ES2265353T3 - IMPREGNATION PROCEDURE. - Google Patents

Abstract

Procedure for impregnation and for the treatment of substances / objects that can be degraded by microbes, which can be contaminated and / or corruptible, where the substances / objects are selected from wood, basketry, textiles and textile raw materials, filters, washing agents and cleaning agents, comprising - the distribution or application of an antimicrobial composition on the surface of the substances / objects that can be degraded, which can be contaminated and / or corrupted previously cited and / or - the incorporation of the antimicrobial composition into the substances / objects that can be degraded, that can become contaminated and / or corruptible, where the antimicrobial composition contains at least two GRAS flavoring substances (generally recognized as safe).

Description

Impregnation procedure.

         \ global \ parskip0.900000 \ baselineskip
      

The present invention relates to a procedure for impregnation, incorporation or treatment of surface, which comprises the application of a composition special antimicrobial on substances / objects that may degrade by microbes, which can become contaminated and / or corruptible, or the incorporation of the antimicrobial composition in the substances, to the use of these special antimicrobial compositions for the impregnation or surface treatment of substances that they can be degraded by microbes, which can become contaminated and / or corruptible as well as its use in substances and products that must Be self-polluting.

The impregnation and surface treatment of substances and targets sensitive to microbes and parasites, that is, that can become contaminated, deg radar and / or corruptible is a problem fundamental in the industrial processing of such substances and objects (such as wood and wood products, textiles and textile raw materials, plastics with growth risk of germs, soundproofing and sealing materials). I also know claims as problematic the self-decontamination of agents of cleaning or body hygiene agents, for example, deodorants With harmless substances.

Until today one fights against an infestation microbiological or parasitic exclusively "by means toxic ", that is, with bactericidal substances, fungicides, virucidal, sporicidal, insecticidal, which however are very toxic for the most part, so that people who enter Contact with the products so treated are in danger. In addition to this there are also problems in eliminating products, substances and objects processed with such substances Toxic

Compositions have been described several times. antimicrobials containing one or more flavoring substances GRAS (generally recognized as safe). Thus the document WO 98/58540 discloses additives containing substances GRAS flavorings for consistency improvement and stabilization of different foods as well as for the decontamination and cleaning of food, raw materials, cosmetics, pharmaceuticals, dyes, paper, cellulose, cattle, birds, fish and waste. From WO 96/29895 is taken a procedure to improve consistency and / or stabilization of corruptible products by microbes, where use process aids that contain flavoring substances GRAS for the production of food and feed, cosmetics, Pharmaceutical products, dyes, paper and / or cellulose. Of the WO 00/03612 additives containing GRAS aromas are removed for the improvement of consistency and / or stabilization of products corruptable by microbes, such as food and feed, products pharmacists and cosmetics as well as process aids for food and feed production, cosmetics, products Pharmaceuticals, dyes, paper and / or celluloses.

Document SE 8900902 discloses as object the use of cinnamic aldehyde alone or together with terpene compounds As an insecticidal agent.

JP 62126931 aims to stabilize E. coli bacteria adhered to fresh vegetables by wetting with an aqueous solution of an organic acid and / or a calcium salt.

Document CA 2012288 refers to an agent of plant disinfection consisting of a mixture that can contain, among others, thymol, eugenol or carvacrol as a component as well as benzyl alcohol and / or cinnamic alcohol as another component.

Document GB 1060447 discloses a composition for the preservation of cosmetics, which contains certain etheric oils, acetic acid or citric acid and ethyl alcohol or iso-propyl alcohol.

The objective of the present invention is based on provide an impregnation or treatment procedure for surface that does not present the disadvantages of the state of the technique.

Surprisingly it was found now that special antimicrobial compositions, which contain as antimicrobial constituents two or more flavoring substances GRAS (generally recognized as safe) (as they are known, by example, of WO 96/29895 and 98/58540 as adjuvants of process and food additives), also present very good fungicidal and antiparasitic properties. Based on this, found that these compositions are very suitable for the impregnation and surface treatment of substances / objects that they can be degraded by microbes, which can become contaminated and / or corruptible or for incorporation into these substances / objects, without having the problem of toxicity of impregnating agents, treatment of usual surface or incorporation. By incorporating it can reinforce a decontaminating effect of the product (if given the case) and with this you can replace toxic substances used so far for that purpose. It has been found especially that compositions containing benzyl alcohol have a antimicrobial and antiparasitic activity especially high.

Consequently it is the subject of this request

(1) a procedure for impregnation and for the treatment of substances / objects that can be degraded by microbes, which can become contaminated and / or corruptible, where substances / objects are selected from wood, basketry, textiles and textile raw materials, filters, washing agents and agents cleaning, which includes

         \ global \ parskip0.990000 \ baselineskip
      

-

the distribution or application of an antimicrobial composition on the surface of substances / objects that can be degraded, which may be contaminated and / or corrupted previously cited I

-

the incorporation of the antimicrobial composition in the substances / objects that can be degraded, that can become contaminated and / or corruptible, where the antimicrobial composition contains the At least two GRAS flavoring substances (generally recognized as safe);

(2) a preferred embodiment of the procedure defined in (1), where the composition antimicrobial contains one or more alcohols of GRAS aroma (generally recognized as insurance) or its derivatives (a) and one or various flavoring substances selected from compounds of polyphenol (b) and acids of GRAS aromas or their derivatives (c),

(3) another preferred embodiment of the procedure defined in (1), where the composition antimicrobial contains

(i)

to the less a lipophilic GRAS flavoring substance (recognized in general as safe) and

(ii)

to the less a hydrophilic GRAS flavoring substance;

(4) a preferred embodiment of the procedure defined in (1) to (3), wherein the composition GRAS aroma alcohol antimicrobial contains benzyl alcohol as an essential constituent;

(5) the use of the composition defined in (1) a (4) for impregnation or surface treatment of substances / objects that can be degraded by microbes, which can be contaminated and / or corruptible, or of substances / objects that must be self decontaminants; where substances / objects are as they are defined in (1), and

(6) the use of an antimicrobial composition, as defined in (1) to (4), for incorporation into substances / objects that can be degraded by microbes, which can be contaminated and / or corruptible, or in substances / objects that must be self-decontaminants, where substances / objects are as defined in (1).

