ES2348066T3 - Injerto metalico-esponjoso y procedimineto de fabricación del mismo. - Google Patents
Injerto metalico-esponjoso y procedimineto de fabricación del mismo. Download PDFInfo
- Publication number
- ES2348066T3 ES2348066T3 ES06775783T ES06775783T ES2348066T3 ES 2348066 T3 ES2348066 T3 ES 2348066T3 ES 06775783 T ES06775783 T ES 06775783T ES 06775783 T ES06775783 T ES 06775783T ES 2348066 T3 ES2348066 T3 ES 2348066T3
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- ES
- Spain
- Prior art keywords
- bone
- metallic
- sponge
- graft
- modules
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
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- 238000004519 manufacturing process Methods 0.000 title abstract description 9
- 239000011148 porous material Substances 0.000 claims abstract description 6
- 229910001069 Ti alloy Inorganic materials 0.000 claims abstract description 5
- 229910052751 metal Inorganic materials 0.000 claims description 15
- 239000002184 metal Substances 0.000 claims description 15
- QNRATNLHPGXHMA-XZHTYLCXSA-N (r)-(6-ethoxyquinolin-4-yl)-[(2s,4s,5r)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]methanol;hydrochloride Chemical compound Cl.C([C@H]([C@H](C1)CC)C2)CN1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OCC)C=C21 QNRATNLHPGXHMA-XZHTYLCXSA-N 0.000 claims description 2
- 230000001464 adherent effect Effects 0.000 claims description 2
- 239000000316 bone substitute Substances 0.000 claims description 2
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 2
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 2
- 229910052715 tantalum Inorganic materials 0.000 claims description 2
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 claims description 2
- 238000003325 tomography Methods 0.000 claims description 2
- 229910000389 calcium phosphate Inorganic materials 0.000 claims 1
- 239000001506 calcium phosphate Substances 0.000 claims 1
- 235000011010 calcium phosphates Nutrition 0.000 claims 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 abstract description 34
- 230000007547 defect Effects 0.000 abstract description 15
- 239000007943 implant Substances 0.000 abstract description 14
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 abstract description 13
- 229910052719 titanium Inorganic materials 0.000 abstract description 10
- 239000010936 titanium Substances 0.000 abstract description 10
- 208000001132 Osteoporosis Diseases 0.000 abstract description 6
- 239000000463 material Substances 0.000 abstract description 6
- 238000000034 method Methods 0.000 abstract description 5
- 206010028980 Neoplasm Diseases 0.000 abstract description 4
- 230000000399 orthopedic effect Effects 0.000 abstract description 2
- 238000001356 surgical procedure Methods 0.000 abstract description 2
- 206010061728 Bone lesion Diseases 0.000 abstract 1
- 238000011156 evaluation Methods 0.000 abstract 1
- 230000035515 penetration Effects 0.000 abstract 1
- 230000010354 integration Effects 0.000 description 8
- 206010017076 Fracture Diseases 0.000 description 5
- 230000001009 osteoporotic effect Effects 0.000 description 4
- 208000010392 Bone Fractures Diseases 0.000 description 3
- 210000000588 acetabulum Anatomy 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 230000004927 fusion Effects 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- 208000001164 Osteoporotic Fractures Diseases 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- 208000005250 Spontaneous Fractures Diseases 0.000 description 2
- 229910000883 Ti6Al4V Inorganic materials 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 210000001624 hip Anatomy 0.000 description 2
- 239000011368 organic material Substances 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 229910000531 Co alloy Inorganic materials 0.000 description 1
- 229910000684 Cobalt-chrome Inorganic materials 0.000 description 1
- 206010027476 Metastases Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 238000003723 Smelting Methods 0.000 description 1
- WAIPAZQMEIHHTJ-UHFFFAOYSA-N [Cr].[Co] Chemical compound [Cr].[Co] WAIPAZQMEIHHTJ-UHFFFAOYSA-N 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000037182 bone density Effects 0.000 description 1
- 201000008275 breast carcinoma Diseases 0.000 description 1
- 239000010952 cobalt-chrome Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 210000002758 humerus Anatomy 0.000 description 1
- 239000000411 inducer Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 230000001394 metastastic effect Effects 0.000 description 1
- 206010061289 metastatic neoplasm Diseases 0.000 description 1
- 230000000278 osteoconductive effect Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000003236 psychic effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 210000002303 tibia Anatomy 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000001173 tumoral effect Effects 0.000 description 1
- 210000000689 upper leg Anatomy 0.000 description 1
- 210000000707 wrist Anatomy 0.000 description 1
Classifications
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Abstract
Injerto metálico-esponjoso (3, 6) como sustituto óseo aloplástico a base de una esponja metálica de porosidad abierta altamente resistente, por ejemplo en titanio o una aleación de titanio, caracterizado porque la esponja presenta una porosidad del 75% al 94%, está graduada, aumentando continuamente el tamaño de los poros desde dentro hacia fuera, y la esponja está confeccionada de tal manera, que se compone de varios módulos conectados de un sistema modular o de un módulo conformado individualmente sobre la base de una tomografía computerizada.
