofenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(4-clorofenil)ciclohept-1-en-1-ilmetil)piperazin-1il)fenilcarbonilo, 4-(1-(2-(4-clorofenil)ciclohex-1-en-1-ilmetil)-1,2,3,6-tetrahidropiridin-4-il)fenilcarbonilo, 4-(4-(2-(4clorofenil)ciclohex-1-en-1-ilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(4-clorofenil)ciclopent-1-en-1-ilmetil)piperazin-1il)fenilcarbonilo, 4-(4-(2-(4-clorofenil)ciclooct-1-en-1-ilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-((4-(4-clorofenil)-5,6dihidro-2H-piran-3-il)metil)piperazin-1-il)fenilcarbonilo, 4-(4-((4-(4-clorofenil)-5,6-dihidro-2H-piran-3-il)metil)piperazin1-il)fenilcarbonilo, 4-(1-((2-(4-clorofenil)-5,5-dimetil-1-ciclohex-1-en-1-il)metil)-1,2,3,6-tetrahidropiridin-4-il)fenilmetilo, 4-(4-(2-(4-clorofenil)naft-3-ilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(4-clorofenil)piridin-3-ilmetil)piperazin-1il)fenilcarbonilo, 4-(4-(3-(4-clorofenil)piridin-4-ilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-((4-(4-clorofenil)piridin-5il)metil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(4-clorofenil)fenilcarbonil)piperazin-1-il)fenilcarbonilo, 4-(1-(2-(4
65 clorofenil)fenilcicloprop-1-il)piperazin-1-il)fenilcarbonilo o 4-(4-(2-(4-clorofenil)fenilmetil)ciclohex-1-en-1il)fenilcarbonilo.
12
Aún otra realización pertenece a compuestos que tienen la fórmula (I), o sales terapéuticamente aceptables, profármacos o sales de profármacos de los mismos, en la que A1 es C(A2); A2 es H, F, CN, C(O)OH, C(O)OCH3 o C(O)NH2; B1 es (1R)-3-((1S,4S)-2-oxa-5-azabiciclo[2,2,1]hept-5-il)-1-((fenilsulfanil)metil)propilamino, (1R)-3-((1R,4R)2-oxa-5-azabiciclo[2,2,1]hept-5-il)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(azetidin-1-il)-15 ((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(ciclobutilamino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3(ciclopropilamino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(dimetilamino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(dimetilamino)-1-((fenilsulfonilmetil)metil)propilamino, (1R)-3-oxo-3-(dimetilamino)-1-((pirimidin-1ilsulfanil)metil)propilamino, (1R)-3-oxo-3-((1,1-dimetiletil)amino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3(diisopropilamino)-1-((fenilsulfanil)metil)-propilamino, (1R)-3-oxo-3-(1,1-dioxotiomorfolin-4-il)-1((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(N-metil-N-(1,1-dimetiletil)amino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(piperidin-1-il)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-amino-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(metilamino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(4-metilpiperazin-1-il)-1((fenilsulfanil)metil)-propilamino, (1R)-3-oxo-3-(morfolin-1-il)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(2(morfolin-1-il)etil)-1-((fenilsulfanil)metil)propilamino, (2-fenoxietil)amino, 4-(1-(fenilmetil)piperidin-4-il)amino, 4-(115 (fenilmetil)piperidin-4-il)metilamino, (4-fenil-1,3-tiazol-2-ilsulfanil)etilamino, (1R,2S)-2-(fenilsulfanil)ciclohex-1-ilamino, (1S,2R)-2-(fenilsulfanil)ciclohex-1-ilamino, 2-(fenilsulfanil)ciclopentilamino, 2-(fenilsulfanil)etoxi, 2(fenilsulfanil)etilamino, 2-(fenilsulfonil)etilamino, (1R)-1-((fenilsulfanil)metil)-3-(morfolin-4-il)propilamino, (1R)-1((fenilsulfanil)metil)-3-((2,2,2-trifluoroetil)amino)propilamino, 4-(fenilsulfonil)tetrahidrofurano-3-ilamino, 4(fenilsulfanil)tetrahidrofurano-3-ilamino, (1R)-1-((fenilsulfanil)metil)-3-((2,2,2-trifluoroetil)-amino)propilamino, (1S)-1((fenilsulfanil)metil)propilamino, (1R)-1-((fenilsulfanil)metil)-3-(piridin-4-ilsulfanil)propilamino, (1R)-1((fenilsulfanil)metil)-3-(tiomorfolin-4-il)propilamino, (1R)-1-((fenilsulfanil)metil)-3-(piperazin-1-il)propilamino, (1R)-1((fenilsulfanil)metil)-3-((2-(piridin-2-il)etil)amino)propilamino, (1R)-1-((fenilsulfanil)metil)-3-((piridin-4ilmetil)amino)propilamino, (1R)-1-((fenilsulfanil)metil)-3-(piridin-3-ilamino)propilamino, (1R)-1-((fenilsulfanil)metil)-3(pirrolidin-1-ilamino)propilamino), (1R)-1-((fenilsulfanil)metil)-3-(2H-tetrazol-5-il)propilamino, (1R)-125 ((fenilsulfanil)metil)-3-(pirrolidin-1-il)propilamino, (1R)-1-((fenilsulfanil)metil)3-((piridin-2-ilmetil)amino)propilamino, (1S)-2-(fenilsulfanil)-1-(piridin-3-ilmetil)etilamino, (3S,4R)-(fenilsulfanil)pirrolidin-4-ilamino, 2-(fenilsulfanil)-1,1espirobutiletilamino, 2-(fenilsulfanil)-1,1-espiroetiletilamino, 2-(fenilsulfanil)-1,1-espiropentiletilamino, piperidin-4-iloxi, (1-propilpiperidin-4-il)metilamino, piran-4-ilamino, 2-(piridin-4-ilsulfanil)etilamino, 2-(pirimidin-2-ilsulfanil)etilamino, 1,1espirobutil-2-(fenilsulfanil)etilo, 2-(tien-2-ilsulfanil)etilamino, sulfanilpiran-4-ilamino, (1R)-3-(2-(2H-tetrazol-3il)pirrolidin-1-il)-1-((fenilsulfanil)metil)propilamino, (1R)-3-(3-(2H-tetrazol-3-il)azetidin-1-il)-1((fenilo,sulfanil)metil)propilamino o 2-(1,3-tiazol-2-ilsulfanil)etilamino; D1 es H, F, Cl o CF3; E1 es H, F o Cl; Y1 es H, CN, NO2, F, Cl, CF3, OCF3, NH2 o C(O)NH2; y Z1 es 4-(5-(2-(4-clorofenil)fenilmetil)hexahidropirrolo[3,4-c]pirrol-2(1H)il)fenilcarbonilo, 4-(4-(2-(4-clorofenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(4-clorofenil)fenilmetil)-4metoxipiperidin-1-il)fenilcarbonilo, 4-(4-(2-(4-clorofenil)fenilmetil)-piperazin-1-il)-3,5-difluorofenilcarbonilo, 4-(4-(2-(4
35 clorofenil)fenilmetil)piperazin-1-il)-2-fluorofenilcarbonilo, 4-(4-(2-(4-clorofenil)fenilmetil)piperazin-1-il)-3fluorofenilcarbonilo, 2-(4-(2-(4-clorofenil)fenilmetil)piperazin-1-il)piridin-5-ilcarbonilo, 4-(1-(2-(4clorofenil)fenilmetil)piperidin-4-il)fenilcarbonilo, 5-(4-(2-(4-clorofenil)fenilmetil)piperazin-1-il)piridin-2-ilcarbonilo, 4-(1(2-(4-clorofenil)fenilmetil)-1,2,3,6-tetrahidropiridin-4-il)fenilcarbonilo, 4-(4-(2-(ciclohex-1-ilamino)fenilmetil)piperazin-1il)fenilcarbonil4-(4-(2-ciclohex-1-ilfenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(3-cianofenil)fenilmetil)piperazin-1il)fenilcarbonilo, 4-(4-(2-(2,4-diclorofenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(3,4diclorofenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(2,4-difluorofenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(2(1,3-dihidro-2H-isoindol-2-il)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(3-(1,1dimetiletoxicarbonilamino)fenil)piperazin-1-il)fenilcarbonilo, 4-(2-(4-(2-(dimetilamino)etoxi)fenil)fenilmetil)piperazin-1il)fenilcarbonilo o 4-(4-(3-(dimetilamino)fenil)piperazin-1-il)fenilcarbonilo.
