ES2470991A1 - Additive for animal feed and procedure for manufacturing said additive (Machine-translation by Google Translate, not legally binding) - Google Patents
Additive for animal feed and procedure for manufacturing said additive (Machine-translation by Google Translate, not legally binding) Download PDFInfo
- Publication number
- ES2470991A1 ES2470991A1 ES201430415A ES201430415A ES2470991A1 ES 2470991 A1 ES2470991 A1 ES 2470991A1 ES 201430415 A ES201430415 A ES 201430415A ES 201430415 A ES201430415 A ES 201430415A ES 2470991 A1 ES2470991 A1 ES 2470991A1
- Authority
- ES
- Spain
- Prior art keywords
- additive
- animal feed
- ceramic matrix
- documents
- matrix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Fodder In General (AREA)
Abstract
Description
Aditivo para piensos de animales y procedimiento de fabricación de dicho aditivo. Additive for animal feed and manufacturing process of said additive.
La presente invención est� relacionada con la alimentación animal, proponiendo un aditivo para piensos, con el cual se suplementan los mismos para mejorar sus propiedades en las condiciones del tracto intestinal de los animales en relación con factores que benefician el desarrollo y evitan anomalías perjudiciales, al margen de la función alimenticia propia de los piensos. The present invention is related to animal feed, by proposing a feed additive, with which they are supplemented to improve their properties in the conditions of the intestinal tract of animals in relation to factors that benefit development and prevent harmful abnormalities, regardless of the feeding function of feed.
Es un hecho comprobado que la inclusión de pequeñas dosis de algunos metales en la alimentación animal proporciona efectos beneficiosos para mejorar el desarrollo de los animales y evitar problemas que pueden ser significativamente perjudiciales. It is a proven fact that the inclusion of small doses of some metals in animal feed provides beneficial effects to improve the development of animals and avoid problems that can be significantly harmful.
En ese sentido, es conocido, por documentos como EP1593381, US3950546 � CN101218959, que el óxido de zinc en la alimentación de los lechones, durante el periodo de destete, reduce la incidencia y severidad de las diarreas, minimizando como consecuencia los perjuicios de esa anomalía. In that sense, it is known, by documents such as EP1593381, US3950546 � CN101218959, that zinc oxide in the feeding of piglets, during the period of weaning, reduces the incidence and severity of diarrhea, minimizing as a consequence the damages of that anomaly.
En la práctica actual, es conocido el uso de óxido de zinc en dosis de 3100 ppm en los piensos, durante un periodo prescrito por el veterinario, con lo cual experimentalmente se ha comprobado que se consigue un control eficaz de las diarreas en lechones recién destetados. Sin embargo, la administración de óxido de zinc en dosis tan altas y periodos prolongados de tiempo, puede causar problemas en los animales, como ralentizaci�n del crecimiento y acumulación superior a los niveles basales normales, de metales pesados. Además de problemas medioambientales debido a la excreci�n de grandes cantidades de metales pesados en los purines, que provocan contaminación en suelos, acuíferos, etc. In current practice, it is known to use zinc oxide at a dose of 3100 ppm in feed, during a period prescribed by the veterinarian, which has been proven experimentally to achieve effective control of diarrhea in recently weaned piglets . However, the administration of zinc oxide in such high doses and prolonged periods of time, can cause problems in animals, such as growth slowdown and accumulation above normal basal levels, of heavy metals. In addition to environmental problems due to the excretion of large amounts of heavy metals in slurry, causing pollution in soils, aquifers, etc.
Por ello, es evidente la necesidad de un aditivo que permita obtener unas ventajas efectivas de la incorporación de partículas de zinc y otros metales en los piensos de animales, pero sin los inconvenientes derivados de las dosis medicamentosas que se utilizan en las prácticas actuales Therefore, the need for an additive that allows obtaining effective advantages of the incorporation of particles of zinc and other metals into animal feed is evident, but without the inconvenience arising from the drug doses used in current practices
De acuerdo con la invención se propone un aditivo para piensos de animales que cumple con las perspectivas anteriormente indicadas, siendo objetivo de la invención también un procedimiento de fabricación que permite obtener dicho aditivo de una manera eficiente y rentable. In accordance with the invention, an animal feed additive is proposed that meets the above-mentioned perspectives, the object of the invention being also a manufacturing process that allows obtaining said additive in an efficient and cost-effective manner.
