[go: up one dir, main page]

ES2397671T8 - Procedimiento para preparar voriconazol - Google Patents

Procedimiento para preparar voriconazol Download PDF

Info

Publication number
ES2397671T8
ES2397671T8 ES08793030T ES08793030T ES2397671T8 ES 2397671 T8 ES2397671 T8 ES 2397671T8 ES 08793030 T ES08793030 T ES 08793030T ES 08793030 T ES08793030 T ES 08793030T ES 2397671 T8 ES2397671 T8 ES 2397671T8
Authority
ES
Spain
Prior art keywords
procedure
voriconazole
prepare
prepare voriconazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES08793030T
Other languages
English (en)
Other versions
ES2397671T3 (es
Inventor
Young Ho Moon
Moon Sub Lee
Jae Ho Yoo
Ji Sook Kim
Han Kyong Kim
Chang Ju Choi
Young Kil Chang
Gwan Sun Lee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hanmi Pharmaceutical Co Ltd
Hanmi Science Co Ltd
Hanmi Pharmaceutical Industries Co Ltd
Original Assignee
Hanmi Pharmaceutical Co Ltd
Hanmi Science Co Ltd
Hanmi Pharmaceutical Industries Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hanmi Pharmaceutical Co Ltd, Hanmi Science Co Ltd, Hanmi Pharmaceutical Industries Co Ltd filed Critical Hanmi Pharmaceutical Co Ltd
Application granted granted Critical
Publication of ES2397671T3 publication Critical patent/ES2397671T3/es
Publication of ES2397671T8 publication Critical patent/ES2397671T8/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ES08793030T 2007-08-06 2008-08-04 Procedimiento para preparar voriconazol Active ES2397671T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR1020070078439A KR100889937B1 (ko) 2007-08-06 2007-08-06 보리코나졸의 제조방법
KR20070078439 2007-08-06
PCT/KR2008/004516 WO2009020323A2 (en) 2007-08-06 2008-08-04 Process for preparing voriconazole

Publications (2)

Publication Number Publication Date
ES2397671T3 ES2397671T3 (es) 2013-03-08
ES2397671T8 true ES2397671T8 (es) 2013-05-23

Family

ID=40341890

Family Applications (1)

Application Number Title Priority Date Filing Date
ES08793030T Active ES2397671T3 (es) 2007-08-06 2008-08-04 Procedimiento para preparar voriconazol

Country Status (11)

Country Link
US (1) US8263769B2 (es)
EP (1) EP2173736B1 (es)
JP (1) JP5232230B2 (es)
KR (1) KR100889937B1 (es)
CN (1) CN101765595A (es)
AU (1) AU2008284593B2 (es)
CA (1) CA2695359C (es)
ES (1) ES2397671T3 (es)
IL (1) IL203646A (es)
RU (1) RU2434009C1 (es)
WO (1) WO2009020323A2 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101109215B1 (ko) 2009-06-17 2012-01-30 보령제약 주식회사 보리코나졸의 신규 중간체 및 이를 이용한 보리코나졸의 제조방법
WO2011045807A2 (en) * 2009-10-14 2011-04-21 Neuland Laboratories Ltd. A novel process to manufacture (2r,3s)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1h-1,2,4-triazol-1-yl)butan-2-ol
KR100971371B1 (ko) * 2010-02-04 2010-07-20 동국제약 주식회사 신규한 중간체를 이용한 보리코나졸의 제조방법
WO2011110198A1 (en) 2010-03-10 2011-09-15 Synthron B.V. A process for making voriconazole
CN102344441B (zh) * 2010-07-25 2015-05-06 浙江华海药业股份有限公司 一种制备伏立康唑中间体的工艺改进方法
CN102516233B (zh) * 2011-12-09 2014-04-09 北京联本医药化学技术有限公司 生产伏立康唑的方法
DK2906555T3 (en) * 2012-10-15 2017-02-06 Pfizer Ireland Pharmaceuticals Process for the preparation of voriconazole and analogs thereof
KR101435741B1 (ko) 2013-01-17 2014-08-29 (주) 에프엔지리서치 신규한 보리코나졸 중간체 및 이를 이용한 보리코나졸의 제조 방법
AU2015231275B2 (en) 2014-03-19 2019-03-07 Mycovia Pharmaceuticals, Inc. Antifungal compound process
JP2017509646A (ja) 2014-03-19 2017-04-06 ヴィアメット ファーマスーティカルズ，インコーポレイテッド 抗真菌化合物の調製方法
EP3119771B1 (en) 2014-03-19 2020-05-06 Mycovia Pharmaceuticals, Inc. Antifungal compound process
BR112016021257B1 (pt) 2014-03-19 2021-03-02 Viamet Pharmaceuticals (NC), Inc. 2-(2,4- difluorofenil-1,1-diflúor-1-(5-substituído-piridin-2-il)-3- (1h-tetrazol-1-il)propan-2-óis e processos para preparação e uso dos mesmos
MX365494B (es) 2014-03-19 2019-06-05 Us Health Procedimiento de compuesto antifungico.
JP2017514790A (ja) 2014-03-19 2017-06-08 ヴィアメット ファーマスーティカルズ，インコーポレイテッド 抗真菌化合物の調製方法
WO2015143192A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation
JP6572234B2 (ja) 2014-03-19 2019-09-04 ヴィアメット ファーマスーティカルズ（エヌシー），インコーポレイテッド 抗真菌化合物の調製方法
US10399943B2 (en) 2014-03-19 2019-09-03 Mycovia Pharmaceuticals, Inc. Antifungal compound process
DK3297998T3 (da) * 2015-05-18 2020-03-16 Viamet Pharmaceuticals Nc Inc Antisvampeforbindelser
US10513505B2 (en) 2015-09-18 2019-12-24 Nqp 1598, Ltd. Antifungal compound process
CN106432198B (zh) * 2016-09-08 2022-10-21 浙江华海药业股份有限公司 一种制备伏立康唑拆分中间体的方法
CN108169382B (zh) * 2018-02-06 2020-05-12 成都倍特药业股份有限公司 伏立康唑起始物料4-氯-6-乙基-5-氟嘧啶中杂质的检测方法
CN111217758A (zh) * 2020-03-18 2020-06-02 湖南复瑞生物医药技术有限责任公司 一种6-乙基-5-氟-4-氯嘧啶的制备方法
CN112079819B (zh) * 2020-09-24 2022-06-17 南京易亨制药有限公司 一种改进的伏立康唑消旋体制备方法
CN113929660B (zh) * 2021-10-18 2022-10-04 深圳市海滨制药有限公司 一种环氧乙烷衍生物开环方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9002375D0 (en) * 1990-02-02 1990-04-04 Pfizer Ltd Triazole antifungal agents
GB9121456D0 (en) * 1991-10-10 1991-11-27 Pfizer Ltd Triazole antifungal agents
GB9516121D0 (en) 1995-08-05 1995-10-04 Pfizer Ltd Organometallic addition to ketones
GB9602080D0 (en) * 1996-02-02 1996-04-03 Pfizer Ltd Pharmaceutical compounds
CN1488630A (zh) * 2002-10-08 2004-04-14 张文更 制备三唑类抗真菌剂的方法
US7887880B2 (en) * 2004-06-30 2011-02-15 Auburn University Preparation and application of stabilized iron nanoparticles for dechlorination of chlorinated hydrocarbons in soils, sediments, and ground water
CA2590687C (en) * 2004-12-14 2013-09-10 Dr. Reddy's Laboratories Ltd. Process for preparing voriconazole
WO2007013096A1 (en) * 2005-06-30 2007-02-01 Msn Laboratories Limited Improved process for the preparation of 2r, 3s-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1h-1,2,4-triazol-1-yl) butan-2-ol (voriconazole)
CN1814597A (zh) * 2005-12-09 2006-08-09 北京丰德医药科技有限公司 一种制备伏立康唑的新方法
EP2024344A2 (en) * 2006-02-01 2009-02-18 Medichem, S.A. Process for preparing voriconazole, new polymorphic form of intermediate thereof, and uses thereof
GB2452049A (en) * 2007-08-21 2009-02-25 Alpharma Aps Process for the preparation of voriconazole
WO2009084029A2 (en) * 2007-12-03 2009-07-09 Neuland Laboratories Ltd Improved process for the preparation of (2r,3s)-2-(2,4- difluqrophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1h-1,2,4-triazol-1-yl) butan-2-ol