45 Aún otra realización pertenece a compuestos que tienen la fórmula (I), o sales terapéuticamente aceptables, profármacos o sales de profármacos de los mismos, en la que A1 es C(A2); A2 es H, F, CN, C(O)OH, C(O)OCH3 o C(O)NH2; B1 es (1R)-3-((1S,4S)-2-oxa-5-azabiciclo[2,2,1]hept-5-il)-1-((fenilsulfanil)metil)propilamino, (1R)-3-((1R,4R)2-oxa-5-azabiciclo[2,2,1]hept-5-il)-1-((fenilsulfanil)metil)-propilamino, (1R)-3-oxo-3-(azetidin-1-il)-1((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(ciclobutilamino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3(ciclopropilamino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(dimetilamino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(dimetilamino)-1-((fenilsulfonilmetil)metil)propilamino, (1R)-3-oxo-3-(dimetilamino)-1-((pirimidin-1ilsulfanil)metil)propilamino, (1R)-3-oxo-3-((1,1-dimetiletil)amino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3(diisopropilamino)-1-((fenilsulfanil)metil)-propilamino, (1R)-3-oxo-3-(1,1-dioxotiomorfolin-4-il)-1
55 ((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(N-metil-N-(1,1-dimetiletil)amino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(piperidin-1-il)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-amino-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(metilamino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(4-metilpiperazin-1-il)-1((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(morfolin-1-il)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(2(morfolin-1-il)etil)-1-((fenilsulfanil)metil)propilamino, (2-fenoxietil)amino, 4-(1-(fenilmetil)piperidin-4-il)amino, 4-(1(fenilmetil)piperidin-4-il)metilamino, (4-fenil-1,3-tiazol-2-ilsulfanil)etilamino, (1R,2S)-2-(fenilsulfanil)ciclohex-1-ilamino, (1S,2R)-2-(fenilsulfanil)ciclohex-1-ilamino, 2-(fenilsulfanil)ciclopentilamino, 2-(fenilsulfanil)etoxi, 2(fenilsulfanil)etilamino, 2-(fenilsulfonil)etilamino, (1R)-1-((fenilsulfanil)metil)-3-(morfolin-4-il)propilamino, (1R)-1((fenilsulfanil)metil)-3-((2,2,2-trifluoroetil)amino)propilamino, 4-(fenilsulfonil)tetrahidrofurano-3-ilamino, 4(fenilsulfanil)tetrahidrofurano-3-ilamino, (1R)-1-((fenilsulfanil)metil)-3-((2,2,2-trifluoroetil)amino)propilamino, (1S)-1
65 ((fenilsulfanil)metil)propilamino, (1R)-1-((fenilsulfanil)metil)-3-(piridin-4-ilsulfanil)propilamino, (1R)-1((fenilsulfanil)metil)-3-(tiomorfolin-4-il)propilamino, (1R)-1-((fenilsulfanil)metil)-3-(piperazin-1-il)propilamino, (1R)-1
13
((fenilsulfanil)metil)-3-((2-(piridin-2-il)etil)amino)propilamino, (1R)-1-((fenilsulfanil)metil)-3-((piridin-4ilmetil)amino)propilamino, (1R)-1-((fenilsulfanil)metil)-3-(piridin-3-ilamino)propilamino, (1R)-1-((fenilsulfanil)metil)-3(pirrolidin-1-ilamino)propilamino), (1R)-1-((fenilsulfanil)metil)-3-(2H-tetrazol-5-il)propilamino, (1R)-1((fenilsulfanil)metil)-3-(pirrolidin-1-il)propilamino, (1R)-1-((fenilsulfanil)metil)-3-((piridin-2-ilmetil)amino)propilamino, 5 (1S)-2-(fenilsulfanil)-1-(piridin-3-ilmetil)etilamino, (3S,4R)-(fenilsulfanil)pirrolidin-4-ilamino, 2-(fenilsulfanil)-1,1espirobutiletilamino, 2-(fenilsulfanil)-1,1-espiroetiletilamino, 2-(fenilsulfanil)-1,1-espiropentiletilamino, piperidin-4-iloxi, (1-propilpiperidin-4-il)metilamino, piran-4-ilamino, 2-(piridin-4-ilsulfanil)etilamino, 2-(pirimidin-2-ilsulfanil)etilamino, 1,1espirobutil-2-(fenilsulfanil)etilo, 2-(tien-2-ilsulfanil)etilamino, sulfanilpiran-4-ilamino, (1R)-3-(2-(2H-tetrazol-3il)pirrolidin-1-il)-1-((fenilsulfanil)metil)propilamino, (1R)-3-(3-(2H-tetrazol-3-il)azetidin-1-il)-1((fenilsulfanil)metil)propilamino o 2-(1,3-tiazol-2-ilsulfanil)etilamino; D1 es H, F, Cl o CF3; E1 es H, F o Cl; Y1 es H, CN, NO2, F, Cl, CF3, OCF3, NH2 o C(O)NH2; y Z1 es 4-(2-(4-(dimetilamino)fenil)fenilcarbonil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(4-(dimetilamino)fenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-((2-(4-(dimetilamino)fenil)piridin-3il)metil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(5,5-dimetil-2-oxo-1,3-oxazolidin-3-il)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(4-fluorofenil)ciclopent-1-en-1-ilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(4-fluorofenil)-315 fluorofenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(4-fluorofenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-((2-(4fluorofenil)piridin-3-il)metil)piperazin-1-il)fenilcarbonilo, 4-(2-(isopropilamino)fenilmetil)piperazin-1-il)fenilcarbonilo, 4(4-(2-(4-(isopropilsulfanil)fenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(4-metoxifenil)ciclopent-1-en-1ilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(3-metoxifenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(4metoxifenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-((2-(4-metoxifenil)piridin-3-il)metil)piperazin-1-il)fenilcarbonilo, 4-(4-metoxi-4-(2-(piridin-3-il)fenilmetil)piperidin-1-il)fenilcarbonilo, 4-(4-(2-(2-metil-4-diclorofenil)fenilmetil)piperazin-1il)fenilcarbonilo, 4-(4-(2-(2-metilfenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(4(metilsulfonil)fenil)metil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(4-metilsulfonilfenil)fenilmetil)piperazin-1-il)fenilcarbonilo
o 4-(4-((2-(4-metilsulfonilfenil)piridin-3-il)metil)piperazin-1-il)fenilcarbonilo.
