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ES2562447T3 - Derivados de piridina - Google Patents

Derivados de piridina Download PDF

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Publication number
ES2562447T3
ES2562447T3 ES09700450.1T ES09700450T ES2562447T3 ES 2562447 T3 ES2562447 T3 ES 2562447T3 ES 09700450 T ES09700450 T ES 09700450T ES 2562447 T3 ES2562447 T3 ES 2562447T3
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Prior art keywords
nmr
mhz
dmso
broad
ddd
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Inventor
Claire Adcock
Urs Baettig
Peter Hunt
Catherine Leblanc
Maude Nadine Pierrette Pipet
Robert Alexander Pulz
Katrin Spiegel
Nikolaus Johannes Stiefl
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Novartis AG
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Novartis AG
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

Un compuesto de Fórmula X como se define a continuación:**Fórmula** en, forma libre o de sal, donde**Fórmula**

Description

imagen1
imagen2
imagen3
imagen4
imagen5
imagen6
imagen7
Ej.
IC50 (µM)
1.3
0.023
1.6
0.029
1.10
0.057
1.15
0.190
1.23
0.214
2.1
0.017
2.2
0.030
2.12
0.209
2.17
0.236
2.23
0.016
2.24
0.014
2.26
0.012
2.28
0.052
2.30
0.008
2.31
0.004
2.62
0.235
2.69
0.028
2.70
0.089
2.71
0.074
2.72
0.042
2.80
0.039
2.81
0.028
2.82
0.036
2.83
0.059
2.84
0.020
2.85
0.074
2.86
0.092
2.87
0.139
2.88
0.022
2.89
0.017
9
imagen8
imagen9
imagen10
imagen11
imagen12
donde T1, T2 y T3 son como se muestra a continuación, en la Tabla 1 y la Tabla 2. Siendo el método de preparación descrito en lo sucesivo.
TABLA 1
Ej.
T1 T2 T3 [M+H]+
1.1
imagen13 imagen14 imagen15 381 367 395
1.2
1.3
14
imagen16
imagen17
imagen18
imagen19
imagen20
imagen21
imagen22
imagen23
imagen24
imagen25
imagen26
imagen27
imagen28
imagen29
imagen30
imagen31
imagen32
imagen33
imagen34
imagen35
imagen36
imagen37
imagen38
imagen39
imagen40
imagen41
imagen42
imagen43
imagen44
imagen45
imagen46
imagen47
imagen48
imagen49
imagen50
imagen51
imagen52
imagen53
imagen54
imagen55
imagen56
imagen57
imagen58
imagen59
imagen60
imagen61
imagen62
imagen63
imagen64
imagen65
imagen66
imagen67
imagen68
imagen69
imagen70
imagen71
imagen72
imagen73
imagen74
imagen75
imagen76
imagen77
imagen78
imagen79
imagen80
imagen81
imagen82
imagen83
imagen84
imagen85
imagen86
imagen87
imagen88
imagen89
imagen90
imagen91
imagen92
imagen93
Ej.
Datos físicos
1.10
