[go: up one dir, main page]

ES2361459A8 - Gel de quitosano para aplicaciones dermatológicas, proceso de obtención y uso del mismo. - Google Patents

Gel de quitosano para aplicaciones dermatológicas, proceso de obtención y uso del mismo. Download PDF

Info

Publication number
ES2361459A8
ES2361459A8 ES201050012A ES201050012A ES2361459A8 ES 2361459 A8 ES2361459 A8 ES 2361459A8 ES 201050012 A ES201050012 A ES 201050012A ES 201050012 A ES201050012 A ES 201050012A ES 2361459 A8 ES2361459 A8 ES 2361459A8
Authority
ES
Spain
Prior art keywords
gel
skin
give
chitosan
obtaining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES201050012A
Other languages
English (en)
Other versions
ES2361459A1 (es
ES2361459B1 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Igloo Zone Chile SL
Gynopharm SA
Original Assignee
Igloo Zone Chile SL
Gynopharm SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Igloo Zone Chile SL, Gynopharm SA filed Critical Igloo Zone Chile SL
Publication of ES2361459A1 publication Critical patent/ES2361459A1/es
Publication of ES2361459A8 publication Critical patent/ES2361459A8/es
Application granted granted Critical
Publication of ES2361459B1 publication Critical patent/ES2361459B1/es
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/164Amides, e.g. hydroxamic acids of a carboxylic acid with an aminoalcohol, e.g. ceramides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/201Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716Glucans
    • A61K31/722Chitin, chitosan
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/324Boswellia, e.g. frankincense
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/328Commiphora, e.g. mecca myrrh or balm of Gilead
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/36Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A61K47/48
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12Carboxylic acids; Salts or anhydrides thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Mycology (AREA)
  • Botany (AREA)
  • Biotechnology (AREA)
  • Medical Informatics (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Gel de quitosano para aplicaciones dermatológicas, proceso de obtención y uso del mismo, se protegen las composiciones farmacéuticas que son apropiadas para dejar una película protectora sobre la piel, en base a quitosano y agentes que le confieren propiedades curativas, calmantes e hidratantes en pieles irritadas. Este gel se caracteriza por incorporar quitosano en un porcentaje que va entre 2 y un 8% y otros componentes, también en proporción definida como la Portulaca, entre 0,1 y 90% y Pantenol en proporción entre 0,1 y 45% que le confieren mejores características terapéuticas al producto y otros componentes que le dan sus características propias al gel y le confieren una estabilidad adecuada y prolongadas en el tiempo. Este gel es de aplicación externa y puede ser usado en pieles irritadas, quemaduras superficiales, dermoabrasiones, post-peeling, post-laser y en general en pieles erosionadas.
ES201050012A 2008-01-18 2009-01-21 Gel de quitosano para aplicaciones dermatológicas, proceso de obtención y uso del mismo. Expired - Fee Related ES2361459B1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CL0156-2008 2008-01-18
CL200800156A CL2008000156A1 (es) 2008-01-18 2008-01-18 Gel estable hidrofilo en base a un polimero para aplicacion topica porque comprende quitosano disuelto en un solvente; proceso para obtener el gel para uso topico antes mencionado; uso del gel.
PCT/IB2009/050228 WO2009090624A2 (es) 2008-01-18 2009-01-21 Gel de quitosano para aplicaciones dermatológicas, proceso de obtención y uso del mismo

Publications (3)

Publication Number Publication Date
ES2361459A1 ES2361459A1 (es) 2011-06-17
ES2361459A8 true ES2361459A8 (es) 2011-07-21
ES2361459B1 ES2361459B1 (es) 2012-04-24

Family

ID=40261146

Family Applications (1)

Application Number Title Priority Date Filing Date
ES201050012A Expired - Fee Related ES2361459B1 (es) 2008-01-18 2009-01-21 Gel de quitosano para aplicaciones dermatológicas, proceso de obtención y uso del mismo.