25 Aún otra realización pertenece a compuestos que tienen la fórmula (I), o sales terapéuticamente aceptables, profármacos o sales de profármacos de los mismos, en la que A1 es C(A2); A2 es H, F, CN, C(O)OH, C(O)OCH3 o C(O)NH2; B1 es (1R)-3-((1S,4S)-2-oxa-5-azabiciclo[2,2,1]hept-5-il)-1-((fenilsulfanil)metil)propilamino, (1R)-3-((1R,4R)2-oxa-5-azabiciclo[2,2,1]hept-5-il)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(azetidin-1-il)-1((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(ciclobutilamino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3(ciclopropilamino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(dimetilamino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(dimetilamino)-1-((fenilsulfonilmetil)metil)propilamino, (1R)-3-oxo-3-(dimetilamino)-1-((pirimidin-1ilsulfanil)metil)propilamino, (1R)-3-oxo-3-((1,1-dimetiletil)amino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo(diisopropilamino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(1,1-dioxotiomorfolin-4-il)-1((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(N-metil-N-(1,1-dimetiletil)amino)-1-((fenilsulfanil)metil)propilamino,
35 (1R)-3-oxo-3-(piperidin-1-il)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-amino-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(metilamino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(4-metilpiperazin-1-il)-1((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(morfolin-1-il)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(2(morfolin-1-il)etil)-1-((fenilsulfanil)metil)propilamino, (2-fenoxietil)amino, 4-(1-(fenilmetil)piperidin-4-il)amino, 4-(1(fenilmetil)piperidin-4-il)metilamino, (4-fenil-1,3-tiazol-2-ilsulfanil)etilamino, (1R,2S)-2-(fenilsulfanil)ciclohex-1-ilamino, (1S,2R)-2-(fenilsulfanil)ciclohex-1-ilamino, 2-(fenilsulfanil)ciclopentilamino, 2-(fenilsulfanil)etoxi, 2(fenilsulfanil)etilamino, 2-(fenilsulfonil)etilamino, (1R)-1-((fenilsulfanil)metil)-3-(morfolin-4-il)propilamino, (1R)-1((fenilsulfanil)metil)-3-((2,2,2-trifluoroetil)amino)propilamino, 4-(fenilsulfonil)tetrahidrofurano-3-ilamino, 4(fenilsulfanil)tetrahidrofurano-3-ilamino, (1R)-1-((fenilsulfanil)metil)-3-((2,2,2-trifluoroetil)-amino)propilamino, (1S)-1((fenilsulfanil)metil)propilamino, (1R)-1-((fenilsulfanil)metil)-3-(piridin-4-ilsulfanil)propilamino, (1R)-1
45 ((fenilsulfanil)metil)-3-(tiomorfolin-4-il)propilamino, (1R)-1-((fenilsulfanil)metil)-3-(piperazin-1-il)propilamino, (1R)-1((fenilsulfanil)metil)-3-((2-(piridin-2-il)etil)amino)propilamino, (1R)-1-((fenilsulfanil)metil)-3-((piridin-4ilmetil)amino)propilamino, (1R)-1-((fenilsulfanil)metil)-3-(piridin-3-ilamino)propilamino, (1R)-1-((fenilsulfanil)metil)-3(pirrolidin-1-ilamino)propilamino), (1R)-1-((fenilsulfanil)metil)-3-(2H-tetrazol-5-il)propilamino, (1R)-1((fenilsulfanil)metil)-3-(pirrolidin-1-il)propilamino, (1R)-1-((fenilsulfanil)metil)-3-((piridin-2-ilmetil)amino)propilamino, (1S)-2-(fenilsulfanil)-1-(piridin-3-ilmetil)etilamino, (3S,4R)-(fenilsulfanil)pirrolidin-4-ilamino, 2-(fenilsulfanil)-1,1espirobutiletilamino, 2-(fenilsulfanil)-1,1-espiroetiletilamino, 2-(fenilsulfanil)-1,1-espiropentiletilamino, piperidin-4-iloxi, (1-propil-piperidin-4-il)metilamino, piran-4-ilamino, 2-(piridin-4-ilsulfanil)etilamino, 2-(pirimidin-2-ilsulfanil)etilamino, 1,1-espirobutil-2-(fenilsulfanil)etilo, 2-(tien-2-ilsulfanil)etilamino, sulfanilpiran-4-ilamino, (1R)-3-(2-(2H-tetrazol-3il)pirrolidin-1-il)-1-((fenilsulfanil)metil)propilamino, (1R)-3-(3-(2H-tetrazol-3-il)azetidin-1-il)-1
55 ((fenilsulfanil)metil)propilamino o 2-(1,3-tiazol-2-ilsulfanil)etilamino; D1 es H, F, Cl o CF3; E1 es H, F o Cl; Y1 es H, CN, NO2, F, Cl, CF3, OCF3, NH2 o C(O)NH2; y Z1 es 4-(4-(2-(5-metiltien-2-il)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2(4-metilsulfanilfenil)ciclohex-1-en-1-ilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(4metilsulfanilfenil)fenilcarbonil)piperazin-1-il)fenilcarbonilo, 4-(4-((2-(4-metilsulfanilfenil)piridin-3-il)metil)piperazin-1il)fenilcarbonilo, 4-(4-(2-(4-metilsulfanilfenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(4-(2-(morfolin-1il)etoxi)fenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(morfolin-1-il)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2(naft-1-il)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(naft-2-il)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(4fenoxifenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-((1-fenil-1H-imidazol-2-il)metil)piperazin-1-il) fenilcarbonilo, 4(4-((1-fenil-1H-imidazol-5-il)metil)piperazin-1-il)fenilcarbonilo, 4-(2-((fenilmetil)amino)fenilmetil)piperazin-1il)fenilcarbonilo, 4-(4-(2-(fenil)fenilmetil)-4-(2-(dimetilamino)etoxi))piperidin-1-il)fenilcarbonilo, 4-((2-(fenil)fenilmetil)-4
65 metoxipiperidin-1-il)fenilcarbonilo, 4-(4-(2-(fenil)fenilmetil)-4-(2-(morfolin-1-il)etoxi))piperidin-1-il)fenilcarbonilo, 4-(4-(2(fenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(3-(fenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(4
14
(fenil)fenil)fenilmetil)piperazin-1-il)fenilcarbonilo o 4-(4-(2-(fenil)fenilmetil)-4-(2-(piperidin-1-il)etoxi))piperidin-1il)fenilcarbonilo.
Aún otra realización pertenece a compuestos que tienen la fórmula (I), o sales terapéuticamente aceptables,
5 profármacos o sales de profármacos de los mismos, en la que A1 es C(A2); A2 es H, F, CN, C(O)OH, C(O)OCH3 o C(O)NH2; B1 es (1R)-3-((1S,4S)-2-oxa-5-azabiciclo[2,2,1]hept-5-il)-1-((fenilsulfanil)metil)propilamino, (1R)-3-((1R,4R)2-oxa-5-azabiciclo[2,2,1]hept-5-il)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(azetidin-1-il)-1((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(ciclobutilamino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3(ciclopropilamino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(dimetilamino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(dimetilamino)-1-((fenilsulfonilmetil)metil)propilamino, (1R)-3-oxo-3-(dimetilamino)-1-((pirimidin-1ilsulfanil)metil)propilamino, (1R)-3-oxo-3-((1,1-dimetiletil)amino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3(diisopropilamino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(1,1-dioxotiomorfolin-4-il)-1((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(N-metil-N-(1,1-dimetiletil)amino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(piperidin-1-il)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-amino-1-((fenilsulfanil)metil)propilamino,
15 (1R)-3-oxo-3-(metilamino)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(4-metilpiperazin-1-il)-1((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(morfolin-1-il)-1-((fenilsulfanil)metil)propilamino, (1R)-3-oxo-3-(2(morfolin-1-il)etil)-1-((fenilsulfanil)metil)propilamino, (2-fenoxietil)amino, 4-(1-(fenilmetil)piperidin-4-il)amino, 4-(1(fenilmetil)piperidin-4-il)metilamino, (4-fenil-1,3-tiazol-2-ilsulfanil)etilamino, (1R,2S)-2-(fenilsulfanil)ciclohex-1-ilamino, (1S,2R)-2-(fenilsulfanil)ciclohex-1-ilamino, 2-(fenilsulfanil)ciclopentilamino, 2-(fenilsulfanil)etoxi, 2(fenilsulfanil)etilamino, 2-(fenilsulfonil)etilamino, (1R)-1-((fenilsulfanil)metil)-3-(morfolin-4-il)propilamino, (1R)-1((fenilsulfanil)metil)-3-((2,2,2-trifluoroetil)amino)propilamino, 4-(fenilsulfonil)tetrahidrofurano-3-ilamino, 4(fenilsulfanil)tetrahidrofurano-3-ilamino, (1R)-1-((fenilsulfanil)metil)-3-((2,2,2-trifluoroetil)amino)propilamino, (1S)-1((fenilsulfanil)metil)propilamino, (1R)-1-((fenilsulfanil)metil)-3-(piridin-4-ilsulfanil)propilamino, (1R)-1((fenilsulfanil)metil)-3-(tiomorfolin-4-il)propilamino, (1R)-1-((fenilsulfanil)metil)-3-(piperazin-1-il)propilamino, (1R)-1
25 ((fenilsulfanil)metil)-3-((2-(piridin-2-il)etil)amino)propilamino, (1R)-1-((fenilsulfanil)metil)-3-((piridin-4ilmetil)amino)propilamino, (1R)-1-((fenilsulfanil)metil)-3-(piridin-3-ilamino)propilamino, (1R)-1-((fenilsulfanil)metil)-3(pirrolidin-1-ilamino)propilamino), (1R)-1-((fenilsulfanil)metil)-3-(2H-tetrazol-5-il)propilamino, (1R)-1((fenilsulfanil)metil)-3-(pirrolidin-1-il)propilamino, (1R)-1-((fenilsulfanil)metil)-3-((piridin-2-ilmetil)amino)propilamino, (1S)-2-(fenilsulfanil)-1-(piridin-3-ilmetil)etilamino, (3S,4R)-(fenilsulfanil)pirrolidin-4-ilamino, 2-(fenilsulfanil)-1,1espirobutiletilamino, 2-(fenilsulfanil)-1,1-espiroetiletilamino, 2-(fenilsulfanil)-1,1-espiropentiletilamino, piperidin-4-iloxi, (1-propilpiperidin-4-il)metilamino, piran-4-ilamino, 2-(piridin-4-ilsulfanil)etilamino, 2-(pirimidin-2-ilsulfanil)etilamino, 1,1espirobutil-2-(fenilsulfanil)etilo, 2-(tien-2-ilsulfanil)etilamino, sulfanilpiran-4-ilamino, (1R)-3-(2-(2H-tetrazol-3il)pirrolidin-1-il)-1-((fenilsulfanil)metil)propilamino, (1R)-3-(3-(2H-tetrazol-3-il)azetidin-1-il)-1((fenilsulfanil)metil)propilamino o 2-(1,3-tiazol-2-ilsulfanil)etilamino; D1 es H, F, Cl o CF3; E1 es H, F o Cl; Y1 es H, CN,
35 NO2, F, Cl, CF3, OCF3, NH2 o C(O)NH2 y Z1 es 4-(4-(2-(fenil)fenilmetil)-4-(2-(pirrolidin-1-il)etoxi))piperidin-1il)fenilcarbonilo, 4-(4-((2-(fenil)piridin-3-il)metil)piperazin-1-il)fenilcarbonilo, 4-(4-((1-fenil-1H-pirazol-5il)metil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(piperidin-1-il)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(pirid-3il)fenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(quinolin-3-ilfenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2(quinolin-8-ilfenil)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(tien-2-il)fenilmetil)-4-metoxipiperazin-1il)fenilcarbonilo, 4-(4-(2-(tien-2-il)fenilmetil)piperazin-1-il)fenilcarbonilo, 4-(4-(2-(4trifluorometoxifenil)fenilmetil)piperazin-1-il)fenilcarbonilo o 4-(4-(2-(4-trifluorometil-fenil)fenilmetil)piperazin-1il)fenilcarbonilo.