1H RMN (500 MHz, DMSO-d6) δ 10.86 (1H, Br), 8.91 (1H, d, 2.5 Hz), 8.67 (1H, dd, 1.8 Hz), 8.66 (1H, dd, 1.7 Hz), 8.40 (1H, d, 8.4 Hz), 8.11 (1H, ddd, 8.0, 2.0, 2.0 Hz), 7.95 (1H, ddd, 7.7, 7.7, 1.9 Hz), 7.85 (1H, d, 1.5 Hz), 7.63 (1H, d, 7.8 Hz), 7.55 (1H, ddd, 7.9 Hz, 4.8 Hz), 7.43 (1H, ddd, 7.5, 4.6, <0.5 Hz), 7.37 (1H, d, 8.1 Hz), 7.25 (1H, d, 2.4 Hz), 7.09 (1H, ddd, 7.3, 7.0, <0.5 Hz), 7.0 (1H, dd, 7.3 Hz, 7.3 Hz), 6.94 (1H, br t, 7 Hz), 6.85 (1H, d, 1Hz), 3.77 (2H, dt, 7.3, 7 Hz), 3.08 (2H, t, 7.3 Hz)
2.1
1H RMN (400 MHz, DMSO-d6) δ 8.99 (1H, d, 1.2 Hz), 8.93 (1H, d, 1.1 Hz), 8.66 (1H, dd, 4.7 Hz, 1.6 Hz), 8.40 (1H, dd, 7.9 Hz, 1.1 Hz), 8.37 (1H, dd, 1.2 Hz, 1.1 Hz), 7.95 (1H, m), 7.94 (2H, d, 8.1 Hz), 7.93 (1H, d, 1.5 Hz), 7.54 (2H, d, 8.1 Hz), 7.42 (1H, m), 6.91 (1H, d, 1.5Hz), 6.75 (1H, q, 4.8 Hz), 3.64-3.40 (4H, hombros anchos), 2.97 (3H, d, 4.8 Hz), 2.33 (4H, hombro ancho), 2.23 (3H, s)
2.2
1H RMN (400 MHz, DMSO-d6) δ 8.91 (1H, d, 1.72 Hz), 8.8 (1H, s), 8.67 (1H, d, 4.56 Hz), 8.41 (1H, d, 7.96 Hz), 8.23 (1H, m), 7.94 (2H, m), 7.73 (2H, d, 8.64 Hz), 7.43 (1H, m), 7.07 (2H, d, 8.68 Hz), 6.88 (1H, s), 6.75 (1H, m), 3.3-3.2 (8H, hombro ancho), 2.97 (3H, d, 4.68Hz), 2.26 (3H, s).
2.12
1H RMN (400 MHz, DMSO-d6) δ 8.93 (1H, d, 2.17 Hz), 8.88 (1H, d, 2.15 Hz), 8.68 (1H, dd, 7.9 Hz, 1.72 Hz), 8.4 (1H, dd, 1.2 Hz, 1.1 Hz), 8.27 (1H, m), 7.94 (1H, m), 7.9 (1H, d, 1.56 Hz), 7.43 (1H, m), 7.33 (1H, t), 7.0 (1H, d,2.32 Hz), 6.88 (2H, m), 6.78 (1H, m), 6.64 (1H, dd, 8, 2.48 Hz), 3.34 (4H, hombro ancho), 2.97 (3H, d, 4.8 Hz), 1.99 (4H, amplio).
2.23
1H RMN (400 MHz, DMSO-d6) δ 8.95 (1H, d, 2.16 Hz), 8.9 (1H, d, 2.12 Hz), 8.67 (1H, m), 8.41 (1H, d, 7.91 Hz), 8.31 (1H, m), 7.96 (1H, m), 7.92 (1H, m), 7.73 (2H, m), 7.48 (2H, m), 7.42 (1H, m), 6.9 (1H, d, 1.36 Hz), 6.75 (1H, m), 3.56 (2H, s), 2.97 (3H, d, 4.8 Hz), 2.55-2.20 (8H, hombros anchos), 2.15 (3H, s)
2.24
1H RMN (500 MHz, DMSO-d6) δ 8.95 (1H, d, 1.8 Hz), 8.89 (1H, d, 1.8 Hz), 8.66 (1H, m), 8.39 (1H, d, 8.0 Hz), 8.31 (1H, m), 7.95 (1H, m), 7.91 (1H, m), 7.8 (2H, d, 8.0 Hz), 7.44 (2H, d, 8.0 Hz), 7.42 (1H, m), 6.9 (1H, d, 1.0 Hz), 6.74 (1H, q, 4.8 Hz), 3.51 (2H, s), 2.96 (3H, d, 4.7 Hz), 2.59 (1H, septeto, 6.5 Hz), 2.55-2.20 (8H, hombros anchos), 0.95 (6H, d, 6.5 Hz)
2.26
1H RMN (400 MHz, DMSO-d6) δ 8.96 (1H, d, 2.16 Hz), 8.89 (1H, d, 2.12 Hz), 8.67 (1H, m), 8.41 (1H, d, 7.93 Hz), 8.31 (1H, m), 7.96 (1H, m), 7.92 (1H, m), 7.8 (2H, m), 7.46 (2H, m), 7.42 (1H, m), 6.9 (1H, d, 1.32 Hz), 6.75 (1H, m), 3.53 (2H, s), 2.97 (3H, d, 4.8 Hz), 2.55-2.20 (8H, hombros anchos), 2.17 (3H, s)
2.28
1H RMN (400 MHz, MeOD-d4) δ 8.94 (2H, dd), 8.48 (1H, t), 8.20 (1H, m), 7.91 (2H, m), 7.83 (2H, d, 1.32 Hz), 7.62 (2H, m), 7.31 (1H, d, 7.56 Hz), 6.88 (1H, d, 1.4 Hz), 3.82 (2H, br), 3.56 (2H, br), 3.06 (3H, s), 2.65 (3H, s), 2.36 (3H, s).
