ES2349598T3 - EMULSIONED PREPARATION FOR EXTERNAL USE FOR SKIN, AND PROCEDURE TO STABILIZE PREPARATION FOR EXTERNAL USE FOR SKIN. - Google Patents

Abstract

Emulsified preparation for external use for the skin comprising 0.03 to 25% by mass of a derivative of tocopherol glycinate, and 0.05 to 25% by mass of at least one fatty acid ester selected from the group consisting of monoester of fatty acid with glycerin, fatty acid ester with polyglycerin and fatty acid ester with dextrin, the tocopherol glycinate derivative being represented by Formula (1): ** (See formula) ** in which R1 and R2 are each a lower alkyl group or a hydrogen atom, and they cannot be hydrogen atoms at the same time, and R3, R4 and R5 are each a hydrogen atom or a methyl group, with the proviso that preparations are excluded that they contain the following components (i) to (xii): (i) 0.20% by weight of a glycine ester with tocopherol, 3.00% by weight of an ester of ascorbic acid-2-phosphoric acid, 72.10 % by weight of pure water, 1.0% by weight of sodium surfactin; or 1.00% by weight of a glycine ester with tocopherol, 9.00% by weight of an ester of ascorbic acid-2-phosphoric acid, 65.30% by weight of pure water, 1.0% by weight of sodium surfactin; or 1.00% by weight of a glycine ester with tocopherol, 1.00% by weight of an ester of ascorbic acid-2-phosphoric acid, 73.30% by weight of pure water, 1.0% by weight of sodium surfactin; or 0.20% by weight of a glycine ester with tocopherol, 3.00% by weight of an ester of ascorbic acid-2-phosphoric acid, 73.00% by weight of pure water, 0.1% by weight of sodium surfactin; or 1.00% by weight of a glycine ester with tocopherol, 1.00% by weight of an ester of ascorbic acid-2-phosphoric acid, 74.20% by weight of pure water, 0.1% by weight of sodium surfactin; or 0.20% by weight of a glycine ester with tocopherol, 3.00% by weight of an ester of ascorbic acid-2-phosphoric acid, 73.10% by weight of pure water, 0.01% by weight of sodium surfactin; or 1.00% by weight of a glycine ester with tocopherol, 1.00% by weight of an ester of ascorbic acid-2-phosphoric acid, 74.30% by weight of pure water, 0.01% by weight of sodium surfactin, (ii) 7.00% by weight of 1,3-butylene glycol, (iii) 0.10% by weight of xanthan gum, (iv) 2.50% by weight of POE monostearate (20) sorbitan , (v) 1.0% by weight of lipophilic glyceryl monostearate, (vi) 0.50% by weight of stearic acid, (vii) 1.50% by weight of behenyl alcohol, (viii) 0.50% by weight of cetyl palmitate, (ix) 5.00% by weight of squalane, (x) 5.00% by weight of cetyl 2-ethylhexanoate, (xi) 0.50% by weight of methylpolysiloxane (100 cSt), and (xii) 0.10% by weight of methyl para-hydroxybenzoate, in which the glycine ester with tocopherol is selected from the group consisting of dimethylglycine ester hydrochloride with dl-α-tocopherol, dimethylglycine ester hydrochloride with d-α-tocopherol, dimethylglycine ester hydrochloride with d-δ-tocopherol, ester hydrochloride er of dimethylglycine with d-γ-tocopherol, sarcosine ester hydrochloride with dl-α-tocopherol, sarcosine ester hydrochloride with d-α-tocopherol, sarcosine ester hydrochloride with d-δ-tocopherol, and ester hydrochloride of sarcosine with d-γ-tocopherol, and wherein the ascorbic acid-2-phosphoric acid ester is selected from the group consisting of the sodium salt of the ascorbic acid-2-phosphoric acid ester, the magnesium salt of the ester of ascorbic acid-2-phosphoric acid, the sodium salt of the ester of ascorbic acid-2-phosphoric acid-6-palmitic acid, and the sodium salt of the ester of ascorbic acid-2-phosphoric acid-6-hexyldecanoic acid.

Description

Emulsified preparation for external use for skin, and procedure to stabilize the preparation for external use for the skin.

Technical field

The present invention relates to a stable emulsified preparation for external use for the skin that It contains a derivative of tocopherol glycinate.

The invention also relates to a procedure to stabilize an emulsified preparation for use external to the skin that contains a glycinate derivative of tocopherol

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Prior art

Tocopherol (α-tocopherol, β-tocopherol, γ-tocopherol and δ-tocopherol), known as vitamin E, and its derivatives, such as tocopherol acetate and nicotinate tocopherol (hereinafter, tocopherols), are known for produce effects such as antioxidation, stabilization of the biomembrane, immunostimulation and for facilitating circulation blood They have been used in medicines, cosmetics and diets.

The present applicant has announced external use preparations for the skin containing glycinate of tocopherol and its derivatives based on the finding that, between tocopherols, tocopherol glycinate and its derivatives have a conversion efficiency in active tocopherol particularly excellent in skin tissues (documents JP-A-2004-2277 and JP-A-2004-2278).

However, the formulation of derivatives of tocopherol glycinate in emulsified preparations for external use for the skin it has often resulted in changes in appearance, such as viscosity reduction, and separation during storage.

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Description of the invention

It is an object of the invention to provide a emulsified preparation for external use for skin that contains a tocopherol glycinate derivative that has excellent stability during storage, without viscosity reduction during the storage.

It is another object of the invention that the provision of the external use preparation for the skin provides a procedure to stabilize the preparation for external use to skin that contains a derivative of tocopherol glycinate.

In view of the problems mentioned previously, the present inventors have investigated diligently and have found that the problems are solved adding esters of specific fatty acids. The invention has been completed based on the finding.

The invention relates to the following.

[1] An emulsified preparation for external use for skin comprising 0.03 to 25% by mass of a derivative of tocopherol glycinate, and 0.05 to 25% by mass of at least one fatty acid ester selected from the group consisting of fatty acid monoester with glycerin, fatty acid ester with polyglycerin and fatty acid ester with dextrin, being represented Tocopherol glycinate derivative by Formula (1):

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one

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where R 1 and R 2 are each a lower alkyl group or a hydrogen atom, and not they can be hydrogen atoms at the same time, and R 3, R 4 and R 5 are each a hydrogen atom or a group methyl,

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on condition that they be excluded preparations containing the following components (i) a (xii):

(i)

0.20% by weight of a glycine ester with tocopherol, 3.00% by weight of an ester of ascorbic acid-2-acid  phosphoric, 72.10% by weight of pure water, 1.0% by weight of surfactin sodium or

quad

1.00% by weight of a glycine ester with tocopherol, 9.00% by weight of an ester of ascorbic acid-2-acid phosphoric, 65.30% by weight of pure water, 1.0% by weight of surfactin sodium or

quad

1.00% by weight of a glycine ester with tocopherol, 1.00% by weight of an ester of ascorbic acid-2-acid phosphoric, 73.30% by weight of pure water, 1.0% by weight of surfactin sodium or

quad

0.20% by weight of a glycine ester with tocopherol, 3.00% by weight of an ester of ascorbic acid-2-acid phosphoric, 73.00% by weight of pure water, 0.1% by weight of surfactin sodium or

quad

1.00% by weight of a glycine ester with tocopherol, 1.00% by weight of an ester of ascorbic acid-2-acid phosphoric, 74.20% by weight of pure water, 0.1% by weight of surfactin sodium or

quad

0.20% by weight of a glycine ester with tocopherol, 3.00% by weight of an ester of ascorbic acid-2-acid phosphoric, 73.10% by weight of pure water, 0.01% by weight of surfactin sodium or

quad

1.00% by weight of a glycine ester with tocopherol, 1.00% by weight of an ester of ascorbic acid-2-acid phosphoric, 74.30% by weight of pure water, 0.01% by weight of surfactin sodium

(ii)

7.00% by weight of 1,3-butylene glycol,

(iii)

0.10% by weight of xanthan gum,

(iv)

2.50% by weight of POE monostearate (20) -sorbitan,

(v)

1.0% by weight of glyceryl monostearate lipophilic,

(saw)

0.50% by weight of stearic acid,

(vii)

1.50% by weight of behenyl alcohol,

(viii)

0.50% by weight of cetyl palmitate,

(ix)

5.00% by weight of squalane,

(x)

5.00% by weight of 2-ethylhexanoate cetyl,

(xi)

0.50% by weight of methylpolysiloxane (100 cSt), Y

(xii)

0.10% by weight of methyl para-hydroxybenzoate,

in which the glycine ester with tocopherol is select from the group consisting of ester hydrochloride of dimethylglycine with dl-? -tocopherol hydrochloride of dimethylglycine ester with d-? -tocopherol, hydrochloride of dimethylglycine ester with d- δ-tocopherol hydrochloride of dimethylglycine ester with d-? -tocopherol, hydrochloride of the sarcosine ester with dl-? -tocopherol hydrochloride of the sarcosine ester with d-? -tocopherol, hydrochloride of the sarcosine ester with d- \ delta-tocopherol, e sarcosine ester hydrochloride with d-? -tocopherol,

and in which the acid ester Ascorbic-2-phosphoric acid is selected from the group consisting of the sodium salt of the acid ester ascorbic-2-phosphoric acid, the magnesium salt of ascorbic acid-2-phosphoric acid ester, salt sodium ester of ascorbic acid-2-acid phosphoric-6-palmitic acid, and the sodium salt of ascorbic acid-2-acid ester phosphoric-6-hexyldecanoic acid.