Aún otra realización pertenece a compuestos que tienen la fórmula (I) que son
45 N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1-((fenilsulfanil)metil)propil)amino)-3nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, 4-(((1R)-3-(dimetilamino)-1-((fenilsulfanil)metil)propil)amino)-N-(4-(4-((4'-metoxi(1,1'-bifenil)-2-il)metil)piperazin-1il)benzoil)-3-nitrobencenosulfonamida, 4-(((1R)-3-(dimetilamino)-1-((fenilsulfanil)metil)propil)amino)-N-(4-(4-((4'-fluoro(1,1'-bifenil)-2-il)metil)piperazin-1il)benzoil)-3-nitrobencenosulfonamida, 4-(((1R)-3-(dimetilamino)-1-((fenilsulfanil)metil)propil)amino)-N-(4-(4-((4'-(metilsulfanil)(1,1'-bifenil)-2-il)metil)piperazin1-il)benzoil)-3-nitrobencenosulfonamida,
55 N-((4-(((1R)-3-(dimetilamino)-1-((fenilsulfanil)metil)propil)amino)-3-nitrofenil)sulfonil)-4-(4-(4'-fenil-1,1'-bifenil-2ilmetil)piperazin-1-il)benzamida, 4-(((1R)-3-(dimetilamino)-1-((fenilsulfanil)metil)propil)amino)-3-nitro-N-(4-(4-((4'-fenoxi(1,1'-bifenil)-2-il)metil)piperazin1-il)benzoil)bencenosulfonamida, N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)benzoil)-4-((1,1-dimetil-2-(fenilsulfanil)etil)amino)-3nitrobencenosulfonamida, N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il) benzoil)-4-(((1R)-3-(morfolin-4-il)-1-((fenilsulfanil)metil)propil)amino)-3nitrobencenosulfonamida, N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)benzoil)-3-nitro-4-((2-(fenilsulfanil)etil)amino)bencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3-nitro-4-((2
65 (fenilsulfanil)etil)amino)bencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(morfolin-4-il)-1
15
((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-((1,1-dimetil-2-(fenilsulfanil)etil)amino)-3nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-4-(dimetilamino)-1
5 ((fenilsulfanil)metil)butil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-5-(dimetilamino)-1((fenilsulfanil)metil)pentil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-fluoro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(morfolin-4-il)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro-4-fluoro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1((fenilsulfanil)metil)propil)amino)-3-(trifluorometil)bencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(morfolin-4-il)-1
15 ((fenilsulfanil)metil)propil)amino)-3-(trifluorometil)bencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3-nitro-4-(((1R)-1-((fenilsulfanil)metil)-3-(pirrolidin-1il)propil)amino)bencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-((1,1-dimetil-2-(1,3-tiazol-2-ilsulfanil)etil)amino)-3nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1-((1,3-tiazol-2ilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1-((tien-2ilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-2-(2-(dimetilamino)etoxi)-1
25 ((fenilsulfanil)metil)etil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1S)-3-(dimetilamino)-1-metil-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(metilamino)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, ácido (3R)-3-(4-(((4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)amino)sulfonil)-2-nitroanilino)-4(fenilsulfanil)butanoico, (3R)-3-(4-(((4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)amino)sulfonil)-2-nitroanilino)-N-isopropil-4(fenilsulfanil)butanamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(diisopropilamino)-1
35 ((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, 4-(((1R)-3-(azetidin-1-il)-1-((fenilsulfanil)metil)propil)amino)-N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1il)benzoil)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3-nitro-4-((4-(fenilsulfanil)tetrahidro-3furanil)amino)bencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-hidroxi-1-((fenilsulfanil)metil)propil)amino)-3nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(isopropilamino)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, 4-(((1R)-3-(dimetilamino)-1-((fenilsulfanil)metil)propil)amino)-N-(4-(4-(2-(2-naftil)bencil)piperazin-1-il)benzoil)-3
45 nitrobencenosulfonamida, 4-(((1R)-3-(dimetilamino)-1-((fenilsulfanil)metil)propil)amino)-N-(4-(4-(2-(1-naftil)bencil)piperazin-1-il)benzoil)-3nitrobencenosulfonamida, N-(4-(4-((3'-ciano(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, 4-(((1R)-3-(dimetilamino)-1-((fenilsulfanil)metil)propil)amino)-N-(4-(4-((3'-metoxi(1,1'-bifenil)-2-il)metil)piperazin-1il)benzoil)-3-nitrobencenosulfonamida, N-(4-(4-((3'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida N-(4-(4-((2'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1
55 ((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-(2-(1,3-benzodioxol-5-il)bencil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, 4-(((1R)-3-(dimetilamino)-1-((fenilsulfanil)metil)propil)amino)-3-nitro-N-(4-(4-(2-(3-tienil)bencil)piperazin-1il)benzoil)bencenosulfonamida, 4-(((1R)-3-(dimetilamino)-1-((fenilsulfanil)metil)propil)amino)-3-nitro-N-(4-(4-(2-(piridin-3-il)bencil)piperazin-1il)benzoil)bencenosulfonamida, 4-(((1R)-3-(dimetilamino)-1-((fenilsulfanil)metil)propil)amino)-3-nitro-N-(4-(4-(2-(quinolin-8-il)bencil)piperazin-1il)benzoil)bencenosulfonamida, N-(4-(4-(2-(1-benzofuran-2-il)bencil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1
65 ((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, 4-(((1R)-3-(dimetilamino)-1-((fenilsulfanil)metil)propil)amino)-N-(4-(4-((2'-metil(1,1'-bifenil)-2-il)metil)piperazin-1
16
il)benzoil)-3-nitrobencenosulfonamida, 4-(((1R)-3-(dimetilamino)-1-((fenilsulfanil)metil)propil)amino)-3-nitro-N-(4-(4-(2-(quinolin-3-il)bencil)piperazin-1il)benzoil)bencenosulfonamida, N-(4-(4-((1-(4-clorofenil)-2-naftil)metil)piperazin-1-il)benzoil)-3-nitro-4-((2
5 (fenilsulfanil)etil)amino)bencenosulfonamida, N-(4-(4-((1-(4-clorofenil)-2-naftil)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((1-(4-clorofenil)-2-naftil)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(morfolin-4-il)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3-nitro-4-((2(fenilsulfanil)ciclopentil)amino)bencenosulfonamida, N-(4-(4-((4'-fluoro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3-nitro-4-((2(fenilsulfanil)etil)amino)bencenosulfonamida, N-(4-(4-((3',4'-dicloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3-nitro-4-((2
15 (fenilsulfanil)etil)amino)bencenosulfonamida, N-(4-(4-((3',4'-dicloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((3',4'-dicloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(morfolin-4-il)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, 3-nitro-4-((2-(fenilsulfanil)etil)amino)-N-(4-(4-((4'-(trifluorometil)(1,1'-bifenil)-2-il)metil)piperazin-1il)benzoil)bencenosulfonamida, 4-(((1R)-3-(dimetilamino)-1-((fenilsulfanil)metil)propil)amino)-3-nitro-N-(4-(4-((4'-(trifluorometil)(1,1'-bifenil)-2il)metil)piperazin-1-il)benzoil)bencenosulfonamida, 4-(((1R)-3-(morfolin-4-il)-1-((fenilsulfanil)metil)propil)amino)-3-nitro-N-(4-(4-((4'-(trifluorometil)(1,1'-bifenil)-2
25 il)metil)piperazin-1-il)benzoil)bencenosulfonamida, 3-nitro-4-((2-(fenilsulfanil)etil)amino)-N-(4-(4-((4'-(trifluorometoxi) (1,1'-bifenil)-2-il)metil)piperazin-1il)benzoil)bencenosulfonamida, 3-nitro-4-((2-(fenilsulfanil)etil)amino)-N-(4-(4-((4'-(trifluorometoxi)(1,1'-bifenil)-2-il)metil)piperazin-1il)benzoil)bencenosulfonamida, 4-(((1R)-3-(morfolin-4-il)-1-((fenilsulfanil)metil)propil)amino)-3-nitro-N-(4-(4-((4'-(trifluorometoxi)(1,1'-bifenil)-2il)metil)piperazin-1-il)benzoil)bencenosulfonamida, 3-nitro-N-(4-(4-((4'-fenoxi(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-((2(fenilsulfanil)etil)amino)bencenosulfonamida, 4-(((1R)-3-(morfolin-4-il)-1-((fenilsulfanil)metil)propil)amino)-3-nitro-N-(4-(4-((4'-fenoxi(1,1'-bifenil)-2-il)metil)piperazin