With "substances / objects that can degrade by microbes, which can become contaminated and / or corruptible " understand in the sense of the present invention the following natural and / or chemical materials:

- wood and basketry,

- textiles and textile raw materials

- filters,

- washing agents and cleaning agents.

With "impregnation, incorporation or treatment of surface "is understood in this regard in the case of wood both a direct spray after felling the trees, a pulverization in the crushed (sawn and brushed) by continuous addition to the crushing device, a treatment of crushed material, for example, during transport, a pressure impregnation of the product being processed as well as also long-term conservation through application of oils and paintings As for cellulose and paper, impregnating means the product treatment during processing, for example, by adding in the preparation of these products as well as also an initial surface treatment on or during the equipment installation. In addition to this you can extend the shelf life, for example in air filters, also by means of a back surface treatment. The coatings of Natural chemical and / or chemical materials can be impregnated well by adding the impregnating agent in the process of preparation or by subsequent surface treatment. further impregnate this may mean in the sense of the present invention also the addition of the antimicrobial composition to dyes and paints Surface sterilization takes place or impregnation especially by spraying, immersion, nebulization, washing and rubbing. This can be done with or without pressure, at room temperature or hot.

The following describes the substances that they can be used according to the invention individually individually detailed:

GRAS flavoring substances, alcohols GRAS aromas and acids of GRAS aromas previously cited in (1) to (4) are recognized by the FDA for use in food as industrial insurance (GRAS = generally recognized as insurance in foods). Regarding GRAS flavoring substances mentioned are those compounds that are mentioned in FEMA / FDA GRAS Flavor Substances Lists GRAS 3-15 Nr. 2001-3815 (Stand 1997). This list indicates natural and identical to natural flavoring substances, which are allowed by the American sanitary authority FDA for use in food: FDA regulation 21 CFR 172.515 for substances flavorings identical to natural (flavoring substances synthetic and adjuvants) and FDA regulation 21 CFR 182.20 for natural flavoring substances (flavoring substances natural and adjuvant). Suitable GRAS flavoring substances according to the present invention are, for example, (a) alcohols of GRAS aromas or their derivatives, (b) polyphenol compounds, (c) acids of GRAS aromas or their derivatives, (d) phenols or their derivatives, (e) esters, (f) terpenes, (g) acetals, (h) aldehydes and (i) oils etheric

You can individually consider the use, by For example, the following GRAS aromas alcohols (a):

benzyl alcohol, acetoin (acetylmethylcarbinol), ethyl alcohol (ethanol), propyl alcohol (1-propanol), iso-propyl alcohol (2-propanol, isopropanol), propylene glycol, glycerin, n-butyl alcohol (n-propylcarbinol), alcohol iso-butyl (2-methyl-1-propanol), hexyl alcohol (hexanol), L-menthol, alcohol octyl (n-octanol), cinnamic alcohol (3-phenyl-2-propen-1-ol), α-methylbenzyl alcohol (1-phenylethanol), heptyl alcohol (heptanol), n-amyl alcohol (1-pentanol), iso-amyl alcohol (3-methyl-1-butanol), anisic alcohol (4-methoxybenzyl alcohol, alcohol p-anisic), citronella, alcohol n-decyl (n-decanol), geraniol, β- γ-hexanol (3-hexenol), lauric alcohol (dodecanol), linalool, nerolidol, nonadienol (2,6-nonadien-1-ol), nonyl alcohol (nonanol-1), rodinol, terpineol, borneol, clineol (eucalyptol), anisole, cuminyl alcohol (cuminol), 10-undecen-1-ol, 1-hexadecanol. As derivatives you can use both natural or identical to natural derivatives as derivatives synthetic Suitable derivatives are, for example, esters, ethers and carbonates of the alcohols of GRAS aromas previously cited. Especially preferred GRAS aromas are those GRAS aromas alcohols from the previous list (in this invention it is especially preferred benzyl alcohol), 1-propanol, glycerin, propylene glycol, alcohol n-butyl, citronella, hexanol, linalool, acetoin and Their derivatives.

As component (b) you can use the following polyphenols:

pyrocatechin, resorcinol, hydroquinone, floroglucin, pyrogallol, resveratrol, single acid, acylpolyphenols, lignin, anthocyanin, flavones, catechin, gallic acid derivatives (for example, tannins, galotanino, tannic acids, acids gallic-tannic), carnosol, carnosolic acid (including its derivatives as substitutions (2,5-dihydroxyphenyl) carboxy- and (2,5-dihydroxyphenyl) alkylenecarboxyl, salts, esters, amides), caffeic acid and its esters and amides, flavonoids (for example, flavone, flavonol, isoflavone, gossypetin, mirecetin, robinetin, apigenin, morin, taxifoline, eriodictiol, naringin, rutin, hesperidin, troxerutin, chrysin, tangeritin, luteolin, catechin, quercetin, fisetin, camphor oil, galangina, rotenoids, aurone, flavonols, diols), extracts of, for example, Camellia Primula. In addition you can also use their possible derivatives, for example, salts, acids, esters, oxides and ethers Especially preferred polyphenol is tannin (a compound GRAS).

As component (c) the use can be considered, for example, of the following GRAS acids:

acetic acid, aconitic acid, adipic acid, formic acid, malic acid (acid 1-hydroxysuccinic), caproic acid, acid hydroxycinnamic (acid 3-phenyl-1-propionic), pelargonic acid (nonanoic acid), lactic acid (acid 2-hydroxypropionic), phenoxyacetic acid (ether glycolic acid phenyl), phenylacetic acid (acid α-toluenic), valeric acid (acid pentanoic acid, iso-valeric acid (acid 3-methylbutanoic acid, cinnamic acid (acid 3-phenylpropenoic acid), citric acid, mandelic acid (hydroxyphenylacetic acid), tartaric acid (acid 2,3-dihydroxybutanedioic acid) 2,3-dihydroxysuccinic), fumaric acid, acid Tannic and its derivatives.