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[2] The emulsified preparation for external use for the skin as described in [1], in which the derivative of tocopherol glycinate is N, N-dimethylglycinate from tocopherol, or tocopherol sarcosinate.

[3] The emulsified preparation for external use for the skin as described in [1] or [2], in which the derivative Tocopherol glycinate is at least one derivative selected from the group consisting of glycinate derivatives of α-tocopherol, glycinate derivatives of γ-tocopherol, and glycinate derivatives of δ-tocopherol.

[4] The emulsified preparation for external use for the skin as described in any one of [1] to [3], in the that the tocopherol glycinate derivative is at least one derivative selected from the group consisting of derivatives of dl-? -tocopherol glycinate, glycinate derivatives of d-? -tocopherol, derivatives of d-? -tocopherol glycinate and glycinate derivatives of d- \ delta-tocopherol.

[5] The emulsified preparation for external use for the skin as described in [1], in which the monoester of fatty acid with glycerin is at least one fatty acid ester selected from the group consisting of glyceryl laurate, glyceryl myristate, glyceryl stearate, isostearate glyceryl, glyceryl behenate, glyceryl linoleate, oleate glyceryl, coconut fatty acid ester with glyceryl, ricinoleate of glyceryl, glyceryl hydroxystearate and erucate glyceryl

[6] The emulsified preparation for external use for the skin as described in [1], in which the acid ester fatty acid with polyglycerin is an ester of fatty acid with polyglycerin It has two to ten glycerin molecules.

[7] The emulsified preparation for external use for the skin as described in [6], in which the acid ester fatty with polyglycerin that has two to ten glycerin molecules it is at least one fatty acid ester selected from the group that consists of poly (2) glyceryl monolaurate, poly monomiristate (2) glyceryl, poly (2) glyceryl monostearate, poly (2) glyceryl monostearate, poly (10) monolaurate glyceryl, poly (10) glyceryl monomiristate, monostearate poly (10) glyceryl and poly (10) glyceryl monoisoestearate.

[8] The emulsified preparation for external use for the skin as described in [1], in which the acid ester fatty with dextrin is at least one fatty acid ester selected from the group consisting of dextrin myristate, dextrin palmitate, (dextrin palmitate / octanoate), and dextrin stearate.

[9] An emulsified cosmetic comprising the emulsified preparation for external use for one's skin any of [1] to [8].

[10] A procedure to stabilize a emulsified preparation for external use for the skin, characterized because a tocopherol glycinate derivative is used in combination with at least one fatty acid ester selected from the group that consists of monoester of fatty acid with glycerin, acid ester fatty with polyglycerin and fatty acid ester with dextrin, the tocopherol glycinate derivative being represented by the Formula 1):

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2

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where R 1 and R 2 are each a lower alkyl group or a hydrogen atom, and not they can be hydrogen atoms at the same time, and R 3, R 4 and R 5 are each a hydrogen atom or a methyl group, with the condition that the claimed procedure does not apply to the preparations excluded by the exclusion of the claim one.

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The emulsified preparation for external use for the skin according to the present invention has excellent stability during storage, so that such defects are avoided such as viscosity reduction and separation during storage. The emulsified preparation for external use for skin is useful as general preparations for external use for skin, particularly useful as a cosmetic.

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Best way to carry out the invention

The emulsified preparation for external use for the skin, the emulsified cosmetic, and the procedure for stabilize the emulsified preparation for external use for the skin according to the present invention will be described in more detail down.

Emulsified preparation for external use for the skin

The emulsified preparation for external use for the skin includes a derivative of tocopherol glycinate, and so minus a fatty acid ester selected from the group consisting of fatty acid monoester with glycerin, fatty acid ester with polyglycerin, and fatty acid ester with dextrin.

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Tocopherol glycinate derivative

The tocopherol glycinate derivative used in The invention is represented by Formula (1):

3

where R 1 and R 2 are each a lower alkyl group or a hydrogen atom, and not they can be hydrogen atoms at the same time, and R 3, R 4 and R 5 are each a hydrogen atom or a group methyl.

As shown in Formula (1), the derivative Tocopherol glycinate is composed of a main chain of tocopherol and a main chain of a glycine derivative.

Examples of tocopherols for the chain Main tocopherol include α-tocopherol, β-tocopherol, γ-tocopherol and δ-tocopherol, being preferred α-tocopherol, γ-tocopherol and δ-tocopherol.

Tocopherols have an asymmetric carbon in position 2 of the chromanol ring, and stereoisomers are possible  such as isomer d and isomer dl. The present invention you can use any such isomer.

Preferred examples of tocopherols for the main tocopherol chain include dl-? -tocopherol, d-? -tocopherol, d-? -tocopherol and d- \ delta-tocopherol, being more preferable dl-? -tocopherol, d-? -tocopherol and d-? -tocopherol.

With respect to the main chain of the derivative of glycine, the lower alkyl groups R 1 and R 2 in the Formula (1) include linear or branched alkyl groups of 1 to 6 carbon atoms Specific examples include methyl groups, ethyl, n-propyl, n-butyl, isopropyl, isobutyl, 1-methylpropyl, tert-butyl, n-pentyl, 1-ethylpropyl, isoamyl and n-hexyl, the methyl group being particularly preferred.

That is, N, N-dimethylglycine and Sarcosine are preferable glycine derivatives for derivatives of tocopherol glycinate.

In the preparation of external use for the skin, Tocopherol glycinate derivatives can be used individually or in combination of two or more types.

Tocopherol glycinate derivatives they generally account for 0.03 to 25% by mass, preferably 0.1 at 10% by mass, more preferably 0.5 to 5% by mass of the Emulsified preparation for external use for the skin. When the amount of tocopherol glycinate derivatives is less than previous interval, the external use preparation for the skin to It often does not produce desired effects. Any amount that exceeds of the previous interval is not effective because they are not expected Additional improvements in effects.

Fatty acid monoester with glycerin

The fatty acid monoester with glycerin used in the invention is a compound in which a molecule of an acid fatty is linked by ester bond to any group Glycerin hydroxyl. The ester is otherwise called monoacrylic glycerol or monoglyceride. Examples of fatty acids include linear chain fatty acids, chain fatty acids branched, saturated fatty acids, unsaturated fatty acids, and fatty hydroxy acids.

Examples of fatty acid monoesters With glycerin include glyceryl laurate, glyceryl myristate,  glyceryl stearate, glyceryl linoleate, oleate glyceryl, glyceryl isostearate, glyceryl behenate, glyceryl erucate, coconut fatty acid ester with glyceryl, glyceryl ricinoleate, glyceryl hydroxystearate, wheat germ oil fatty acid monoglyceride, safflower oil fatty acid monoglyceride, monoglyceride hydrogenated soy bean fatty acid, acid monoglyceride saturated fatty, monoglyceride fatty acid seed oil of cotton, tallow fatty acid monoglyceride, and monoglyceride of lanolin fatty acid.

Of these, laurate of glyceryl, glyceryl myristate, glyceryl stearate, linoleate  of glyceryl, glyceryl oleate, glyceryl isostearate, glyceryl behenate, glyceryl erucate, fatty acid ester Coconut with glyceryl, glyceryl ricinoleate and hydroxystearate glyceryl, and glyceryl myristate are more preferable, glyceryl stearate, and glyceryl isostearate.

The monoesters of fatty acids with glycerin can be used individually or in combination of two or more types.

Fatty acid ester with polyglycerin

The fatty acid ester with polyglycerin used in the invention it is a compound that results when glycerin is dehydrates and condenses in a polyglycerin, and one or more molecules of a fatty acid are linked by ester bond to any hydroxyl group in polyglycerin. Preferred examples of polyglycerin fatty acid esters include compounds in the that one or more molecules of a fatty acid are linked by ester bond to any hydroxyl group in the polyglycerins that have an average degree of polymerization of 2 to 10. Examples of fatty acids include fatty acids of linear chain, branched chain fatty acids, fatty acids saturated, unsaturated fatty acids and fatty hydroxy acids.