2.30
1H RMN (400 MHz, DMSO-d6) δ 9 (1H, d, 1.2 Hz), 8.95 (1H, d, 1.1 Hz), 8.66 (1H, dd, 4.7 Hz, 1.6 Hz), 8.40 (1H, dd, 7.9 Hz, 1.1 Hz), 8.37 (1H, dd, 1.2 Hz, 1.1 Hz), 7.95 (1H, m), 7.94 (2H, d, 8.1 Hz), 7.93 (1H, d, 1.5 Hz), 7.54 (2H, d, 8.1 Hz), 7.42 (1H, m), 7.08 (1H, d, 1.5Hz), 7.02 (1H, q, 4.8 Hz), 5.76 (1H, s), 3.64-3.40 (4H, hombros anchos), 3.63 (1H, amplio), 2.78 (4H, hombro ancho), 0.80 (2H, m), 0.54 (2H, m).
2.31
1H RMN (500 MHz, DMSO-d6) δ 8.96 (1H, d, 2.2 Hz), 8.91 (1H, d, 2.1 Hz), 8.67 (1h, dd, 5 Hz, 1.5 Hz), 8.36 (1H, dd, 7.9 Hz, <1 Hz), 8.37 (1h, m), 7.96 (1H, d, 1.5 Hz), 7.93 (1H, m), 7.80 (2h, d, 7.7 Hz), 7.45 (2H, d, 7.7 Hz), 7.45 (1H, m), 7.08 (1H, d, 2.5 Hz), 7.01 (1h, d, 1.5 Hz), 3.51 (2H, s), 2.73 (1H, m), 2.60 (1H, septeto, 6.4 Hz), 2.502.30 (8H, hombro ancho), 0.95 (6H, d, 6.4 Hz), 0.79 (2H, m), 0.53 (2H, m).
2.62
1H RMN (500 MHz, DMSO-d6) δ 8.96 (1H, d, 1.79 Hz), 8.9 (1H, d, 1.79 Hz), 8.66 (1H,d, 3.4 Hz), 8.36 (1H, d, 7.9 Hz), 8.32 (1H, br s), 7.96 (1H, s), 7.93 (1H, t, 7.72 Hz), 7.8 (2H, d, 7.95 Hz), 7.45 (2H, d, 7.82 Hz), 7.42 (1H, br t, 6.0 Hz), 7.08 (1H, s), 7.00 (1H, s), 3.61 (2H, br m), 2.73 (1H, m), 2.72 (1H, m), 2.68-2.29 (2H, m), 2.59-2.46 (2H, m), 2.09 (6H, s), 1.85-1.62 (2H, m), 0.79-0.53 (4H, m).
2.72
1H RMN (400 MHz, DMSO-d6) δ 8.96 (1H, d, 3.0 Hz), 8.87 (1H, d, 2.0 Hz), 8.66 (1H, d, 4.0 Hz), 8.32 (1H, s), 8.29 (1H, d, 3.0 Hz), 7.92 (2H, m), 7.81 (2H, d, 1.3 Hz), 7.44 (3H, m), 6.91 (1H, d, 1.0Hz), 6.23 (1H, s), 3.53 (2H, s), 3.31 (1H, m), 2.49 (8H, br), 0.98 (6H, s)
93
Ej.
Datos físicos
2.80
1H RMN (500 MHz, DMSO-d6) δ 8.99 (1H, d, 2.2 Hz), 8.98 (1H, d, 2.2 Hz), 8.71 (1H, m), 8.58 (1H, d, 1.7 Hz), 8.5 (1H, dd, 7.9 Hz), 8.42 (1H, dd, 2.2 Hz, 2.2 Hz), 8.1 (1H, d, 1.7 Hz), 7.99 (1H, ddd, 7.9, 7.9, 1.6 Hz), 7.82 (2H, d, 8.1 Hz), 7.48 (1H, m), 7.45 (2H, d, 8.1 Hz), 5.4 (1H, s), 3.5 (2H, s), 2.59 (1H, septeto, 6.4 Hz), 2.48-2.28 (8H, hombros anchos), 1.6 (6H, s), 0.95 (6H, d, 6.4 Hz).