As suitable derivatives of aromatic acids GRAS within the meaning of the present invention are understood as esters (for example, C 1-6 alkyl ester and ester benzyl), amides (including N-substituted amides) and salts (alkaline, alkaline earth and ammonium salts of acids previously cited). Equally derivatives in the sense of present invention comprise modifications of the functions side chain hydroxy (for example, acyl derivatives and alkyl) and modifications of the double bonds (for example, the perhydrogenated and hydroxylated derivatives of the cited acids).

As component (d) the use can be considered of the following phenol compounds:

thymol, methyleneugenol, acetylenegenol, safrole, eugenol, isoeugenol, anethole, phenol, methylcavicol (estragol; 3-4-methoxyphenyl-1-propene), carvacrol, α-bisabolol, fornesol, anisole (methoxybenzene) and propenylguaetol (5-profenyl-2-ethoxaphenol) and its derivatives. Derivatives in the sense of the invention are compounds in which the phenolic hydroxyl group is esterified or etherified.

As GRAS esters (component (e)) it is considered the use, for example, of allicin and the following acetates acetate iso-amyl (acetate 3-methyl-1-butyl), benzyl acetate, benzylphenyl acetate, n-butyl, cinnamyl acetate ( 3-phenylpropenyl), cintronellyl acetate, acetate of ethyl (acetic ester), eugenol acetate (acetylene hydrogen), geranyl acetate, hexyl acetate (hexanyl ethanoate), hydrocinamyl acetate ( 3-phenyl-propyl), acetate linalyl, octyl acetate, phenylethyl acetate, terpinyl, triacetin (glyceryl triacetate), potassium acetate, sodium acetate and sodium acetate. Other suitable esters are ester derivatives of previously defined acids (component (c)).

As terpenes (component (f)) are taken in account, for example, camphor, limonene and β-Caryophylene.

To useful acetalenes (component (g)) belong, for example, acetal, acetaldehyde, dibutyl acetal, acetaldehyde dipropylacetal, acetaldehydofenetylpropylacetal, cinaldehyde ethylene glycol, decanaldimethyl acetal, heptanaldimethylacetal, heptanalglyceryl acetal and benzaldehydepropylene glycol

As aldehydes (component (h)) are useful, for example, acetylaldehyde, anisaldehyde, benzaldehyde, iso-butyl aldehyde (methyl-1-propanal), citral, citronella, n-caprinaldehyde (n-decanal), ethylvainillin, fufurol, heliotropin (piperonal), heptyldehyde (heptanal), hexyldehyde (hexanal), 2-hexenal (β-propylacrolein), hydrocinaldehyde (3-phenyl-1-propanal), lauryldehyde (dodecanal), nonilaldehyde (n-nonanal), octylaldehyde (n-octanal), phenylacetaladehyde (1-oxo-2-phenylethane), propionaldehyde (propanal), vanillin, cinaldehyde (3-phenylpropenal), perilaldehyde and cuminaldehyde

According to the invention they are useful, for For example, also the etheric oils indicated below and / or alcoholic, glycolic or extracts obtained by High pressure CO2 procedures of the plants mentioned (component (i)):

(i1)

oils or extracts with high proportion in alcohols: melissa, coriander, cardamom, eucalyptus;

(i2)

oils or extracts with high proportion in aldehydes: citrus eucalyptus, cinnamon, lemon, grass lemon, lemon balm, citronella, limeta, orange;

(i3)

oils or extracts with high proportion in phenols: oregano, thyme, rosmarine, orange, cloves, fennel, camphor, tangerine, anise, husk, tarragon and pepper From jamaica;

(i4)

oils or extracts with high proportion in acetals: lavender;

(i5)

oils or extracts with high proportion in esters: mustard, onion, garlic;

(i6)

oils or extracts with high proportion in terpenes: pepper, bitter orange, cumin, dill, Lemon, mint, nutmeg.

A preferred embodiment of the antimicrobial composition (1) contains at least one aroma alcohol GRAS (a), especially benzyl alcohol. In this respect they are preferred those compositions containing less than 50% in weight, preferably less than 30% by weight, with special preference less than 20% by weight of ethanol, isopropanol or alcohol benzyl or a mixture of these substances.

In another preferred embodiment of the present invention the antimicrobial composition contains at least one GRAS hydrophilic, alcoholic and / or a substance flavoring substance GRAS hydrophilic, non-alcoholic flavoring. The proportion of Hydrophilic, alcoholic GRAS flavoring substances could be of up to 99% by weight of the composition and is preferably 30 to 98% by weight, especially 80 to 95% by weight. The proportion of hydrophilic GRAS flavoring substances, not alcoholic in the insecticidal composition could be up to 90% by weight and is preferably 0.1 to 50% by weight. In this regard those compositions that in addition to the compounds are preferred cited hydrophilic contain benzyl alcohol and / or a compound of polyphenol (b1).

GRAS hydrophilic flavoring substances, Alcoholics are in this respect monohydric alcohols or polyhydroxy with 2 to 10 carbon atoms, preferably with 2 at 7 C atoms. Especially preferred compounds are 1-propanol, glycerin, propylene glycol and acetoin. Hydrophilic, non-alcoholic GRAS flavoring substances select from organic acids with 1 to 15 C atoms and salts physiologically acceptable thereof, hydrophilic acetates and hydrophilic aldehydes. Preferred organic acids are those with 2 at 10 C atoms and especially acetic acid, aconitic acid, formic acid, malic acid, lactic acid, phenylacetic acid, citric acid, mandelic acid, tartaric acid, fumaric acid, tannic acid, hydrocinamic acid and its physiologically salts acceptable. The hydrophilic acetate is preferably selected from allicin, triacetin, potassium acetate, sodium acetate and acetate of calcium and the hydrophilic aldehyde is preferably selected from furfurol, propionaldehyde and vanillin.

