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ES2547011T3 - Implantes que comprenden metales biodegradables y procedimiento para la fabricación de los mismos - Google Patents

Implantes que comprenden metales biodegradables y procedimiento para la fabricación de los mismos Download PDF

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Publication number
ES2547011T3
ES2547011T3 ES07833020.6T ES07833020T ES2547011T3 ES 2547011 T3 ES2547011 T3 ES 2547011T3 ES 07833020 T ES07833020 T ES 07833020T ES 2547011 T3 ES2547011 T3 ES 2547011T3
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Spain
Prior art keywords
magnesium
based alloy
implants
manufacturing process
test
Prior art date
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Active
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ES07833020.6T
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English (en)
Inventor
Seok-Jo Yang
Hyun-Kwang Seok
Jung-Gu Kim
Tae-Hong Lim
Kyeong-Ho Baik
Yu-Chan Kim
Ja-Kyo Koo
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U&I Corp
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U&I Corp
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Application filed by U&I Corp filed Critical U&I Corp
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Publication of ES2547011T3 publication Critical patent/ES2547011T3/es
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/04—Metals or alloys
    • A61L27/047—Other specific metals or alloys not covered by A61L27/042 - A61L27/045 or A61L27/06
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/306—Other specific inorganic materials not covered by A61L27/303 - A61L27/32
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
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    • A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
    • A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
    • A61B17/80—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
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    • A61C8/0012—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools characterised by the material or composition, e.g. ceramics, surface layer, metal alloy
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • A—HUMAN NECESSITIES
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
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    • A61F2/442—Intervertebral or spinal discs, e.g. resilient
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/31504—Composite [nonstructural laminate]
    • Y10T428/31678—Of metal

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Dentistry (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Dental Preparations (AREA)
  • Dental Prosthetics (AREA)

Abstract

Implante que comprende una aleación a base de magnesio biodegradable, en el que la aleación a base de magnesio biodegradable es representada por la fórmula MgaCabXc, en la que a, b y c son una proporción molar de cada componente, satisfaciendo las condiciones siguientes: 0,5 <= a <= 1, 0 < b <= 0,4 y 0 < c <= 0,4, y siendo X níquel (Ni) e hierro (Fe) que están comprendidos en una cantidad de hasta 0,01% de Ni y 0,1% de Fe.

Description

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55 E07833020
10-09-2015
microscopio óptico. Se descubre que la microestructura en forma de pétalo de rosa representada en la aleación de fundición de la figura 4 se deforma bajo la extrusión.
Prueba para la medición de la resistencia de la aleación a base de magnesio
Con el fin de someter a prueba la resistencia del material de aleación a base de magnesio de la presente invención, los materiales de aleación a base de magnesio producidos en los ejemplos 1 y 2 se someten a mecanizado por electrodescarga, y son tratados en una forma que presenta un diámetro de 3 mm y una longitud de 6 mm. La parte inferior y la parte superior de las muestras tratadas son pulidas con un papel esmeril nº 100 para ajustar el nivel de la superficie. Las muestras de prueba tratadas son dispuestas horizontalmente sobre una plantilla realizada en carburo de wolframio, y a continuación es aplicada una fuerza verticalmente sobre las muestras utilizando un cabezal de un comprobador de compresión con unas cargas máximas de 20 ton. Entonces, la velocidad vertical del cabezal es de 10-4/s. Durante la prueba, los cambios en el esfuerzo de compresión y la deformación son registrados en tiempo real utilizando un extensómetro y una célula de carga, previstos en el comprobador de compresión. En este momento, el tamaño de la muestra es demasiado pequeño para proporcionar el extensómetro en la muestra, y el extensómetro es proporcionado en la plantilla de comprobador que comprime la muestra. Por lo tanto, la deformación de la muestra es medida tan elevada como su deformación actual.
La figura 10 es un gráfico que representa un resultado de la prueba de resistencia sobre las aleaciones a base de magnesio de la presente invención preparadas añadiendo unas cantidades diferentes de calcio. A partir del resultado de la figura 10, se descubre que en la aleación a base de magnesio, al aumentar el contenido de calcio, aumenta la resistencia de la aleación. Por otro lado, se descubre que cuando el contenido de calcio aumenta de 22% a 33%, la aleación a base de magnesio se rompe a un esfuerzo inferior. Debe apreciarse que la aleación que presenta un contenido superior de calcio es utilizada preferentemente como el material de implante aplicado a la zona de un cuerpo que requiere una capacidad de soporte de carga elevada.
