[go: up one dir, main page]

ES2138603T3 - Procedimiento para el aislamiento de los factores ix, x y ii altamente purificados a partir del complejo protrombinico o del plasma humano. - Google Patents

Procedimiento para el aislamiento de los factores ix, x y ii altamente purificados a partir del complejo protrombinico o del plasma humano.

Info

Publication number
ES2138603T3
ES2138603T3 ES93104633T ES93104633T ES2138603T3 ES 2138603 T3 ES2138603 T3 ES 2138603T3 ES 93104633 T ES93104633 T ES 93104633T ES 93104633 T ES93104633 T ES 93104633T ES 2138603 T3 ES2138603 T3 ES 2138603T3
Authority
ES
Spain
Prior art keywords
human plasma
factors
complex
combin
proto
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93104633T
Other languages
English (en)
Inventor
Silvana Arrighi
Francesco Norelli
Maria Giuseppina Borri
Enzo Bucci
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ISI IST SIEROVACCINOGENO ITAL
Sclavo SpA
Original Assignee
ISI IST SIEROVACCINOGENO ITAL
Sclavo SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ISI IST SIEROVACCINOGENO ITAL, Sclavo SpA filed Critical ISI IST SIEROVACCINOGENO ITAL
Application granted granted Critical
Publication of ES2138603T3 publication Critical patent/ES2138603T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

SE OFRECE LA DESCRIPCION DE UN PROCESO PARA LA PURIFICACION DEL FACTOR IX, DEL FACTOR X Y DEL FACTOR II A PARTIR DEL PLASMA HUMANO O DE FRACCIONES DEL MISMO, EN EL UNA SOLUCION QUE CONTENGA FACTORES DE COMPLEJO DE PROTROMBINA SE PURIFICA MEDIANTE REPETIDAS SEPARACIONES CROMATOGRAFICAS DE INTERCAMBIO DE IONES SEGUIDAS POR CROMATOGRAFIA DE ABSORCION SOBRE LOS IONES DE METAL.
ES93104633T 1992-03-27 1993-03-22 Procedimiento para el aislamiento de los factores ix, x y ii altamente purificados a partir del complejo protrombinico o del plasma humano. Expired - Lifetime ES2138603T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITFI920078A IT1262899B (it) 1992-03-27 1992-03-27 Processo per l'isolamento di fattore ix, fattore x e fattore ii altamente purificati dal complesso protrombinico o dal plasma umano

Publications (1)

Publication Number Publication Date
ES2138603T3 true ES2138603T3 (es) 2000-01-16

Family

ID=11350034

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93104633T Expired - Lifetime ES2138603T3 (es) 1992-03-27 1993-03-22 Procedimiento para el aislamiento de los factores ix, x y ii altamente purificados a partir del complejo protrombinico o del plasma humano.

Country Status (6)

Country Link
US (1) US5378365A (es)
EP (1) EP0617049B1 (es)
AT (1) ATE184018T1 (es)
DE (1) DE69326227T2 (es)
ES (1) ES2138603T3 (es)
IT (1) IT1262899B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3336631A1 (de) * 1983-10-08 1985-04-18 Behringwerke Ag, 3550 Marburg Verfahren zur pasteurisierung von plasma oder von konzentraten der blutgerinnungsfaktoren ii, vii, ix und x
DE19504852C2 (de) * 1995-02-15 2003-01-23 Octapharma Ag Lachen Verfahren zur Reinigung Vitamin K-abhängiger Gerinnungsfaktoren durch Affinitäts-Chromatographie
US5714583A (en) * 1995-06-07 1998-02-03 Genetics Institute, Inc. Factor IX purification methods
HUP9700603A3 (en) * 1996-03-20 2001-08-28 Baxter Ag Pharmaceutical preparation for the treatment of blood coagulation disorders
DE19625642A1 (de) * 1996-06-26 1998-01-08 Max Planck Gesellschaft Verfahren zur Herstellung einer Antidotausgangssubstanz für natürliche und synthetische Thrombininhibitoren
AT409334B (de) * 1997-09-19 2002-07-25 Immuno Ag Pharmazeutisches präparat enthaltend vitamin k-abhängige einzelfaktoren
ITBO20010426A1 (it) * 2001-07-06 2003-01-06 Alfa Wassermann Spa Processo per la purificazione di proteine farmacologicamente attive mediante cromatografia in scambio cationico
SE0203551D0 (sv) * 2002-12-02 2002-12-02 Biovitrum Ab Prothrombin purification
GB0614315D0 (en) 2006-07-19 2006-08-30 Ge Healthcare Bio Sciences Ab Chromatography columns, systems and methods
US9597610B2 (en) * 2007-03-09 2017-03-21 Ge Healthcare Bioprocess R&D Ab Packing system and method for chromatography columns
GB0704603D0 (en) * 2007-03-09 2007-04-18 Ge Healthcare Bio Sciences Ab Packing system and method for chromatography columns
US9597611B2 (en) * 2007-03-09 2017-03-21 Ge Healthcare Bioprocess R&D Ab Packing system and method for chromatography columns
GB0710321D0 (en) * 2007-05-30 2007-07-11 Nhs Blood & Transplant Method
US9956272B2 (en) 2007-05-30 2018-05-01 Bio Products Laboratory Limited Methods for preparing factor X, activated factor X, inactivated factor X and inactivated factor Xa, and pharmaceutical compositions comprising same
US7934704B2 (en) * 2007-10-16 2011-05-03 Environmental Dynamics, Inc. Retrievable diffuser module with internal ballast/buoyancy chamber
AU2009324204B2 (en) 2008-12-02 2014-10-16 Novo Nordisk Health Care Ag Polypeptide purification
EP2526115B1 (en) 2010-01-18 2018-08-01 Novo Nordisk Health Care AG Purification of blood coagulation factors
SG191186A1 (en) 2010-12-15 2013-07-31 Baxter Int Eluate collection using conductivity gradient
CN107915769A (zh) 2011-03-29 2018-04-17 葛兰素史密斯克莱有限责任公司 用于蛋白纯化的缓冲液体系
US9663553B2 (en) 2014-01-29 2017-05-30 Hemarus Therapeutics Limited Integrated process for the production of therapeutics (human albumin, immunoglobulins, clotting factor VIII and clotting factor IX) from human plasma