Another preferred antimicrobial composition is the composition previously indicated with (2). The composition can contain 0.1 to 99.9% by weight, preferably of 0.5 to 99% by weight, of component (a), 0 to 25% by weight, preferably from 0.01 to 10% by weight, of component (b) and from 0 to 70% by weight, preferably 0.01 to 30% by weight of component (C).

Component (a) contains in this form of embodiment of the invention one or more alcohols of GRAS aromas. The use of two or three alcohols of GRAS aromas is preferred. The mixing ratio of component (a) to components (b) is preferably between 10,000: 1 and 1: 10,000, with special preference between 1000: 1 and 1: 1000 and with very special preference between 100: 1 and 1: 100.

In an embodiment especially preferred of the method according to the invention the antimicrobial composition contains

(a1)

benzyl alcohol as constituent essential and if necessary

(a2)

one or several GRAS aroma alcohols or their derivatives and

(b)

one or various polyphenol compounds and / or

(C)

one or several GRAS acids or their derivatives.

Suitable quantities of the components (a1), (a2), (b) and (c) are in this regard:

from 0.1 to 99% in weight, preferably 0.1 to 75% by weight of alcohol benzylic;

from 0.01 to 99.8% by weight, preferably 0.01 to 99% by weight of component (a2);

from 0.01 to 25% in weight, preferably 0.01 to 10% by weight of component (b) I

from 0.01 to 70% in weight, preferably 0.01 to 30% by weight of component (C).

In these compositions they are especially preferred those that necessarily contain a compound of polyphenol (b) and optionally also one or several GRAS acids (C).

The especially preferred antimicrobial composition may also contain flavoring substances.
GRAS already mentioned (d) to (i).

The proportion of components (d) to (i) in the antimicrobial composition is preferably less than or equal to 25% by weight and is preferably in the range of 0.001 at 9% by weight. As for additional GRAS flavoring substances phenols (d) and etheric oils (i) are preferred.

In the composition used in the form of embodiment (3) of the process according to the invention is select lipophilic GRAS flavoring substances preferably of (ai) alcohols of GRAS aromas or their derivatives, (b) polyphenol compounds, (ci) aromatic acids Lipophilic FAT or its derivatives, (d) phenols or their derivatives, (e) lipophilic esters, (f) terpenes, (g) acetals, (h) aldehydes lipophilic and (i) etheric oils. The antimicrobial composition preferably contains two of the GRAS flavoring substances cited.

Suitable lipophilic GRAS aromas alcohols (a_ {i}) of the previously defined alcohols (a) are to this respect especially:

aromatic GRAS aromatic alcohols, which they comprise benzyl alcohol, 2-phenylethanol, 1-phenylethanol, cinnamic alcohol, alcohol hydrokinetic, 1-phenyl-1-propanol and anisic alcohol and alcohols of aliphatic GRAS aromas, which comprise n-butyl alcohol, alcohol iso-butyl, hexyl alcohol, L-menthol, octyl alcohol, heptyl alcohol, n-amyl alcohol, alcohol iso-amyl, anisic alcohol, citronella, alcohol n-decyl, geraniol, β- γ-hexanol, alcohol lauric, linalool, nerolidol, nonadienol, nonyl alcohol, rodinol, Terpineol, Borneol, Clineol, Anisole, Cuminyl Alcohol, 10-undecen-1-ol and 1-hexadecanol and its derivatives. In this regard, they prefer the aromatic GRAS aromatic alcohols and especially the benzyl alcohol

In the sense of the present invention the flavoring substance hydrophilic GRAS is a flavoring substance FAT hydrophilic, alcoholic (a h) or a flavoring substance Hydrophilic, non-alcoholic GRAS, where the flavoring substance GRAS hydrophilic, alcoholic (a_ {h}) is -as already mentioned previously- preferably a monohydroxy alcohol or polyhydroxy with 2 to 10, especially preferably 2 to 7 atoms of C, which is specially selected from acetoin, ethyl alcohol, propyl alcohol, iso-propyl alcohol, propylene glycol and glycerin. GRAS flavoring substance hydrophilic, non-alcoholic is preferably a substance organic hydrophilic GRAS (c h) flavoring with 1 to 15 atoms of C or a physiological salt thereof, a hydrophilic acetate (e h) or a hydrophilic aldehyde (h h). Hydrophilic organic acids Preferred (c_ {h}) are in this respect those that have 2 at 10 C atoms and especially acetic acid, aconitic acid, formic acid, malic acid, lactic acid, phenylacetic acid, citric acid, mandelic acid, tartaric acid, fumaric acid, tannic acid, hydrocinamic acid and its physiologically salts acceptable. The hydrophilic acetate (e h) is preferably allicin, triacetin, potassium acetate, sodium acetate and acetate of calcium and the hydrophilic aldehyde (h h) is preferably furfurol, propionaldehyde and vanillin.

The polyphenol (b) lipophilic compound, phenols or its derivatives (d), terpenes (f), acetals (g) and etheric oils (i) in the composition of the procedure (3) are in this respect preferably the previously defined compounds (b), (d), (f), (g) e (i). Acids of lipophilic GRAS aromas or their derivatives (c_ {i}), lipophilic esters (e_ {i}) and lipophilic aldehydes they comprise all acids, esters and aldehydes specifically cited with the exception of the compounds (c_ {h}), (e_ {h}) and (h_ {h}) specifically cited above.