La figura 11 es un resultado de la medición del esfuerzo de compresión de la aleación de fundición extrudida. Los límites de deformación (esfuerzo aplicado al material al que el material es deformado a partir de recto a curvo) de la mayoría de las aleaciones de Mg-Ca son aumentados por la extrusión. Sin embargo, en caso de que el contenido de calcio sea superior un 23%, el límite de deformación es reducido de manera importante. Esto es debido a que Mg2Ca con una fragilidad elevada ampliamente distribuida en la estructura de base de Mg se rompe o separa de la estructura de base de Mg en el proceso de extrusión para existir como defectos. En caso de que el contenido de calcio aumente hasta resultar 33%, la mayoría de los materiales de aleación llegan a consistir en una fase de Mg2Ca que presenta una fragilidad superior. Por lo tanto, los cambios en la resistencia antes y después de la extrusión son muy pequeños.
Prueba de velocidad de corrosión sobre la aleación a base de magnesio
Con el fin de evaluar las características de corrosión de las aleaciones a base de magnesio, se utiliza una prueba potenciodinámica. En primer lugar, el material de aleación a base de magnesio fabricado mediante fusión es cortado y pulido con un papel de esmeril nº 1000. La zona superficial del material de aleación a base de magnesio pulido excepto una zona de 1 cm2 es revestida con un material aislante. A continuación, la aleación a base de magnesio es conectada en ánodo, y Pt y Ag-AgCl como referencia son conectados en cátodo, y a continuación el ánodo y el cátodo son sumergidos en una solución de ataque para medir la corriente mientras aumenta gradualmente la tensión eléctrica. La solución de ataque consiste en componentes similares al líquido corporal humano, y es utilizada mezclando los componentes ilustrados en la tabla 1 siguiente en 1 litro de agua. La temperatura de la solución se mantiene a 37ºC durante la prueba.
Tabla 1
Composición de solución de ataque utilizada en la prueba de corrosión (basada en el peso total de 1 litro)
Componente
Peso (g)
NaCl (Cloruro de sodio)
8
KCl (Cloruro de potasio)
0,4
NaHCO3 (Hidrogenocarbonato de sodio)
0,35
NaH2PO4 · H2O (A430846 420)
0,25
Na2HPO4 · 2H2O (K32618380 408)
0,06
MgCl2 (Cloruro de magnesio)
0,19
MgSO4 · 7H2O (Sulfato de magnesio heptahidratado)
0,06
Glucosa
1
CaCl2 · 2H2O (Cloruro de calcio dihidratado)
0,19
La figura 12 es un gráfico que representa un resultado de la prueba de corrosión para las aleaciones a base de 8
imagen7
imagen8

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Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003002243A2 (en) 2001-06-27 2003-01-09 Remon Medical Technologies Ltd. Method and device for electrochemical formation of therapeutic species in vivo
AU2006231652A1 (en) 2005-04-05 2006-10-12 Elixir Medical Corporation Degradable implantable medical devices
US8840660B2 (en) 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US8089029B2 (en) 2006-02-01 2012-01-03 Boston Scientific Scimed, Inc. Bioabsorbable metal medical device and method of manufacture
US8048150B2 (en) 2006-04-12 2011-11-01 Boston Scientific Scimed, Inc. Endoprosthesis having a fiber meshwork disposed thereon