Examples of fatty acid esters with Polyglycerin include diglyceryl isopalmitate, monolaurate poly (4-10) glyceryl, poly (10) monomiristate glyceryl, poly (2-10) glyceryl monostearate, poly (2-10) glyceryl monostearate, poly (2-10) glyceryl monooleate, sesquioleate diglyceryl, poly (2-10) diisoestearate glyceryl, poly (6-10) glyceryl distearate, diglyceryl triisoestearate, poly triestearate (10) glyceryl, poly (10) glyceryl trioleate, tetraisoestearate poly (2) glyceryl, decaglyceryl pentaestearate, pentaoleate poly (6-10) glyceryl, poly (10) heptaestearate glyceryl, decaglyceryl decaestearate, poly (10) decaoleate glyceryl, and condensed poly (6) glyceryl ricinoleate.

Of these, poly monolaurate are preferable. (2) glyceryl, poly (2) glyceryl monomiristate, monostearate of poly (2) glyceryl, poly (2) glyceryl monoisoesterate, poly (10) glyceryl monolaurate, poly (10) monomiristate glyceryl, poly (10) glyceryl monostearate and monoisoestearate of poly (10) glyceryl, and the monomiristate of poly (10) glyceryl, poly (10) glyceryl monostearate and poly (10) glyceryl monostearate.

Fatty acid esters with polyglycerin can be used individually or in combination of two or more types.

Dextrin fatty acid ester

The dextrin fatty acid ester used in the invention is a higher fatty acid ester with a dextrin starch derivative. Examples of fatty acids include linear chain fatty acids, branched chain fatty acids, saturated fatty acids and unsaturated fatty acids.

Examples of fatty acid esters with dextrin include dextrin myristate, dextrin palmitate, (dextrin palmitate / octanoate) and dextrin stearate.

Of these, the myristate of dextrin and dextrin palmitate, and is particularly preferable dextrin palmitate

The fatty acid esters with dextrin are They can use individually or in combination of two or more types.

Fatty acid esters generally give 0.05 to 25% by mass, preferably 1.5 to 10% by mass, more preferably 2 to 5% by mass of the emulsified preparation of external use for the skin. The amount of acid esters fatty allows the stable preparation of external use for the skin.

Other components

The external use preparation for the skin can contain a component that is commonly used in preparations  for external use for the skin, together with the glycinate derivative of tocopherol and at least one fatty acid ester selected from fatty acid monoesters with glycerin, fatty acid esters with polyglycerin, and fatty acid esters with dextrin. The Examples of such additional components include:

hydrocarbons, such as ozoquerite, oligomers α-olefins, light isoparaffin, isoparaffin light liquid, squalane, synthetic squalane, phytoscale, ceresin, paraffin, polyethylene powder, polybutene, wax microcrystalline, liquid isoparaffin, liquid paraffin, oil mineral and petroleum jelly;

natural fats and oils, such as natural waxes, including jojoba oil, carnauba wax, candelilla wax, rice bran wax, shellac, lanolin, mink oil wax, whale wax, sugar cane wax, sperm oil, beeswax and lignite wax; Avocado oil, almond oil, olive oil, extra virgin olive oil, sesame oil, rice bran oil, rice oil, rice germ oil, corn oil, safflower oil, seed oil soybeans, corn oil, rapeseed oil, Persian oil, palm kernel oil, palm oil, castor oil, sunflower oil, sunflower oil high in oleic acid, grape seed oil, cottonseed oil, coconut oil, hydrogenated coconut oil, beef tallow, hydrogenated oil, horse oil, mink oil, egg yolk oil, egg yolk fatty oil, rose hip oil, fruit oil of kukui, primrose oil, wheat germ oil, peanut oil, tea oil, Camellia sasanqua oil, cocoa butter, Japan wax, veal bone fat, cattle leg oil, lard, horse fat, lamb tallow, shea butter, oil of macadamia nut, and foam oil from the prairies;

fatty acids, such as lauric acid, acid myristic, palmitic acid, stearic acid, behenic acid, acid oleic, linoleic acid, linolenic acid, acid γ-linolenic acid, isostearic acid, acid 12-hydroxystearic acid, undecylenic acid and acid coconut nutty fat;

higher alcohols such as alcohol isostearyl, octyldodecanol, hexyldodecanol, cholesterol, phytosterol, lauryl alcohol, myristyl alcohol, cetanol, stearyl alcohol, oleyl alcohol, behenyl alcohol, and ketostearyl alcohol;

alkyl glyceryl esters, such as alcohol Batyl, chimyl alcohol, selakyl alcohol and isostearyl glyceryl ether;

esters, such as isopropyl myristate, butyl myristate, isopropyl palmitate, ethyl stearate, butyl stearate, ethyl oleate, ethyl linoleate, linoleate of isopropyl, cetyl caprylate, hexyl laurate, myristate of isooctyl, decyl myristate, myristyl myristate, myristate of cetyl, octadecyl myristate, cetyl palmitate, stearate stearyl, decyl oleate, oleyl oleate, ricinoleate cetyl, isostearyl laurate, isotridecyl myristate, isocetyl myristate, isostearyl myristate, octyldodecyl, 2-ethylhexyl palmitate, palmitate of isocetyl, isostearyl palmitate, stearate 2-ethylhexyl, isocetyl stearate, oleate isodecyl, octyldodecyl oleate, octyldodecyl ricinoleate, ethyl isostearate, isopropyl isostearate, Cetyl 2-ethylhexanoate, Ketostearyl 2-ethylhexanoate, Stearyl 2-ethylhexanoate, isostearate hexyl, ethylene glycol dioctanoate, ethylene glycol dioleate, Propylene Glycol Dicaprilate, Dicaprilate / Dicaprate Propylene Glycol, Propylene Glycol Dicaprate, Dioleate Propylene Glycol, Neopentyl Glycol Dicaprate, Dioctanoate neopentyl glycol, glyceryl tricaprilate, glyceryl tri-2-ethylhexanoate, glyceryl tricaprylate / tricaprate, tricaprilato / tricaprato / glyceryl triestearate, triumphacrylate glyceryl, glyceryl triisopalmitate, triisoestearate glyceryl, tri-2-ethylhexanoate trimethylolpropane, trimethylolpropane triisoestearate, tetra-2-ethylhexanoate pentaerythrityl, pentaerythrityl tetramiristate, pentaerythrityl tetraisoestearate, tetraisoestearate diglyceryl, octyldodecyl neopentonate, isocetyl octanoate, isostearyl octanoate, isopelargonate 2-ethylhexyl, hexyldecyl dimethyloctanoate, Octyldodecyl dimethyloctanoate, isopalmitate 2-ethylhexyl, isocetyl isostearate, isostearyl isostearate, octyldodecyl isostearate, lactate lauryl, myristyl lactate, cetyl lactate, lactate octyldodecyl, triethyl citrate, acetyltriethyl citrate, acetyltributyl citrate, trioctyl citrate, citrate triisocetyl, trioctyldodecyl citrate, diisoestearyl malate, 2-ethylhexyl hydroxystearate, succinate di-2-ethylhexyl adipate diisopropyl, diisobutyl adipate, dioctyl adipate, adipate of diheptylundecyl, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, cholesteryl stearate, isostearate cholesteryl, cholesteryl hydroxystearate, cholesteryl oleate,  dihydrocholesteryl oleate, phytosteryl isostearate, oleate Phytosteryl, 12-stearoylhydroxystearate isocetyl, 12-stearoylhydroxystearate stearyl, 12-stearoylhydroxystearate isostearyl, polyoxyethylene (3) polyoxypropylene acetate (1) cetyl ether, polyethylene (3) polyoxypropylene (1) isocetyl acetate ether, isononyl isononanoate, octyl isononanoate, tridecyl isononanoate and isotridecyl isononanoate;

silicone oils, such as methylpolysiloxane, methylphenylpolysiloxane, methylhydrogen polysiloxane, methylcyclopolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, octamethyltrisiloxane, decamethyltetrasiloxane, tetradecamethylhexasiloxane, methylpolyloxyloxane highly polymerized, copolymer of dimethylsiloxane / methyl (polyoxyethylene) siloxane / methyl (polyoxypropylene) siloxane, copolymer of dimethylsiloxane / methyl (polyoxyethylene) siloxane, copolymer of dimethylsiloxane / methyl (polyoxypropylene) siloxane, dimethylsiloxane / methyl acetyloxysiloxane copolymer, copolymer of dimethylsiloxane / methyltearoxysiloxane, silicones modified with polyether, alcohol modified silicones, modified silicones with alkyl and amino modified silicones;