Description
El invento se refiere al uso modular de esponjas metálicas de porosidad abierta como sustituto óseo aloplástico en cirugía traumatológica y ortopedia, cuya aplicación resulta particularmente adecuada para el relleno permanente de defectos óseos postraumáticos y defectos óseos de origen osteoporótico o tumoral en pacientes ancianos.
Más de 100.000 transplantes óseos al año en Alemania implican una considerable importancia económica. El relleno de defectos óseos de origen postraumático o tu-moral representa de este modo, sobre todo si se tiene además en cuenta la estructura de edades de la población, un problema clínico de trascendencia cada vez mayor. Las desventajas del transplante autólogo residen en las intervenciones secundarias necesarias y en la disponibilidad limitada de material autólogo. Por otro lado, existen sustitutos metálicos, en especial a base de aleaciones de cobalto-cromo, titanio o aleaciones de titanio, cuya utilidad ha quedado demostrada para numerosas aplicaciones clínicas. Sin embargo, los implantes disponibles en la actualidad no solucionan, o solucionan tan sólo en parte, el problema de la intervención secundaria, cuyas consecuencias físicas y psíquicas negativas afectan en particular a los pacientes ancianos.
La osteoporosis implica para el organismo del paciente una reducción de la masa ósea unida a una rarefacción de la estructura trabecular. En pacientes de 65 años de edad suele ser habitual una disminución de la densidad ósea de un 30% en consecuencia del proceso de envejecimiento. Por ello no resulta sorprendente constatar un incremento exponencial de las fracturas patológicas de origen osteoporótico con el aumento de la edad, cuyo cuidado se complica con frecuencia justamente porque los defectos remanentes sólo pueden reconstruirse o rellenarse de forma insatisfactoria después de la reposición.
Fracturas derivadas de un trauma inadecuado suelen ser consecuencia de una osteoporosis no detectada ni tratada previamente, una condición que afecta más o menos a la mitad de la población femenina así como a un tercio de la población masculina de más de 50 años de edad. De importancia primordial es aquí que las personas con osteoporosis que han sufrido ya una fractura están expuestas a un riesgo relevantemente mayor de padecer más fracturas, quedando así incluidas en
el grupo crítico de pacientes que requieren atención.
Las fracturas osteoporóticas pueden producirse en todas las zonas del esqueleto
5 troncal y periférico, pero suelen ser aparecer con la mayor asiduidad en las proximidades de la articulación coxofemoral y a nivel de la columna vertebral, la muñeca y el húmero proximal .
Más allá de las consecuencias individuales y sanitarias, las fracturas osteoporóticas
10 representan además, tanto en forma directa como a través de los gastos derivados, una enorme carga socioeconómica para la sociedad. Según las estimaciones económicas se gastan en Alemania un mínimo de tres mil millones de euros para el tratamiento de la osteoporosis, la mayor parte de los cuales recae en el cuidado de las fracturas patológicas.