In the most preferred embodiment of the procedure (3) the antimicrobial composition contains well

(i)

two lipophilic GRAS aromas alcohols (a_), however none benzyl alcohol and no polyphenol compound (b) or good

(ii)

benzyl alcohol and / or a compound of polyphenol (b), however, no other aroma alcohol GREAS

In this invention it is especially preferred that The antimicrobial composition contains only substances Non-alcoholic, hydrophilic GRAS flavorings, especially exclusively a hydrophilic GRAS aroma acid (c h) and that the antimicrobial composition contains from 0.01 to 99% by weight, preferably from 0.1 to 90% by weight of benzyl alcohol or polyphenol compounds (b) and 0.01 to 50% by weight, preferably 0.1 to 30% by weight of hydrophilic GRAS flavoring substances, not alcoholic

In another preferred embodiment of the procedure (1) the antimicrobial composition contains

(A) one or more alcohols with GREAT aromas (a) or its derivatives and

(B) one or more flavoring substances, selected from compounds of polyphenol (b) and acids of GRAS aromas lipophilic or its derivatives (c).

It is preferred in this respect that the composition contain from 0.1 to 99% by weight, preferably from 0.5 to 99% by weight, of component (a), from 0 to 25% by weight, preferably from 0.01 to 10% by weight, component (b) and 0 to 70% by weight, preferably of 0.01 to 30% by weight of component (c).

Along with this the antimicrobial composition can contain other GRAS flavoring substances, selected from (d) phenols or their derivatives, (ei) lipophilic esters, (f) terpenes, (g) acetals, (h_) lipophilic aldehydes and (i) oils etheric

It is further preferred that component (A) of the antimicrobial composition contains benzyl alcohol as essential constituent (a1) and, if necessary, one or more alcohols with different lipophilic GRAS aromas or their derivatives (ai}). This antimicrobial composition contains preferably:

from 0.1 to 99% in weight, preferably 0.1 to 75% by weight of alcohol benzylic;

from 0 to 99.8% in weight, preferably 0.01 to 99% by weight of component (ai});

from 0 to 25% in weight, preferably 0.01 to 10% by weight of component (b),

from 0 to 70% in weight, preferably 0.01 to 30% by weight of component (C).

The composition used in this invention can contain other lipophilic GRAS flavoring substances, as previously defined, preferably from 0.001 to 25% by weight, with special preference of 0.01 to 9% by weight, of other substances GRAS flavorings (d) to (i). These other flavoring substances Lipophilic Fats are especially preferred phenols (d) and / or oils etheric (i).

In another embodiment especially Preferred method (3) component (A) of the composition antimicrobial comprises two alcohols of lipophilic GRAS aromas and the Component (B) contains at least one polyphenol compound (b). In this invention the polyphenol (b) tannin compound is preferred, in where a composition containing from 20 to 98% by weight is preferred of benzyl alcohol and 0.01 to 10% by weight of tannin.

In the sense of the present invention they are especially preferred antimicrobial compositions whose active antimicrobial constituent is composed of substances GRAS flavorings, that is, it does not contain any "derivative" of GRAS flavoring substances. As an example of a composition of this type it is worth mentioning a mixture of benzyl alcohol, one or two of the previously mentioned GRAS aroma alcohols (a2) and tannin. This mixture preferably contains 0.1 to 98% by weight of benzyl alcohol and from 0.01 to 10% by weight, preferably 1 to 10% by weight of tannin. An example more than one Preferred composition is a mixture of 2 alcohols, a polyphenol (especially tannin) and an etheric oil (especially an oil etheric phenolic component (i3).

In addition to components (a) to (i) you can also use other compounds (j) as alcohols (j1), emulsifiers (j2), stabilizers (j3), antioxidants (j4), preservatives (j5), solvents (j6), vehicles (j7) etc.

The proportion of components (j) in the Antimicrobial composition can be up to 95% by weight, preferably it is less than 10% by weight and is preferably in the range of 0.1 to 5% by weight.

As for alcohols (j1) they are about according to the invention of monohydric alcohols or polyhydroxy with 2 to 10 C atoms, preferably with 2 to 7 C atoms, where the GRAS (a) alcohols of these are not understood. Preferably those amounts of Aromas alcohols GRAS (a) and other alcohols (j1) whose Mixing ratio is between 1000: 1 and 1: 1000, especially between 100: 1 and 1: 100 and with special preference between 10: 1 and 1:10.

In the process according to the invention Especially preferred is the use of systems, which are composed exclusively of GRAS flavoring substances, especially if the treated products will be in contact with food, since this also prevents the danger of contamination of the food with non-GRAS compounds. In addition attention should be paid that the antimicrobial composition is free of dosages dangers of ethanol and isopropanol, since these substances can be breathed by people who contact the impregnation. In addition, danger may arise in the use of these compounds by exposition.

By the procedure according to the invention effective protection against following microorganisms or parasites described:

Molds : types of mildew, uredines, leaf dirt fungus, types of Fusarium, types of Aspergillus, types of Penicillium, Rhizoctonia, Peronaspora, Phytophtora, Botrytis cinerea , Rhizoctonia Solani , Aspergillus Ocraceus , Aspergillus Niger , Clavosporium Penium , Clovesporium Penium .

Parasites : lepidoptera ( Chilo suppressalis , Chaphalocrosis medinalis , Ostrina nubilalis ), Myzus persicae , (springende) insects, tobacco beetle, mites, leaf lice, flies, moths.

Virus : tomato mosaic virus, X virus, Y virus, rice stretch marks virus, TYM virus, rhizomania, BNYVV.

