ES2334768T1 - Formulacion farmaceutica extruible de liberacion controlada. - Google Patents
Formulacion farmaceutica extruible de liberacion controlada. Download PDFInfo
- Publication number
- ES2334768T1 ES2334768T1 ES09003265T ES09003265T ES2334768T1 ES 2334768 T1 ES2334768 T1 ES 2334768T1 ES 09003265 T ES09003265 T ES 09003265T ES 09003265 T ES09003265 T ES 09003265T ES 2334768 T1 ES2334768 T1 ES 2334768T1
- Authority
- ES
- Spain
- Prior art keywords
- pharmaceutical formulation
- formulation according
- ethylene oxide
- poly
- molecular weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Una formulación farmacéutica oral de liberación controlada basada en poli(óxido de etileno) extruible de fusión en caliente que comprende una cantidad eficaz de un compuesto terapéutico y un poli(óxido de etileno) de alto peso molecular, teniendo el poli(óxido de etileno) un peso molecular medio en el intervalo de aproximadamente 1.000.000 a aproximadamente 10.000.000 Daltons, y siendo el compuesto terapéutico un analgésico.
Claims (15)
1. Una formulación farmacéutica oral de
liberación controlada basada en poli(óxido de etileno) extruible de
fusión en caliente que comprende una cantidad eficaz de un compuesto
terapéutico y un poli(óxido de etileno) de alto peso molecular,
- teniendo el poli(óxido de etileno) un peso molecular medio en el intervalo de aproximadamente 1.000.000 a aproximadamente 10.000.000 Daltons, y siendo el compuesto terapéutico un analgésico.
2. La formulación farmacéutica de acuerdo con la
reivindicación 1, donde la formulación es una forma de dosificación
unitaria sólida.
3. La formulación farmacéutica de acuerdo con la
reivindicación 1 ó 2, 5 donde la formulación está en forma de un
comprimido.
4. La formulación farmacéutica de acuerdo con
una cualquiera de las reivindicaciones 1 a 3, en la que la relación
poli(óxido de etileno):compuesto terapéutico está en el intervalo
de aproximadamente el 99,99:0,01 a aproximadamente el 80:20% en
peso.
5. La formulación farmacéutica de acuerdo con
una cualquiera de las reivindicaciones 1 a 4, en la que el
poli(óxido de etileno) de alto peso molecular es un homopolímero de
poli(óxido de etileno) de alto peso molecular.
6. La formulación farmacéutica de acuerdo con
una cualquiera de las reivindicaciones 1 a 5, en la que el
poli(óxido de etileno) tiene un peso molecular medio menor que o
igual a aproximadamente 5.000.000.
7. La formulación farmacéutica de acuerdo con
una cualquiera de las reivindicaciones 1 a 5, en la que el
poli(óxido de etileno) tiene un peso molecular medio mayor de
aproximadamente 5.000.000.
8. La formulación farmacéutica de acuerdo con
una cualquiera de las reivindicaciones anteriores, donde la
formulación no contiene un plastificante.
9. La formulación farmacéutica de acuerdo con
una cualquiera de las reivindicaciones anteriores, en la que el
compuesto terapéutico es un compuesto hidrófilo.
10. La formulación farmacéutica de acuerdo con
una cualquiera de las reivindicaciones anteriores, en la que el
compuesto terapéutico se formula en forma de su sal
farmacéuticamente aceptable.
11. La formulación farmacéutica de acuerdo con
la reivindicación 10, en la que la sal farmacéuticamente aceptable
se obtiene a partir de ácido clorhídrico.
12. La formulación farmacéutica de acuerdo con
una cualquiera de las reivindicaciones 2 a 11, donde la formulación
contiene un lubricante.
13. La formulación farmacéutica de acuerdo con
la reivindicación 12, en la que el lubricante es estearato de
magnesio.
14. La formulación farmacéutica de acuerdo con
una cualquiera de las reivindicaciones anteriores, donde la
formulación se prepara por un proceso distinto de, pero equivalente
a, extrusión por fusión en caliente.