US8052743B2 (en) 2006-08-02 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis with three-dimensional disintegration control
JP2010503489A (ja) 2006-09-15 2010-02-04 ボストン サイエンティフィック リミテッド 生体内分解性内部人工器官およびその製造方法
EP2399616A1 (en) 2006-09-15 2011-12-28 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis with biostable inorganic layers
CA2663271A1 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Bioerodible endoprostheses and methods of making the same
CA2663220A1 (en) 2006-09-15 2008-03-20 Boston Scientific Limited Medical devices and methods of making the same
EP2068962B1 (en) 2006-09-18 2013-01-30 Boston Scientific Limited Endoprostheses
KR100929133B1 (ko) 2006-09-22 2009-12-01 유앤아이 주식회사 생체분해성 금속을 포함하는 임플란트 및 이의 제조방법
US8080055B2 (en) 2006-12-28 2011-12-20 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
DE102007023284A1 (de) * 2007-06-15 2008-12-18 Biotronik Vi Patent Ag Implantat mit einer oberflächennahen magnesiumhaltigen Diffusionsschicht und dazugehöriges Herstellungsverfahren
US8052745B2 (en) 2007-09-13 2011-11-08 Boston Scientific Scimed, Inc. Endoprosthesis
US7998192B2 (en) 2008-05-09 2011-08-16 Boston Scientific Scimed, Inc. Endoprostheses
JP2011524465A (ja) * 2008-06-06 2011-09-01 ジンテス ゲゼルシャフト ミット ベシュレンクテル ハフツング 吸収性マグネシウム合金
US8236046B2 (en) 2008-06-10 2012-08-07 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
US7985252B2 (en) 2008-07-30 2011-07-26 Boston Scientific Scimed, Inc. Bioerodible endoprosthesis
US8382824B2 (en) 2008-10-03 2013-02-26 Boston Scientific Scimed, Inc. Medical implant having NANO-crystal grains with barrier layers of metal nitrides or fluorides
US8267992B2 (en) 2009-03-02 2012-09-18 Boston Scientific Scimed, Inc. Self-buffering medical implants
US8435281B2 (en) 2009-04-10 2013-05-07 Boston Scientific Scimed, Inc. Bioerodible, implantable medical devices incorporating supersaturated magnesium alloys
CN102548589A (zh) * 2009-04-22 2012-07-04 友和安股份公司 生物可降解植入物及其制备方法
CN101690676B (zh) * 2009-10-26 2011-03-23 上海交通大学 可吸收金属髓内钉及其制备方法
JP2013512069A (ja) * 2009-12-07 2013-04-11 ユー アンド アイ コーポレーション インプラント
WO2011119573A1 (en) 2010-03-23 2011-09-29 Boston Scientific Scimed, Inc. Surface treated bioerodible metal endoprostheses
WO2011163596A1 (en) 2010-06-25 2011-12-29 Fort Wayne Metals Research Products Corporation Biodegradable composite wire for medical devices
US11491257B2 (en) 2010-07-02 2022-11-08 University Of Florida Research Foundation, Inc. Bioresorbable metal alloy and implants
WO2012003502A2 (en) * 2010-07-02 2012-01-05 University Of Florida Research Foundation, Inc. Bioresorbable metal alloy and implants made of same
EP2637603B1 (en) * 2010-11-09 2017-10-11 Transluminal Technologies, LLC Closure device for sealing an opening formed through a blood vessel
KR101250700B1 (ko) 2010-12-06 2013-04-03 성균관대학교산학협력단 생체분해성 마그네슘의 분해속도 제어방법 및 이를 이용한 의료기기용 생체분해성 마그네슘
CN103328015B (zh) * 2011-01-24 2016-01-06 奥林巴斯株式会社 生物降解性移植材料及其制造方法
JP6157484B2 (ja) 2011-10-06 2017-07-05 ユニバーシティ オブ ピッツバーグ オブ ザ コモンウェルス システム オブ ハイヤー エデュケーションＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｐｉｔｔｓｂｕｒｇｈ Ｏｆ Ｔｈｅ Ｃｏｍｍｏｎｗｅａｌｔｈ Ｓｙｓｔｅｍ Ｏｆ Ｈｉｇｈｅｒ Ｅｄｕｃａｔｉｏｎ 生分解性金属合金