2.81
1H RMN (400 MHz, DMSO-d6) δ 9 (1H, d, 2.2 Hz), 8.99 (1H, d, 2.2 Hz), 8.73 (1H, m), 8.59(1H, d, 1.7 Hz), 8.51 (1H, dd, 7.9 Hz), 8.43 (1H, dd, 2.2 Hz, 2.2 Hz), 8.1 (1H, d, 1.7 Hz), 7.99 (1H, ddd, 7.9, 7.9, 1.6 Hz), 7.82 (2H, d, 8.1 Hz), 7.48 (1H, m), 7.45 (2H, d, 8.1 Hz), 5.4 (1H, s), 3.5 (2H, s), 2.71 (4H, m), 2.32 (4H, m), 1.6 (6H, s).
2.82
1H RMN (400 MHz, DMSO-d6) δ 9.00 (2H, q), 8.74 (1H, d, 4.58 Hz), 8.59 (1H, s), 8.51 (1H, d, 7.92 Hz), 8.45 (1H, s), 8.12 (1H, s), 8.00 (1H, t), 7.84 (2H, d, 8.04 Hz), 7.47 (3H, m), 5.41 (1H, s), 3.52 (2H, s), 2.39 (8H, br), 1.62 (6H, s), 1.00 (9H, s).
2.83
1H RMN (400 MHz, DMSO-d6) δ 9.06 (2H, q), 8.74 (1H, d, 4.26 Hz), 8.61 (1H, s), 8.52 (1H, s), 8.50 (1H,s), 8.12 (1H, d, 1.27 Hz), 7.98 (3H, m), 7.57 (2H, d, 8.12 Hz), 7.50 (1H, m), 5.42 (1H, s), 3.67 (4H, br), 2.37 (4H br), 1.63 (6H, s).
2.84
1H RMN (400 MHz, DMS0-d6) δ 8.99 (1H, s), 8.81 (1H, d, 1.91 Hz), 8.74 (1H, m), 8.60 (1H, s), 8.55 (1H, s), 8.50 (1H, d, 7.93 Hz), 8.39 (1H, s), 8.17 (1H, s), 8.05 (1H, s), 8.00 (1H, t), 7.51 (1H, m), 4.45 (1H, m), 3.99 (2H, m), 3.51 (2H, m), 2.02 (4H, m), 1.62 (6H, s).
2.85
1H RMN (400 MHz, DMSO-d6) δ 9.01 (2H, q), 8.73 (1H, d, 4.29 Hz), 8.61 (1H, s), 8.52 (1H, d, 7.89 Hz), 8.44 (1H, s), 8.13 (1H, s), 8.00 (1H, t), 7.84 (2H, d), 7.47 (3H, m), 5.41 (1H, s), 3.56 (2H, s), 2.42 (8H, br), 1.62 (6H, s).
2.86
1H RMN (400 MHz, DMSO-d6) δ 8.95 (1H, d, 2.08 Hz), 8.8 (1H, d, 2.16 Hz), 8.74 (1H, m), 8.54 (1H, d, 1.64 Hz), 8.5 (1H, m), 8.44 (1H, m), 8.37 (1H, m), 8.13 (1H, d, 0.6 Hz), 8.05 (1H, d, 1.65 Hz), 7.98 (1H, m), 7.49 (1H, m), 5.4 (1H, s), 3.9 (3H, s), 1.6 (6H, s)
2.87
1H RMN (400 MHz, DMSO-d6) δ 9.06 (2H, q), 8.74 (1H, d, 3.96 Hz), 8.62 (1H, d, 1.57 Hz), 8.52 (2H, m), 8.13 (1H, d, 1.58), 7.99 (3H, m), 7.56 (2H, d, 8.19), 7.50 (1H, m), 5.42 (1H, s), 2.19 (4H, br), 1.63 (6H, s), 1.10 (6H, t), 0.94 (3H, br).
2.88
1H RMN (400 MHz, DMSO-d6) δ 8.98 (1H, d, 1.89 Hz), 8.80 (1H, m), 8.75 (1H, m), 8.54 (3H, m), 8.50 (1H, d, 7.89 Hz), 8.40 (1H, s), 8.17 (1H, s), 8.06 (1H, s), 8.01 (1H, t), 7.50 (1H, m), 5.41 (1H, s), 4.25 (1H, br), 3.09 (2H, br), 2.64 (2H, br), 2.02 (2H, br), 1,86 (2H, br), 1.62 (6H, s).