15. Uso de una formulación farmacéutica oral de
liberación controlada basada en poli(óxido de etileno) extruible de
fusión en caliente de acuerdo con una cualquiera de las
reivindicaciones anteriores para la fabricación de un medicamento
para el tratamiento del dolor.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2062396P | 1996-06-26 | 1996-06-26 | |
| US20623P | 1996-06-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2334768T1 true ES2334768T1 (es) | 2010-03-16 |
Family
ID=21799669
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97931455T Expired - Lifetime ES2325046T3 (es) | 1996-06-26 | 1997-06-24 | Formulacion farmaceutica extruible por fusion en caliente. |
| ES09003265T Pending ES2334768T1 (es) | 1996-06-26 | 1997-06-24 | Formulacion farmaceutica extruible de liberacion controlada. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES97931455T Expired - Lifetime ES2325046T3 (es) | 1996-06-26 | 1997-06-24 | Formulacion farmaceutica extruible por fusion en caliente. |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6488963B1 (es) |
| EP (3) | EP2065055A1 (es) |
| AT (1) | ATE427124T1 (es) |
| AU (1) | AU3508097A (es) |
| DE (2) | DE69739343D1 (es) |
| DK (1) | DK1014941T3 (es) |
| ES (2) | ES2325046T3 (es) |
| PT (1) | PT1014941E (es) |
| WO (1) | WO1997049384A1 (es) |
Families Citing this family (123)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPP279698A0 (en) * | 1998-04-03 | 1998-04-30 | Sunscape Developments Limited | Sustained release formulation |
| DE10026698A1 (de) | 2000-05-30 | 2001-12-06 | Basf Ag | Selbstemulgierende Wirkstoffformulierung und Verwendung dieser Formulierung |
| EP2932964A1 (en) * | 2000-10-30 | 2015-10-21 | Euro-Celtique S.A. | Controlled release hydrocodone formulations |
| US20030068375A1 (en) | 2001-08-06 | 2003-04-10 | Curtis Wright | Pharmaceutical formulation containing gelling agent |
| US20110033542A1 (en) | 2009-08-07 | 2011-02-10 | Monosol Rx, Llc | Sublingual and buccal film compositions |
| US10285910B2 (en) | 2001-10-12 | 2019-05-14 | Aquestive Therapeutics, Inc. | Sublingual and buccal film compositions |
| US8900497B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for making a film having a substantially uniform distribution of components |
| US8765167B2 (en) | 2001-10-12 | 2014-07-01 | Monosol Rx, Llc | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
| US8900498B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for manufacturing a resulting multi-layer pharmaceutical film |
| US20190328679A1 (en) | 2001-10-12 | 2019-10-31 | Aquestive Therapeutics, Inc. | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
| US11207805B2 (en) | 2001-10-12 | 2021-12-28 | Aquestive Therapeutics, Inc. | Process for manufacturing a resulting pharmaceutical film |
| US20070281003A1 (en) | 2001-10-12 | 2007-12-06 | Fuisz Richard C | Polymer-Based Films and Drug Delivery Systems Made Therefrom |
| US8603514B2 (en) | 2002-04-11 | 2013-12-10 | Monosol Rx, Llc | Uniform films for rapid dissolve dosage form incorporating taste-masking compositions |
| US7357891B2 (en) | 2001-10-12 | 2008-04-15 | Monosol Rx, Llc | Process for making an ingestible film |
