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ES2491866T3 - Disolución biopolimérica acuosa autogelificante controlada por la temperatura y dependiente del pH - Google Patents

Disolución biopolimérica acuosa autogelificante controlada por la temperatura y dependiente del pH Download PDF

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Publication number
ES2491866T3
ES2491866T3 ES00975711.3T ES00975711T ES2491866T3 ES 2491866 T3 ES2491866 T3 ES 2491866T3 ES 00975711 T ES00975711 T ES 00975711T ES 2491866 T3 ES2491866 T3 ES 2491866T3
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ES
Spain
Prior art keywords
hydroxyethyl
sulfonate
piperazine
bis
hydroxymethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES00975711.3T
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English (en)
Inventor
Abdellatif Chenite
Cyril Chaput
Dong Wang
Amine Selmani
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Piramal Healthcare Canada Ltd
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Piramal Healthcare Canada Ltd
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Application granted granted Critical
Publication of ES2491866T3 publication Critical patent/ES2491866T3/es
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Materials For Medical Uses (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)

Abstract

Una composición líquida autogelificante, que permite la formación de geles biopoliméricos controlados por la temperatura y dependientes del pH a una temperatura entre 30 y 80°C, caracterizada porque comprende: a) un medio ácido basado en agua, y b) 0,1 a 10% en peso de un biopolímero soluble en ácidos que gelifica por acción del pH seleccionado de colágeno y un biopolímero quitosano catiónico que porta grupos amino, y c) 0,1 a 10% en peso de una molécula soluble en agua, capaz de capturar protones en disolución acuosa dando de este modo lugar a un aumento del pH, seleccionada del grupo que consiste en: - sales de sodio, magnesio o hierro de N-[carbamoilmetil]-2-aminoetano-sulfonato (ACES), N,Nbis[ 2-hidroxietil]-2-aminoetano-sulfonato (BES), 3-[N,N-bis(2-hidroxietil)amino]-2-hidroxipropano sulfonato (DIPSO), N-[2-hidroxietil]piperazina-N'-3-propano-sulfonato (EPPS), N-[2- hidroxietil]piperazina-N'-4-butano-sulfonato (HEPBS), N-[2-hidroxietil]piperazina-N'-2-etanosulfonato (HEPES), N-[2-hidroxietil]piperazina-N'-2-hidroxipropano-sulfonato (HEPSO), 2-[Nmorfolino] etano-sulfonato (MES), 4-[N-morfolino]butano-sulfonato (MOBS), 3-[Nmorfolino] propano-sulfonato (MOPS), 3-[N-morfolino]-2-hidroxipropano-sulfonato (MOPSO), piperazina-N',N'-bis[2-etanosulfonato] (PIPES), piperazina-N,N'-bis[2-hidroxipropanosulfonato] (POPSO), 3-[N-tris(hidroximetil)metilamino]-2-hidroxipropano-sulfonato (TAPSO), o Ntris[ hidroximetil]metil-2-aminoetano-sulfonato (TES), o mezclas de los mismos; - N,N-bis[hidroxietil]glicina (BICINE), bis[2-hidroxietil]iminotris-[hidroximetil]metano (BIS-TRIS), glicil-glicina (GLY-GLY), trietanolamina (TEA), N-tris[hidroximetil]metilglicina (TRICINE), tris[hidroximetil]aminometano (TRIZMA), o mezclas de los mismos; - un residuo aminoácido seleccionado del grupo que consiste en histidina, arginina, lisina, asparagina, y glutamina o una mezcla de los mismos, residuo aminoácido que opcionalmente está modificado con un radical acetilo, t-butilo, bencilo, benzoilo, etilo, formilo, o metilo; - una secuencia de aminoácidos que incluye alanina, histidina, arginina, lisina, ácido aspártico, glutamina, glicina, hidroxiprolina, isoleucina, leucina, norleucina, fenilalanina, prolina, serina, treonina, tirosina, o valina, donde dicha composición líquida tiene un pH final que varía de 5,8 a 7,4.

Description

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Claims (1)

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ES00975711.3T 1999-11-15 2000-11-10 Disolución biopolimérica acuosa autogelificante controlada por la temperatura y dependiente del pH Expired - Lifetime ES2491866T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16564199P 1999-11-15 1999-11-15
US165641P 1999-11-15
PCT/CA2000/001341 WO2001036000A1 (en) 1999-11-15 2000-11-10 Temperature-controlled and ph-dependant self-gelling biopolymeric aqueous solution

Publications (1)

Publication Number Publication Date
ES2491866T3 true ES2491866T3 (es) 2014-09-08

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ES00975711.3T Expired - Lifetime ES2491866T3 (es) 1999-11-15 2000-11-10 Disolución biopolimérica acuosa autogelificante controlada por la temperatura y dependiente del pH

Country Status (7)

Country Link
US (1) US8920842B2 (es)
EP (1) EP1229940B1 (es)
AU (1) AU1375301A (es)
CA (2) CA2685349C (es)
DK (1) DK1229940T3 (es)
ES (1) ES2491866T3 (es)
WO (1) WO2001036000A1 (es)

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