2.89
1H RMN (400 MHz, DMSQ-d6) δ 8.98 (1H, d, 2.01 Hz), 8.80 (1H, d, 2.12 Hz), 8.74 (1H, d, 3.95 Hz), 8.60 (1H, s), 8.55 (1H, s), 8.50 (1H, d, 1.55 Hz), 8.40 (1H, s), 8.16 (1H, s), 8.05 (1H, s), 8.01 (1H, t), 7.51 (1H, m), 5.41 (1H, s), 4.51 (1H, br m), 2.93 (2H, br d), 2.78 (1H, br m), 2.30 (2H, br t), 2.07 (2H, br), 1.94 (2H, br q), 1.61 (6H, s), 1.02 (6H, s).
2.90
1H RMN (400 MHz, DMSO-d6) δ 9.02 (1H, d, 2.08 Hz), 8.72 (1H, d, 4 Hz), 8.69 (1H, d, 1.92 Hz), 8.57 (1H, d, 1.42 Hz), 8.51 (1H, d, 7.93 Hz), 8.18 (1H, s), 8.09 (1H, s), 7.98 (1H, m), 7.49 (1H, m), 7.32 (3H, m), 5.38 (1H, s), 3.49 (2H, s), 2.60 (1H, septeto), 2.43 (8H, br), 2.30 (3H, s), 1.62 (6H, s), 0.97 (6H, d, 6.52 Hz).
2.91
1H RMN (400 MHz, DMSO-d6) δ 9.01 (2H, dd), 8.74 (1H, d, 4.08), 8.60 (1H, d, 1.31 Hz), 8.52 (1H, d, 7.93 Hz), 8.45 (1H, s), 8.11 (1H, s), 8.01 (1H, t), 7.84 (2H, d, 8.08 Hz), 7.48 (4H, m), 5.43 (1H, s), 3.51 (3H, m), 2.69 (6H, m), 1.62 (6H, s), 0.91 (3H, s).
2.92
1H RMN (400 MHz, DMSO-d6) δ 9.00 (2H, dd), 8.75 (1H, d, 3.94 Hz), 8.60 (1H, d, 1.48 Hz), 8.51 (1H, d, 7.91 Hz), 8.46 (1H, m), 8.12 (1H, d, 1.42 Hz), 8.01 (1H, t), 7.85 (2H, d, 7.7 Hz), 7.47 (3H, m), 5.41 (1H, s), 3.48 (2H, s), 2.78 (2H, br), 2.28 (2H, br), 2.09 (2H, br), 1.63 (6H, s), 1.07 (6H, s).
94
Ej.
Datos físicos
2.95
1H RMN (400 MHz, DMSO-d6) δ 9.01 (1H, d, 2.2 Hz), 8.98 (1H, d, 2.2 Hz), 8.72 (1H, m), 8.54 (1H, d, 1.6 Hz), 8.50 (1H, dd, 7.9, 1.2, 1.2 Hz), 8.30 (1H, dd, 2.2, 2.2 Hz), 7.99 (1H, ddd, 7.9, 7.9, 1.9 Hz), 7.91 (1H, d, 1.6 Hz), 7.83 (2H, d, 7.8 Hz), 7.48 (1h, ddd, 7.9, 4.8, 1.2 Hz), 7.45 (2H, d, 7.8 Hz), 3.52 (2H, s), 2.59 (1H, m), 2.55-2.3 (8H, hombro ancho), 1.48 (9H, s), 0.95 (6H, d, 6.2 Hz).