KR102122707B1 (ko) * 2011-11-07 2020-06-29 신세스 게엠바하 마그네슘 임플란트 재료 상의 생체적합성 플라즈마 전해질 코팅을 위한 린 전해질
JP5959260B2 (ja) * 2012-03-26 2016-08-02 オリンパス株式会社 マグネシウム合金製インプラントの加工方法
JP6786214B2 (ja) 2012-06-26 2020-11-18 バイオトロニック アクチェンゲゼルシャフト マグネシウム合金、その製造方法およびその使用
SG11201406026TA (en) 2012-06-26 2014-10-30 Biotronik Ag Magnesium-zinc-calcium alloy, method for production thereof, and use thereof
EP2864516B1 (en) 2012-06-26 2020-05-06 Biotronik AG Implant made from magnesium-zinc-calcium alloy, and method for production thereof
CN109022976A (zh) 2012-06-26 2018-12-18 百多力股份公司 镁合金、其制造方法及其用途
WO2014028599A1 (en) * 2012-08-14 2014-02-20 Guo Yuebin A biodegradable medical device having an adjustable degradation rate and methods of making the same
US10246763B2 (en) * 2012-08-24 2019-04-02 The Regents Of The University Of California Magnesium-zinc-strontium alloys for medical implants and devices
US9469889B2 (en) 2012-08-31 2016-10-18 DePuy Synthes Products, Inc. Ultrapure magnesium alloy with adjustable degradation rate
JP2014136816A (ja) * 2013-01-16 2014-07-28 Olympus Corp 陽極酸化処理用治具
EP2971206A1 (en) 2013-03-14 2016-01-20 DePuy Synthes Products, Inc. Magnesium alloy with adjustable degradation rate
US9593397B2 (en) 2013-03-14 2017-03-14 DePuy Synthes Products, Inc. Magnesium alloy with adjustable degradation rate
CN104069542B (zh) * 2013-03-26 2017-12-29 深圳先进技术研究院 髌骨组织工程支架及其制造材料和制备方法
CN103147023B (zh) * 2013-04-08 2015-05-20 河北工业大学 一种增强泡沫镁合金热处理工艺
JP2014240455A (ja) * 2013-06-11 2014-12-25 オリンパス株式会社 離型材スラリとインプラントの製造方法
EP3011979A4 (en) * 2013-06-18 2017-02-15 Olympus Corporation Implant for living organisms
WO2015003112A1 (en) 2013-07-03 2015-01-08 University Of Florida Research Foundation, Inc. Biodegradable magnesium alloys, methods of manufacture thereof and articles comprising the same
DE102013214636A1 (de) 2013-07-26 2015-01-29 Heraeus Medical Gmbh Bioresorbierbare Werkstoffverbunde, enthaltend Magnesium und Magnesiumlegierungen sowie Implantate aus diesen Verbunden
CN103465542B (zh) * 2013-09-16 2015-11-18 天津大学 基于生物学骨愈合可降解铁锌镁基梯度复合材料及其制备
CN104511049B (zh) * 2013-09-27 2016-08-17 上海交通大学医学院附属第九人民医院 一种可治疗类风湿关节炎的生物医用可降解金属及其应用
WO2015069724A1 (en) * 2013-11-05 2015-05-14 University Of Florida Research Foundation, Inc. Articles comprising reversibly attached screws comprising a biodegradable composition, methods of manufacture thereof and uses thereof
CN103736152B (zh) * 2013-12-26 2016-12-07 西安爱德万思医疗科技有限公司 一种人体可吸收的耐蚀高强韧锌合金植入材料
CN103757511B (zh) * 2013-12-27 2016-09-07 南通河海大学海洋与近海工程研究院 弥散强化型医用Mg-Zn-Ce-Ca-Mn合金及其制备方法
US9863020B2 (en) 2014-04-03 2018-01-09 University of Pittsburgh—of the Commonwealth System of Higher Education Biodegradable metal alloys
JP2015228906A (ja) * 2014-06-03 2015-12-21 オリンパス株式会社 骨接合用インプラント
DE102014008449A1 (de) * 2014-06-04 2015-12-31 Celgen Ag Distraktionsmembran auf Magnesiumbasis
KR101485296B1 (ko) * 2014-07-21 2015-01-21 유앤아이 주식회사 생체분해성 임플란트 및 이의 제조방법
CN104274863B (zh) * 2014-10-23 2015-11-04 山东建筑大学 一种镁合金/转化膜复合生物材料
WO2016118444A1 (en) 2015-01-23 2016-07-28 University Of Florida Research Foundation, Inc. Radiation shielding and mitigating alloys, methods of manufacture thereof and articles comprising the same