Fungi / special parasites, which can be submit with the procedure according to the invention, are summarized in the next table:

one

2

3

         \ vskip1.000000 \ baselineskip
      

Cultivation / Object Harmful organism / purpose Coniferous wood / wood frond Feed butterfly caterpillars free Frond wood Bag's Caterpillar common Coniferous wood / wood frond Common hairy lizard Wood conifers / frond wood None Wood of conifers Pine Spinner Wood conifers Spruce-headed fir red Coniferous wood Beetle large brown snout Wood conifers / frond wood Scab Beetle wood incubation Coniferous wood / wood frond Incubation scab beetle on calves Coniferous wood Mold mite of the Apple

The composition for impregnation according to present invention may contain in addition to the composition previously defined antimicrobial also coloring agents, such as dyes and pigments, dispersants, solvents, hardeners, Natural wood protection biocides. Such biocides of Natural wood protection and its maximum preferred content in the compositions according to the invention are shown in the following table:

         \ newpage
      

Biocide used Maximum content in% Tar oil be there 29 Bark of Oak 1.0 Wood distillate Pine tree - Galanga 1.0 Wood of guaiac 1.0 Vinegar wood 10 Tar of conifers 12.0 Bark of neem - Oil of nail - Oregano 1.0 Wood juniper 1.0 Oil of periwinkle

         \ vskip1.000000 \ baselineskip
      

The proportion of the antimicrobial composition in the composition regarding impregnation, treatment of surface or incorporation is 0.001 to 99% by weight, preferably from 0.1 to 10% by weight.

An effect can then be observed antimicrobial when the content of the antimicrobial composition it is 0.001 to 100 mg / g, preferably 0.1 to 50 mg / g (in the incorporation or impregnation) or 0.1 to 50 g / m2 (in the surface treatment) on the treated substrate.

With the present invention it is provided by both a harmless treatment procedure for health and compatible with the environment, which can be adjusted to the corresponding product that is degraded by microbes, contaminated and / or corruptible. Other preferred antimicrobial compositions are known from the WO 96/29895 and WO 98/58540.

The present invention is further clarified. in detail based on the following examples.

         \ vskip1.000000 \ baselineskip
      

Examples

Product protection agents (PSM) contain the following constituents (in% by weight)

PSM I : 10.0% polyphenol (here: tannin) 18.2% of benzyl alcohol 60.0% propylene glycol 8.0% lactic acid 3.8% etheric oil (here: an oil etheric containing phenol)

         \ vskip1.000000 \ baselineskip
      

PSM II : Alcohol benzylic fifty% a1 Aldehyde cinnamic fifty% g

         \ vskip1.000000 \ baselineskip
      

PSM III : Alcohol benzylic fifty% a1 Propylene glycol fifty% b1

         \ newpage
      

PSM IV : to) Alcohol benzylic fifty% a1  \ hskip0.3cm Polyphenol (Tannin) fifty% b1

b) Alcohol benzylic fifty% a1  \ hskip0.3cm Polyphenol (tannin) 25% b1  \ hskip0.3cm Lactic acid 25% b2

c) Alcohol benzylic 25% a1  \ hskip0.3cm Propylene glycol fifty% a2  \ hskip0.3cm Polyphenol (Tannin) 25% b1

d) Alcohol benzylic 25% a1  \ hskip0.3cm Propylene glycol 25% a2  \ hskip0.3cm Polyphenol (tannin) 25% b1  \ hskip0.3cm Lactic acid 25% b2

         \ vskip1.000000 \ baselineskip
      

PSM V : to) Propylene glycol 25% a2  \ hskip0.3cm Glycerin 25% a2  \ hskip0.3cm Acid lactic 25% b2  \ hskip0.3cm Tannin 25% b1

b) Propylene glycol fifty% a2  \ hskip0.3cm Glycerin 25% b2  \ hskip0.3cm Lactic acid 25% b2

C) Propylene glycol fifty% a2  \ hskip0.3cm Glycerin 25% b2  \ hskip0.3cm Tannin 25% b1

Example 1 Surface self decontamination

Use:

work surface treatment, bands transport etc.

Food product:

for example meat

Issue:

increase of germs by biomass in increase

Dosage:

undiluted spray on surface

Realization (on work table of steel stainless):

one.

Cleaning and disinfection of work surfaces (with 70% alcohol)

2.

Spraying with PSM I and elimination

3.

Contamination with fresh meat

Four.

Spraying with PSM I and elimination

5.

Sampling

The process is carried out in five intervals, 15 minutes apart.

Bacteriology: were isolated or differentiated following germs / groups of germs according to the procedure of official analysis according to \ NAK 35 LMBG: RTC (total count of colonies), enterobacteriaceae, lactobacilli.

Sampling: enter the intervals of treatment.

Assessment

Test Object:

steel surface V 2 A, which contaminated at regular distances with a sirloin

Control:

Before the start of the test, clean the table and 70% alcohol disinfection

quad

The steel surface V 2 A was rubbed to 15 minute intervals with a sirloin for the formation of a biomass From the second interval the meat was pulverized with Water.

PSM:

Spraying the test table after cleaning and disinfection with PSM I and removal using a scraper rubber.

quad

After contamination with the sirloin, it was pulverized with PSM and removed, then the sample was taken.

quad

Recontamination and withdrawal took place immediately after.

Test procedure:

a surface area of 100 cm2 is collected with a spatula

Outcome:

see below

Commentary:

PSM I can reduce with the technique of use according to RTC (total colony count) contamination at 10 5, enterobacteriaceae in 10 2 and lactobacilli in 10 5 over the contaminated surfaces, that is, reduction factor 5 RTC and Lactobacillus

Results of the studies

RTC / Spatula Enterobacteriaceae / Lactobacilli / spatula spatula 1st Pollution without withdrawal 6.7 x 10 4 twenty 6.6 x 10 4 6th contamination after withdrawal 2.3 x 10 3 - 2.3 x 10 3 Control without PSM I 3.9 x 10 5 5.5 x 10 2 3.8 x 10 5 righ now 6.1 x 10 3 - 5.3 x 10 3 After 15 minutes 7.4 x 10 3 - 4.3 x 10 3 1.43 x 10 4 - 1.36 x 10 4 After 30 minutes 3.2 x 10 3 - 2.1 x 10 3 1.29 x 10 4 10 1.09 x 10 4 After 45 minutes 6.4 x 10 3 - 3.8 x 10 3 8.1 x 10 3 - 6.8 x 10 3 After 60 minutes 7.8 x 10 3 - 6.1 x 10 3 3.6 x 10 4 fifty 3.6 x 10 4 After 75 minutes 7.6 x 10 3 - 7.4 x 10 3 1.93 x 10 4 - 1.82 x 10 4 After 90 minutes 5.8 x 10 3 - 5.3 x 10 3 1.25 x 10 4 - 1.14 x 10 4 Control with PSM righ now 10 - - After fifteen minutes - - - - - - After of 30 minutes - - - - - - After of 45 minutes - - - - - - After of 60 minutes - - - - - - After of 75 minutes - - - - - - After of 90 minutes - - - - - -