Country Status (14)

Country Link
US (1) US20100316739A1 (es)
EP (1) EP2452673B1 (es)
JP (1) JP5615717B2 (es)
CN (1) CN101977589B (es)
AR (1) AR071334A1 (es)
BR (1) BRPI0906932A2 (es)
CA (1) CA2712527C (es)
CL (1) CL2008000156A1 (es)
CO (1) CO6331421A2 (es)
EC (1) ECSP10010352A (es)
ES (1) ES2361459B1 (es)
MX (1) MX2010007902A (es)
PE (1) PE20091363A1 (es)
WO (1) WO2009090624A2 (es)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103889434B (zh) 2011-06-21 2017-02-15 Bvw控股公司 含有乳香酸的医疗装置
US9480747B2 (en) 2012-01-24 2016-11-01 Bvw Holding Ag Class of anti-adhesion hydrogels with healing aspects
RU2526183C1 (ru) * 2013-02-28 2014-08-20 Федеральное государственное унитарное предприятие Научно-производственный центр "Фармзащита" Федерального медико-биологического агентства (ФГУП НПЦ "Фармзащита" ФМБА России) Гемостатическая противоожоговая ранозаживляющая композиция
WO2015139085A1 (en) * 2014-03-17 2015-09-24 Gfs Corporation Aus Pty Ltd Antimicrobial sanitizer compositions and their use
CN103919689A (zh) * 2014-03-20 2014-07-16 金红叶纸业集团有限公司 湿巾乳液、湿巾及湿巾的制备方法
GB201501330D0 (en) * 2015-01-27 2015-03-11 Medtrade Products Ltd Composition for a wound dressing
GB201501333D0 (en) 2015-01-27 2015-03-11 Medtrade Products Ltd Composition for a wound dressing
EA026104B1 (ru) * 2015-04-02 2017-03-31 Общество С Ограниченной Ответственностью "Тектум" Кровоостанавливающее и ранозаживляющее средство
US10660945B2 (en) 2015-08-07 2020-05-26 Victor Matthew Phillips Flowable hemostatic gel composition and its methods of use
US10751444B2 (en) 2015-08-07 2020-08-25 Victor Matthew Phillips Flowable hemostatic gel composition and its methods of use
CN105055582B (zh) * 2015-08-18 2018-09-04 云南同方科技有限公司 一种用于皮肤轻度烧烫伤的配方精油
WO2018005145A1 (en) * 2016-06-28 2018-01-04 Victor Matthew Phillips Flowable hemostatic gel composition and its methods of use
CA3066321A1 (en) 2017-07-19 2019-01-24 Universidade Da Beira Interior Film for topical application in the treatment of skin lesions and method of obtaining and applying it
CN108514546B (zh) * 2018-05-14 2020-09-29 山东师范大学 一种二氢杨梅素的壳聚糖水凝胶制剂及制备方法
CN109731021A (zh) * 2019-03-20 2019-05-10 武汉市思泰利医疗器械发展有限公司 一种用于治疗修复造口皮肤的壳聚糖水凝胶及其制备方法
JP2022528460A (ja) * 2019-04-08 2022-06-10 メドデルム ゲーエムベーハー 対象の皮膚の微生物叢に影響を与えるキトサンを有する液体組成物
US20220289999A1 (en) * 2019-07-11 2022-09-15 StenCo, LLC Biodegradable material
CN111920742A (zh) * 2020-09-18 2020-11-13 微著生物科技(东营)有限责任公司 一种壳聚糖多效修复面膜及制备方法
US20230381217A1 (en) * 2020-10-14 2023-11-30 Medoderm Gmbh Liquid composition for use in the prevention or reduction of skin irritation, allergy and/or an infectious disease
DE102021109834A1 (de) * 2021-04-19 2022-10-20 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein Zusammensetzung zur Desinfektion und für kosmetische Anwendungen
WO2023233299A1 (en) 2022-05-31 2023-12-07 Instituto Politécnico Da Guarda Wound dressing comprising a ph sensor composition and method of producing the same
WO2024136811A1 (en) * 2022-12-20 2024-06-27 Istanbul Medipol Universitesi Wound healing gel formulation comprising melaleuca viridiflora l. and boswellia carterii l.
US11845859B1 (en) 2023-03-28 2023-12-19 King Faisal University Biopolymer derived from algae
CN118496398B (zh) * 2024-07-16 2024-10-11 广州和佳润颜医药有限公司 一种医用高分子聚合物载体及其作为皮肤保护剂的用途