| US7666337B2 (en) | 2002-04-11 | 2010-02-23 | Monosol Rx, Llc | Polyethylene oxide-based films and drug delivery systems made therefrom |
| US8017150B2 (en) | 2002-04-11 | 2011-09-13 | Monosol Rx, Llc | Polyethylene oxide-based films and drug delivery systems made therefrom |
| DE10224607B4 (de) * | 2002-06-04 | 2008-03-13 | Lts Lohmann Therapie-Systeme Ag | Filmförmige, zerfallsfähige Zubereitungen zur Wirkstofffreisetzung und Verfahren zu deren Herstellung |
| US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
| US7442387B2 (en) * | 2003-03-06 | 2008-10-28 | Astellas Pharma Inc. | Pharmaceutical composition for controlled release of active substances and manufacturing method thereof |
| ES2570454T3 (es) | 2003-03-26 | 2016-05-18 | Egalet Ltd | Sistema de liberación controlada de morfina |
| DE102004032051A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten, festen Darreichungsform |
| US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
| US8075872B2 (en) | 2003-08-06 | 2011-12-13 | Gruenenthal Gmbh | Abuse-proofed dosage form |
| DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| DE102005005446A1 (de) * | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
| PT1842533E (pt) | 2003-08-06 | 2013-05-17 | Gruenenthal Gmbh | Forma de dosagem protegida contra abuso |
| DE10336400A1 (de) * | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
| US8025899B2 (en) | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
| US8377952B2 (en) | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
| US7201920B2 (en) | 2003-11-26 | 2007-04-10 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of opioid containing dosage forms |
| CA2557848C (en) | 2004-03-30 | 2013-12-10 | Ilypsa, Inc. | Ion binding compositions |
| TW201509943A (zh) | 2004-03-30 | 2015-03-16 | Euro Celtique Sa | 含有小於２５ｐｐｍ１４-羥可待因酮之羥可酮鹽酸鹽之組成物、醫藥劑型、延遲釋出口服劑型及醫藥上可以接受的包裝 |
| US20050238721A1 (en) * | 2004-04-07 | 2005-10-27 | Acquarulo Lawrence A Jr | One step compounding extrusion of drug filled polymers |
| WO2005107702A2 (en) * | 2004-05-11 | 2005-11-17 | Glenmark Pharmaceuticals Limited | Sustained release, mucoadhesive vaginal pharmaceutical compositions |
| EP3326617A1 (en) | 2004-06-12 | 2018-05-30 | Collegium Pharmaceutical, Inc. | Abuse-deterrent drug formulations |
| PL1765303T5 (pl) † | 2004-07-01 | 2023-05-22 | Grünenthal GmbH | Tabletka doustna zabezpieczona przed nadużywaniem |
| DE102004032103A1 (de) * | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
| DE102004032049A1 (de) * | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
| US20080152595A1 (en) * | 2004-11-24 | 2008-06-26 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse of orally administered pharmaceutical products |
| US20060147518A1 (en) * | 2004-12-30 | 2006-07-06 | Pierre Fabre Medicament | Stable solid dispersion of a derivative of vinca alkaloid and process for manufacturing it |
| DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| EP1962808B1 (en) * | 2005-12-14 | 2010-09-29 | F. Hoffmann-La Roche AG | Hcv prodrug formulation |
| EP1978940B1 (en) * | 2006-01-19 | 2010-12-29 | Dow Global Technologies Inc. | Biologically active composition comprising ethylcellulose |