15 En los injertos desarrollados, el problema principal era desde el principio el prendimiento y/o la integración a nivel óseo. Al contrario de los implantes provistos de superficies rugosas y radiadas que permiten solamente un prendimiento del hueso, y de los implantes provistos de superficies microporosas, generadas en su mayor par
20 te por spray de plasma, que permiten una integración ósea limitada, los injertos de superficie metálico-esponjosa conocidos desde los años 80 del siglo pasado tienen como objetivo una integración ósea integral en el sentido de una fusión ósea. Semejantes injertos sustitutivos de huesos esponjosos se dieron a conocer principalmente a través de los documentos DE 31 06 917 C2, DE 32 24 265 C2, DE 39 17 033 C1 y
Primero se propuso una estructura superficial esponjosa y bidimensional con poros de 0,5 a 1,5 mm de tamaño, pero sin unión espacial en la profundidad metálica, produciéndose en consecuencia tan sólo un prendimiento y una integración en el hueso,
30 pero no una fusión ósea. En DE 32 24 265 C2 se presentó un injerto tridimensional, cuya estructura superficial metálico-esponjosa forma una unidad con un núcleo metálico macizo. El implante correspondiente tiene una porosidad superficial de aproximadamente un 60%, poros de entre 0,3 y 2,5 mm de tamaño y una estructura de aproximadamente 3 mm de altura. Los experimentos realizados ya en 1981 con cubos metálico-esponjosos sobre animales confirmaron la existencia de una fusión
ósea con el injerto, y justificaron en 1982 la aplicación humana del método.
Para atender mejor a los esfuerzos mecánicos se propuso en DE 39 17 033 C1 un
5 procedimiento que permite la fabricación de una estructura con poros de 0,9 a 4,3 mm de tamaño y una porosidad incrementada de aproximadamente un 70%. Sin embargo, el procedimiento no permitía influenciar parámetros técnicos como la altura y el espesor de los espacios entre huecos (puentes) de la estructura, por lo que esta solución se reveló finalmente insatisfactoria en la práctica, tanto más cuando los
10 parámetros no eran reproducibles en la aplicación práctica (publicación corporativa “ESKA Aktuell” E-10/05). DE 41 06 971 C1 ofrece finalmente un procedimiento de fabricación de un implante provisto de una estructura metálica de células abiertas que cubre al menos parte de su superficie y se distingue por la disposición simétrica de los puentes. Las prótesis de cadera y rodilla equipadas con esta solución permi
15 ten la integración ósea a través de estas trabéculas, que sujetan en cierto modo al igual que una hamaca el injerto.
El estado de la tecnología se encuentra caracterizado además en especial por los documentos DE 41 33 877 C1, DE 42 08 247 C1, DE 42 14 357 C2, DE 43 36 819
Para el presente invento se plantea la tarea de desarrollar un injerto de estructura
esponjosa de características rígidas y biocompatibles y fabricación al mismo tiempo
25 económica, capaz de rellenar de manera permeable defectos en huesos osteoporóticos o defectos tumorales. El implante tiene que estar modificado aquí de tal modo, que el cirujano pueda recurrir intraoperatoriamente a una posibilidad de solución especial para las características óseas respectivas.
30 Esta tarea es resuelta por medio de las características de la reivindicación 1, convenientemente ampliadas por las características de las reivindicaciones 2 a 8.
Conforme al invento está previsto que el injerto se componga exclusivamente de una
o varias estructuras metálicas de porosidad abierta y disposición modular semejante a la de un sistema modular estandarizado. La esponja metálica tiene a este efecto una forma cuneiforme, cúbica, cilíndrica, anular, disciforme y/o rómbica. Los módulos, diferentemente combinables entre sí, están disponibles respectivamente en diversos tamaños, de manera que los implantes así conformados pueden ajustarse en
5 función del diagnóstico para rellenar los defectos mencionados arriba. La posibilidad de conectar las diferentes formas prefabricadas en función de la situación respectiva constituye una de las ventajas esenciales del invento. Pero también existe la posibilidad de personalizar los citados módulos o el injerto entero en función de los resultados de una tomografía computerizada (custom made). Conforme a la naturaleza
10 del invento está previsto intercombinar los módulos y/o partes de los mismos en unión positiva y/o unión no positiva. Los módulos pueden estar conectados a este efecto ventajosamente mediante cierres de enganche, cierres adherentes o tornillos compuestos asimismo de una esponja metálica de porosidad abierta de las mismas características.