KR101722310B1 (ko) * 2015-02-17 2017-03-31 서울대학교산학협력단 생체 분해성 마그네슘 및 생체 분해성 마그네슘의 분해속도 제어방법
CN104689378B (zh) * 2015-03-13 2017-04-05 西安爱德万思医疗科技有限公司 一种人体可降解的耐蚀高强韧Zn‐Fe‐X系锌合金及其应用
CN106048347A (zh) * 2015-04-15 2016-10-26 丁永新 机械强度和生物相容性较好的医用镁基合金材料
WO2017035072A1 (en) * 2015-08-21 2017-03-02 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Degradable magnesium-based implant devices for bone fixation
CN105435302A (zh) * 2015-12-28 2016-03-30 青岛博泰美联化工技术有限公司 一种骨填充材料及制备方法
CN105603277A (zh) * 2015-12-28 2016-05-25 青岛博泰美联化工技术有限公司 一种易降解的医用镁合金材料及制备方法
CN105381508A (zh) * 2015-12-28 2016-03-09 青岛博泰美联化工技术有限公司 一种血管内支架及制备方法
CN105624496A (zh) * 2015-12-28 2016-06-01 青岛博泰美联化工技术有限公司 一种骨钉及制备方法
CN105624495A (zh) * 2015-12-28 2016-06-01 青岛博泰美联化工技术有限公司 一种医用缝合线材料及制备方法
CN105559840A (zh) * 2016-01-25 2016-05-11 北京天助畅运医疗技术股份有限公司 含有钛钉的软组织固定装置
KR20170115429A (ko) * 2016-04-07 2017-10-17 랩앤피플주식회사 생체분해성 금속을 이용한 마이크로 니들
CN106929726B (zh) * 2017-02-20 2018-06-29 岳阳宇航新材料有限公司 一种可降解镁合金井下工具底座材料及其制备方法
CN107266039B (zh) * 2017-06-06 2019-10-22 苏州轩朗塑料制品有限公司 一种医用环保型复合金属材料的制备方法及其应用
CN109652769A (zh) * 2017-10-10 2019-04-19 中国科学院金属研究所 一种医用植入材料用镁-银涂层及其制备方法
US10512495B2 (en) 2017-12-28 2019-12-24 Industrial Technology Research Institute Method for fabricating medical device and applications thereof
CN107974567A (zh) * 2018-01-30 2018-05-01 山东建筑大学 一种可控的医用降解镁合金的制备工艺与方法
CN108286003A (zh) * 2018-03-12 2018-07-17 王甲林 一种骨科植入镁合金材料及制备方法
KR102059960B1 (ko) 2018-06-11 2019-12-30 장희지 생분해성 물질을 구비한 임플란트
KR102059964B1 (ko) 2018-07-19 2019-12-30 장희지 생분해성 물질을 구비한 임플란트
CN109439986B (zh) * 2018-11-26 2019-08-27 杭州电子科技大学 一种具有较高医用性能的镁合金
CN109280828B (zh) * 2018-12-10 2021-03-02 南京工程学院 一种高强度可降解植入器械用复合材料及其制备方法
CN111321331B (zh) * 2018-12-13 2021-04-02 有研工程技术研究院有限公司 一种Mg-Zn-Ca系生物医用镁合金制备方法
CN110106413B (zh) * 2019-04-18 2021-06-04 北京大学 Mg-Si-Ca-Zn系镁合金及其制备方法与应用
EP3975942B1 (en) 2019-06-03 2024-07-10 Fort Wayne Metals Research Products, LLC Magnesium-based absorbable alloys
RU2724437C1 (ru) * 2019-08-26 2020-06-23 Общество с ограниченной ответственностью "НС ТЕХНОЛОГИЯ" Способ изготовления дентального имплантата из нанотитана с использованием лазерного структурирования поверхности и наноструктурированного композитного покрытия и имплатат
CN111020253B (zh) * 2019-11-14 2021-11-16 李健 一种生物医用镁合金加工方法
JP7761246B2 (ja) * 2020-11-05 2025-10-28 株式会社丸ヱム製作所 生体適合性材料及びその製造方法
EP4241796A4 (en) * 2020-11-05 2024-08-28 Maruemu Works Co., Ltd BIOCOMPATIBLE MATERIAL AND ITS PRODUCTION PROCESS
US20220354999A1 (en) 2021-05-10 2022-11-10 Cilag Gmbh International Bioabsorbable staple comprising mechanisms for slowing the absorption of the staple
JP2023028834A (ja) * 2021-08-20 2023-03-03 トレジェムバイオファーマ株式会社 インプラント体及び歯科インプラント
EP4397327A4 (en) * 2021-08-31 2025-08-13 Maruemu Works Co Ltd BIOCOMPATIBLE FILM AND BIOCOMPATIBLE MATERIAL HAVING SAID FILM
WO2023032947A1 (ja) 2021-08-31 2023-03-09 株式会社丸ヱム製作所 生体適合性材料およびその製造方法
CN114618013B (zh) * 2022-03-10 2023-09-15 苏州卓恰医疗科技有限公司 MnO2改性镁基骨水泥粉剂、骨水泥及其制备方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1237035A (en) * 1969-08-20 1971-06-30 Tsi Travmatologii I Ortopedii Magnesium-base alloy for use in bone surgery