El aditivo preconizado consta de una matriz inorgánica intercalada con material orgánico, en la cual se encuentran distribuidas homog�neamente nanopart�culas met�licas de zinc, cobre, hierro o mezclas de las mismas, estando ancladas dichas nanopart�culas entre las capas de la matriz, impidiendo su liberación. The recommended additive consists of an inorganic matrix interspersed with organic material, in which metallic nanoparticles of zinc, copper, iron or mixtures thereof are homogeneously distributed, said nanoparticles being anchored between the layers of the matrix, preventing its release.
La matriz inorgánica es de un material cerámico seleccionado de entre el grupo que comprende: caolinita, pirofilita, bentonita, esmectita, montmorillonita, hectorita, sepiolita saponita, laponita, halloysita, vermiculita, mica, clorita, ilita, o mezclas de las mismas. The inorganic matrix is a ceramic material selected from the group comprising: kaolinite, pyrophyllite, bentonite, smectite, montmorillonite, hectorite, sepiolite saponite, laponite, halloysite, vermiculite, mica, chlorite, ilite, or mixtures thereof.
Los componentes orgánicos intercalados en la matriz son surfactantes del grupo que comprende: aminas cuaternarias, pol�meros, proteínas, lípidos, biopol�meros, poliamidas, polisac�ridos o mezclas de los mismos. The organic components interspersed in the matrix are surfactants of the group comprising: quaternary amines, polymers, proteins, lipids, biopolymers, polyamides, polysaccharides or mixtures thereof.
Y para la obtención de las nanopart�culas met�licas que se incluyen ancladas en la matriz, se utilizan métodos de proceso solvotermal, microondas, ultrasonidos, sol-gel, radiación ultravioleta, plasma o llama. And to obtain the metallic nanoparticles that are included anchored in the matrix, solvotermal process methods, microwaves, ultrasound, sol-gel, ultraviolet radiation, plasma or flame are used.
Se obtiene as� un aditivo en el que las nanopart�culas met�licas no se liberan sino que permanecen en la matriz, cumpliendo sus funciones y actuando a nivel iónico. De este modo, con mínimas dosis de nanopart�culas met�licas se logra actuar localmente sobre el intestino de los animales, favoreciendo el desarrollo de la flora intestinal y controlando el crecimiento de bacterias pat�genas. An additive is thus obtained in which the metal nanoparticles are not released but remain in the matrix, fulfilling their functions and acting at the ionic level. In this way, with minimal doses of metallic nanoparticles, it is possible to act locally on the intestines of animals, favoring the development of intestinal flora and controlling the growth of pathogenic bacteria.
Dicho objetivo se consigue además sin bio-acumulación de metales pesados en los animales, ya que las dosis de los mismos son mínimas (nutricionales) y cuando los animales excretan las matrices del aditivo, llegan al ecosistema también unas mínimas cantidades de metales pesados, que son totalmente aceptables dentro de la vigente normativa de la Unión Europea para estos casos. This objective is also achieved without bio-accumulation of heavy metals in animals, since their doses are minimal (nutritional) and when the animals excrete the additive matrices, minimal amounts of heavy metals reach the ecosystem, which They are totally acceptable within the current regulations of the European Union for these cases.
El uso de este aditivo, formado por una matriz inorgánica funcionalizada con nanopart�culas met�licas, durante periodos de seis semanas, no altera los parámetros basales de animales, es decir la cantidades de cobre, zinc, y/o hierro en plasma sanguíneo, hígado, riñones, páncreas y musculo, permanecen dentro de los parámetros normales y no presentan variación significativa entre los animales alimentados con o sin aditivo. The use of this additive, formed by an inorganic matrix functionalized with metal nanoparticles, for periods of six weeks, does not alter the basal parameters of animals, that is, the amounts of copper, zinc, and / or iron in blood plasma , liver, kidneys, pancreas and muscle, remain within normal parameters and do not show significant variation among animals fed with or without additive.