15 La esponja metálica, de la cual se compone el injerto, está fabricada preferiblemente en titanio o una aleación de titanio y se distingue por una porosidad sumamente elevada. Así ha quedado sorprendentemente demostrado que el titanio, un material tan biocompatible como no inductor de tumores y osteoconductor, sí permite fabricar
20 implantes rígidos con una porosidad superior al 90%. Se puede suponer fundada-mente que la fabricación de injertos compuestos exclusivamente de una estructura esponjosa es asimismo posible en aleaciones de cobalto, un material de idoneidad fundamentalmente similar. Aunque el uso de un injerto esponjoso de titanio no requiere en realidad una biofuncionalización, sí puede resultar en ciertos casos útil
25 recubrir la estructura con hidroxilapatita o tantalio, siendo aquí suficiente un espesor de 5 µm, como máximo 8 µm.
La ventaja principal del presente invento es la disponibilidad de un implante plenamente permeable capaz de asegurar, en función de la estabilidad requerida, el grado
30 de integración individualmente necesario en el hueso esponjoso. La plena porosidad abierta y la rigidez del injerto ofrecen la posibilidad de una integración ósea integral en el hueso solicitado. Determinante para la utilización práctica del injerto es – además de la muy alta porosidad – que la estabilidad necesaria es reproducible en alto grado y al mismo fabricable a bajo coste, siendo al efecto indispensable que los
puentes de la estructura sean relativamente gruesos.
Teniendo en cuenta estos aspectos, está previsto fabricar el injerto a base de una
5 estructura reticular, preferiblemente una estructura esponjosa reticular, estabilizando los canales de fundición generados por estas estructuras con materiales orgánicos antes de llenar el metal y espesando los puentes de las estructuras reticulares mediante uno o varios recubrimientos. El material orgánico empleado para recubrir los puentes puede ser cera líquida, cera en polvo, polvo de poliestireno o polvo de po
10 liamida, necesitando el poliestireno / la poliamida una ligera concentración, preferiblemente de un 5%, de cola. En caso de múltiple recubrimiento de los puentes, las capas individuales se aplican a distintas temperaturas en el rango de 40°C a 80°C.
Con el invento existe por primera vez un implante capaz de posibilitar una integra
15 ción ósea integral. Además de contar con las ventajas citadas, la integración ósea a largo plazo del injerto permite evitar eficazmente la generación de deformaciones secundarias residuales en huesos osteoporóticos. Posibilidades concretas de uso conforme del injerto propuesto son por ejemplo:
20 -Fractura proximal patológica de la tibia con osteoporosis grave (incapacidad de carga) -Fractura distal patológica del fémur con enclavamiento intramedular
• Terapia practicada: Doble relleno del defecto con esponja metálica de porosidad abierta en titanio y osteosíntesis con placa aditiva
25 -Defecto fibular con carcinoma metastásico de mama e inestabilidad (fuerte limitación de la capacidad de deambulación y la capacidad de carga)
• Terapia practicada: Resección de metástasis y relleno del defecto con es
ponja metálica de porosidad abierta en titanio y osteosíntesis con placa 30 aditiva
-Defecto acetabular con endoprótesis de cadera cementada (incapacidad de deambulación)
• Terapia practicada: Cambio de endoprótesis. Relleno del defecto con esponja metálica de porosidad abierta en titanio y reconstrucción acetabular mediante acetábulo metálico
5 La aplicación del invento se detalla además a través de representaciones esquemáticas. A este efecto,
-la Fig. 1 muestra el principio de reparación de un defecto óseo 1 con un injerto 3 consistente únicamente en un sistema de módulos en la aleación de titanio 10 Ti6Al4V y una férula 4, que estabiliza la posición del hueso 2 y el injerto 3.