| SA07280459B1 (ar) | 2006-08-25 | 2011-07-20 | بيورديو فارما إل. بي. | أشكال جرعة صيدلانية للتناول عن طريق الفم مقاومة للعبث تشتمل على مسكن شبه أفيوني |
| US20080181959A1 (en) * | 2006-09-01 | 2008-07-31 | Ilan Zalit | Solid composites of a calcium receptor-active compound |
| DE102007011485A1 (de) | 2007-03-07 | 2008-09-11 | Grünenthal GmbH | Darreichungsform mit erschwertem Missbrauch |
| EP2155167A2 (en) | 2007-06-04 | 2010-02-24 | Egalet A/S | Controlled release pharmaceutical compositions for prolonged effect |
| KR20100067655A (ko) * | 2007-08-28 | 2010-06-21 | 다우 글로벌 테크놀로지스 인크. | 세정 용도를 위한 캡슐화된 활성 성분 |
| AU2009207796B2 (en) | 2008-01-25 | 2014-03-27 | Grunenthal Gmbh | Pharmaceutical dosage form |
| US8372432B2 (en) | 2008-03-11 | 2013-02-12 | Depomed, Inc. | Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic |
| CA2720108C (en) | 2008-03-11 | 2016-06-07 | Depomed, Inc. | Gastric retentive extended-release dosage forms comprising combinations of a non-opioid analgesic and an opioid analgesic |
| KR101690094B1 (ko) | 2008-05-09 | 2016-12-27 | 그뤼넨탈 게엠베하 | 분무 응결 단계의 사용하에 중간 분말 제형 및 최종 고체 제형을 제조하는 방법 |
| JP2012501967A (ja) * | 2008-08-20 | 2012-01-26 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | 調節放出型多粒子のホットメルト押出成形 |
| TWI478712B (zh) | 2008-09-30 | 2015-04-01 | Astellas Pharma Inc | 釋控性醫藥組成物 |
| MY160340A (en) * | 2008-10-07 | 2017-02-28 | Astrazeneca Uk Ltd | Pharmaceutical formulation 514 |
| WO2010089132A1 (en) | 2009-02-06 | 2010-08-12 | Egalet A/S | Immediate release composition resistant to abuse by intake of alcohol |
| CA2766179A1 (en) | 2009-06-24 | 2010-12-29 | Egalet Ltd. | Controlled release formulations |
| ES2428938T3 (es) | 2009-07-22 | 2013-11-12 | Grünenthal GmbH | Forma de dosificación resistente a la manipulación y estabilizada frente a la oxidación |
| CA2765971C (en) | 2009-07-22 | 2017-08-22 | Gruenenthal Gmbh | Hot-melt extruded controlled release dosage form |
| WO2011041414A1 (en) * | 2009-09-30 | 2011-04-07 | Acura Pharmaceuticals, Inc. | Methods and compositions for deterring abuse |
| US10668060B2 (en) | 2009-12-10 | 2020-06-02 | Collegium Pharmaceutical, Inc. | Tamper-resistant pharmaceutical compositions of opioids and other drugs |
| US9198861B2 (en) | 2009-12-22 | 2015-12-01 | Mallinckrodt Llc | Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans |
| US8597681B2 (en) | 2009-12-22 | 2013-12-03 | Mallinckrodt Llc | Methods of producing stabilized solid dosage pharmaceutical compositions containing morphinans |
| WO2011095314A2 (en) | 2010-02-03 | 2011-08-11 | Grünenthal GmbH | Preparation of a powdery pharmaceutical composition by means of an extruder |
| JP5849947B2 (ja) | 2010-03-29 | 2016-02-03 | アステラス製薬株式会社 | 放出制御医薬組成物 |
| RU2604676C2 (ru) | 2010-09-02 | 2016-12-10 | Грюненталь Гмбх | Устойчивая к разрушению лекарственная форма, содержащая неорганическую соль |
| PL2611425T3 (pl) | 2010-09-02 | 2014-09-30 | Gruenenthal Gmbh | Odporna na ingerencję postać dawki zawierająca polimer anionowy |
| US9149959B2 (en) | 2010-10-22 | 2015-10-06 | Monosol Rx, Llc | Manufacturing of small film strips |
| EP2635258A1 (en) | 2010-11-04 | 2013-09-11 | AbbVie Inc. | Drug formulations |