polymers, such as sodium alginate, carrageenan, agar, Danish agar, guar gum, quince seeds, konjac mannan, tamarind gum, tara gum, dextrin, starch, garrofin gum, gum arabic, ghatti gum, gum karaya, gum tragacanth, arabinogalactan, pectin, quince, chitosan, curdlan, xanthan gum, gellan gum, cyclodextrin, dextran, pululane, microcrystalline cellulose, methylcellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, carboxymethyl cellulose, carboxy starch, cationized cellulose, starch phosphate, cationized guar gum, carboxymethyl / hydroxypropylated guar gum, guar gum hydroxypropylated, albumin, casein, gelatin, sodium polyacrylate, polyacrylic acid amide, carboxyvinyl polymers, polyethyleneimine, highly polymerized polyethylene glycol, alcohol polyvinyl, polyvinylpyrrolidone, polyvinyl ether, polyacrylamide, acrylic acid copolymers, methacrylic acid copolymers, maleic acid copolymers, vinylpyridine copolymers, ethylene / acrylic acid copolymer, polymers vinyl pyrrolidone, vinyl alcohol / vinyl pyrrolidone copolymers, nitrogen substituted acrylamide polymers, silicones modified with amino groups, cationized polymers, polymers of dimethylacrylammonium, anionic polymers based on acrylic acid, anionic polymers based on methacrylic acid, silicones modified, alkyl acrylate or methacrylate copolymers (C 10-30) acrylate / methacrylate and copolymers of polyoxyethylene / polyoxypropylene;

alcohols, such as ethanol, alcohol isopropyl, 1-butanol, 2-butanol and benzyl alcohol;

dihydroxylated alcohols, such as ethylene glycol, propylene glycol, 1,3-butanediol, 3-methyl-1,3-butanediol,  1,2-pentanediol, 1,2-hexanediol, diethylene glycol, triethylene glycol, polyethylene glycol, dipropylene glycol and polypropylene glycol;

trihydric alcohols, such as glycerol;

ethers of trihydric alcohols, such as diglycerol and polyglycerol;

sugar alcohols, such as mannitol, sorbitol, xylitol, maltitol, erythritol and pentaerythritol;

monosaccharides, such as glucose, fructose and xylose;

oligosaccharides, such as sucrose, lactose, maltose and trehalose;

anionic surfactants, such as ester coconut fatty acid potassium, fatty acid sodium ester of coconut, triethanolamine ester with coconut fatty acid, laurate potassium, sodium laurate, triethanolamine laurate, myristate potassium, sodium myristate, isopropanolamine myristate, palmitate potassium, sodium palmitate, isopropanolamine palmitate, potassium stearate, sodium stearate, triethanolamine stearate, potassium oleate, sodium oleate, sodium fatty acid ester of castor oil, zinc undecylenate, zinc laurate, myristate zinc, magnesium myristate, zinc palmitate, stearate zinc, calcium stearate, magnesium stearate, stearate aluminum, calcium myristate, magnesium myristate, dimiristate of aluminum, aluminum isostearate, polyoxyethylene lauryl ether acid acetic, polyoxyethylene lauryl ether sodium acetate, acid polyoxyethylene tridecyl ether acetic acid, polyoxyethylene tridecyl ether sodium acetate, sodium stearoyl lactate, isostearoyl lactate sodium, sodium lauroylsarcosinate, sarcosine ester with acid coconut fatty, sodium sarcosine ester with coconut fatty acid, triethanolamine sarcosinate ester with coconut fatty acid, lauroylsarcosine, potassium lauroylsarcosinate, lauroylsarcosinate triethanolamine, oleoylsarcosine, sodium myristoysarcosinate, sodium stearoylglutamate, cocoylglutamic acid, cocoylglutamate potassium, sodium cocoylglutamate, cocoylglutamate triethanolamine, lauroylglutamic acid, potassium lauroylglutamate, sodium lauroylglutamate, triethanolamine lauroylglutamate, acid myristoylglutamic, potassium myristoylglutamate, myristoylglutamate sodium, stearoylglutamic acid, potassium stearoylglutamate, disodium stearoylglutamate, sodium hydrogenated seboylglutamate, sodium hydrogenated cocoyl / seboylglutamate, methylalaninate ester sodium with coconut fatty acid, lauroylmethylalanine, sodium lauroylmethylalaninate, lauroylmethylalaninate triethanolamine, sodium myristoylmethylalaninate, sodium lauroylmethyltaurinate, potassium methyltaurinate ester with coconut fatty acid, sodium methyltaurinate ester with fatty acid of coconut, magnesium methyltaurinate ester with coconut fatty acid, sodium myristoylmethyltaurinate, sodium palmitoylmethyltaurinate, sodium stearoylmethyltaurinate, sodium oleoylmethyltaurinate, sodium alkanesulfonate, sodium tetradecenesulfonate, dioctyl sulfosuccinate sodium, lauryl sulfosuccinate disodium, coconut fatty acid ethyl ester sodium sulphonate, sodium lauryl sulfate, triethanolamine lauryl sulfate, cetyl sulfate sodium, alkyl sulfates (11, 13, 15) of triethanolamine, sodium alkyl sulfates (12, 13), alkyl sulfates (12, 13) of triethanolamine, alkyl sulfates (12, 14, 16) of ammonium, alkyl sulfates (12, 13) of diethanolamine, alkyl sulfates (12 to 14) of triethanolamine, alkyl sulfates (12 to 15) of triethanolamine, triethanolamine magnesium cocoalkyl sulfate, lauryl sulfate ammonium, potassium lauryl sulfate, magnesium lauryl sulfate, monoethanolamine lauryl sulfate, diethanolamine lauryl sulfate, sodium myristyl sulfate, sodium stearylsulfate, oleyl sulfate sodium, triethanolamine oleyl sulfate, polyoxyethylene lauryl ether sodium sulfate, polyoxyethylene lauryl ether sulfate triethanolamine, polyoxyethylene (1) alkyl (11, 13, 15) ether sulfate sodium, polyoxyethylene (1) alkyl (11, 13, 15) ether sulfate triethanolamine, polyoxyethylene (3) alkyl (11 to 15) ether sulfate sodium, polyoxyethylene (2) alkyl (12, 13) sodium ether sulfate, polyoxyethylene (3) alkyl (12 to 14) sodium ether sulfate, polyoxyethylene (3) alkyl (12 to 15) sodium ether sulfate, polyoxyethylene (2) sodium lauryl ether sulfate, polyoxyethylene (3) myristyl ether sodium sulfate, sodium alkanolamide sulfate higher fatty acid, lauryl phosphoric acid, sodium lauryl phosphate, potassium cetyl phosphate, diethanolamine cetyl phosphate, acid polyoxyethylene oleyl phosphoric acid, polyoxyethylene lauryl ether phosphoric, polyoxyethylene lauryl ether sodium phosphate, acid polyoxyethylene phosphoric cetyl ether, polyoxyethylene phosphate cetyl ether sodium, polyoxyethylene stearyl phosphoric acid, acid polyoxyethylene phosphoric oleyl ether, polyoxyethylene oleyl phosphate sodium, polyoxyethylene alkylphenyl ether phosphoric acid, polyoxyethylene alkylphenyl ether phosphate sodium, polyoxyethylene alkylphenyl ether triethanolamine phosphate, polyoxyethylene acid Octyl phosphoric ether, polyoxyethylene (10) alkyl (12, 13) ether phosphoric, polyoxyethylene alkyl (12 to 15) phosphoric ether, polyoxyethylene alkyl (12 to 16) phosphoric ether, polyoxyethylene lauryl ether triethanolamine phosphate and polyoxyethylene oleyl ether diethanolamine phosphate;

cationic surfactants, such as dioctylamine, dimethylstearylamine, trilaurylamine, stearic acid diethylaminoethylamide chloride lauryltrimethylammonium, cetyltrimethylammonium chloride, bromide cetyltrimethylammonium, cetyltrimethylammonium saccharin, chloride Stearyltrimethylammonium, alkyl chloride (20 to 22) trimethylammonium, lauryltrimethylammonium bromide, alkyl chloride (16,18) trimethylammonium, stearyltrimethylammonium bromide, saccharin from Stearyltrimethylammonium, alkyl chloride (28) trimethylammonium, di (polyoxyethylene) oleylmethylammonium (2EO) chloride, dipolyloxyethylene stearylmethylammonium chloride, polyoxyethylene (1) polyoxypropylene (25) diethylmethylammonium, chloride of tri (polyoxyethylene) stearylammonium (5EO), chloride distearyl dimethyl ammonium, dialkyl chloride (12 to 15) dimethylammonium, dialkyl chloride (12 to 18) dimethylammonium, chloride of dialkyl (14 to 18) dimethylammonium chloride dicocoyldimethylammonium, diketyldimethylammonium chloride, isostearyluryldimethylammonium, benzalkonium chloride, myristyldimethylbenzylammonium chloride lauryl dimethyl (ethylbenzyl) ammonium chloride stearyl dimethylbenzylammonium, laurylpyridinium chloride, cetylpyridinium, lauroylcholaminoformylmethylpyridinium chloride, Stearoylcolaminoformylmethylpyridinium chloride, alkyl isoquinolinium, methylbenzethonium chloride and benzethonium;