-la Fig. 2 muestra un ejemplo, en el que el hueso 2 está estabilizado por un clavo 5 y una parte del hueso está sustituido íntegramente por la estructura esponjosa
3.
15
-la Fig. 3 muestra un ejemplo, en el que el hueso 2 es rellenado con módulos de injerto 6, los cuales son fijados por su parte mediante tornillos 7 compuestos igualmente de esponja de titanio.
20 -la Fig. 4 muestra un injerto 8 en unión material consistente en la esponja de titanio 3 y la férula de titanio 4, fabricadas por medio del procedimiento de fundición descrito.
-la Fig. 5 muestra un acetábulo 9 para una articulación coxofemoral artificial 10 25 estabilizado por un injerto en esponja de titanio 3.
Lista de las marcas de referencia empleadas
- 1
- Defecto óseo
- 2
- Hueso
- 5
- 3 Injerto en estructura esponjosa de Ti6Al4V
- 4
- Férula
- 5
- Clavo
- 6
- Módulos del injerto
- 7
- Tornillo en esponja de titanio
- 10
- 8 Injerto en unión material esponja metálica/férula
- 9
- Acetábulo
- 10
- Articulación coxofemoral artificial
- 15
Claims (6)
- Reivindicaciones1. Injerto metálico-esponjoso (3, 6) como sustituto óseo aloplástico a base de una esponja metálica de porosidad abierta altamente resistente, por ejemplo en tita5 nio o una aleación de titanio, caracterizado porque la esponja presenta una porosidad del 75% al 94%, está graduada, aumentando continuamente el tamaño de los poros desde dentro hacia fuera, y la esponja está confeccionada de tal manera, que se compone de varios módulos conectados de un sistema modular o de un módulo conformado individualmente sobre la base de una tomografía computerizada.10
- 2. Injerto según la reivindicación 1 y una de las reivindicaciones precedentes, caracterizado porque los módulos y/o partes de los mismos pueden combinarse entre sí en unión positiva y/o unión no positiva.15 3. Injerto según la reivindicación 2, caracterizado porque los módulos están unidos por un cierre de enganche o un cierre adherente.
- 4. Injerto según la reivindicación 3, caracterizado porque los módulos están unidos por tornillos de una estructura metálica de porosidad abierta y características 20 similares.
- 5. Injerto según la reivindicación 1 y una de las reivindicaciones precedentes, caracterizado porque los módulos del sistema modular estandarizado son de forma cuneiforme, cúbica, cilíndrica, anular, disciforme, esférica y/o rómbica y están res25 pectivamente disponibles en diferentes tamaños.
- 6. Injerto según las reivindicaciones 1 a 5, caracterizado porque la estructura de esponja metálica está recubierta con hidroxilapatita.30 7. Injerto según las reivindicaciones 1 a 5, caracterizado porque la estructura de esponja metálica está recubierta con tantalio.