Example 2 Quantitative suspension test according to DVG directive PSM I product

Activity test: impregnation, treatment surface, incorporation, decontamination, self decontamination, for example, deo, dyes, paints, lubricants, washing agents, hygiene agents.

5

6

Example 3 Protection of wood product with adhered cheese (test of provocation) PSM I product - surface treatment and impregnation of wood

         \ newpage
      

7

Example 4A Protection of wood product with adhered cheese (test of provocation) Product PSM II and III - wood surface treatment in PSM II and III concentration function

Do not treaty Treaty Treaty Humidity of the Growth of Growth of air / temperature mold PSM II mold PSM III 100 fifty 100 fifty Wood glued X 8 - X 11 - 85% / 15ºC from fir tree Red X 12 Wood solid X 11 - X13 - 85% / 15ºC from fir tree Red X 18 Bankirai X 11 - X 15 - 85% / 15ºC X 14 * Wood tropical X: positive mold growth (index given on the day it took place mold growth between cheese and board) -:  \ begin {minipage} [t] {155mm} negative mold growth, up to on day 35 o after treatment no growth of mold. Then the trial was interrupted (end of maturation of cheese). \ end {minipage} PSM dosage: Glued red spruce wood: 100: 15 g / m2 PSM II or III // 50: 7.5 g / m2 PSM II or III Glued red spruce wood: 100: 20 g / m2 PSM II or III // 50:10 g / m2 PSM II or III Bankirai: 100: 5 g / m2 PSM II or III // 50: 2.5 g / m2 PSM II or III

         \ vskip1.000000 \ baselineskip
      

Example 4B Protection of wood product with adhered cheese (test of provocation) PSM IV product - wood surface treatment

Untreated Treaty Humidity of the Mold growth PSM IV air / temperature to to b b C C d d 100 fifty 100 fifty 100 fifty 100 fifty Wood glued X 8 - - - - - - - - 85% / 15ºC from fir tree Red Wood solid X 11 - - - - - - - - 85% / 15ºC from fir tree Red Bankirai X 11 - - - - - - - - 85% / 15ºC * Wood tropical X: positive mold growth (index given on the day it took place mold growth between cheese and board) -:  \ begin {minipage} [t] {155mm} negative mold growth, up to on day 35 o after treatment no growth of mold. Then the trial was interrupted (end of maturation of cheese). \ end {minipage} PSM IV dosage: Glued red spruce wood: 100: 15 g / m2 IVa, b, c or d // 50: 7.5 g / m2 IVa, b, c or d Glued wood red spruce: 100: 20 g / m2 IVa, b, c or d // 50: 105 g / m2 IVa, b, c or d Bangkerei: 100: 5 g / m2 IVa, b, c or d // 50: 2.5 g / m2 IVa, b, c or d

Example 4C Protection of wood product with adhered cheese (test of provocation) PSM V product - wood surface treatment

Untreated Treaty Humidity of the Mold growth PSM V air / temperature to to b b C C 100 fifty 100 fifty 100 fifty Wood glued X 8 - X 20 - X 10 - X 14 85% / 15ºC from fir tree Red Wood solid X 11 - X 20 - X 10 - X 14 85% / 15ºC from fir tree Red Bankirai X 11 - X 20 - X 10 - X 14 85% / 15ºC * Wood tropical X: positive mold growth (index given on the day it took place mold growth between cheese and board) -:  \ begin {minipage} [t] {155mm} negative mold growth, up to on day 35 o after treatment no growth of mold. Then the trial was interrupted (end of maturation of cheese). \ end {minipage} PSM V dosage: Glued red spruce wood: 100: 15 g / m2 Va, b or c // 50: 7.5 g / m2 Va, b or c Glued red spruce wood: 100: 20 g / m2 Va, b or c // 50: 105 g / m2 Va, b or c Bankirai: 100: 5 g / m2 Va, b or c // 50: 2.5 g / m 2 Va, b or c

         \ vskip1.000000 \ baselineskip
      

Example 5 Reduction of mold growth by coating on the cheese ripening example

Use:

cheese device

Food product:

Slice of cheese

Issue:

mold growth during ripening of cheese

Dosage:

2% by weight until coated (PSM I)

Sample Quantity:

respectively 10 x 30 g of samples O and samples

Realization:

Simulation in a heated room for cheese maturation

Temperature: 15ºC, relative air humidity: approximately 75%

Treatment of 8 raw cheeses respectively with neutral coating as well as PSM I.

Cheeses are turned over daily.

Final / result: reduced growth of mold in front of sample O during ripening.

Visual controls: mold and yeast on the Cheese surface.

Sample taking: daily visual checks As for external presence.

         \ newpage
      

Assessment

Results of the stay in K heated room 43: 15 ° C, relative humidity of 75%

Slicing goat cheese:

07/15 withdrawal from the salt bath Covering: on 07/28 by one side 08/29 by the face opposite

then daily investment and control.

K 34 mold load test by RCS team:

he 07/21 210 / m 3 he 07/24 65 / m 3

Results of the test series: controls visuals about mold

Control day n = 8, without PSM n = 8, with PSM 08/09 one 0 08/10 4 0 n = number of cheeses

Comment: untreated and treated cheeses (PSM I in the coating) matured under the possible conditions in a heated room (see mold load test). The null samples showed in contrast that the samples with PSM I a from day 12 of maturation mold growth visually.