| CA2816330A1 (en) | 2010-11-04 | 2012-05-10 | Abbvie Inc. | Method for producing monolithic tablets |
| AU2011346757B2 (en) | 2010-12-22 | 2015-08-20 | Purdue Pharma L.P. | Encased tamper resistant controlled release dosage forms |
| PH12013501345A1 (en) | 2010-12-23 | 2022-10-24 | Purdue Pharma Lp | Tamper resistant solid oral dosage forms |
| SMT201700010T1 (it) | 2011-04-29 | 2017-03-08 | Moberg Pharma Ab | Composizioni farmaceutiche comprendenti un anestetico locale come bupivacaina per somministrazione locale alla bocca o alla gola |
| US8858963B1 (en) | 2011-05-17 | 2014-10-14 | Mallinckrodt Llc | Tamper resistant composition comprising hydrocodone and acetaminophen for rapid onset and extended duration of analgesia |
| US8741885B1 (en) | 2011-05-17 | 2014-06-03 | Mallinckrodt Llc | Gastric retentive extended release pharmaceutical compositions |
| US8658631B1 (en) | 2011-05-17 | 2014-02-25 | Mallinckrodt Llc | Combination composition comprising oxycodone and acetaminophen for rapid onset and extended duration of analgesia |
| HRP20171458T1 (hr) | 2011-07-29 | 2017-11-17 | Grünenthal GmbH | Tableta otporna na mijenjanje koja pruža neposredno oslobađanje lijeka |
| PL2736495T3 (pl) | 2011-07-29 | 2018-01-31 | Gruenenthal Gmbh | Tabletka odporna na ingerencję, zapewniająca natychmiastowe uwalnianie leku |
| WO2013127831A1 (en) | 2012-02-28 | 2013-09-06 | Grünenthal GmbH | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
| LT2838512T (lt) | 2012-04-18 | 2018-11-12 | GrĆ¼nenthal GmbH | Pažeidimui atspari ir dozės atpalaidavimo nuokrypiui atspari farmacinė vaisto forma |
| US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
| WO2014011830A1 (en) | 2012-07-12 | 2014-01-16 | Mallinckrodt Llc | Extended release, abuse deterrent pharmaceutical compositions |
| US10702453B2 (en) | 2012-11-14 | 2020-07-07 | Xerox Corporation | Method and system for printing personalized medication |
| RU2018141241A (ru) | 2012-11-30 | 2019-01-24 | Экьюра Фармасьютикалз, Инк. | Саморегулируемое высвобождение фармацевтического ингредиента |
| KR101659983B1 (ko) | 2012-12-31 | 2016-09-26 | 주식회사 삼양바이오팜 | 용융 압출된 방출 제어용 약학 조성물, 및 이를 포함하는 경구용 제제 |
| MX2015010041A (es) | 2013-02-05 | 2015-10-30 | Purdue Pharma Lp | Formulacion farmaceuticas resistentes a la alteracion. |
| US10751287B2 (en) | 2013-03-15 | 2020-08-25 | Purdue Pharma L.P. | Tamper resistant pharmaceutical formulations |
| AR096438A1 (es) | 2013-05-29 | 2015-12-30 | Gruenenthal Gmbh | Forma de dosificación resistente al uso indebido con perfil de liberación bimodal, proceso |
| JP6445537B2 (ja) | 2013-05-29 | 2018-12-26 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | １個または複数の粒子を含有する改変防止（ｔａｍｐｅｒ−ｒｅｓｉｓｔａｎｔ）剤形 |
| US10624862B2 (en) | 2013-07-12 | 2020-04-21 | Grünenthal GmbH | Tamper-resistant dosage form containing ethylene-vinyl acetate polymer |
| JP6539274B2 (ja) | 2013-08-12 | 2019-07-03 | ファーマシューティカル マニュファクチュアリング リサーチ サービシズ，インコーポレーテッド | 押出成形された即放性乱用抑止性丸剤 |
| JP6480936B2 (ja) | 2013-11-26 | 2019-03-13 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | クライオミリングによる粉末状医薬組成物の調製 |