- 8. Injerto según las reivindicaciones 1 a 5, caracterizado porque la estructura de esponja metálica está recubierta con fosfato de calcio.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102005037141A DE102005037141A1 (de) | 2005-08-06 | 2005-08-06 | Spongiös-metallisches Implantat und Verfahren zu seiner Herstellung |
| DE102005037141 | 2005-08-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2348066T3 true ES2348066T3 (es) | 2010-11-29 |
Family
ID=37420793
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES06775783T Active ES2348066T3 (es) | 2005-08-06 | 2006-08-02 | Injerto metalico-esponjoso y procedimineto de fabricación del mismo. |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1917051B1 (es) |
| AT (1) | ATE471728T1 (es) |
| DE (2) | DE102005037141A1 (es) |
| ES (1) | ES2348066T3 (es) |
| WO (1) | WO2007016902A2 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2932674B1 (fr) | 2008-06-20 | 2011-11-18 | Tornier Sa | Procede de modelisation d'une surface glenoidienne d'une omoplate, dispositif d'implantation d'un composant glenoidien d'une prothese d'epaule, et procede de fabrication d'un tel compose. |
| EP2696809A1 (en) * | 2011-04-13 | 2014-02-19 | Synthes GmbH | Patient specific joint prosthesis |
| US9186252B2 (en) | 2011-07-26 | 2015-11-17 | Rita Leibinger GmbH & Co. KG | Tibia implant for tightening the patella tendons |
| DE102011079821A1 (de) | 2011-07-26 | 2013-01-31 | Rita Leibinger GmbH & Co. KG | Tibiaimplantat zur Straffung der Kniescheibenbänder |
| US20150112443A1 (en) * | 2012-05-14 | 2015-04-23 | Mobelife N.V. | Implantable bone augment and method for manufacturing an implantable bone augment |
| US10405993B2 (en) | 2013-11-13 | 2019-09-10 | Tornier Sas | Shoulder patient specific instrument |
| DE102014118177A1 (de) | 2013-12-19 | 2015-06-25 | Mayser Gmbh & Co. Kg | Verfahren zum Herstellen von metallischen Formkörpern, metallischer Formkörper und Verfahren zum Ausbilden eines Bauteils mit einem Wärmetauscher |
| AU2016371425B2 (en) | 2015-12-16 | 2021-09-02 | Howmedica Osteonics Corp. | Patient specific instruments and methods for joint prosthesis |
| US10537661B2 (en) | 2017-03-28 | 2020-01-21 | DePuy Synthes Products, Inc. | Orthopedic implant having a crystalline calcium phosphate coating and methods for making the same |
| US10537658B2 (en) | 2017-03-28 | 2020-01-21 | DePuy Synthes Products, Inc. | Orthopedic implant having a crystalline gallium-containing hydroxyapatite coating and methods for making the same |
| US11166733B2 (en) | 2017-07-11 | 2021-11-09 | Howmedica Osteonics Corp. | Guides and instruments for improving accuracy of glenoid implant placement |
| US11076873B2 (en) | 2017-07-11 | 2021-08-03 | Howmedica Osteonics Corp. | Patient specific humeral cutting guides |
| WO2019104392A1 (en) * | 2017-11-30 | 2019-06-06 | Queensland University Of Technology | Modular tissue implants |
| WO2019133905A1 (en) | 2017-12-29 | 2019-07-04 | Tornier, Inc. | Patient specific humeral implant components |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3106917C2 (de) * | 1981-02-25 | 1984-04-05 | Schuett Und Grundei Gmbh Medizintechnische Fabrikation, 2400 Luebeck | Verfahren zur Herstellung eines Implantates als Knochenersatz |
| DE3224265C2 (de) * | 1982-06-28 | 1987-01-08 | S + G Implants GmbH, 2400 Lübeck | Verfahren zur Herstellung eines Implantates als Knochenersatz |
| DE3917033C1 (es) * | 1989-05-26 | 1990-08-02 | Olaf 2000 Hamburg De Ahlers | |