amphoteric surfactants, such as betaine from 2-alkyl-N-carboxymethyl-N-hydroxyethyl-imidazolinium, alkyldiaminoethylglycine hydrochloride, lauryl diaminoethylglycine sodium, undecyl hydroxyethylimidazolium sodium betaine, betaine undecyl-N-carboxymethylimidazolium, cocoyl-N-carboxyethyl-N-hydroxyethylethylenediamine disodium cocoyl-N-carboxyethoxyethyl-N-carboxy-ethylethylenediamine  disodium cocoyl-N-carboxymethoxyethyl-N-carboxymethylethylenediamine disodium, sodium laurylamine propionate, laurylamine dipropionate sodium, triethanolamine laurylaminopropionate, palmoyl-N-carboxyethyl-N-hydroxyethylethylenediamine sodium, lauryl dimethylaminoacetate betaine, betaine oil coco-alkyldimethylaminoacetate, betaine from stearyl dimethylaminoacetate, sodium stearyl dimethyl betaine, cocoamidopropyl betaine, palmamidopropyl betaine, betaine lauramidopropylacetate, ricinamidopropyl betaine, stearyldihydroxyethylbetaine, and laurylhydroxysulfobetaine;

nonionic surfactants, such as polyoxyethylene (10) alkyl (12, 13) ether, polyoxyethylene lauryl ether, polyoxyethylene cetyl ether, polyoxyethylene stearyl ether, polyoxyethylene oleyl ether, polyoxyethylene (3, 7, 12) alkyl (12 to 14) ether, polyoxyethylene tridecyl ether, polyoxyethylene myristyl ether, polyoxyethylene-sec-alkyl (14) ether, polyoxyethylene isocetyl ether, polyoxyethylene ketostearyl ether, polyoxyethylene (2, 10, 20) isostearyl ether, polyoxyethylene Oleylcetyl ether, polyoxyethylene (20) arakyl ether, polyoxyethylene octyldodecyl ether, polyoxyethylene behenyl ether, polyoxyethylene octylphenyl ether, polyoxyethylene nonylphenyl ether, polyoxyethylene Dinonylphenyl ether, polyoxyethylene (1) polyoxypropylene (1, 2, 4, 8) cetyl ether, polyoxyethylene (5) polyoxypropylene (1, 2, 4, 8) cetyl ether, polyoxyethylene (10) polyoxypropylene (1, 2, 4, 8) cetyl ether, polyoxyethylene (20) polyoxypropylene (1, 2, 4, 8) cetyl ether, polyoxyethylene polyoxypropylene lauryl ether, polyoxyethylene (3) polyoxypropylene (34) stearyl ether, polyoxyethylene (4) polyoxypropylene (30) stearyl ether, polyoxyethylene (34) polyoxypropylene (23) stearyl ether, polyoxyethylene polyoxypropylene cetyl ether, polyoxyethylene polyoxypropylene decyltetradecyl ether,

polyethylene glycol monolaurate, monostearate ethylene glycol, polyethylene glycol monostearate, monooleate polyethylene glycol, fatty acid ester with ethylene glycol, self-emulsifiable ethylene glycol monostearate, diethylene glycol laurate, polyethylene glycol myristate, palmitate polyethylene glycol, diethylene glycol stearate, monostearate polyethylene glycol (2) self-emulsifiable, isostearate polyethylene glycol, ethylene glycol dioctanoate, dilaurate diethylene glycol, polyethylene glycol dilaurate, dipalmitate polyethylene glycol (150), ethylene glycol distearate, distearate diethylene glycol, polyethylene glycol distearate, dioleate ethylene glycol, polyethylene glycol dioleate, dirricinoleate polyethylene glycol, polyoxyethylene monolaurate (20) sorbitan, polyoxyethylene monopalmitate (20) sorbitan, monostearate polyoxyethylene (6) sorbitan, polyoxyethylene monostearate (20) sorbitan, polyoxyethylene trytearate (20) sorbitan, monooleate polyoxyethylene (6) sorbitan, polyoxyethylene monooleate (20) sorbitan, polyoxyethylene trioleate (20) sorbitan, acid ester coconut fatty with polyoxyethylene (20) sorbitan, monolaurate polyoxyethylene (10 to 80) sorbitan, polyoxyethylene triestearate sorbitan, polyoxyethylene isostearate (20) sorbitan, triestearate polyoxyethylene (150) sorbitan,

polyoxyethylene castor oil, oil hydrogenated castor polyoxyethylene, polyoxyethylene oil (10) hydrogenated castor, polyoxyethylene oil (20) hydrogenated of castor, hydrogenated polyoxyethylene (40) castor oil, polyoxyethylene (50) hydrogenated castor oil, oil hydrogenated polyoxyethylene (60) castor, caprylate glyceryl, glyceryl caprate, glyceryl laurate, myristate glyceryl, glyceryl stearate, glyceryl linoleate, oleate of glyceryl, glyceryl isostearate, glyceryl behenate, glyceryl erucate, coconut fatty acid ester with glyceryl, glyceryl ricinoleate, glyceryl hydroxystearate, wheat germ oil fatty acid monoglyceride, safflower oil fatty acid monoglyceride, monoglyceride hydrogenated soy bean fatty acid, acid monoglyceride saturated fatty, monoglyceride fatty acid seed oil cotton, tallow fatty acid monoglyceride, monoglyceride lanolin fatty acid,

glyceryl monomyristate monostearate, glyceryl sesquioleate, glyceryl distearate, diisoestearate of glyceryl, glyceryl diaraquidate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan monoisoestearate, sorbitan monooleate, sorbitan sesquiestearate, sorbitan sesquioleate, triestearate sorbitan, sorbitan trioleate, coconut fatty acid ester with sorbitan, sorbitan isoestearate, sorbitan sesquiisoestearate, sorbitan distearate, diglyceryl isopalmitate, monolaurate of poly (4 to 10) glyceryl, poly (10) glyceryl monomiristate, poly (2 to 10) glyceryl monostearate, poly monostearate (2 to 10) glyceryl, poly (2 to 10) glyceryl monooleate, diglyceryl sesquioleate, poly diisoestearate (2 to 10) glyceryl, poly (6 to 10) glyceryl distearate, triisoestearate of diglyceryl, poly (10) glyceryl triestearate, trioleate poly (10) glyceryl, poly (2) glyceryl tetraisoestearate, decaglyceryl pentaestearate, poly pentaoleate (6 to 10) glyceryl, poly (10) glyceryl heptaestearate, decaglyceryl, poly (10) glyceryl decaoleate, ricinoleate poly (6) condensed glyceryl, fatty acid ester with sugar cane, coconut fatty acid ester with cane sugar, alkyl glycoside, oil oxide coco alkyldimethylamine oxide lauryldimethylamine, dihydroxyethylurethyldimethylamine oxide, oxide of stearyl dimethylamine, oxyldimethylamine oxide and oxide polyoxyethylene oil coco-alkyldimethylamine;

natural surfactants, such as saponin, lecithin, soy bean phospholipid, hydrogenated phospholipid soya bean, lysophospholipid soya bean, lysophospholipid Hydrogenated soy bean, egg yolk lecithin, egg yolk hydrogenated lysophosphatidylcholine, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingophospholipid, sphingomyelin, sphingomyelin, ganglioside, bile acid, acid colic, deoxycholic acid, sodium cholate, sodium deoxycholate, spiculisphoric acid, ramnolipid, trehalose lipid, mannosyritritol soforolipid and lipid;

UV absorbers, including para-aminobenzoic acid derivatives, such as para-aminobenzoic acid, ethyl para-aminobenzoate, glyceryl para-aminobenzoate, amyl para-dimethylaminobenzoate and para-dimethylaminobenzoate 2-ethylhexyl; cinnamic acid derivatives, such as benzyl cinnamate, mono-2-ethylhexanoate glyceryl dipara-methoxycinnamate, Methyl 2,4-diisopropylcinamate, Ethyl 2,4-diisopropylcinamate, para-methoxycinnamate, sodium potassium para-methoxycinnamate, isopropyl para-methoxycinnamate, 2-ethylhexyl para-methoxycinnamate, 2-ethoxyethyl para-methoxycinnamate and ethyl para-ethoxycinnamate; acid derivatives urocanic, such as uracanic acid and ethyl urocanate; benzophenone derivatives, such as 2,4-dihydroxybenzophenone, 2,2 ', 4,4'-tetradihydroxybenzophenone, 2-hydroxy-4-methoxy-5-sulfobenzophenone sodium acid 2-hydroxy-4-methoxybenzophenon-5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone Y 2,2'-dihydroxy-4,4'-dimethoxy-5-sulfobenzophenone sodium salicylic acid derivatives, such as salicylate ethylene glycol, 2-ethylhexyl salicylate, salicylate phenyl, benzyl salicylate, salicylate p-tert-butylphenyl, salicylate homomentyl and salicylate of 3,3,5-trimethylcyclohexyl; 2- (2'-hydroxy-5'-methoxyphenyl) benzotriazole Y 4-tert-butyl-4'-methoxybenzoylmethane;

