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ES2295609T3 - Derivados de tiadiazolilpiperazina utiles para tratar o prevenir un dolor. - Google Patents

Derivados de tiadiazolilpiperazina utiles para tratar o prevenir un dolor. Download PDF

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Publication number
ES2295609T3
ES2295609T3 ES03743718T ES03743718T ES2295609T3 ES 2295609 T3 ES2295609 T3 ES 2295609T3 ES 03743718 T ES03743718 T ES 03743718T ES 03743718 T ES03743718 T ES 03743718T ES 2295609 T3 ES2295609 T3 ES 2295609T3
Authority
ES
Spain
Prior art keywords
sup
pain
tiadiazolilpiperazina
treat
prevent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES03743718T
Other languages
English (en)
Inventor
Donald J Kyle
Qun Sun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euro Celtique SA
Original Assignee
Euro Celtique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Euro Celtique SA filed Critical Euro Celtique SA
Application granted granted Critical
Publication of ES2295609T3 publication Critical patent/ES2295609T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Compuesto de fórmula: o una sal farmacéuticamente aceptable del mismo, en la que: R1 es metilo o halo; R3 es: (a) alquilo -(C1-C6), alquenilo -(C2-C6), alquinilo -(C2-C6), o -(CH2)nOR6, que no es sustituido o es sustituido con uno o más de entre -CN, -OH, -halo, -NO2, -CH=NR6, o -NR6OH; o (b) -H, -halo, -NO2, -CN, o -NH2; R4 es -H; R5 es: (a) alquilo -(C1-C6), alquenilo -(C2-C6), alquinilo -(C2-C6); o (b) cicloalquilo -(C3-C8), cicloalquenilo -(C5-C8), -fenilo, -naftilo, arilo -(C14), heterociclo -(C3-C7), alquilfenilo -(C1-C6), alquilnaftilo -(C1-C6), alquil -(C1-C6)arilo (C14), alquil -(C1-C6)heterociclo (C3-C7), alquenilfenilo -(C2-C6), alquenilnaftilo -(C2-C6), alquenil -(C2-C6)arilo (C14), alquenil -(C2-C6)heterociclo (C3-C7), alquinil -(C2-C6)cicloalquilo (C3-C8), alquinil -(C2-C6)cicloalquenilo (C5-C8), alquinilfenilo -(C2-C6), alquinilnaftilo -(C2-C6), alquinil -(C2-C6)arilo (C14), o alquinil -(C2-C6)heterociclo (C3-C7), que no es sustituido o es sustituido por uno o más grupos R7;cada R6 es independientemente -H, alquilo -(C1-C6), alquenilo -(C2-C6), alquinilo -(C2-C6), cicloalquilo -(C3-C8), cicloalquenilo -(C5-C8), -fenilo, heterociclo -(C3-C5), C(halo)3, o -CH(halo)2; cada R7 es independientemente alquilo -(C1-C6), alquenilo -(C2-C6), alquinilo -(C2-C6), cicloalquilo -(CH2)n(C3-C8), cicloalquenilo -(CH2)n(C5-C8), fenilo -(CH2)n, -(CH2)nSR6, -(CH2)nCH(halo)2, -(CH2)nC(halo)3, -halo, ó -(CH2)nOR6; y
ES03743718T 2002-03-01 2003-02-28 Derivados de tiadiazolilpiperazina utiles para tratar o prevenir un dolor. Expired - Lifetime ES2295609T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36017202P 2002-03-01 2002-03-01
US41108402P 2002-09-17 2002-09-17

Publications (1)

Publication Number Publication Date
ES2295609T3 true ES2295609T3 (es) 2008-04-16

Family

ID=27791632

Family Applications (1)

Application Number Title Priority Date Filing Date
ES03743718T Expired - Lifetime ES2295609T3 (es) 2002-03-01 2003-02-28 Derivados de tiadiazolilpiperazina utiles para tratar o prevenir un dolor.

Country Status (11)

Country Link
US (2) US6974818B2 (es)
EP (1) EP1487829B1 (es)
JP (1) JP4663984B2 (es)
AT (1) ATE375341T1 (es)
AU (1) AU2003225617A1 (es)
CY (1) CY1107850T1 (es)
DE (1) DE60316779T2 (es)
DK (1) DK1487829T3 (es)
ES (1) ES2295609T3 (es)
PT (1) PT1487829E (es)
WO (1) WO2003074520A1 (es)

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Also Published As

Publication number Publication date
US20060074090A1 (en) 2006-04-06
US20040006091A1 (en) 2004-01-08
JP2005525365A (ja) 2005-08-25
WO2003074520A1 (en) 2003-09-12
DE60316779D1 (de) 2007-11-22
PT1487829E (pt) 2007-12-24
US6974818B2 (en) 2005-12-13
DK1487829T3 (da) 2008-02-11
CY1107850T1 (el) 2013-06-19
JP4663984B2 (ja) 2011-04-06
ATE375341T1 (de) 2007-10-15
DE60316779T2 (de) 2008-07-17
EP1487829A1 (en) 2004-12-22
US7342017B2 (en) 2008-03-11
AU2003225617A1 (en) 2003-09-16
EP1487829B1 (en) 2007-10-10

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