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT368883B (de) * 1980-07-22 1982-11-25 Immuno Ag Verfahren zur herstellung einer neuen blutgerinnungsfoerdernden praeparation auf basis von humanproteinen
DE3043857A1 (de) * 1980-11-21 1982-07-08 Behringwerke Ag, 3550 Marburg Verfahren zur herstellung von blutgerinnungsfaktoren und danach hergestellte praeparation der faktoren ii und vii
US4470968A (en) * 1983-01-13 1984-09-11 Miles Laboratories, Inc. Pasteurized therapeutically active blood coagulation factor concentrates
US4720385A (en) * 1983-03-29 1988-01-19 Miles Laboratories, Inc. Protein compositions substantially free from infectious agents
AT399095B (de) * 1986-03-27 1995-03-27 Vukovich Thomas Dr Verfahren zur auftrennung von proteinen mittels gradientenelution und vorrichtung zur durchführung des verfahrens
GB8729822D0 (en) * 1987-12-22 1988-02-03 Central Blood Lab Authority Chemical process
US4981952A (en) * 1988-10-04 1991-01-01 Eli Lilly And Company Method for the purification of vitamin K-dependent proteins
DE3914869C1 (es) * 1989-05-05 1990-08-09 Biotest Pharma Gmbh, 6072 Dreieich, De
US5138034A (en) * 1989-07-12 1992-08-11 The Green Cross Corporation Method of fractionating plasma proteins
US5286849A (en) * 1992-07-14 1994-02-15 Alpha Therapeutic Corporation Purification of factor IX

Also Published As

Publication number Publication date
ATE184018T1 (de) 1999-09-15
ITFI920078A1 (it) 1993-09-27
EP0617049A1 (en) 1994-09-28
IT1262899B (it) 1996-07-22
DE69326227T2 (de) 2000-02-17
EP0617049B1 (en) 1999-09-01
DE69326227D1 (de) 1999-10-07
ITFI920078A0 (it) 1992-03-27
US5378365A (en) 1995-01-03

Similar Documents

Publication Publication Date Title
ES2138603T3 (es) Procedimiento para el aislamiento de los factores ix, x y ii altamente purificados a partir del complejo protrombinico o del plasma humano.
NZ324603A (en) Treatment of the CNS effects of HIV with VX-478, alone or in combination with AZT or 3TC
ES2093494T3 (es) Fracciones de heparina purificadas, procedimiento de obtencion y composiciones farmaceuticas que los contienen.
DE69031748D1 (de) Plasmabehandlung mit Metallmasken-Integration
CO4950529A1 (es) Dihidropirimidinas y productos que las contienen
ES2191292T3 (es) Compuestos antivirales poliaromaticos.
EP0651437A3 (en) Plasma etching process.
ATE148130T1 (de) Typ-iv-dipeptidyl-aminopeptidase-inhibitoren
ES2182837T3 (es) Piran-2-onas y 5,6-dihidropiran-2-onas utiles en el tratamiento del sida y de otros retrovirus.
ES2085468T3 (es) Albuterol r(-) opticamente puro para tratar el asma.
ES2186714T3 (es) Uso de sustipo simple alpha 8 en la preparacion de medicamentos para el tratamiento de infecciones virales del higado.
MX9300550A (es) Estructura de fibra absorbente.
ES2051675T1 (es) Uso de ciertos herbicidas en el tratamiento del cancer y produccion de protoporfirina ix.
MX9302279A (es) Metodo para la produccion del factor viii presenteen el plasma, altamente purificado.
ES2098725T3 (es) Procedimiento para la purificacion de perfluorocarbonos y utilizacion de los perfluorocarbonos purificados.
ES2187534T3 (es) Procedimiento para la preparacion de n-metil-3-(metil-4-piperi dinil)-14-indol-5-etanosulfonamida.
MD960168A (ro) Metodă şi compuşi pentru tratamentul infecţiilor virale
ES2073501T3 (es) Procedimiento para el tratamiento de laminas de poliolefina.
MX9304749A (es) Lentes de contacto que comprenden ciclodextrinas lipofilizadas.
BR0111545A (pt) Produto combinado, método para a produção de um kit de partes, kit de partes, método de tratamento de uma condição, usos de um produto combinado ou de um kit de partes, e, de um melagatrano e de um inibidor de fator xa, ou de um derivado farmaceuticamente aceitável dos mesmos
MX9305992A (es) Modificacion con laser de superficies de objectos a traves de ablacion.
ES2187635T3 (es) Uso de inmunoglobulinas de clase g para el tratamiento topico de dermatitis atopica.
DE69129693D1 (de) Verwendung von nickel und bromide ionen für die behandlung von psoriasis
ES2134430T3 (es) Procedimiento de fluoracion.
PT633928E (pt) Microrganismos processo de preparacao e utilizacao

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 617049

Country of ref document: ES