| DE4033291A1 (de) * | 1990-10-19 | 1992-04-23 | Draenert Klaus | Werkstoff und verfahren zu seiner herstellung |
| DE4106971C1 (es) * | 1991-03-05 | 1992-03-19 | Eska Medical Luebeck Medizintechnik Gmbh & Co, 2400 Luebeck, De | |
| DE4133877C1 (es) * | 1991-10-12 | 1993-05-19 | S + G Implants Gmbh, 2400 Luebeck, De | |
| US5282861A (en) * | 1992-03-11 | 1994-02-01 | Ultramet | Open cell tantalum structures for cancellous bone implants and cell and tissue receptors |
| DE4208247C1 (de) * | 1992-03-14 | 1993-10-14 | Eska Medical Gmbh & Co | Implantat als Knochenersatz |
| DE4214357C2 (de) * | 1992-05-05 | 1994-02-24 | Eska Medical Gmbh & Co | Verfahren zur Herstellung eines Implantates mit einer seiner Oberfläche zumindest teilweise bedeckenden metallischen, offenmaschigen dreidimensionalen Struktur |
| DE4336819C1 (de) * | 1993-10-28 | 1995-03-23 | Eska Medical Gmbh & Co | Femurhüftgelenks-Endoprothese |
| DE19543530C1 (de) * | 1995-11-22 | 1997-05-07 | Eska Implants Gmbh & Co | Implantat als Knochenersatz |
| DE19614949A1 (de) * | 1996-04-16 | 1997-10-23 | Horst Broziat | Knochenimplantat |
| DE19725210C1 (de) * | 1997-06-14 | 1998-11-05 | Access Aachener Ct Fuer Erstar | Verfahren zur Herstellung metallischer Schwämme |
| US6296667B1 (en) * | 1997-10-01 | 2001-10-02 | Phillips-Origen Ceramic Technology, Llc | Bone substitutes |
| DE29822563U1 (de) * | 1998-12-18 | 1999-02-18 | Aesculap AG & Co. KG, 78532 Tuttlingen | Implantat |
| DE19907489C1 (de) * | 1999-02-16 | 2000-11-16 | Eska Implants Gmbh & Co | Hohlendoprothese |
| SE515227C2 (sv) * | 1999-04-28 | 2001-07-02 | Bruce Medical Ab | Kropp för åstadkommande av in- och tillväxt av benvävnad och/ eller bindväv och sätt för framställning av kroppen |
| DE19939155A1 (de) * | 1999-08-20 | 2001-02-22 | Pore M Gmbh | Verfahren und Vorrichtung zur Herstellung von Glitternetzstrukturen |
| DE20010346U1 (de) * | 2000-06-09 | 2000-08-17 | Stuckenbrock Medizintechnik Gmbh, 78532 Tuttlingen | Implantat zur Verwendung in spongiösen Knochenbereichen |
| NL1016040C2 (nl) * | 2000-08-29 | 2002-03-01 | Giles William Melsom | Poreus aanhechtingsmateriaal voor cellen, werkwijze voor de vervaardiging daarvan, alsmede toepassingen. |
| DE10248056A1 (de) * | 2002-10-11 | 2004-04-22 | Adolf Würth GmbH & Co. KG | Metallelement, Verfahren zu seiner Herstellung und Anwendung |
| US6974625B2 (en) * | 2003-12-16 | 2005-12-13 | Smith & Nephew, Inc. | Oxidized zirconium on a porous structure for bone implant use |
| DE102004027657A1 (de) * | 2004-06-07 | 2006-02-02 | Zow Ag | Gekammerter Werkstoff als Implantat, Knochenersatz und allgemein als Werkstoff |
| DE102004045410A1 (de) * | 2004-09-15 | 2006-03-30 | Glatt Gmbh | Knochenersatzimplantat für human- und veterinärmedizinische Anwendungen |
-
2005
- 2005-08-06 DE DE102005037141A patent/DE102005037141A1/de not_active Withdrawn
-
2006
- 2006-08-02 EP EP06775783A patent/EP1917051B1/de not_active Not-in-force
- 2006-08-02 DE DE502006007273T patent/DE502006007273D1/de active Active
- 2006-08-02 AT AT06775783T patent/ATE471728T1/de active
- 2006-08-02 WO PCT/DE2006/001342 patent/WO2007016902A2/de not_active Ceased
- 2006-08-02 ES ES06775783T patent/ES2348066T3/es active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP1917051B1 (de) | 2010-06-23 |
| WO2007016902A2 (de) | 2007-02-15 |
| DE502006007273D1 (de) | 2010-08-05 |
| ATE471728T1 (de) | 2010-07-15 |
| EP1917051A2 (de) | 2008-05-07 |
| DE102005037141A1 (de) | 2007-02-08 |
| WO2007016902A3 (de) | 2007-05-18 |
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