De acuerdo con ello, el aditivo as� formado garantiza un óptimo aprovechamiento de los metales utilizados, ya que la matriz inorgánica impide la liberación descontrolada de las nanopart�culas met�licas dentro del tracto digestivo de los animales, evitando la absorción de las mismas por el organismo y excret�ndose por las heces en unas cantidades que no son significativamente perjudiciales para el medio ambiente Accordingly, the additive thus formed guarantees optimum use of the metals used, since the inorganic matrix prevents the uncontrolled release of the metal nanoparticles within the digestive tract of the animals, preventing their absorption by the organism and excreted by feces in amounts that are not significantly harmful to the environment
El aditivo funciona como agente atrapador de microtoxinas. As�, es un potente atrapador de de aflatoxinas, zearalenona, ocratoxinas y deoxynivalenol. Además debido a su composición y estructura es un adsorbente de amplio espectro para capturar microtoxinas polares y no polares. The additive works as a mycotoxin trapping agent. Thus, it is a potent trap of aflatoxins, zearalenone, ocratoxins and deoxynivalenol. In addition, due to its composition and structure, it is a broad spectrum adsorbent to capture polar and non-polar mycotoxins.
El objeto de la invención se refiere a un aditivo para piensos de animales, que se compone de una matriz cerámica, intercalada con materiales orgánicos y nanopart�culas met�licas de zinc, cobre, hierro o mezclas de las mismas, pudiendo ser la matriz cerámica de: caolinita, pirofilita, bentonita, esmectita, montmorillonita, hectorita, sepiolita, saponita, laponita, halloysita, vermiculita, mica, clorita, ilita y/o mezclas de las mismas. The object of the invention relates to an additive for animal feed, which is composed of a ceramic matrix, interspersed with organic materials and metallic nanoparticles of zinc, copper, iron or mixtures thereof, the matrix being able to be ceramics of: kaolinite, pyrophyllite, bentonite, smectite, montmorillonite, hectorite, sepiolite, saponite, laponite, halloysite, vermiculite, mica, chlorite, ilite and / or mixtures thereof.
Dicho aditivo se obtiene mediante un procedimiento que comprende las etapas siguientes: Said additive is obtained by a process comprising the following steps:
- --
- Tratamiento de la matriz cerámica, con agua o disolventes orgánicos (alcoholes, acetato de etileno o acetona), en una proporción de entre 5 - 40 veces de disolvente respecto de la cantidad de matriz cerámica; haciéndose el tratamiento en un reactor, con el material cerámico en continua agitaci�n, durante 1 - 3 horas, a 45 – 60 �C. Treatment of the ceramic matrix, with water or organic solvents (alcohols, ethylene acetate or acetone), in a proportion between 5-40 times of solvent with respect to the amount of ceramic matrix; the treatment being carried out in a reactor, with the ceramic material in continuous agitation, for 1-3 hours, at 45-60 ° C.
- --
- Intercalaci�n de surfactantes (aminas cuaternarias, pol�meros, proteínas, lípidos, biopol�meros, poliamidas, polisac�ridos y/o mezclas de los mismos) en la estructura laminar de la matriz cerámica, con una cantidad de surfactante entre 1 y 3 CEC (mili-equivalentes por 100 gramos) respecto de la matriz cerámica; realizándose esta fase durante 3 - 8 horas, a 45 - 60 �C, en continua agitaci�n, hasta conseguir una completa exfoliación de la matriz cerámica. Intercalation of surfactants (quaternary amines, polymers, proteins, lipids, biopolymers, polyamides, polysaccharides and / or mixtures thereof) in the laminar structure of the ceramic matrix, with a quantity of surfactant between 1 and 3 CEC (milli-equivalents per 100 grams) with respect to the ceramic matrix; this phase being carried out for 3-8 hours, at 45-60 ° C, in continuous agitation, until a complete exfoliation of the ceramic matrix is achieved.
- --
- Adición de nanopart�culas met�licas, las cuales se pueden generar sobre la propia matriz cerámica mediante procesos sol-gel o solvotermal, a partir de sal met�lica y un reductor, o pueden añadirse sobre la matriz cerámica previamente sintetizadas por plasma, llama ultravioleta o microondas. Addition of metal nanoparticles, which can be generated on the ceramic matrix itself by sol-gel or solvotermal processes, from metal salt and a reducer, or can be added on the ceramic matrix previously synthesized by plasma, UV flame or microwave.