| US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| US10172797B2 (en) | 2013-12-17 | 2019-01-08 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| JP6403780B2 (ja) * | 2013-12-17 | 2018-10-10 | ファーマシューティカル マニュファクチュアリング リサーチ サービシズ，インコーポレーテッド | 押出成形された持続放出性乱用抑止性丸剤 |
| WO2015120201A1 (en) | 2014-02-05 | 2015-08-13 | Kashiv Pharma, Llc | Abuse-resistant drug formulations with built-in overdose protection |
| WO2015145459A1 (en) | 2014-03-26 | 2015-10-01 | Sun Pharma Advanced Research Company Ltd. | Abuse deterrent immediate release coated reservoir solid dosage form |
| JP2017518980A (ja) | 2014-05-12 | 2017-07-13 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | タペンタドールを含む、改変防止即時放出カプセル製剤 |
| CN106456550A (zh) | 2014-05-26 | 2017-02-22 | 格吕伦塔尔有限公司 | 避免乙醇剂量倾泻的多颗粒 |
| EP3169315B1 (en) | 2014-07-17 | 2020-06-24 | Pharmaceutical Manufacturing Research Services, Inc. | Immediate release abuse deterrent liquid fill dosage form |
| US9132096B1 (en) | 2014-09-12 | 2015-09-15 | Alkermes Pharma Ireland Limited | Abuse resistant pharmaceutical compositions |
| AU2015317358A1 (en) * | 2014-09-19 | 2017-04-27 | Board Of Regents, The University Of Texas System | Methods of preparing extrudates |
| US20160106737A1 (en) | 2014-10-20 | 2016-04-21 | Pharmaceutical Manufacturing Research Services, Inc. | Extended Release Abuse Deterrent Liquid Fill Dosage Form |
| KR20170139158A (ko) | 2015-04-24 | 2017-12-18 | 그뤼넨탈 게엠베하 | 즉시 방출되고 용매 추출 방지된 변조 방지된 투여 형태 |
| JP6938462B2 (ja) | 2015-07-28 | 2021-09-22 | ボード オブ リージェンツ, ザ ユニバーシティ オブ テキサス システムBoard Of Regents, The University Of Texas System | 治療用化合物の脳への一方向送達のためのインプラント組成物 |
| US11103581B2 (en) | 2015-08-31 | 2021-08-31 | Acura Pharmaceuticals, Inc. | Methods and compositions for self-regulated release of active pharmaceutical ingredient |
| WO2017042325A1 (en) | 2015-09-10 | 2017-03-16 | Grünenthal GmbH | Protecting oral overdose with abuse deterrent immediate release formulations |
| US9861629B1 (en) | 2015-10-07 | 2018-01-09 | Banner Life Sciences Llc | Opioid abuse deterrent dosage forms |
| US11065246B2 (en) | 2016-02-08 | 2021-07-20 | SpecGx LLC | Glucomannan containing pharmaceutical compositions with extended release and abuse deterrent properties |
| MX2018011799A (es) | 2016-03-31 | 2019-01-24 | SpecGx LLC | Formas de dosificacion de liberacion prolongada disuasivas de abuso. |
| US10335405B1 (en) | 2016-05-04 | 2019-07-02 | Patheon Softgels, Inc. | Non-burst releasing pharmaceutical composition |
| US11273131B2 (en) | 2016-05-05 | 2022-03-15 | Aquestive Therapeutics, Inc. | Pharmaceutical compositions with enhanced permeation |
| KR20190005199A (ko) | 2016-05-05 | 2019-01-15 | 어퀘스티브 테라퓨틱스, 아이엔씨. | 강화된 전달 에프네프린 조성물 |
| US12433850B2 (en) | 2016-05-05 | 2025-10-07 | Aquestive Therapeutics, Inc. | Enhanced delivery epinephrine and prodrug compositions |
| US12427121B2 (en) | 2016-05-05 | 2025-09-30 | Aquestive Therapeutics, Inc. | Enhanced delivery epinephrine compositions |
| US9737530B1 (en) | 2016-06-23 | 2017-08-22 | Collegium Pharmaceutical, Inc. | Process of making stable abuse-deterrent oral formulations |
| EP3269361A1 (en) | 2016-07-14 | 2018-01-17 | Omya International AG | Dosage form |
| US10335375B2 (en) | 2017-05-30 | 2019-07-02 | Patheon Softgels, Inc. | Anti-overingestion abuse deterrent compositions |