35 1-il)benzoil)bencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1S)-3-(dimetilamino)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-((1,1-dimetil-2-(fenilsulfonil)etil)amino)-3nitrobencenosulfonamida, N-(4-(4-((2',4'-dicloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, 4-(((1R)-3-(dimetilamino)-1-((fenilsulfanil)metil)propil)amino)-3-nitro-N-(4-(4-(2-(2-tienil)bencil)piperazin-1il)benzoil)bencenosulfonamida, N-(4-(4-((4'-cloro-2'-metil(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1
45 ((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((2',4'-difluoro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)benzoil)-3-nitro-4-((2-(fenilsulfonil)etil)amino)bencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3-nitro-4-((2(fenilsulfonil)etil)amino)bencenosulfonamida, N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)benzoil)-3-nitro-4-((4-(fenilsulfanil)tetrahidro-3furanil)amino)bencenosulfonamida, 4-(((1R)-3-(dimetilamino)-1-((fenilsulfanil)metil)propil)amino)-N-(4-(4-(2-(5-metil-2-tienil)bencil)piperazin-1-il)benzoil)3-nitrobencenosulfonamida,
55 N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3-nitro-4-((4-(fenilsulfonil)tetrahidro-3furanil)amino)bencenosulfonamida, N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)benzoil)-3-nitro-4-((4-(fenilsulfonil)tetrahidro-3furanil)amino)bencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-((1-metil-4-(fenilsulfanil)pirrolidin-3-il)amino)-3nitrobencenosulfonamida, N-(4-(4-((2-(4-clorofenil)-1-ciclohexen-1-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(morfolin-4-il)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((2-(4-clorofenil)-1-ciclohexen-1-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(morfolin-4-il)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida,
65 N-(4-(4-((4'-bromo(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida,
17
imagen8
4-(((1R)-5-amino-1-((fenilsulfanil)metil)pentil)amino)-N-(4-(4-((4'-cloro(1,1'-bifenil)-4-il)metil)-1-piperazinil)benzoil)-3nitrobencenosulfonamida, N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)benzoil)-4-(((1R)-4-metil-1-((fenilsulfanil)metil)pentil)amino)-3nitrobencenosulfonamida,
5 (5R)-5-(4-(((4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)amino)sulfonil)-2-nitroanilino)-6(fenilsulfanil)hexilcarbamato de terc-butilo, 4-(((1R)-5-amino-1-((fenilsulfanil)metil)pentil)amino)-N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-Q-(((1R)-5-((metilsulfonil)amino)-1((fenilsulfanil)metil)pentil)amino)-3-nitrobencenosulfonamida, 4-(((1R)-5-((aminocarbonil)amino)-1-((fenilsulfanil)metil)pentil)amino)-N-(4-(4-((4'-cloro(1,1'-bifenil)-2il)metil)piperazin-1-il)benzoil)-3-nitrobencenosulfonamida, 4-(((1R)-3-(dimetilamino)-1-((fenilsulfanil)metil)propil)amino)-N-(4-(4-(2-(5,5-dimetil-2-oxo-1,3-oxazolidin-3il)bencil)piperazin-1-il)benzoil)-3-nitrobencenosulfonamida,
15 N-(4-(4-(2-ciclohexilbencil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1-((fenilsulfanil)metil)propil)amino)-3nitrobencenosulfonamida, 4-(((1R)-3-(dimetilamino)-1-((fenilsulfanil)metil)propil)amino)-N-(4-(4-(2-(morfolin-4-il)bencil)piperazin-1-il)benzoil)-3nitrobencenosulfonamida, N-(4-(4-((2-(4-clorofenil)-1-ciclohexen-1-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(isopropil(metil)amino)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((2-(4-clorofenil)-1-ciclohexen-1-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dipropilamino)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dipropilamino)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida,
25 N-(4-(4-((2-(4-clorofenil)-1-ciclohexen-1-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dietilamino)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dietilamino)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((1,1'-bifenil)-3-ilmetil)piperazin-1-il)benzoil)-3-nitro-4-((2-(fenilsulfanil)etil)amino)bencenosulfonamida, N-(4-(4-((1,1'-bifenil)-3-ilmetil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1-((fenilsulfanil)metil)propil)amino)-3nitrobencenosulfonamida, N-(4-(4-((1,1'-bifenil)-3-ilmetil)piperazin-1-il)benzoil)-4-(((1R)-3-(morfolin-4-il)-1-((fenilsulfanil)metil)propil)amino)-3nitrobencenosulfonamida, N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)-3-fluorobenzoil)-4-(((1R)-3-(dimetilamino)-1
35 ((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)-3-fluorobenzoil)-3-nitro-4-((2(fenilsulfanil)etil)amino)bencenosulfonamida, N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)-3-fluorobenzoil)-4-(((1R)-3-(morfolin-4-il)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)-3,5-difluorobenzoil)-4-(((1R)-3-(dimetilamino)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)-3,5-difluorobenzoil)-3-nitro-4-((2(fenilsulfanil)etil)amino)bencenosulfonamida, N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)-3,5-difluorobenzoil)-4-(((1R)-3-(morfolin-4-il)-1
45 ((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, 3-nitro-N-(4-(4-((1-fenil-1H-imidazol-2-il)metil)piperazin-1-il)benzoil)-4-((2(fenilsulfanil)etil)amino)bencenosulfonamida, 4-(((1R)-3-(morfolin-4-il)-1-((fenilsulfanil)metil)propil)amino)-3-nitro-N-(4-(4-((1-fenil-1H-imidazol-2-il)metil)piperazin-1il)benzoil)bencenosulfonamida, 3-nitro-N-(4-(4-((1-fenil-1H-pirazol-5-il)metil)piperazin-1-il)benzoil)-4-((2-(fenilsulfanil)etil)amino)bencenosulfonamida, 4-(((1R)-3-(morfolin-4-il)-1-((fenilsulfanil)metil)propil)amino)-3-nitro-N-(4-(4-((1-fenil-1H-pirazol-5-il)metil)piperazin-1il)benzoil)bencenosulfonamida, 4-(((1R)-3-(morfolin-4-il)-1-((fenilsulfanil)metil)propil)amino)-3-nitro-N-(4-(4-((1-fenil1H-pirazol-5-il)metil)piperazin-1-il)benzoil)bencenosulfonamida 4-(((1R)-3-(morfolin-4-il)-1-((fenilsulfanil)metil)propil)amino)-3-nitro-N-(4-(4-((1-fenil-1H-imidazol-5-il)metil)piperazin-1
55 il)benzoil)bencenosulfonamida, ácido 1-((3R)-3-(4-(((4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)amino)sulfonil)-2-nitroanilino)-4(fenilsulfanil)butil)-3-azetidinacarboxílico, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-((2-hidroxi-2-metilpropil)amino)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, ácido (((3R)-3-(4-(((4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)amino)sulfonil)-2-nitroanilino)-4(fenilsulfanil)butil)(metil)amino)acético, ácido (2R)-1-((3R)-3-(4-(((4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)amino)sulfonil)-2-nitroanilino)-4(fenilsulfanil)butil)-2-pirrolidinacarboxílico ácido 1-((3R)-3-(4-(((4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)amino)sulfonil)-2-nitroanilino)-4
65 (fenilsulfanil)butil)-4-piperidinacarboxílico N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-((2-hidroxietil)(metil)amino)-1
19
((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, ácido (2S)-1-((3R)-3-(4-(((4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)amino)sulfonil)-2-nitroanilino)-4(fenilsulfanil)butil)-2-pirrolidinacarboxílico, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3-nitro-4-(((1R)-1-((fenilsulfanil)metil)-3-(3-(2H-tetrazol