El producto resultante es un nanocompuesto formado por matrices cerámicas intercaladas con materiales orgánicos y nanopart�culas met�licas, en el cual la proporción de nanopart�culas met�licas se determina en función del uso de destino del producto mezclado con piensos de alimentación animal, para que en el pienso de aplicación haya entre 1 ppm y 1000 ppm de nanopart�culas met�licas respecto del pienso. The resulting product is a nanocomposite formed by ceramic matrices interspersed with organic materials and metallic nanoparticles, in which the proportion of metallic nanoparticles is determined based on the destination use of the product mixed with animal feedstuffs , so that in the application feed there is between 1 ppm and 1000 ppm of metal nanoparticles with respect to the feed.
En un ejemplo de realización, para aplicación en el control de diarreas y como promotor de crecimiento en lechones recién destetados, se utiliza una sal de zinc para formar las nanopart�culas met�licas que se intercalan en la matriz cerámica del producto nanocompuesto, el cual se mezcla con el pienso de alimentación de los lechones para que resulte una dosis de zinc del orden de 150 ppm respecto del pienso. In an exemplary embodiment, for application in the control of diarrhea and as a growth promoter in freshly weaned piglets, a zinc salt is used to form the metal nanoparticles that are embedded in the ceramic matrix of the nanocomposite product, the which is mixed with the feed of the piglets to result in a dose of zinc of the order of 150 ppm with respect to the feed.
Otro ejemplo de aplicación, como promotor de crecimiento, es la utilización de una matriz cerámica inorgánica funcionalizada con nanopart�culas de oxido de cobre (25 ppm de cobre), el cual añadido a la dieta es un potenciador del crecimiento en la etapas de cebo, donde se produce una ralentizaci�n del crecimiento. Another example of application, as a growth promoter, is the use of an inorganic ceramic matrix functionalized with copper oxide nanoparticles (25 ppm copper), which added to the diet is a growth enhancer in the bait stages , where there is a slowdown in growth.
Claims (10)
- --
- Tratamiento de la matriz cerámica con agua o disolventes orgánicos, en agitaci�n continua, durante 1 – 3 horas, a 45 – 60 �C, en continua agitaci�n. Treatment of the ceramic matrix with water or organic solvents, in continuous agitation, for 1-3 hours, at 45-60 ° C, in continuous agitation.
- --
- Intercalación de surfactantes en la estructura laminar de la matriz cerámica, durante 3 – 8 horas, a 45 – 60 �C, en continua agitaci�n. Intercalation of surfactants in the laminar structure of the ceramic matrix, for 3-8 hours, at 45-60 ° C, in continuous agitation.
- --
- Adición de nanopat�culas met�licas de zinc, cobre, hierro o mezclas de las mismas, en la estructura de la matriz cerámica intercalada con surfactantes. Addition of zinc, copper, iron, metal mixtures or mixtures thereof, in the structure of the ceramic matrix interspersed with surfactants.
- Categor�a Category
- 56 Documentos citados Reivindicaciones afectadas 56 Documents cited Claims Affected
- X X
- CHIAO, Shu-Her, et al. Efficacy and safety of nanohybrids comprising silver nanoparticles and silicate clay for controlling Salmonella infection. Int. Journal Nanomedicine, 2012, vol. 7, p. 2421-2432; todo el documento. 1-3 CHIAO, Shu-Her, et al. Efficacy and safety of nanohybrids comprising silver nanoparticles and silicate clay for controlling Salmonella infection. Int. Journal Nanomedicine, 2012, vol. 7, p. 2421-2432; whole document. 1-3
- X X
- US 2006216322 A1 (TSUCHIBE SATOMI et al.) 28.09.2006, párrafos [0028]-[0034]; ejemplo 1. 1-3 US 2006 216322 A1 (TSUCHIBE SATOMI et al.) 28.09.2006, paragraphs [0028] - [0034]; Example 1. 1-3
- X X
- ES 2325647 A1 (ARGENOL S L LAB) 10.09.2009, reivindicaciones 1-6. 1-3 ES 2325647 A1 (ARGENOL S L LAB) 10.09.2009, claims 1-6. 1-3
- A TO
- WO 2006108845 A2 (IRMA et al.) 19.10.2006, ejemplos 1,2. 1-9 WO 2006108845 A2 (IRMA et al.) 19.10.2006, examples 1.2. 1-9
