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ES2472367B1 - Inhibidores no simétricos de colina quinasa con actividad antitumoral y antimalárica - Google Patents

Inhibidores no simétricos de colina quinasa con actividad antitumoral y antimalárica Download PDF

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Publication number
ES2472367B1
ES2472367B1 ES201300033A ES201300033A ES2472367B1 ES 2472367 B1 ES2472367 B1 ES 2472367B1 ES 201300033 A ES201300033 A ES 201300033A ES 201300033 A ES201300033 A ES 201300033A ES 2472367 B1 ES2472367 B1 ES 2472367B1
Authority
ES
Spain
Prior art keywords
symmetric
antitumor
choline kinase
kinase inhibitors
antimalarial activity
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES201300033A
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English (en)
Other versions
ES2472367A1 (es
Inventor
Ana CONEJO GARCÍA
Antonio José ENTRENA GUADIX
Belén RUBIO RUIZ
Miguel Ángel Gallo Mezo
Antonio Espinosa Úbeda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidad de Granada
Original Assignee
Universidad de Granada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidad de Granada filed Critical Universidad de Granada
Priority to ES201300033A priority Critical patent/ES2472367B1/es
Publication of ES2472367A1 publication Critical patent/ES2472367A1/es
Application granted granted Critical
Publication of ES2472367B1 publication Critical patent/ES2472367B1/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Inhibidores no simétricos de colina quinasa con actividad antitumoral y antimalárica.#La presente invención se enmarca en el campo farmacéutico, concretamente la invención se refiere a compuestos no simétricos de bispiridinio inhibidores de la enzima colina quinasa, su síntesis y su uso como medicamento antitumoral y/o antiparasitario.

Description

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Claims (1)

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ES201300033A 2012-12-28 2012-12-28 Inhibidores no simétricos de colina quinasa con actividad antitumoral y antimalárica Active ES2472367B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES201300033A ES2472367B1 (es) 2012-12-28 2012-12-28 Inhibidores no simétricos de colina quinasa con actividad antitumoral y antimalárica

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES201300033A ES2472367B1 (es) 2012-12-28 2012-12-28 Inhibidores no simétricos de colina quinasa con actividad antitumoral y antimalárica

Publications (2)

Publication Number Publication Date
ES2472367A1 ES2472367A1 (es) 2014-06-30
ES2472367B1 true ES2472367B1 (es) 2015-06-02

Family

ID=50980796

Family Applications (1)

Application Number Title Priority Date Filing Date
ES201300033A Active ES2472367B1 (es) 2012-12-28 2012-12-28 Inhibidores no simétricos de colina quinasa con actividad antitumoral y antimalárica

Country Status (1)

Country Link
ES (1) ES2472367B1 (es)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2237332B1 (es) * 2004-01-14 2006-11-01 Consejo Sup. Investig. Cientificas Derivados de piridinio y quinolinio.

Also Published As

Publication number Publication date
ES2472367A1 (es) 2014-06-30

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