US5324328A (en) * 1992-08-05 1994-06-28 Siemens Pacesetter, Inc. Conductor for a defibrillator patch lead
DE19731021A1 (de) * 1997-07-18 1999-01-21 Meyer Joerg In vivo abbaubares metallisches Implantat
WO2000015273A1 (de) * 1998-09-11 2000-03-23 Gerhard Schmidmaier Biologisch aktive implantate
EP1153621A1 (de) * 2000-05-12 2001-11-14 MERCK PATENT GmbH Biozemente auf TCP-PHA-Basismischung mit verbesserter Kompressionsfestigkeit
DE10118603A1 (de) * 2001-04-12 2002-10-17 Gerd Hausdorf Biologisch abbaubare medizinische Implantate aus der Kombination von metallischen und nichtmetallischen Werkstoffen
DE10128100A1 (de) * 2001-06-11 2002-12-19 Hannover Med Hochschule Medizinisches Implantat für den menschlichen und tierischen Körper
DE10163106A1 (de) * 2001-12-24 2003-07-10 Univ Hannover Medizinische Implantate, Prothesen, Protheseteile, medizinische Instrumente, Geräte und Hilfsmittel aus einem halogenid-modifizierten Magnesiumwerkstoff
DE10253634A1 (de) * 2002-11-13 2004-05-27 Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin Endoprothese
KR100487119B1 (ko) * 2002-11-26 2005-05-03 설영택 마그네슘 티타네이트 산화막 임플란트 및 그 제조방법
DE10361941A1 (de) * 2003-12-24 2005-07-28 Restate Patent Ag Magnesiumhaltige Beschichtung
DE102004026104A1 (de) * 2004-05-25 2005-12-15 Restate Patent Ag Implantat zur Gefäßligatur
US20060085081A1 (en) * 2004-06-07 2006-04-20 Shadduck John H Implants and methods for treating bone
JP2006061381A (ja) * 2004-08-26 2006-03-09 Terumo Corp 血管内インプラント
CN1743486A (zh) * 2004-08-31 2006-03-08 唐智荣 镁元素为基质的合金及作为骨折内固定器的应用
DE102004044679A1 (de) * 2004-09-09 2006-03-16 Biotronik Vi Patent Ag Implantat mit geringer Radialfestigkeit
JP2006167078A (ja) * 2004-12-15 2006-06-29 Terumo Corp 医療用インプラント
DE102005003188A1 (de) * 2005-01-20 2006-07-27 Restate Patent Ag Medizinisches Implantat aus einer amorphen oder nanokristallinen Legierung
KR20060092308A (ko) 2005-02-17 2006-08-23 알앤엘생명과학주식회사 양귀비과 식물의 조직 배양에 의한 생귀나린의 제조방법
KR101082476B1 (ko) 2005-02-17 2011-11-11 한라공조주식회사 압축기용 사판의 코팅장치
EP1959025B1 (en) * 2005-11-16 2012-03-21 National Institute for Materials Science Magnesium-based biodegradable metal material
CN1792383A (zh) * 2005-12-22 2006-06-28 上海交通大学 生物体内可吸收的Mg－Zn－Ca三元镁合金材料
CN100340308C (zh) * 2005-12-22 2007-10-03 上海交通大学 生物体内可吸收的Mg－Zn－Fe三元镁合金材料
CN100372574C (zh) * 2005-12-22 2008-03-05 上海交通大学 生物体内可吸收的Mg-Zn-Ca-Fe多元镁合金材料
DE102006015457A1 (de) * 2006-03-31 2007-10-04 Biotronik Vi Patent Ag Magnesiumlegierung und dazugehöriges Herstellungsverfahren
CN101484599A (zh) * 2006-04-28 2009-07-15 生物镁系统有限公司 生物可降解的镁合金及其用途
US20080015578A1 (en) * 2006-07-12 2008-01-17 Dave Erickson Orthopedic implants comprising bioabsorbable metal
KR100929133B1 (ko) 2006-09-22 2009-12-01 유앤아이 주식회사 생체분해성 금속을 포함하는 임플란트 및 이의 제조방법

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KR20080027202A (ko) 2008-03-26
CN101516292B (zh) 2013-08-21
AU2007297991A1 (en) 2008-03-27
AU2007297991B2 (en) 2011-02-17
JP5705163B2 (ja) 2015-04-22
CN101516292A (zh) 2009-08-26
JP2010503509A (ja) 2010-02-04
EP2063816A4 (en) 2011-07-20
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CN102512711A (zh) 2012-06-27
WO2008035948A1 (en) 2008-03-27

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