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4659700A (en) * 1984-03-02 1987-04-21 Johnson & Johnson Products, Inc. Chitosan-glycerol-water gel
US5013769A (en) * 1988-08-22 1991-05-07 Medipro Sciences Limited Method of making a hydrogel-forming wound dressing or skin coating material
US5142010A (en) * 1990-05-10 1992-08-25 H. B. Fuller Licensing & Financing Inc. Polymeric biocidal agents
AU9115791A (en) * 1990-11-30 1992-06-25 Baker Cummins Dermatologicals, Inc. Skin protective compositions and method of inhibiting skin irritation
US5420197A (en) 1994-01-13 1995-05-30 Hydromer, Inc. Gels formed by the interaction of polyvinylpyrrolidone with chitosan derivatives
US5620706A (en) 1995-04-10 1997-04-15 Universite De Sherbrooke Polyionic insoluble hydrogels comprising xanthan and chitosan
SE507028C2 (sv) * 1996-08-06 1998-03-16 Medicarb Ab Ny medicinsk användning
DE19719856A1 (de) * 1997-05-12 1998-11-19 Henkel Kgaa Hautpflegemittel
CA2212300A1 (en) 1997-08-04 1999-02-04 Abdellatif Chenite In vitro or in vivo gelfying chitosan and therapeutic uses thereof
DE19826503A1 (de) * 1998-06-13 1999-12-16 Beiersdorf Ag Kosmetische und dermatologische Zubereitungen mit einem Gehalt an Chitosan und Phospholipiden
US6121375A (en) 1999-02-11 2000-09-19 Hydromer, Inc. Gels formed by the interaction of poly(aldehyde) with various substances
JP2003503367A (ja) * 1999-06-11 2003-01-28 シアウォーター・コーポレイション キトサンとポリ(エチレングリコール)または関連ポリマーから得られるヒドロゲル
AU2127700A (en) 1999-10-27 2001-05-08 Department Of Atomic Energy A process for manufacture of hydrogels for burn and injury treatment
DE10010199A1 (de) * 2000-03-02 2001-09-06 Beiersdorf Ag Wäßrig-alkoholische Zubereitungen mit einem Gehalt an Chitosan
US6379702B1 (en) 2000-07-05 2002-04-30 Hydromer, Inc. Gels formed by the interaction of polyvinylpyrrolidone with chitosan derivatives
KR100391781B1 (ko) * 2000-12-14 2003-07-16 주식회사 제닉 키토산과 젤라틴으로 조성된 연질 겔
US6521243B2 (en) 2000-12-22 2003-02-18 Pharma C And D, Limited Ionic chitosan -iodine complexes: antiseptic hydrogels and wound healing promoters
AU2002244123A1 (en) 2001-02-23 2002-09-12 Techquip International, Inc. Stacked panel processing apparatus and methods
JP3947391B2 (ja) * 2001-11-28 2007-07-18 独立行政法人 日本原子力研究開発機構 橋かけ構造を有するキチン誘導体及び/又はキトサン誘導体の製造方法
FR2836044A1 (fr) * 2002-02-15 2003-08-22 Octaris Composition pour la reparation et la cicatrisation cutanee comprenant exclusivement un vrai hydrogel physique de chitosane
JP2007500196A (ja) * 2003-05-24 2007-01-11 バイヤースドルフ・アクチエンゲゼルシヤフト 化粧品の成分として使用される組織培養培地
KR100506543B1 (ko) * 2003-08-14 2005-08-05 주식회사 제닉 온도 감응성 상태변화 하이드로겔 조성물 및 그 제조방법
JP2006045181A (ja) * 2003-11-18 2006-02-16 Sekisui Chem Co Ltd 皮膚外用組成物
GB0403938D0 (en) 2004-02-21 2004-03-24 West Pharm Serv Drug Res Ltd Chitosan containing solution
US20050196450A1 (en) * 2004-03-04 2005-09-08 Elka Touitou Method and composition for burned skin
KR100676937B1 (ko) * 2005-06-01 2007-02-02 주식회사 제닉 피부미용 및 상처치료용 수용성 필름 및 그 제조방법
US20070048358A1 (en) * 2005-08-31 2007-03-01 Schorr Phillip A Antimicrobial substrates
US20070237811A1 (en) * 2006-04-10 2007-10-11 Scherr George H Chitosan wound dressing
CN101057953A (zh) * 2006-04-21 2007-10-24 陈祖辉 对付病毒感染疾患的多靶协同防治制剂