2.100
1H RMN (400 MHz, DMSO-d6) δ 8.96 (1H, d, 1.8 Hz), 8.89 (1H, d, 1.8 Hz), 8.66 (1H, m), 8.39 (1H, d, 8.0 Hz), 8.31 (1H, m), 7.96 (1H, m), 7.91 (1H, m), 7.81 (2H, d, 8.0 Hz), 7.46 (2H, d, 8.0 Hz), 7.42 (1H, m), 6.9 (1H, d, 1.0 Hz), 6.72 (1H, q, 4.8 Hz), 3.51 (2H, s), 2.60 (1H, septeto, 6.5 Hz), 2.55-2.20 (8H, hombros anchos), 0.95 (6H, d, 6.5 Hz)
2.102
1H RMN (400 MHz, DMSO-d6) δ 8.96 (1H, d, 1.8 Hz), 8.89 (1H, d, 1.8 Hz), 8.66 (1H, m), 8.39 (1H, d, 8.0 Hz), 8.31 (1H, m), 7.96 (1H, m), 7.91 (1H, m), 7.81 (2H, d, 8.0 Hz), 7.46 (2H, d, 8.0 Hz), 7.42 (1H, m), 6.9 (1H, d, 1.0 Hz), 6.72 (1H, q, 4.8 Hz), 3.51 (2H, s), 2.83 (4H, hombros anchos), 2.41 (4h, hombro ancho).
2.104
1H RMN (400 MHz, DMSO-d6) δ 8.91 (1H, d, 2.08 Hz), 8.7 (1H, s), 8.68 (1H, d, 3.96 Hz), 8.41 (1H, d, 8.3 Hz), 8.39 (1H, m), 8.25 (1H, m), 8.1 (1H, m), 7.94 (1H, t), 7.87 (1H, m), 7.43 (1H, m), 6.84 (1H, m), 6.74 (1H, q, 4.8 Hz), 3.9 (3H, s)
2.106
1H RMN (400 MHz, DMSO-d6) δ 9.00 (1H, d, 1.9 Hz), 8.9 (1H, d, 1,84 Hz), 8.65 (1H, d, 4.01 Hz), 8.45 (2H, m), 7.95 (4H, m), 7.55 (2H, d, 7.95 Hz), 7.45 (1H, m), 6.9 (1H, s), 6.7 (1H, s), 3.65 (4H, br), 2.5 (4H, br).
2.107
1H RMN (400 MHz, DMSO-d6) δ 8.5 (1H, d, 2.14 Hz), 8.0 (1H, d, 2.12 Hz), 8.65 (1H, d, 3.9 Hz), 8.4 (1H, d, 3.9 Hz), 8.3 (1H, d, 7.97 Hz), 7.95 (1H, m), 7.90 (1H, s), 7.80 (2H, d, 8.05 Hz), 7.45 (3H, m), 6.9 (1H, d, 1.36 Hz), 6.7 (1H, s), 3.5 (2H, br), 2.5 (4H, br), 2.4 (4H, br), 1.0 (9H, s).
2.111
1H RMN (400 MHz, DMSO-d6 δ 8.99 (1H, m), 8.96 (1H, s), 8.90 (1H, d, 2Hz), 8.81 (1H, m), 8.67 (1H, d, 8.51 Hz), 8.40 (1H, d, 7.93 Hz), 8.30 (1H, m), 7.95 (1H, t), 7.90 (1H, s), 7.78 (1H, br), 7.54 (1H, m), 7.43 (2H, m), 6.89 (1H, m), 6.80 (1H, t), 3.72 (2H, s), 3.45 (4H, br), 3.02 (2H, br), 2.40 (2H, br), 1.24 (12H, br)
2.114
1H RMN (400 MHz, DMSO-d6) δ 8.95 (1H, d, 8.13 Hz), 8.90 (1H, d, 8.04), 8.66 (1H, d, 3.94 Hz), 8.39 (1H, d, 7.94 Hz), 8.29 (1H, s), 7.96 (1H, t), 7.89 (1H, s), 7.71 (2H, m), 7.51 (1H, t), 7.41 (2H, m), 6.90 (1H, s), 6.78 (1H, t), 5.76 (1H, s), 3.57 (2H, s), 3.47 (2H, t), 2.60 (2H, br), 2.43 (8H, br), 1.24 (3H, t), 0.95 (6H, d).
2.116
1H RMN (400 MHz, DMSO-d6) δ 8.93 (1H, d, 2.16 Hz), 8.90 (1H, d, 2.12 Hz), 8.65 (1H, d, 5.61 Hz), 8.4 (1H, d, 7.93 Hz), 8.25 (1H, t), 7.95 (1H, t), 7.9 (1H, d, 1.36 Hz), 7.55 (2H, d, 5.75 Hz), 7.4 (1H, m), 7.25 (1H, s), 6.9 (1H, t), 6.75 (1H, t), 5.25 (2H, t), 4.55 (2H, d, 5.67 Hz), 3.45 (2H, q), 2.4 (3H, s), 1.25 (3H, t).