5 5-il)azetidin-1-il)propil)amino)bencenosulfonamida, (2S)-2-amino-N-((1S)-2-(((3R)-3-(4-(((4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)amino)sulfonil)-2nitroanilino)-4-(fenilsulfanil)butil)amino)-1-metil-2-oxoetil)propanamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3-nitro-4-(((1R)-1-((fenilsulfanil)metil)-3-(2-(2H-tetrazol5-il)pirrolidin-1-il)propil)amino)bencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(4-(((metilsulfonil)amino)carbonil)piperidin-1il)-1-((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1((fenilsulfanil)metil)propil)amino)bencenosulfonamida, 1-((3R)-3-(4-(((4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)amino)sulfonil)-2-nitroanilino)-4
15 (fenilsulfanil)butil)-N-hidroxi-4-piperidinacarboxamida, 2-cloro-N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1((fenilsulfanil)metil)propil)amino)bencenosulfonamida, 2,6-dicloro-N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1((fenilsulfanil)metil)propil)amino)bencenosulfonamida, 4-(((1R)-3-((1R,5S)-8-azabiciclo[3,2,1]oct-8-il)-1-((fenilsulfanil)metil)propil)amino)-N-(4-(4-((4'-cloro(1,1'-bifenil)-2il)metil)piperazin-1-il)benzoil)-3-nitrobencenosulfonamida, 4-(((1R)-3-(7-azabiciclo[2,2,1]hept-7-il)-1-((fenilsulfanil)metil)propil)amino)-N-(4-(4-((4'-cloro(1,1'-bifenil)-2il)metil)piperazin-1-il)benzoil)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3-nitro-4-(2-(fenilsulfanil)etoxi)bencenosulfonamida,
25 N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(2-(fenilsulfanil)etoxi)-3(trifluorometil)bencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3-nitro-4-(((1R)-3-((1S,4S)-2-oxa-5azabiciclo[2,2,1]hept-5-il)-1-((fenilsulfanil)metil)propil)amino)bencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3-nitro-4-(((1R)-3-((1R,4R)-2-oxa-5azabiciclo[2,2,1]hept-5-il)-1-((fenilsulfanil)metil)propil)amino)bencenosulfonamida, N-(4-(4-((2-(4-clorofenil)-1-ciclohexen-1-il)metil)piperazin-1-il)benzoil)-3-nitro-4-(((1R)-3-((1S,4S)-2-oxa-5azabiciclo[2,2,1]hept-5-il)-1-((fenilsulfanil)metil)propil)amino)bencenosulfonamida, N-(4-(4-((2-(4-clorofenil)-1-ciclohexen-1-il)metil)piperazin-1-il)benzoil)-3-nitro-4-(((1R)-3-((1R,4R)-2-oxa-5azabiciclo[2,2,1]hept-5-il)-1-((fenilsulfanil)metil)propil)amino)bencenosulfonamida,
35 4-(((1R)-3-(7-azabiciclo[2,2,1]hept-7-il)-1-((fenilsulfanil)metil)propil)amino)-N-(4-(4-((2-(4-clorofenil)-1-ciclohexen-1il)metil)piperazin-1-il)benzoil)-3-nitrobencenosulfonamida, N-(4-(4-((2-(4-clorofenil)-1-ciclohexen-1-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-((2R,5S)-2,5-dimetilpirrolidin-1-il)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3-nitro-4-(((1R)-3-((1R,4R)-2-oxa-5azabiciclo[2,2,1]hept-5-il)-1-((fenilsulfanil)metil)propil)amino)bencenosulfonamida, N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)benzoil)-4-(ciclohexiloxi)-3-nitrobencenosulfonamida, N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)benzoil)-4-(ciclohexilmetoxi)-3-nitrobencenosulfonamida, N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)benzoil)-4-(2-ciclohexiletoxi)-3-nitrobencenosulfonamida, N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)benzoil)-3-nitro-4-(tetrahidro-2H-piran-4-ilamino)bencenosulfonamida,
45 N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)benzoil)-4-((2-ciclohexiletil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)benzoil)-4-(ciclohexil(metil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)benzoil)-4-(4,4-dimetilpiperidin-1-il)-3-nitrobencenosulfonamida, 4-(4-(((4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)benzoil)amino)sulfonil)-2-nitrofenoxi)-1-piperidinacarboxilato de tercbutilo, N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)benzoil)-3-nitro-4-(piperidin-4-iloxi)bencenosulfonamida, N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)benzoil)-4-((1-metilpiperidin-4-il)oxi)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-((ciclohexilmetil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-((ciclohexilmetil)(propil)amino)-3nitrobencenosulfonamida,
55 4-(((1-bencilpiperidin-4-il)metil)amino)-N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)benzoil)-3nitrobencenosulfonamida, N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)benzoil)-4-((ciclohexilmetil)(metil)amino)-3-nitrobencenosulfonamida, 4-((1-bencilpiperidin-4-il)amino)-N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)benzoil)-3-nitrobencenosulfonamida, N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)benzoil)-3-nitro-4-(tetrahidro-2H-sulfanilpiran-4ilamino)bencenosulfonamida, 4-(4-(((4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)benzoil)amino)sulfonil)-2-nitroanilino)-1-piperidinacarboxilato de etilo, N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)benzoil)-3-nitro-4-(((1-propilpiperidin-4il)metil)amino)bencenosulfonamida, N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)benzoil)-4-(isopropilamino)-3-nitrobencenosulfonamida,
65 N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)benzoil)-3-nitro-4-((2-(1,3-tiazol-2ilsulfanil)etil)amino)bencenosulfonamida,
20
imagen9
imagen10
N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3-nitro-4-((1((fenilsulfanil)metil)ciclohexil)amino)benceno-sulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-1-metil-2-(fenilsulfanil)etil)amino)-3nitrobencenosulfonamida,
5 N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)benzoil)-4-(((1S)-1-metil-2-(fenilsulfanil)etil)amino)-3nitrobencenosulfonamida, N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)benzoil)-3-nitro-4-(((1R,2S)-2(fenilsulfanil)ciclohexil)amino)bencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1((fenilsulfanil)metil)propil)amino)-3-(trifluorometil)bencenosulfonamida, 4-(((1R)-5-amino-1-((fenilsulfanil)metil)pentil)amino)-N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3nitrobencenosulfonamida, N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)benzoil)-3-nitro-4-(((1S)-2-(fenilsulfanil)-1-(piridin-3ilmetil)etil)amino)bencenosulfonamida,
15 N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)benzoil)-3-nitro-4-(((1S,2R)-2(fenilsulfanil)ciclohexil)amino)bencenosulfonamida, N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)benzoil)-4-((1-(((2-metil-3-furil)sulfanil)metil)ciclopentil)amino)-3nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-((1-(((2-metil-3-furil)sulfanil)metil)ciclopentil)amino)-3nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3-nitro-4-(((1S)-2-(fenilsulfanil)-1-(piridin-3ilmetil)etil)amino)bencenosulfonamida, N-(4-(4-((2-(4-clorofenil)-3-piridin-3-il)metil)piperazin-1-il)benzoil)-4-(((1R)-(dimetilamino)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida,
25 N-(4-(4-((2-(4-clorofenil)piridin-3-il)metil)piperazin-1-il)benzoil)-3-nitro-4-((2(fenilsulfanil)etil)amino)bencenosulfonamida, N-(4-(4-((2-(4-clorofenil)piridin-3-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(morfolin-4-il)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, 3-nitro-N-(4-(4-((2-fenilpiridin-3-il)metil)piperazin-1-il)benzoil)-4-((2-(fenilsulfanil)etil)amino)bencenosulfonamida, 4-(((1R)-3-(morfolin-4-il)-1-((fenilsulfanil)metil)propil)amino)-3-nitro-N-(4-(4-((2-fenilpiridin-3-il)metil)piperazin-1il)benzoil)bencenosulfonamida, 4-(((1R)-3-(dimetilamino)-1-((fenilsulfanil)metil)propil)amino)-3-nitro-N-(4-(4-((2-fenilpiridin-3-il)metil)piperazin-1il)benzoil)bencenosulfonamida, 4-(((1R)-3-(dimetilamino)-1-((fenilsulfanil)metil)propil)amino)-N-(4-(4-((2-(4-(metilsulfanil)fenil)piridin-3
