ES2469990B1 - Compuestos de estructura híbrida piridazinona ditiocarbamato con actividad antineoplásica - Google Patents
Compuestos de estructura híbrida piridazinona ditiocarbamato con actividad antineoplásica Download PDFInfo
- Publication number
- ES2469990B1 ES2469990B1 ES201201254A ES201201254A ES2469990B1 ES 2469990 B1 ES2469990 B1 ES 2469990B1 ES 201201254 A ES201201254 A ES 201201254A ES 201201254 A ES201201254 A ES 201201254A ES 2469990 B1 ES2469990 B1 ES 2469990B1
- Authority
- ES
- Spain
- Prior art keywords
- dithiocarbamate
- pyridazinone
- hybrid structure
- antineoplastic activity
- structure compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000000118 anti-neoplastic effect Effects 0.000 title 1
- -1 compounds pyridazinone dithiocarbamate Chemical class 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- AAILEWXSEQLMNI-UHFFFAOYSA-N 1h-pyridazin-6-one Chemical group OC1=CC=CN=N1 AAILEWXSEQLMNI-UHFFFAOYSA-N 0.000 abstract 1
- GLZMOHAECHCEBA-UHFFFAOYSA-N C(N)(S)=S.N=1NC(C=CC1)=O Chemical compound C(N)(S)=S.N=1NC(C=CC1)=O GLZMOHAECHCEBA-UHFFFAOYSA-N 0.000 abstract 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 abstract 1
- 206010033128 Ovarian cancer Diseases 0.000 abstract 1
- 206010061535 Ovarian neoplasm Diseases 0.000 abstract 1
- 208000002495 Uterine Neoplasms Diseases 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- DKVNPHBNOWQYFE-UHFFFAOYSA-N carbamodithioic acid Chemical group NC(S)=S DKVNPHBNOWQYFE-UHFFFAOYSA-N 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 201000005202 lung cancer Diseases 0.000 abstract 1
- 208000020816 lung neoplasm Diseases 0.000 abstract 1
- 230000002611 ovarian Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000035755 proliferation Effects 0.000 abstract 1
- 206010046766 uterine cancer Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Esta invención se refiere a nuevos compuestos de estructura híbrida piridazinona-ditiocarbamato de fórmula general I, que son inhibidores in vitro del crecimiento o proliferación de células cancerosas de tumores sólidos, y a su uso para la inhibición o prevención del cáncer de pulmón, ovario y útero. Se trata de derivados de 3(2H)- piridazinona sustituidos en las posiciones 2, 4, 5 y 6, que presentan fragmentos de ditiocarbamato enlazados a la posición 6 a través de una cadena alquílica de longitud variable. Esta invención también se refiere a la preparación de dichos compuestos.
Description
Claims (1)
-
imagen1 imagen2
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201201254A ES2469990B1 (es) | 2012-12-19 | 2012-12-19 | Compuestos de estructura híbrida piridazinona ditiocarbamato con actividad antineoplásica |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201201254A ES2469990B1 (es) | 2012-12-19 | 2012-12-19 | Compuestos de estructura híbrida piridazinona ditiocarbamato con actividad antineoplásica |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2469990A1 ES2469990A1 (es) | 2014-06-20 |
| ES2469990B1 true ES2469990B1 (es) | 2015-01-26 |
Family
ID=50942513
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES201201254A Active ES2469990B1 (es) | 2012-12-19 | 2012-12-19 | Compuestos de estructura híbrida piridazinona ditiocarbamato con actividad antineoplásica |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2469990B1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2544869B2 (es) * | 2014-03-04 | 2016-01-18 | Universidade De Vigo | Derivados de piridazin-3(2H)-ona inhibidores selectivos de la isoforma B de la monoaminooxidasa |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1598348A1 (en) * | 2004-05-18 | 2005-11-23 | Aventis Pharma Deutschland GmbH | Novel pyridazinone derivatives as inhibitors of CDK2 |
| GB0610680D0 (en) * | 2006-05-31 | 2006-07-12 | Istituto Di Ricerche D Biolog | Therapeutic compounds |
-
2012
- 2012-12-19 ES ES201201254A patent/ES2469990B1/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2469990A1 (es) | 2014-06-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1123756T1 (el) | Παραγωγα διπυραζολιου ως αναστολεις jak | |
| CY1122247T1 (el) | Αγωγη καρκινων με τη χρηση τροποποιητων ισομορφης κινασης ρι3 | |
| MX373786B (es) | Derivados de pirimidin-2,4-diamina para el tratamiento de cáncer. | |
| PH12016500024A1 (en) | Bromodomain inhibitor | |
| EA201690752A1 (ru) | Ингибиторы g12c kras | |
| MX2016002544A (es) | Compuestos utiles como inmunomoduladores. | |
| MX375902B (es) | Inhibidores de serina/treonina cinasa. | |
| EA201791563A1 (ru) | Замещенные нуклеозидные производные, полезные в качестве агентов против рака | |
| EA201691194A1 (ru) | Стимуляторы ргц | |
| NZ603151A (en) | N3-substituted-n1-sulfonyl-5-fluoropyrimidinone derivatives | |
| CL2016003214A1 (es) | Derivados de la indolizina como inhibidores de las fosfoinositido-3 quinasas | |
| EA201270535A1 (ru) | Пуриновые производные, применимые в качестве ингибиторов hsp90 | |
| BR112012023660B8 (pt) | usos de uma quantidade terapeuticamente eficaz de um composto, ou de um sal, solvato, hidrato ou pró-fármaco farmaceuticamente aceitável do mesmo para o tratamento de câncer | |
| JOP20190254A1 (ar) | مركبات مضادة للأورام | |
| EA201591024A1 (ru) | Димерные соединения | |
| IL220386B (en) | Compositions for the liquidation of tumors and uses thereof | |
| EA201590552A1 (ru) | Аминохинолины в качестве ингибиторов киназы | |
| CR20120502A (es) | Uso de nuevos inhibidores de pan-cdk para tratar tumores | |
| EA201600434A1 (ru) | Применение производных бензимидазолпролина | |
| EP4585267A3 (en) | Coumarin based hsp90 inhibitors with urea and ether substituents | |
| CU20080169A7 (es) | Derivados de tetrahidronaftalina, procedimientos para prepararlos. | |
| EA201590656A1 (ru) | Азаиндолины | |
| ES2469990B1 (es) | Compuestos de estructura híbrida piridazinona ditiocarbamato con actividad antineoplásica | |
| WO2017027357A8 (en) | Pyridazinones and their use in the treatment of cancer | |
| CL2015003605A1 (es) | Derivados de prodroga de triazolpiridinas sustituidas |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
Ref document number: 2469990 Country of ref document: ES Kind code of ref document: B1 Effective date: 20150126 |