Also Published As

Publication number Publication date
EP2173736A4 (en) 2011-03-23
CA2695359A1 (en) 2009-02-12
KR20090014468A (ko) 2009-02-11
JP2010535197A (ja) 2010-11-18
EP2173736A2 (en) 2010-04-14
AU2008284593A1 (en) 2009-02-12
CA2695359C (en) 2012-03-20
AU2008284593B2 (en) 2011-03-31
KR100889937B1 (ko) 2009-03-20
IL203646A (en) 2014-05-28
RU2434009C1 (ru) 2011-11-20
US8263769B2 (en) 2012-09-11
ES2397671T3 (es) 2013-03-08
US20100190983A1 (en) 2010-07-29
EP2173736B1 (en) 2012-10-17
WO2009020323A2 (en) 2009-02-12
JP5232230B2 (ja) 2013-07-10
RU2010108266A (ru) 2011-09-20
WO2009020323A3 (en) 2009-04-09
CN101765595A (zh) 2010-06-30

Similar Documents

Publication Publication Date Title
ES2397671T8 (es) Procedimiento para preparar voriconazol
BRPI0807453A2 (pt) Preparação sólida
HRP20170963T1 (hr) Modificirani saharidi
BRPI0919466A2 (pt) composição farmacêutica para liberação modificada
EP2281635A4 (en) CUTTER
FIC20240018I1 (fi) Vamoroloni
BRPI0812818A2 (pt) Turbo-reator para aeronave
DK2125048T3 (da) Præparat
BRPI0819633A2 (pt) Métodos para produzir poliolefinas
BR112012008141A2 (pt) arquivo cirúrgico
BRPI0912662A2 (pt) trocarte
DK2173197T3 (da) Fremgangsmåde
BRPI0908497A2 (pt) métodos e composições para um rendimento aumentado
FI20085370L (fi) Pituusleikkuri
ES1070148Y (es) Macolla para barrotes mejorada
ES1065835Y (es) Caperuza para cetreria
ES1070104Y (es) Tirafondo para madera
EP2202304A4 (en) MODIFIED CREATININE AMIDOHYDROLASE
ES1066084Y (es) Poliedro tetraedro desmontable
FI8739U1 (fi) Polttolaite
PT2365818T (pt) Composição dermatológica hipoalergénica
ES1067150Y (es) Soporte-percha para sombreros
ES1066306Y (es) Pieza para corseteria
ES1065263Y (es) Captafaros para bionda
ES1070017Y (es) Plantilla para prevenir juanetes