powders and colored materials, such as kaolin, silicic anhydride, magnesium aluminum silicate, sericite, talc, boron nitride, mica, montmorillonite, hemp cellulose powder, wheat starch, silk powder, corn starch, dyes natural such as nitro dyes, azo dyes, nitrous dyes, triphenylmethane dyes, xanthene dyes, quinoline dyes, anthraquinone dyes, dyes indigo, pyrene dyes, phthalocyanine dyes, flavonoids, quinone, porphyrin, water soluble anato, powder squid ink, caramel, guaiazuleno, gardenia blue, yellow gardenia, cochineal (carmine), shikonin, cupric chlorophyllin sodium, paprika dye (sweet paprika), safflower red, safflower yellow, lacaic acid and riboflavin butyrate; black of carbon, yellow iron oxide, black iron oxide, oxide iron red, iron blue, ultramarine blue, zinc oxide, chrome oxide, titanium oxide, black titanium oxide, oxide zirconium, chromium hydroxide, alumina, magnesium oxide, sulfate barium, aluminum hydroxide, calcium carbonate, titanate lithium cobalt, manganese violet and pearl pigment;

plant extracts, such as Angelica keiskei extract, Urticaria gambir extract, avocado extract, Hydrangea serrata leaf extract, Gynostemma pentaphyllum extract, Althaea extract, Arnica extract, oil-soluble Arnica extract, almond extract , aloe extract, Styrax benzoin resin extract, Ginkgo extract, Urtica extract, Iris rhizome extract, fennel extract, turmeric extract, rose hip fruit extract, Echinacea leaf extract, root extract Scutellaria baicalensis , Phellodendron bark extract, coptis rhizome extract, barley seed extract, okra extract, Hypericum erectum extract, oil soluble Hypericum erectum extract, Lamium album flower extract, Lamium flower extract oil-soluble album , Ononis extract, Nasturtium officinale extract, orange extract, orange blossom water, seaweed extract, tani non-persimmon, Puerariae root extract, valerian extract, enea extract, chamomile extract, oil-soluble chamomile extract, chamomile water, oat grain extract, carrot extract, carrot extract, carrot oil oil soluble, carrot oil, Artemisia capillaris extract, licorice extract, licorice powder extract, licorice flavonoid, cantharid tincture, raspberry extract, kivi extract, Cinchona extract, cucumber extract, seed extract Apricot, quince seed extract, gardenia extract, Sasa veitchii extract, Sophora angustifolia extract, nut shell extract, grapefruit extract, Clematis extract, brown sugar extract, Chlorella extract, blackberry extract, cinnamon bark extract, gentian extract, geranium herb extract, tea extract, yellow water lily extract, Arctium lappa root extract, root extract z oil-soluble Arctium lappa , wheat germ extract, hydrolyzed wheat powder, rice bran extract, fermented rice bran extract, comfrey extract, Asiasarum root extract, saffron extract, Saponaria officinalis extract , oil-soluble sage extract, Crataegus cuneata fruit extract, Xanthoxylum extract, Shiitake fungus extract, Shiitake fungus powder extract, Rehmannia glutinosa extract, Sycon extract, oil soluble Sycon extract, perilla extract , linden extract, oil-soluble linden extract, Filipendula multijuga extract, peony root extract, Coix lacryma-jobi seed extract, ginger extract, oil soluble ginger extract, ginger tincture, root extract of Acorus calamus extract, Betula alba (birch), Betula extract oil soluble alba, Betula alba sage, Lonicera extract, Equisetum arvense extract, Oil-soluble Equisetum arvense extract, scordinin, stevia extract, ivy extract, Crataegus oxyacantha extract, Sambucus nigra flower extract, Juniperus communis extract, Achillea millefolium extract, Achillea millefolium extract, oil extract Mentha piperita, salvia extract, extract soluble sage oil, water sage extract Malva sylvestris extract, celery extract, Cnidium officinale, water Cnidium officinale extract japonica Swertis extract soybean, jojoba extract , thyme extract, leaf extract of Camellia sinensis, distilled dry camellia sinensis seed extract, Camellia sinensis, clove extract, shell extract Citrus unshiu extract seeds Camellia japonica extract, Centella asiatica extract, Oil-soluble Juglans regia , duku extract, Terminalia extract, red pepper tincture, Angelica acut extract iloba , oil-soluble Angelica acutiloba extract, water from Angelica acutiloba , Calendula officinalis flower extract, oil-soluble Calendula officinalis flower extract, soy milk powder, Prunus persica extract, Citrus aurantium amara extract, extract of Houttuynia cordata , tomato extract, Potentilla erecta root extract, natto extract (fermented soybeans), Ginseng extract, oil-soluble Ginseng extract, garlic extract, canine Rosa fruit extract, Rosa fruit extract oil-soluble canine , malt extract, malt root extract, Ophiopogon tuber extract, parsley extract, concentrate of Hordeum vulgare leaf juice, peppermint distillate, witch hazel water, witch hazel extract, flower extract of Rosa centifolia , Parietaria extract, Isodonis japonicus extract, Eriobotrya japonica leaf extract, Eriobotrya japonica soluble leaf extract e in oil, horse nail flower extract, Poria coconuts extract, Ruscus aculeatus root extract, Ruscus aculeatus root powder extract, grape extract, vine leaf extract, grape water flower extract hay, fruit extract Luffa cylindrica fruit water Luffa cylindrica extract, safflower extract miqueliana Tilia oil soluble water miqueliana Tilia, root extract Paeonia suffruticosa, hop extract, extract oil-soluble hops, Pinus sylvestris extract, Silybum marianum fruit extract, horse-chestnut extract, oil-soluble horse chestnut extract, Sapindus mukurossi skin extract, Melissa officinalis leaf extract, Melilotus extract officinalis , peach leaf extract, oil-soluble peach leaf extract, soy bean extract, Centaurea cyanus flower extract, distillate of Centa flowers cyanus urea, eucalyptus extract, saxifrage extract sarmentosa extract bulb Lilum candidum, seed extract Coix lacryma jobi seed extract of Coix lacryma soluble jobi oil extract, Artemisia princeps, water Artemisia princeps extract lavender, lavender water, apple extract, Ganoderma lucidum extract, lettuce extract, lemon extract, Astragalus sinicus extract, rose water, rosemary extract, oil-soluble rosemary extract, Anthemis nobilis flower extract and Sanguisorba officinalis root extract;

amino acids and peptides, such as glycine, alanine, valine, leucine, isoleucine, serine, threonine, phenylalanine, tyrosine, tryptophan, cystine, cysteine, methionine, proline, hydroxyproline, aspartic acid, asparagine, acid glutamic, glutamine, arginine, histidine, lysine, acid γ-aminobutyric acid DL-pyrrolidoncarboxylic acid ε-aminocaproic acid, hydrolyzed elastin, water-soluble elastin, hydrolyzed collagen, water-soluble collagen, casein, glutathione, wheat peptides and soy peptide;

vitamins and factors that act as vitamins, including vitamin A, such as retinol, retinal, retinoic acid, retinol acetate and retinol palmitate; carotenoids, like α-carotene, β-carotene, γ-carotene, δ-carotene, lycopene, zeaxanthin, cryptoxanthin, equinenone and astaxanthin; vitamin B1, such as thiamines; vitamin B2, such as riboflavin; vitamin B6, such as pyridoxine, pyridoxal and pyridoxamine; vitamin B12 such as cyanocobalamin; folic acids, nicotinic acid, nicotinamide, pantothenic acid, biotins; vitamin C, such as acid L-ascorbic, sodium L-ascorbate, L-ascorbyl stearate, palmitate L-ascorbyl, dipalmitate L-ascorbyl, tetraisopalmitate L-ascorbyl, L-ascorbate sulfate disodium, magnesium L-ascorbate, sodium phosphate L-ascorbyl and 2-acid glycoside L-ascorbic; vitamin D, such as ergocalciferol and cholecalciferol; vitamin E, such as d-? -tocopherol, DL-? -Tocopherol acetate dl-? -tocopherol, succinate dl-? -tocopherol, β-tocopherol, γ-tocopherol and d-? -tocopherol; ubiquinonas, vitamin K, carnitine, ferulic acid, γ-oryzanol acid α-lipoic and orotic acid;

antiseptic agents, such as benzoic acid, sodium benzoate, undecylenic acid, salicylic acid, acid sorbic, potassium sorbate, dehydroacetic acid, dehydroacetate sodium, isobutyl parahydroxybenzoate, parahydroxybenzoate Isopropyl, ethyl parahydroxybenzoate, parahydroxybenzoate butyl, propyl parahydroxybenzoate, parahydroxybenzoate benzyl, methyl parahydroxybenzoate, sodium parahydroxybenzoate, phenoxyethanol, photosensitive agent No. 101; photosensitive agent no. 201 and photosensitive agent No. 401;

antioxidant agents, such as butylhydroxyanisole, butylhydroxytoluene, propyl gallate, acid erythorbic, sodium erythorbate, para-hydroxyanisole and ethyl gallate;

sequestering agents, such as trisodium ethylenediaminohydroxyethyltriacetate, edetic acid, edetate disodium, trisodium edetate, tetrasodium edetate, sodium citrate, gluconic acid, phytic acid, sodium polyphosphate and metaphosphate sodium;

wetting agents, such as acid hyaluronic acid, sodium hyaluronate, sodium sulfate salt Chondroitin, sodium lactate, sodium pyrrolidoncarboxylate, betaine, lactic acid bacteria culture solution; extract of yeast and ceramide;

anti-inflammatory agents, such as acid glycyrrhizinic acid, trisodium glycyrrhizinate, dipotassium glycyrrhizinate,  monoammonium glycyrrhizinate, acid β-glyceryl, glyceryl glycinate, stearyl glycyrrheinate, lysozyme chloride, hydrocortisone and allantoin;

pH adjusters, such as sodium hydroxide, potassium hydroxide and triethanolamine;

salts, such as sodium chloride, chloride potassium, magnesium chloride and sodium sulfate;