| WO2019051437A1 (en) * | 2017-09-11 | 2019-03-14 | Board Of Regents, The University Of Texas System | COMPOSITIONS FOR ENHANCED MEDICATION DELIVERY |
| EP3755785A1 (en) | 2018-02-22 | 2020-12-30 | The Procter & Gamble Company | Methods for making unit dose articles |
| US20200147032A1 (en) | 2018-11-14 | 2020-05-14 | Robert K. Prud'homme | Dihydromyricetin hot melt extrusion formulations and methods for forming them |
| WO2023076281A1 (en) | 2021-10-25 | 2023-05-04 | Aquestive Therapeutics, Inc. | Oral and nasal compositions and methods of treatment |
| US12097189B1 (en) | 2024-02-09 | 2024-09-24 | Astellas Pharma Inc. | Pharmaceutical composition for modified release |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3806603A (en) | 1969-10-13 | 1974-04-23 | W Gaunt | Pharmaceutical carriers of plasticized dried milled particles of hydrated cooked rice endosperm |
| US4211681A (en) * | 1978-08-16 | 1980-07-08 | Union Carbide Corporation | Poly(ethylene oxide) compositions |
| US4629621A (en) | 1984-07-23 | 1986-12-16 | Zetachron, Inc. | Erodible matrix for sustained release bioactive composition |
| AU592065B2 (en) | 1984-10-09 | 1990-01-04 | Dow Chemical Company, The | Sustained release dosage form based on highly plasticized cellulose ether gels |
| US4764378A (en) | 1986-02-10 | 1988-08-16 | Zetachron, Inc. | Buccal drug dosage form |
| US4713243A (en) * | 1986-06-16 | 1987-12-15 | Johnson & Johnson Products, Inc. | Bioadhesive extruded film for intra-oral drug delivery and process |
| US4774976A (en) | 1987-09-23 | 1988-10-04 | Applied Power Inc. | Modulating hydraulic pressure control valve and assembly method therefor |
| US5004601A (en) | 1988-10-14 | 1991-04-02 | Zetachron, Inc. | Low-melting moldable pharmaceutical excipient and dosage forms prepared therewith |
| DE69212497T2 (de) | 1991-12-05 | 1996-12-12 | Mallinckrodt Veterinary, Inc., Mundelein, Ill. | Glasartige kohlenhydratenmatrize zur verabreichung von heilmitteln mit verzögerter wirkstoffabgabe |
| CA2124821C (en) | 1991-12-18 | 2003-10-07 | Isaac Ghebre-Sellassie | Novel solid pharmaceutical dispersions |
| DK0661045T3 (da) * | 1992-09-18 | 2002-10-28 | Yamanouchi Pharma Co Ltd | Hydrogelpræparat med forsinket frigivelse |
| FI101039B (fi) | 1992-10-09 | 1998-04-15 | Eeva Kristoffersson | Menetelmä lääkepellettien valmistamiseksi |
| AU679937B2 (en) | 1992-11-18 | 1997-07-17 | Johnson & Johnson Consumer Products, Inc. | Extrudable compositions for topical or transdermal drug delivery |
| ES2199981T3 (es) | 1994-02-16 | 2004-03-01 | Abbott Laboratories | Modo de preparacion de formulaciones farmaceuticas de particulas finas. |
-
1997
- 1997-06-24 AU AU35080/97A patent/AU3508097A/en not_active Abandoned
- 1997-06-24 DE DE69739343T patent/DE69739343D1/de not_active Expired - Lifetime
- 1997-06-24 ES ES97931455T patent/ES2325046T3/es not_active Expired - Lifetime
- 1997-06-24 PT PT97931455T patent/PT1014941E/pt unknown
- 1997-06-24 EP EP09003265A patent/EP2065055A1/en not_active Withdrawn
- 1997-06-24 DE DE09003265T patent/DE09003265T1/de active Pending
- 1997-06-24 EP EP10185104.6A patent/EP2272536B1/en not_active Expired - Lifetime