- A TO
- AllAboutFeed.net [página web de Internet]. Nano technology in animal feed. Doetinchem: The Netherlands: Reed Business; 08.03.2013 [recuperado el 10.06.2014] Recuperado de internet http://www.allaboutfeed.net/Nutrition/Feed-Additives/2013/3/Nano-technology-in-animal-feed1194836W/; todo el documento. 1-9 AllAboutFeed.net [Internet website]. Nano technology in animal feed. Doetinchem: The Netherlands: Reed Business; 08.03.2013 [retrieved 10.06.2014] Recovered from the Internet http://www.allaboutfeed.net/Nutrition/Feed-Additives/2013/3/Nano-technology-in-animal-feed1194836W/; whole document. 1-9
- Categor�a de los documentos citados X: de particular relevancia Y: de particular relevancia combinado con otro/s de la misma categoría A: refleja el estado de la técnica O: referido a divulgación no escrita P: publicado entre la fecha de prioridad y la de presentación de la solicitud E: documento anterior, pero publicado después de la fecha de presentación de la solicitud Category of the documents cited X: of particular relevance Y: of particular relevance combined with other / s of the same category A: reflects the state of the art O: refers to unwritten disclosure P: published between the priority date and the submission of the application E: previous document, but published after the date of submission of the application
- El presente informe ha sido realizado • para todas las reivindicaciones • para las reivindicaciones n�: This report has been prepared • for all claims • for claims no:
- Fecha de realización del informe 13.06.2014 Date of completion of the report 13.06.2014
- Examinador V. Balmaseda Valencia Página 1/4 Examiner V. Balmaseda Valencia Page 1/4
- Novedad (Art. 6.1 LP 11/1986) Novelty (Art. 6.1 LP 11/1986)
- Reivindicaciones Reivindicaciones 4-9 1-3 SI NO Claims Claims 4-9 1-3 IF NOT
- Actividad inventiva (Art. 8.1 LP11/1986) Inventive activity (Art. 8.1 LP11 / 1986)
- Reivindicaciones Reivindicaciones 4-9 1-3 SI NO Claims Claims 4-9 1-3 IF NOT
- Documento Document
- Número Publicación o Identificación Fecha Publicación Publication or Identification Number publication date
- D01 D01
- CHIAO, Shu-Her, et al. Int. Journal Nanomedicine, vol. 7, p. 2421-2432. 2012 CHIAO, Shu-Her, et al. Int. Journal Nanomedicine, vol. 7, p. 2421-2432. 2012
- D02 D02
- US 2006216322 A1 (TSUCHIBE SATOMI et al.) 28.09.2006 US 2006 216322 A1 (TSUCHIBE SATOMI et al.) 28.09.2006
- D03 D03
- ES 2325647 A1 (ARGENOL S L LAB) 10.09.2009 ES 2325647 A1 (ARGENOL S L LAB) 10.09.2009
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201430415A ES2470991B1 (en) | 2014-03-24 | 2014-03-24 | Additive for animal feed and manufacturing process of said additive |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201430415A ES2470991B1 (en) | 2014-03-24 | 2014-03-24 | Additive for animal feed and manufacturing process of said additive |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2470991A1 true ES2470991A1 (en) | 2014-06-24 |
| ES2470991B1 ES2470991B1 (en) | 2015-01-22 |
Family
ID=50943877
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES201430415A Expired - Fee Related ES2470991B1 (en) | 2014-03-24 | 2014-03-24 | Additive for animal feed and manufacturing process of said additive |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2470991B1 (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060216322A1 (en) * | 2005-03-25 | 2006-09-28 | Kenko Corporation | Feed composition and method for breeding animals |
| WO2006108845A2 (en) * | 2005-04-13 | 2006-10-19 | Institut Regional Des Materiaux Avances (Irma) | Non-medicinal food additive for animals, supplemented foods containing same and method for improving animal growth |
| ES2325647A1 (en) * | 2007-05-31 | 2009-09-10 | Argenol S L Lab | Feed additive for animals (Machine-translation by Google Translate, not legally binding) |
-
2014
- 2014-03-24 ES ES201430415A patent/ES2470991B1/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060216322A1 (en) * | 2005-03-25 | 2006-09-28 | Kenko Corporation | Feed composition and method for breeding animals |