2.119
1H RMN (400 MHz, DMSO-d6) δ 8.95 (1H, m), 8.92 (1H, m), 8.68 (1H, m), 8.37 (1H, m), 8.32 (1H, s), 7.97 (2H, m), 7.75 (2H, m), 7.51 (1H, m), 7.40 (2H, m), 7.12 (1H, s), 7.02 (1H, s), 3.57 (2H, s), 2.75 (1H, s), 2.42 (8H, br), 0.98 (9H, s), 0.81 (2H, d, 4.88 Hz), 0.54 (2H, m).
2.120
1H RMN (400 MHz, DMSO-d6) δ 8.97 (1H, s), 8.91 (1H. s), 8.67 (1H, m), 8.36 (2H, d, 7.8 Hz), 7.96 (2H, m), 7.82 (2H, d, 7.76 Hz), 7.44 (3H, m), 7.10 (1H, s), 7.04 (1H, s), 3.52 (2H, s), 2.75 (1H, s), 2.41 (8H, br), 1.00 (9H, s), 0.80 (2H, d, 4.96 Hz), 0.53 (2H, m).
2.125
1H RMN (400 MHz, DMSO-d6) δ 8.95 (1H, d, 2Hz), 8.91 (1H, d, 2 Hz), 8.34 (1H, m), 7.81 (2H, d, 8.08 Hz), 7.45 (2H, d, 8.04 Hz), 7.29 (1H, s), 7.04 (1H, s), 6.94 (1H, d, 3.12 Hz), 6.85 (1H, s), 6.24 (1H, d, 2.28 Hz), 3.54 (2H, s), 2.63 (1H, br), 2.46 (8H, br), 2.36 (3H, s), 0.97 (1H, m), 0.76 (2H, m), 0.49 (2H, m).
2.133
1H RMN (400 MHz, DMSO-d6) δ 8.95 (1H, d, 2 Hz), 8.88 (1H, d, 2.3 Hz), 8.66 (1H, d, 4.04 Hz), 8.38 (1H, d, 8 Hz), 8.27 (1H, s), 7.94 (1H, t), 7.87 (1H, s), 7.73 (2H, m), 7.51 (1H, m), 7.42 (2H, m), 6.88 (1H, s), 6.63 (1H, d, 7.28 Hz), 4.24 (1H, m), 3.55 (2H, s), 2.41 (8H, br), 1.24 (6H, d, 6.44 Hz), 0.99 (9H, s).
2.134
1H RMN (400 MHz, DMSO-d6) δ 8.96 (1H, d, 2.04 Hz), 8.88 (1H, d, 1.96), 8.66 (1H, d, 2.80 Hz), 8.37 (1H, d, 7.88 Hz), 8.29 (1H, s), 7.95 (1H, t), 7.89 (1H, s), 7.81 (1H, d, 8.04 Hz), 7.44 (4H, m), 6.89 (1H, s), 6.62 (1H, d, 7.44 Hz), 4.24 (1H, m), 3.51 (2H, s), 2.40 (8H, br), 1.26 (6H, d, 6.40 Hz), 1.00 (9H, s).
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PE20091316A1 (es) 2009-09-24
ECSP10010336A (es) 2010-08-31
JP5566909B2 (ja) 2014-08-06
MA31947B1 (fr) 2010-12-01
WO2009087212A3 (en) 2009-09-24
IL206276A0 (en) 2010-12-30
MX2010007606A (es) 2010-08-23
US8343966B2 (en) 2013-01-01
ZA201003929B (en) 2011-03-30
AU2009203681A1 (en) 2009-07-16
EP2242742A2 (en) 2010-10-27
CR11490A (es) 2010-08-11
EA201001127A1 (ru) 2011-02-28
KR20100101138A (ko) 2010-09-16
CL2009000029A1 (es) 2009-07-24
WO2009087212A2 (en) 2009-07-16
BRPI0907611A2 (pt) 2015-07-21
CN101918362A (zh) 2010-12-15
TN2010000255A1 (en) 2011-11-11
AR070519A1 (es) 2010-04-14
CN101918362B (zh) 2013-11-27
EP2242742B1 (en) 2015-12-02
CA2711803A1 (en) 2009-07-16
JP2011509277A (ja) 2011-03-24
TW200938536A (en) 2009-09-16
AU2009203681B2 (en) 2012-08-16

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