- 1997-06-24 WO PCT/US1997/011206 patent/WO1997049384A1/en not_active Ceased
- 1997-06-24 EP EP97931455.6A patent/EP1014941B2/en not_active Expired - Lifetime
- 1997-06-24 ES ES09003265T patent/ES2334768T1/es active Pending
- 1997-06-24 AT AT97931455T patent/ATE427124T1/de active
- 1997-06-24 DK DK97931455T patent/DK1014941T3/da active
-
1999
- 1999-03-02 US US09/260,694 patent/US6488963B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP2272536A2 (en) | 2011-01-12 |
| ATE427124T1 (de) | 2009-04-15 |
| DK1014941T3 (da) | 2009-07-27 |
| EP2065055A1 (en) | 2009-06-03 |
| EP1014941A4 (en) | 2005-11-09 |
| WO1997049384A1 (en) | 1997-12-31 |
| DE09003265T1 (de) | 2010-04-29 |
| ES2325046T3 (es) | 2009-08-24 |
| US6488963B1 (en) | 2002-12-03 |
| PT1014941E (pt) | 2009-07-08 |
| AU3508097A (en) | 1998-01-14 |
| EP1014941B1 (en) | 2009-04-01 |
| EP1014941A1 (en) | 2000-07-05 |
| DE69739343D1 (de) | 2009-05-14 |
| EP1014941B2 (en) | 2017-05-17 |
| EP2272536A3 (en) | 2012-05-16 |
| EP2272536B1 (en) | 2016-05-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2334768T1 (es) | Formulacion farmaceutica extruible de liberacion controlada. | |
| US6290984B1 (en) | Pharmaceutical preparation applicable to mucosal surfaces and body tissues | |
| EP0430474B1 (en) | Sustained release compositions for treating periodontal disease | |
| DE69628783T2 (de) | Hydrogelbildende, selbst-solvatisierende, absorbierbare Polyestercopolymere sowie Verfahren zu deren Verwendung | |
| CN1198625C (zh) | 用于治疗粘膜炎、口炎和贝赫切特综合征的药物组合物 | |
| EP0429224B1 (en) | Use of monoolein in the treatment of the periodontal pocket | |
| EP1408034B2 (de) | Verwendung von Chinolon- und Chinolizinon-Derivaten als Chemotherapeutika | |
| RU2075965C1 (ru) | Средство для лечения заболеваний полости рта | |
| GR870935B (en) | Bioadhesive extruded film for intra oral drug delivery and process | |
| CN1929819A (zh) | 递送活性剂的快速溶解膜 | |
| IT1282352B1 (it) | Composizione farmaceutica, in particolare essiccata mediante congelamento, per somministrazione orale di ondansetron e metodo per | |
| BR9612291A (pt) | Forma de dosagem sólida bioadesiva | |
| HUE027226T2 (en) | Treatment of mucosal inflammation and inflammatory pain using a sustained release bioadhesive therapeutic carrier in the mucosa | |
| KR102663478B1 (ko) | 에다라본 약제학적 조성물 | |
| WO2004108162A3 (en) | Controlled release pharmaceutical composition | |
| MY121105A (en) | Sustained release pharmaceutical composition and method of releasing pharmaceutically active agent | |
| DE602004009552D1 (de) | Orales abgabesystem mit einem antibakteriellen und einem entzündungshemmenden mittel | |
| KR910009241A (ko) | 치근막 질환 치료용 서방성 조성물 | |
| JPH09503504A (ja) | 成人歯周炎の治療のためのアジトロマイシンの用途とこの用途のための局所組成物 | |
| JP2002544233A5 (es) | ||
| RU2003105812A (ru) | Композиции и дозируемые формы, предназначенные для применения в полости рта с целью лечения микозов | |
| JP2959833B2 (ja) | 徐放性口腔内疾患治療剤およびその製法 | |
| RU2242963C2 (ru) | Мукоадгезивная композиция для лечения стоматологических заболеваний и способ ее полученияя | |
| JP2000063268A (ja) | 口腔粘膜付着型徐放性錠剤及び歯周疾患治療剤 | |
| CN100345542C (zh) | 用于治疗口腔炎症的替硝唑口腔贴片 |