Also Published As

Publication number Publication date
CO6331421A2 (es) 2011-10-20
US20100316739A1 (en) 2010-12-16
WO2009090624A3 (es) 2009-09-11
EP2452673B1 (en) 2017-04-26
ES2361459A1 (es) 2011-06-17
CN101977589A (zh) 2011-02-16
ES2361459B1 (es) 2012-04-24
EP2452673A4 (en) 2013-04-03
MX2010007902A (es) 2010-11-25
EP2452673A2 (en) 2012-05-16
CN101977589B (zh) 2014-12-10
JP5615717B2 (ja) 2014-10-29
JP2012515710A (ja) 2012-07-12
BRPI0906932A2 (pt) 2015-07-28
CL2008000156A1 (es) 2008-08-01
ECSP10010352A (es) 2010-11-30
PE20091363A1 (es) 2009-10-15
WO2009090624A2 (es) 2009-07-23
CA2712527C (en) 2017-02-28
AR071334A1 (es) 2010-06-16
CA2712527A1 (en) 2009-07-23

Similar Documents

Publication Publication Date Title
ES2361459A8 (es) Gel de quitosano para aplicaciones dermatológicas, proceso de obtención y uso del mismo.
AR124134A2 (es) Formulación de uso tópico para un inhibidor de jak
CY1123334T1 (el) Σκευασματα φιναστεριδης για αποδεσμευση φαρμακου στα μαλλια και στο τριχωτο της κεφαλης
CO6430467A2 (es) Péptidos útiles en el tratamiento y/o cuidado de la piel y/o cabello y su uso en composiciones cosméticas o farmacéuticas
CL2012001673A1 (es) Compuestos derivados de benzamida sustituidos, como moduladores de taar; procedimiento de preparación; composición farmacéutica; y su uso en el tratamiento de la depresión, trastornos de ansiedad, trastorno bipolar, esquizofrenia, epilepsia, migraña, enfermedad de alzheimer, trastornos metabolicos, entre otras.
AR084932A1 (es) Composicion oftalmica que comprende un androgeno y su uso para la fabricacion de un medicamento util para el tratamiento de una enfermedad ocular resultante de una deficiencia androgenica
GB201021937D0 (en) Skin sanitizer compositions comprising alcohol based emulsion
IN2014DN10157A (es)
HN2011002406A (es) 2-acetamido-5-aril-1,2,4-triazolonas sustituidas y su uso
BR112015030031A2 (pt) lenço para tratamento de pele e artigo para tratamento de pele
BR112013026032A2 (pt) composições nutricionais incluindo ácidos graxos de cadeia ramificada para cicatrização de ferida
CO6531482A2 (es) Composiciones limpiadoras liquidas viscosas que comprenden ácidos grasos sulfonados, esteres o sales de los mismos y betamínas o sultaínas
BR112013004436A2 (pt) composições e usos de materiais com atividade microbicida alta e toxicidade baixa
CY1115725T1 (el) Ενωσεις, συνθεσεις και μεθοδοι για την θεραπευτικη αγωγη των βητα-αμυλοειδικων ασθενειων και συνουκλεϊνοπαθειων
AR077139A1 (es) Composiciones farmaceuticas utiles para tratar el vch
UA99645C2 (ru) Гель, имеющий противовоспалительное и противоаллергическое действие
IL273329A (en) Modulation of hepatic-hepatic epidermal growth factor activity to heal the eardrum membrane
AR054249A1 (es) Tratamiento de enfermedades del tejido conectivo de la piel
CO6660486A2 (es) Composición tópica famacéutica o cosmética útil para el tratamiento de enfermedades o condiciones que cursan con un déficit de la maduración de la envoltura córnea
BR112015013125A2 (pt) tratamento de lesões orais usando composições de matrix placentário extracelular
NO20091517L (no) Emulsjon
UY28209A1 (es) Derivados de aminoácidos con cicloalquilo, procedimiento para su preparación y su uso como medicamentos.
AR059864A1 (es) Compuesto de benzamida composicion farmaceutica que lo comprende su uso para preparar un medicamento y procedimientos para su preparacion
SG10201908690WA (en) Novel method of use and compositions
CO6140019A2 (es) Liberacion mejorada para ciertos componentes de fragancia de composiciones de cuidado personal

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 2361459

Country of ref document: ES

Kind code of ref document: B1

Effective date: 20120424

FD2A Announcement of lapse in spain

Effective date: 20211004