α-hydroxy acids, such such as citric acid, glycolic acid, tartaric acid and acid lactic;

bleaching agents, such as arbutin, α-arbutin and placenta extract;

essential oils such as angelica oil, ylang ylang oil, elemi oil, orange oil, German chamomile oil, Anthemis nobilis oil, cardamom oil, calamus oil, galbanum oil, camphor oil, seed oil of carrot, sage oil (sage), grape oil, clove oil, cinnamon bark oil, coriander oil, cypress oil, sandalwood oil, cedar oil, citronella oil, leaf oil cinnamon, jasmine absolute oil, juniper tree berry oil, ginger extract, peppermint oil, sage oil, cedar oil, geranium oil, thyme oil, tea tree oil, nutmeg oil , niaouli oil, neroli oil, pine oil, basil oil, peppermint oil, patchouli oil, palm kernel oil, fennel oil, sour orange oil, black pepper oil, olive oil, olive oil vetivert oil Peppermint peppermint, bergamot oil, benzoin oil, Aniba rosaeodora oil, marjoram oil, tangerine oil, myrrh oil, melissa oil, eucalyptus oil, Chinese lemon oil, lime oil, ravensara oil, Lavandina oil, lavender oil, linden oil, lemon oil, lemongrass oil, rose oil, rosewood oil, rosemary oil and lovage oil;

terpenes, such as limonene, pinene, terpinen, terpinolene, myrcene and longifolene;

fragrances and water.

Emulsified Cosmetic

The emulsified preparation for external use for the skin contains the derivative of tocopherol glycinate, so minus a fatty acid ester selected from the monoesters of fatty acids with glycerin, fatty acid esters with polyglycerin, and fatty acid esters with dextrin, and additional components described above. The cosmetics Emulsified are the most frequent form of preparations Emulsified for external use for the skin.

Emulsified cosmetics are not particularly limited as long as they are used directly on the  skin, and its examples include milky lotions, serums, creams and gels They can be used regardless of gender and age of Username.

The emulsified cosmetic according to the present invention may contain existing cosmetic ingredients, while still achieving the effects of the invention.

Existing cosmetic ingredients include those stated in the following documents: The Japanese Standards of Cosmetic Ingredients, 2nd edition, (edited by Society of Japanese Pharmacopoeia and published by Yakuji Nippo, Ltd (1984)), The Japanese Cosmetic Ingredients Codex (edited by Ministry of Health and Welfare, Pharmaceutical Examination Division and published by Yakuji Nippo, Ltd, (1993)), Supplement to the Japanese Cosmetic Ingredients Codex (edited by the Ministry of Health and Welfare, Pharmaceutical Examination Division and published by Yakuji Nippo, Ltd. (1993)), The Comprehensive Licensing Standards of Cosmetics by Category (edited by the Ministry of Health and Welfare, Pharmaceutical Examination Division and published by Yakuji Nippo, Ltd. (1993)), The Japanese Cosmetic Ingredients Codex by Category (edited by the Ministry of Health and Welfare, Pharmaceutical Examination Division and published by Yakuji Nippo, Ltd. (1997)), and Dictionary of Cosmetic Ingredients (Nikko Chemicals, Co. Ltd. (1991)).

The emulsified preparation for external use for the skin and the emulsified cosmetic of the present invention are they can produce by usual procedures depending on formulations, for example dissolving, mixing or dispersing the ingredients mentioned above in the amounts predetermined

Procedure to stabilize the emulsified preparation for use external to the skin

The emulsified preparation for external use for The skin of the present invention contains the glycinate derivative of tocopherol in combination with at least one fatty acid ester selected from the fatty acid monoesters with glycerin, fatty acid esters with polyglycerin, and acid esters fatty with dextrin, which prevents the reduction of viscosity and separation during storage.

Specifically, the combined use of the derivative of tocopherol glycinate and at least one fatty acid ester selected from the fatty acid monoesters with glycerin, fatty acid esters with polyglycerin and acid esters fatty with dextrin stabilizes the external use preparation for skin containing the tocopherol glycinate derivative. This procedure to stabilize the external use preparation for the skin that contains the tocopherol glycinate derivative is a aspect of the present invention.

Examples

Here below, the present invention is describe in greater detail by examples. However, it I should interpret that the invention is not limited to them.

The fatty acid monoesters with glycerin used in the Examples were glyceryl stearate, isostearate glyceryl, glyceryl laurate, glyceryl myristate, oleate of glyceryl and glyceryl ricinoleate. Acid esters polyglycerin fatty acids used in the Examples were monostearate of poly (10) glyceryl, poly (10) glyceryl monostearate and poly (10) glyceryl myristate. Fatty acid esters with dextrin used in the Examples were dextrin stearate, dextrin palmitate and dextrin myristate. The glycerin used in the Examples it had a purity of at least 98% by mass. The storage stability was tested as next.

Stability test during storage

The sample was placed in a glass bottle and It was allowed to stand at 40 ° C for one month. The state and appearance are They watched visually. In addition, the viscosity was measured before and after rehearsal Samples that have no defect were evaluated such as "AA", and samples that have defects (such as separation and fluidization due to viscosity reduction) were evaluated as "BB". The viscosity was measured with the Type E viscometer (VISCONIC EHD manufactured by Tokyo Keiki Co., Ltd., rotor No. 4) using 1 g of the sample in the condition of 25 ° C and 0.5 rpm.

Examples 1-7 and Comparative Examples 1-2

The materials of component I were mixed together in the amounts shown in Table 1, at 80 ° C, and dissolved. Separately, component II materials are mixed together in the amounts shown in Table 1, at 80 ° C, and dissolved. Component II was added to component I. The The mixture was cooled with stirring and emulsified. The emulsion is cooled to 30 ° C to give a cream. The cream was tested for Determine stability during storage. The results are shown in Table 1, in which the values are in mass% except for the viscosity value.

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As shown in Table 1, Examples 1 to 7 used glyceryl stearate, while Example 1 Comparative did not use glyceryl stearate, and Example 2 Comparative substituted glyceryl stearate with stearic acid and potassium hydroxide. The creams of Examples 1 to 7 were shown they have superior stability during storage at Creams of Comparative Examples 1 and 2.

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Examples 8-15

Creams were prepared as described. previously using the materials in the amounts shown in Table 2. Creams were tested for stability. during storage The results are shown in the Table 2, in which the values are in mass% except for the value of viscosity

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       \ dotable {\ tabskip \ tabcolsep # \ hfil \ tabskip0ptplus1fil \ dddarstrut \ cr} {
\ cr
\ cr}
    

5

       \ newpage
    

As shown in Table 2, the creams of the Examples 8 to 15 showed excellent stability during the storage.

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Examples 16-24

Creams were prepared as described. previously using the materials in the amounts shown in Table 3. Creams were tested for stability. during storage The results are shown in the Table 3, in which the values are in mass% except for the value of viscosity

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(Table goes to page next)

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       \ dotable {\ tabskip \ tabcolsep # \ hfil \ tabskip0ptplus1fil \ dddarstrut \ cr} {
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6

       \ newpage
    

As shown in Table 3, the creams of the Examples 16 to 24 showed excellent stability during the storage.

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Examples 25-31 and Examples 3-4 Comparatives

Creams were prepared as described. previously using the materials in the amounts shown in Table 4. Creams were tested for stability. during storage The results are shown in the Table 4, in which the values are in mass% except for the value of viscosity

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7

As shown in Table 4, Examples 25 a 31 used dextrin palmitate, while Example 3 Comparative did not use dextrin palmitate, and Comparative Example 4 replaced dextrin palmitate with palmitic acid and hydroxide potassium The creams of Examples 25 to 31 showed to have a storage stability superior to the creams of the Examples 3 and 4 Comparatives.