35 il)metil)piperazin-1-il)benzoil)-3-nitrobencenosulfonamida, 4-(((1R)-3-(dimetilamino)-1-((fenilsulfanil)metil)propil)amino)-N-(4-(4-((2-(4-metoxifenil)piridin-3-il)metil)piperazin-1il)benzoil)-3-nitrobencenosulfonamida, N-(4-(4-((2-(4-(dimetilamino)fenil)piridin-3-'il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, 4-(((1R)-3-(dimetilamino)-1-((fenilsulfanil)metil)propil)amino)-N-(4-(4-((2-(4-fluorofenil)piridin-3-il)metil)piperazin-1il)benzoil)-3-nitrobencenosulfonamida, 4-(((1R)-3-(dimetilamino)-1-((fenilsulfanil)metil)propil)amino)-N-(4-(4-((2-(4-(metilsulfonil)fenil)piridin-3il)metil)piperazin-1-il)benzoil)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3-nitro-4-((2-(piridin-4
45 ilsulfanil)etil)amino)bencenosulfonamida, 4-(((1R)-3-(dimetilamino)-1-((fenilsulfanil)metil)propil)amino)-N-(4-(4-((4'-(metilsulfonil)(1,1'-bifenil)-2-il)metil)piperazin1-il)benzoil)-3-nitrobencenosulfonamida, N-(4-(4-((4'-(metilsulfonil)(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(morfolin-4-il)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(morfolin-4-il)-1((fenilsulfonil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-(dimetilamino)(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, (3R)-3-(4-(((4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)amino)sulfonil)-2-nitroanilino)-N,N-dimetil-4
55 (fenilsulfonil)butanamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3-nitro-4-(((3S,4R)-(fenilsulfanil)pirrolidin-4il)amino)bencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3-nitro-4-(((1R)-1-((fenilsulfanil)metil)-3-(piridin-4ilsulfanil)propil)amino)bencenosulfonamida, N-(4-(4-((3-(4-clorofenil)piridin-4-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((3-(4-clorofenil)piridin-4-il)metil)piperazin-1-il)benzoil)-3-nitro-4-((2(fenilsulfanil)etil)amino)bencenosulfonamida, N-(4-(4-((2-(4-clorofenil)-1-ciclopenten-1-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1
65 ((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((2-(4-clorofenil)-1-ciclohexen-1-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1
23
((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((2-(4-clorofenil)-1-ciclohexen-1-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(morfolin-4-il)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((2-(4-clorofenil)-1-ciclohexen-1-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1
5 ((fenilsulfanil)metil)propil)amino)-3-(trifluorometil)bencenosulfonamida, N-(4-(4-((4-(4-clorofenil)-5,6-dihidro-2H-piran-3-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, 4-(((1R)-3-(dimetilamino)-1-((fenilsulfanil)metil)propil)amino)-N-(4-(4-((2-(4-metoxifenil)-1-ciclohexen-1il)metil)piperazin-1-il)benzoil)-3-nitrobencenosulfonamida, 4-(((1R)-3-(dimetilamino)-1-((fenilsulfanil)metil)propil)amino)-N-(4-(4-((2-(4-fluorofenil)-1-ciclohexen-1il)metil)piperazin-1-il)benzoil)-3-nitrobencenosulfonamida, 4-(((1R)-3-(dimetilamino)-1-((fenilsulfanil)metil)propil)amino)-3-nitro-N-(4-(4-((2-fenil-1-ciclohexen-1-il)metil)piperazin1-il)benzoil)bencenosulfonamida, N-(4-(4-((2-(4-clorofenil)-1-cicloocten-1-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1
15 ((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, 4-(((1R)-3-(dimetilamino)-1-((fenilsulfanil)metil)propil)amino)-N-(4-(4-((2-(4-(metilsulfanil)fenil)-1-ciclohexen-1il)metil)piperazin-1-il)benzoil)-3-nitrobencenosulfonamida, N-(4-(4-((2-(4-clorofenil)-1-ciclohepten-1-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((2-(4-clorofenil)-1-ciclohepten-1-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(morfolin-4-il)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((2-(4-clorofenil)-5,5-dimetil-1-ciclohexen-1-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((2-(4-clorofenil)-5,5-dimetil-1-ciclohexen-1-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(morfolin-4-il)-1
25 ((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)benzoil)-4-(((1S)-3-(morfolin-4-il)-1-((fenilsulfanil)metil)propil)amino)-3nitrobencenosulfonamida, N-(4-(4-((4'-(2-(dimetilamino)etoxi)(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-(2-(dimetilamino)etoxi)(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(morfolin-4-il)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-(2-(dimetilamino)etoxi)(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-((1,1-dimetil-2(fenilsulfanil)etil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-(2-(dimetilamino)etoxi)(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3-nitro-4-((2
35 (fenilsulfanil)etil)amino)bencenosulfonamida, 4-(((1R)-3-(dimetilamino)-1-((fenilsulfanil)metil)propil)amino)-N-(4-(4-((4'-(2-(morfolin-4-il)etoxi)(1,1'-bifenil)-2il)metil)piperazin-1-il)benzoil)-3-nitrobencenosulfonamida, N-(4-(4-((4'-(2-(morfolin-4-il)etoxi)(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(morfolin-4-il)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, 4-((1,1-dimetil-2-(fenilsulfanil)etil)amino)-N-(4-(4-((4'-(2-(morfolin-4-il)etoxi)(1,1'-bifenil)-2-il)metil)piperazin-1il)benzoil)-3-nitrobencenosulfonamida, N-(4-(4-((4'-(2-(morfolin-4-il)etoxi)(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3-nitro-4-((2(fenilsulfanil)etil)amino)bencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(1H-imidazol-1-il)-1
45 ((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((1,1'-bifenil)-2-ilmetil)piperazin-1-il)benzoil)-4-(((1R)-3-(1H-imidazol-1-il)-1-((fenilsulfanil)metil)propil)amino)3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-4-(4-metilpiperazin-1-il)-1((fenilsulfanil)metil)butil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-2-((2-(dimetilamino)etil)(metil)amino)-1((fenilsulfanil)metil)etil)amino)-3-nitrobencenosulfonamida, (4R)-4-(4-(((4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)amino)sulfonil)-2-nitroanilino)-N,N-dimetil-5(fenilsulfanil)pentanamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-4-(dimetilamino)-1
55 ((fenilsulfonil)metil)butil)amino)-3-nitrobencenosulfonamida, 2-(((3R)-3-(4-(((4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)amino)sulfonil)-2-nitroanilino)-4(fenilsulfanil)butil)(metil)amino)-N,N-dimetilacetamida, (3R)-N-(terc-butil)-3-(4-(((4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)amino)sulfonil)-2-nitroanilino)-4(fenilsulfanil)butanamida, (3R)-3-(4-(((4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)amino)sulfonil)-2-nitroanilino)-N,N-diisopropil-4(fenilsulfanil)butanamida, (3R)-N-(terc-butil)-3-(4-(((4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)amino)sulfonil)-2-nitroanilino)-Nmetil-4-(fenilsulfanil)butanamida, (3R)-3-(4-(((4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)amino)sulfonil)-2-nitroanilino)-N-isopropil-N
65 metil-4-(fenilsulfanil)butanamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3-nitro-4-(((1R)-3-oxo-1-((fenilsulfanil)metil)-3-(piperidin
24
1-il)propil)amino)bencenosulfonamida, N-((5R)-5-(4-(((4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)amino)sulfonil)-2-nitroanilino)-6(fenilsulfanil)hexil)-2-(dimetilamino)acetamida, (3R)-3-(4-(((4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)amino)sulfonil)-2-nitroanilino)-N,N-dimetil-4
5 (fenilsulfanil)butanamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(1,1-dioxidotiomorfolin-4-il)-3-oxo-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, (3R)-3-(4-(((4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)amino)sulfonil)-2-nitroanilino)-4(fenilsulfanil)butanamida, (3R)-3-(4-(((4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)amino)sulfonil)-2-nitroanilino)-N-ciclopropil-4(fenilsulfanil)butanamida, (3R)-3-(4-(((4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)amino)sulfonil)-2-nitroanilino)-N-ciclobutil-4(fenilsulfanil)butanamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(4-metilpiperazin-1-il)-3-oxo-1