| WO2006108845A2 (en) * | 2005-04-13 | 2006-10-19 | Institut Regional Des Materiaux Avances (Irma) | Non-medicinal food additive for animals, supplemented foods containing same and method for improving animal growth |
| ES2325647A1 (en) * | 2007-05-31 | 2009-09-10 | Argenol S L Lab | Feed additive for animals (Machine-translation by Google Translate, not legally binding) |
Non-Patent Citations (2)
| Title |
|---|
| AllAboutFeed.net [página web de Internet]. Nano technology in animal feed. Doetinchem: The Netherlands: Reed Business; 08-03-2013 [recuperado el 10-06-2014] Recuperado de internet http://www.allaboutfeed.net/Nutrition/Feed-Additives/2013/3/Nano-technology-in-animal-feed-1194836W/; todo el documento. * |
| CHIAO, Shu-Her, et al. Efficacy and safety of nanohybrids comprising silver nanoparticles and silicate clay for controlling Salmonella infection. Int. Journal Nanomedicine, 2012, vol. 7, p. 2421-2432; todo el documento. * |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2470991B1 (en) | 2015-01-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Abbas | Advantages and prospective challenges of nanotechnology applications in fish cultures: a comparative review | |
| AU2015376853B2 (en) | Improved pathogen inhibitor | |
| Sarkheil et al. | Application of silver nanoparticles immobilized on TEPA-Den-SiO2 as water filter media for bacterial disinfection in culture of Penaeid shrimp larvae | |
| CN103974626A (en) | Use of spent fuller's earth from edible oil processing in the formulation of salt and mineral feed blocks or pellets for livestock | |
| KR101615133B1 (en) | Antibiotic water manufacture method using Shungite | |
| ES2470991A1 (en) | Additive for animal feed and procedure for manufacturing said additive (Machine-translation by Google Translate, not legally binding) | |
| Yancey-Gray et al. | Antibacterial activities of copper, silver, and zinc-derived Nanoparticles and their capacity to enhance the antimicrobial activities of antibiotics | |
| Tayel et al. | Nanotechnology for aquaculture | |
| Soltani et al. | Effect of nanosilver particles on hatchability of rainbow trout (Oncorhynchus mykiss) egg and survival of the produced larvae | |
| RU2014102671A (en) | ACTIVE COMPOSITION FOR USE IN FODDER PRODUCTS | |
| KR101246849B1 (en) | Minerals aqueous solution and its manufacturing method | |
| CN109527341B (en) | A multifunctional antibacterial and mildew remover | |
| Amr et al. | Nanoclay in animal diets: properties, structure, applications, and toxicity | |
| Gindaba et al. | Entomotoxicity of ZnO NPs synthesized using Clausena anisata Hook. f. Ex Benth (ulmaayii) leaf extract against maize weevil, Sitophilus zeamais Mostch (Coleoptera: Curculionidae) | |
| KR102390975B1 (en) | Bio ceramic composition and preparation method thereof and masterbatch using the same | |
| RU2013159311A (en) | ANTIOXIDANT AGENT WITH HEPATOPROTECTIVE EFFECT BASED ON NANOSTRUCTURED SELENIUM AND WAYS OF ITS PRODUCTION AND APPLICATION | |
| CN103585961B (en) | A kind of livestock and poultry mold toxin sorbent | |
| Abd Elwanees | Importance of Metal Nanoparticles in Veterinary Medicine | |
| JP4602005B2 (en) | Antibacterial and deodorant for livestock and poultry | |
| JP5076401B2 (en) | Pathogen infection prevention method | |
| Ahuja et al. | Fabrication of copper nano/honey loaded polymeric composite with microbial activity | |
| RU2780152C1 (en) | Sanitary zoohygenic composition for keeping farm animals | |
| CN1555257A (en) | Preventive agent for ascites in poultry | |
| KR101349815B1 (en) | Eco friendly aqueous nano silver colloid including calcium ion for living body and Preparation Method thereof | |
| WO2017221079A1 (en) | Mycotoxin adsorbant based on a betaine derivative for balanced animal feed |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 2470991 Country of ref document: ES Kind code of ref document: B1 Effective date: 20150122 |
|
| FD2A | Announcement of lapse in spain |
Effective date: 20250425 |