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Examples 32-39

Creams were prepared as described. previously using the materials in the amounts shown in Table 5. Creams were tested for stability. during storage The results are shown in the Table 5, in which the values are in mass% except for the value of viscosity

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(Table goes to page next)

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       \ dotable {\ tabskip \ tabcolsep # \ hfil \ tabskip0ptplus1fil \ dddarstrut \ cr} {
\ cr
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8

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As shown in Table 5, the creams of the Examples 32 to 39 showed excellent stability during the storage.

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Examples 40-42

Creams were prepared as described. previously using the materials in the amounts shown in Table 6. Creams were tested for stability. during storage The results are shown in the Table 6, in which the values are in mass% except for the value of viscosity

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TABLE 6

9

As shown in Table 6, the creams of the Examples 40 to 42 showed excellent stability during the storage.

Examples 43-49 and Examples 5-6 Comparatives

Creams were prepared as described. previously using the materials in the amounts shown in Table 7. Creams were tested for stability. during storage The results are shown in the Table 7, in which the values are in mass% except for the value of viscosity

       \ newpage
    

       \ dotable {\ tabskip \ tabcolsep # \ hfil \ tabskip0ptplus1fil \ dddarstrut \ cr} {
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10

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As shown in Table 7, Examples 43 a 49 used dextrin palmitate and poly monostearate (10) glyceryl, while Comparative Example 5 did not use palmitate from poly (10) glyceryl dextrin or monostearate, and Example 6 Comparative substituted dextrin palmitate and monostearate de poly (10) glyceryl by palmitic acid and potassium hydroxide. The creams from Examples 43 to 49 showed stability at storage above the creams of Examples 5 and 6 Comparatives

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Example 50

A cream was prepared as described previously using the materials in the amounts shown in Table 8. The cream was tested for stability. during storage The result is shown in Table 8, in which the values are in mass% except for the value of the viscosity.

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TABLE 8

eleven

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As shown in Table 8, the cream of Example 50 showed excellent stability during storage.

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Example 51

A cream was prepared as described previously using the materials in the amounts shown in Table 9. The cream was tested for stability. during storage The result is shown in Table 9, in which the values are in mass% except for the value of the viscosity.

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TABLE 9

12

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As shown in Table 9, the cream of Example 51 showed excellent stability during storage.

Claims (10)

1. Emulsified preparation for external use for the skin comprising 0.03 to 25% by mass of a derivative of tocopherol glycinate, and 0.05 to 25% by mass of at least one fatty acid ester selected from the group consisting of fatty acid monoester with glycerin, fatty acid ester with polyglycerin and fatty acid ester with dextrin, being represented Tocopherol glycinate derivative by Formula (1): 13 where R 1 and R 2 are each a lower alkyl group or a hydrogen atom, and not they can be hydrogen atoms at the same time, and R 3, R 4 and R 5 are each a hydrogen atom or a group methyl, on condition that they be excluded preparations containing the following components (i) a (xii):

(i)

0.20% by weight of a glycine ester with tocopherol, 3.00% by weight of an ester of ascorbic acid-2-acid  phosphoric, 72.10% by weight of pure water, 1.0% by weight of surfactin sodium or

quad

1.00% by weight of a glycine ester with tocopherol, 9.00% by weight of an ester of ascorbic acid-2-acid phosphoric, 65.30% by weight of pure water, 1.0% by weight of surfactin sodium or

quad

1.00% by weight of a glycine ester with tocopherol, 1.00% by weight of an ester of ascorbic acid-2-acid phosphoric, 73.30% by weight of pure water, 1.0% by weight of surfactin sodium or

quad

0.20% by weight of a glycine ester with tocopherol, 3.00% by weight of an ester of ascorbic acid-2-acid phosphoric, 73.00% by weight of pure water, 0.1% by weight of surfactin sodium or

quad

1.00% by weight of a glycine ester with tocopherol, 1.00% by weight of an ester of ascorbic acid-2-acid phosphoric, 74.20% by weight of pure water, 0.1% by weight of surfactin sodium or

quad

0.20% by weight of a glycine ester with tocopherol, 3.00% by weight of an ester of ascorbic acid-2-acid phosphoric, 73.10% by weight of pure water, 0.01% by weight of surfactin sodium or

quad

1.00% by weight of a glycine ester with tocopherol, 1.00% by weight of an ester of ascorbic acid-2-acid phosphoric, 74.30% by weight of pure water, 0.01% by weight of surfactin sodium

(ii)

7.00% by weight of 1,3-butylene glycol,

(iii)

0.10% by weight of xanthan gum,

(iv)

2.50% by weight of POE monostearate (20) sorbitan,

(v)

1.0% by weight of glyceryl monostearate lipophilic,

(saw)

0.50% by weight of stearic acid,

(vii)

1.50% by weight of behenyl alcohol,

(viii)

0.50% by weight of cetyl palmitate,

(ix)

5.00% by weight of squalane,

(x)

5.00% by weight of 2-ethylhexanoate cetyl,

(xi)

0.50% by weight of methylpolysiloxane (100 cSt), Y

(xii)

0.10% by weight of methyl para-hydroxybenzoate,

in which the glycine ester with tocopherol is select from the group consisting of ester hydrochloride of dimethylglycine with dl-? -tocopherol hydrochloride of dimethylglycine ester with d-? -tocopherol, hydrochloride of dimethylglycine ester with d- δ-tocopherol hydrochloride of dimethylglycine ester with d-? -tocopherol, hydrochloride of the sarcosine ester with dl-? -tocopherol hydrochloride of the sarcosine ester with d-? -tocopherol, hydrochloride of the sarcosine ester with d- \ delta-tocopherol, e sarcosine ester hydrochloride with d-? -tocopherol, and in which the acid ester Ascorbic-2-phosphoric acid is selected from the group consisting of the sodium salt of the acid ester ascorbic-2-phosphoric acid, the magnesium salt of ascorbic acid-2-phosphoric acid ester, salt sodium ester of ascorbic acid-2-acid phosphoric-6-palmitic acid, and the sodium salt of ascorbic acid-2-acid ester phosphoric-6-hexyldecanoic acid.

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2. Emulsified preparation for external use for the skin according to claim 1, wherein the derivative of tocopherol glycinate is N, N-dimethylglycinate from tocopherol, or tocopherol sarcosinate. 3. Emulsified preparation for external use for the skin according to claim 1 or 2, wherein the derivative of tocopherol glycinate is at least one derivative selected from group consisting of glycinate derivatives of α-tocopherol, glycinate derivatives of γ-tocopherol, and glycinate derivatives of δ-tocopherol. 4. Emulsified preparation for external use for the skin according to any one of claims 1 to 3, wherein the tocopherol glycinate derivative is at least one derivative selected from the group consisting of glycinate derivatives of dl-? -tocopherol, derivatives of d-? -tocopherol glycinate, glycinate derivatives of d-? -tocopherol and derivatives of glycinate d- \ delta-tocopherol. 5. Emulsified preparation for external use for the skin according to claim 1, wherein the acid monoester fatty with glycerin is at least one fatty acid ester selected from the group consisting of glyceryl laurate, glyceryl myristate, glyceryl stearate, isostearate glyceryl, glyceryl behenate, glyceryl linoleate, oleate glyceryl, coconut fatty acid ester with glyceryl, ricinoleate of glyceryl, glyceryl hydroxystearate and erucate glyceryl 6. Emulsified preparation for external use for the skin according to claim 1, wherein the acid ester fatty acid with polyglycerin is an ester of fatty acid with polyglycerin It has two to ten glycerin molecules. 7. Emulsified preparation for external use for the skin according to claim 6, wherein the acid ester fatty with polyglycerin that has two to ten glycerin molecules it is at least one fatty acid ester selected from the group that consists of poly (2) glyceryl monolaurate, poly monomiristate (2) glyceryl, poly (2) glyceryl monostearate, poly (2) glyceryl monostearate, poly (10) monolaurate glyceryl, poly (10) glyceryl monomiristate, monostearate poly (10) glyceryl and poly (10) glyceryl monoisoestearate. 8. Emulsified preparation for external use for the skin according to claim 1, wherein the acid ester fatty with dextrin is at least one fatty acid ester selected from the group consisting of dextrin myristate, dextrin palmitate, (dextrin palmitate / octanoate), and dextrin stearate. 9. Emulsified cosmetic comprising the emulsified preparation for external use for the skin claimed in any one of claims 1 to 8. 10. Method for stabilizing an emulsified preparation for external use for the skin, characterized in that a derivative of tocopherol glycinate is used in combination with at least one fatty acid ester selected from the group consisting of monoester of fatty acid with glycerin, ester of fatty acid with polyglycerin and fatty acid ester with dextrin, the tocopherol glycinate derivative being represented by Formula (1): 14 where R 1 and R 2 are each a lower alkyl group or a hydrogen atom, and not they can be hydrogen atoms at the same time, and R 3, R 4 and R 5 are each a hydrogen atom or a methyl group, with the condition that the claimed procedure does not apply to the preparations excluded by the exclusion of the claim one.