15 ((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(morfolin-4-il)-3-oxo-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, 4-(((1R)-3-(azetidin-1-il)-3-oxo-1-((fenilsulfanil)metil)propil)amino)-N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1il)benzoil)-3-nitrobencenosulfonamida, (3R)-3-(4-(((4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)amino)sulfonil)-2-nitroanilino)-N-(2-(morfolin-4il)etil)-4-(fenilsulfanil)butanamida, (3R)-3-(4-(((4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)amino)sulfonil)-2-nitroanilino)-N-metil-4(fenilsulfanil)butanamida, 4-(((1R)-3-amino-1-((fenilsulfanil)metil)propil)amino)-N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3
25 nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-ciano-1-((fenilsulfanil)metil)propil)amino)-3nitrobencenosulfonamida, 4-(((1R)-3-(terc-butilamino)-1-((fenilsulfanil)metil)propil)amino)-N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1il)benzoil)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(ciclopropilamino)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(ciclobutilamino)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dietilamino)-1
35 ((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(isopropil(metil)amino)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, 4-(((1R)-3-(terc-butil(metil)amino)-1-((fenilsulfanil)metil)propil)amino)-N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin1-il)benzoil)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3-nitro-4-(((1R)-1-((fenilsulfanil)metil)-3-(piperidin-1il)propil)amino)bencenosulfonamida, N-(4-,(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(4-hidroxipiperidin-1-il)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, 4-(((1R)-3-(4-acetilpiperazin-1-il)-1-((fenilsulfanil)metil)propil)amino)-N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin
45 1-il)benzoil)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3-nitro-4-(((1R)-1-((fenilsulfanil)metil)-3-(tiomorfolin-4il)propil)amino)bencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-((2-(morfolin-4-il)etil)amino)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3-nitro-4-(((1R)-1-((fenilsulfanil)metil)-3-(piperazin-1il)propil)amino)bencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-((3R)-3-hidroxipirrolidin-1-il)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, 4-(((1R)-3-((3R)-3-aminopirrolidin-1-il)-1-((fenilsulfanil)metil)propil)amino)-N-(4-(4-((4'-cloro(1,1'-bifenil)-2
55 il)metil)piperazin-1-il)benzoil)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(3-hidroxiazetidin-1-il)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(4-metilpiperazin-1-il)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(1,1-dioxidotiomorfolin-4-il)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, 4-(((1R)-3-(1,3-benzodioxol-5-ilamino)-1-((fenilsulfanil)metil)propil)amino)-N-(4-(4-((4'-cloro(1,1'-bifenil)-2il)metil)piperazin-1-il)benzoil)-3-nitrobencenosulfonamida, 4-(((1R)-3-((1,3-benzodioxol-4-ilmetil)amino)-1-((fenilsulfanil)metil)propil)amino)-N-(4-(4-((4'-cloro(1,1'-bifenil)-2
65 il)metil)piperazin-1-il)benzoil)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3-nitro-4-(((1R)-1-((fenilsulfanil)metil)-3-((piridin-2
25
ilmetil)amino)propil)amino)bencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3-nitro-4-(((1R)-1-((fenilsulfanil)metil)-3-((2-(piridin-2il)etil)amino)propil)amino)bencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3-nitro-4-(((1R)-1-((fenilsulfanil)metil)-3-((piridin-4
5 ilmetil)amino)propil)amino)bencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(morfolin-4-ilamino)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(metil(piridin-4-il)amino)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3-nitro-4-(((1R)-1-((fenilsulfanil)metil)-3-(piridin-3ilamino)propil)amino)bencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(2,6-dimetilpiperidin-1-il)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-((2R,6S)-2,6-dimetilpiperidin-1-il)-1
15 ((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3-nitro-4-(((1R)-1-((fenilsulfanil)metil)-3-(pirrolidin-1ilamino)propil)amino)bencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(4-(metoxiimino)piperidin-1-il)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3-nitro-4-(((1R)-1-((fenilsulfanil)metil)-3-(2H-tetrazol-5il)propil)amino)bencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(diisopropilamino)-1((fenilsulfanil)metil)propil)amino)-3-(trifluorometil)bencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(isopropilamino)-1
25 ((fenilsulfanil)metil)propil)amino)-3-(trifluorometil)bencenosulfonamida, 4-(((1R)-3-(bis(2-hidroxietil)amino)-1-((fenilsulfanil)metil)propil)amino)-N-(4-(4-((4'-cloro(1,1'-bifenil)-2il)metil)piperazin-1-il)benzoil)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3-(((1R)-3-(dimetilamino)-1((fenilsulfanil)metil)propil)amino)-4-(trifluorometoxi)bencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(isopropil(metil)amino)-1((fenilsulfanil)metil)propil)amino)-3-(trifluorometil)bencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dietilamino)-1((fenilsulfanil)metil)propil)amino)-3-(trifluorometil)bencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(2,5-dimetilpirrolidin-1-il)-1
35 ((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, 4-(((1R)-3-amino-1-((fenilsulfanil)metil)propil)amino)-N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3(trifluorometil)bencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1((fenilsulfanil)metil)propil)amino)-2-(trifluorometil)bencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1((fenilsulfanil)metil)propil)amino)-3-fluorobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1((fenilsulfanil)metil)propil)amino)-2-(trifluorometoxi)bencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1
45 ((fenilsulfanil)metil)propil)amino)-2,5-difluorobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1((fenilsulfanil)metil)propil)amino)-3-metilbencenosulfonamida, N-(4-(4-((2-(4-clorofenil)-1-ciclohexen-1-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(diisopropilamino)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-((2R,5R)-2,5-dimetilpirrolidin-1-il)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-((2S,5S)-2,5-dimetilpirrolidin-1-il)-1((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-((2R,5S)-2,5-dimetilpirrolidin-1-il)-1
55 ((fenilsulfanil)metil)propil)amino)-3-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1((fenilsulfanil)metil)propil)amino)-3-nitro-5-(trifluorometil)bencenosulfonamida, N-(4-(4-((2-(4-clorofenil)-1-ciclohexen-1-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1((fenilsulfanil)metil)propil)amino)-3-nitro-5-(trifluorometil)bencenosulfonamida, N-(4-(4-((2-(4-clorofenil)-1-ciclohepten-1-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1((fenilsulfanil)metil)propil)amino)-3-nitro-5-(trifluorometil)bencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-3-(((1R)-3-(dimetilamino)-1((fenilsulfanil)metil)propil)amino)-4-nitrobencenosulfonamida, N-(4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)-4-(((1R)-3-(dimetilamino)-1
65 ((fenilsulfanil)metil)propil)amino)-3,5-difluorobencenosulfonamida, 5-(((4-(4-((4'-cloro(1,1'-bifenil)-2-il)metil)piperazin-1-il)benzoil)amino)sulfonil)-2-(((1R)-3-(dimetilamino)-1
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ES04810896.3T 2003-11-13 2004-11-12 Promotores de la apoptosis que contienen N-acilsulfonamida Expired - Lifetime ES2569327T3 (es)

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