Rest times - surface treatment with PSM I

Filter Sprayer Dosage Mold \ NAK 35 Bacteria \ NAK 35 with PSM LMBG LMBG F-0 Sample OR 0 8 x 10 5/25 cm 2 10 4/25 cm2 F-1 0.1 g / m2 7 x 10 3/25 cm 2 8 x 10 1/25 cm2 F-2 one g / m2 2 x 10 2/25 cm 2 <10 F-3 10 g / m2 <10/25 cm2 <10

Claims (14)

1. Procedure for impregnation and for treatment of substances / objects that can be degraded by microbes, which can become contaminated and / or corruptible, where substances / objects are selected from wood, basketry, textiles and textile raw materials, filters, washing agents and agents cleaning, which includes

-

the distribution or application of an antimicrobial composition on the surface of substances / objects that can be degraded, which may be contaminated and / or corrupted previously cited I

-

the incorporation of the antimicrobial composition in the substances / objects that can be degraded, that can become contaminated and / or corruptible, where the antimicrobial composition contains the At least two GRAS flavoring substances (generally recognized as safe).

2. Method according to claim 1, in where the antimicrobial composition contains at least one alcohol of GRAS aroma (a), preferably an aromatic GRAS aroma alcohol and especially benzyl alcohol. 3. Method according to claim 1, in where the antimicrobial composition contains at least one substance GRAS hydrophilic, alcoholic and / or a substance flavoring GRAS hydrophilic, non-alcoholic flavoring. 4. Method according to claim 3, in where the antimicrobial composition also contains alcohol benzyl and / or a polyphenol compound (b). 5. Method according to claim 1, in where the antimicrobial composition contains one or more alcohols of GRAS aromas or their derivatives (a) and one or more substances flavorings, selected from polyphenol compounds (b) and acids of GRAS aromas or their derivatives (c). 6. Method according to claim 5, in where the antimicrobial composition contains

(a1)

a aromatic GRAS aromatic alcohol, especially benzyl alcohol as an essential constituent and if necessary

(a2)

one or several alcohols with additional GRAS aromas or their derivatives Y

(b)

one or various polyphenol compounds and / or

(C)

one or several GRAS acids or their derivatives,

where the antimicrobial composition contains especially

from 0.1 to 99% in weight, preferably 0.1 to 75% by weight of benzyl alcohol Y

from 0.01 to 99.8% by weight, preferably 0.01 to 99% by weight of component (a2);

from 0.01 to 25% in weight, preferably 0.01 to 10% by weight of component (b) I

from 0.01 to 70% in weight, preferably 0.01 to 30% by weight of component (C).

7. Method according to claim 6, in where the antimicrobial composition contains

(i)

one or various polyphenol (b) compounds as constituent essential and, if necessary, one or more GRAS (c) acids or their derivatives, and / or contains

(ii)

other GRAS flavoring substances selected from (d) phenols, (e) esters, (f) terpenes, (g) acetals, (h) aldehydes and (i) etheric oils and especially of 0.001 to 25% by weight, preferably 0.01 to 9% by weight of others GRAS flavoring substances (d) to (i).

8. Method according to claim 6 or 7, wherein the antimicrobial composition contains one or two alcohols of GRAS aromas (a2) and at least one polyphenol compound (b), where the polyphenol compound (b) is preferably tannin, and wherein the antimicrobial composition contains with particular preference of 0.1 to 98% by weight of benzyl alcohol and 0.01 to 10% by weight of tannin. 9. Method according to claim 1, in where the antimicrobial composition contains

(i)

to the less a GRAS flavoring substance (generally recognized as safe) lipophilic and

(ii)

to the less a hydrophilic GRAS flavoring substance,

           \ newpage
        

where preferably the substance GRAS hydrophilic flavoring is a GRAS flavoring substance hydrophilic, alcoholic (a_H) or a GRAS flavoring substance hydrophilic, non-alcoholic, wherein the flavoring substance GRAS hydrophilic, alcoholic (a h) is preferably an alcohol monohydroxy or polyhydroxy with 2 to 10, with special preference 2 to 7 C atoms, which is specially selected from acetoin, ethyl alcohol, propyl alcohol, alcohol iso-propyl, propylene glycol and glycerin, the hydrophilic GRAS flavoring substance, not Alcoholic is a hydrophilic, organic GRAS aroma acid (ch) with 1 to 15 C atoms or a physiological salt thereof, an acetate hydrophilic (e h) or a hydrophilic aldehyde (h h). 10. Method according to claim 9, in where the antimicrobial composition contains

(i)

two lipophilic GRAS aromas alcohols (a_), however none benzyl alcohol and no polyphenol compound (b) or

(ii)

benzyl alcohol and / or a compound of polyphenol (b), however, no other aroma alcohol GREAS

11. Procedure according to one or more of the claims 1 to 10, wherein the antimicrobial composition contains

(i)

also mono- or alcohol alcohols polyhydroxy with 2 to 10 C atoms, emulsifiers, stabilizers, antioxidants, preservatives, solvents and / or vehicles and / or

(ii)

be It consists exclusively of GRAS flavoring substances.

12. Procedure according to one or more of the claims 1 to 11, wherein the substances / objects that can Degrade by microbes, which can become contaminated and / or corruptible They are selected from air filters, wool and cotton. 13. Use of an antimicrobial composition, such as defined in claims 1 to 11, for impregnation or surface treatment of substances / objects that may degrade by microbes, which can become contaminated and / or corruptible or of substances / objects that must be self-decontaminators, where The substances / objects are defined as in claim 1. 14. Use of an antimicrobial composition, as defined in claims 1 to 11, for incorporation into substances / objects that can be degraded by microbes, which can be contaminated and / or corruptible or substances / objects that must be self-decontaminating, wherein substances / objects are defined as in the claim
tion 1.