ES2137131A1 - Piperidinone derivative, process for obtaining it and process for using it - Google Patents
Piperidinone derivative, process for obtaining it and process for using itInfo
- Publication number
- ES2137131A1 ES2137131A1 ES009800225A ES9800225A ES2137131A1 ES 2137131 A1 ES2137131 A1 ES 2137131A1 ES 009800225 A ES009800225 A ES 009800225A ES 9800225 A ES9800225 A ES 9800225A ES 2137131 A1 ES2137131 A1 ES 2137131A1
- Authority
- ES
- Spain
- Prior art keywords
- obtaining
- piperidinone
- derivative
- fluorophenyl
- piperidinone derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title abstract 6
- XUWHAWMETYGRKB-UHFFFAOYSA-N piperidin-2-one Chemical class O=C1CCCCN1 XUWHAWMETYGRKB-UHFFFAOYSA-N 0.000 title abstract 2
- -1 (+-) ethyl Chemical group 0.000 abstract 1
- IBOPBHBOBJYXTD-JQWIXIFHSA-N [(3s,4r)-4-(4-fluorophenyl)piperidin-3-yl]methanol Chemical compound OC[C@@H]1CNCC[C@H]1C1=CC=C(F)C=C1 IBOPBHBOBJYXTD-JQWIXIFHSA-N 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- KYLVWAPVAFLFGV-UHFFFAOYSA-N diethyl 2-[2-cyano-1-(4-fluorophenyl)ethyl]propanedioate Chemical compound CCOC(=O)C(C(=O)OCC)C(CC#N)C1=CC=C(F)C=C1 KYLVWAPVAFLFGV-UHFFFAOYSA-N 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
Landscapes
- Hydrogenated Pyridines (AREA)
Abstract
Piperidinone derivative, process for obtaining it and process for using it. The derivative is called (+-) ethyl trans-4-(4- fluorophenyl)-2-piperidinone-3-carboxylate, the process for obtaining it comprises the hydrogenation of a diethyl 2-[2-cyano-1-(4-fluorophenyl)ethyl]malonate intermediate II in the presence of a catalyst and cyclising this and the process for using it results in the production of (+- ) trans-4-(4-fluorophenyl)-3-hydroxymethyl-piperidine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9800225A ES2137131B1 (en) | 1998-02-06 | 1998-02-06 | DERIVATIVE OF PIPERIDINONE PROCEDURE FOR OBTAINING AND PROCEDURE FOR ITS USE. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES9800225A ES2137131B1 (en) | 1998-02-06 | 1998-02-06 | DERIVATIVE OF PIPERIDINONE PROCEDURE FOR OBTAINING AND PROCEDURE FOR ITS USE. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES2137131A1 true ES2137131A1 (en) | 1999-12-01 |
| ES2137131B1 ES2137131B1 (en) | 2000-09-16 |
Family
ID=8302650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES9800225A Expired - Fee Related ES2137131B1 (en) | 1998-02-06 | 1998-02-06 | DERIVATIVE OF PIPERIDINONE PROCEDURE FOR OBTAINING AND PROCEDURE FOR ITS USE. |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES2137131B1 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002076940A3 (en) * | 2001-03-22 | 2003-05-22 | Pentech Pharmaceuticals Inc | Process for preparing arylpiperidine carbinol intermediates and derivatives |
| EP1140832A4 (en) * | 1998-12-22 | 2004-11-03 | Pentech Pharmaceuticals Inc | Process for preparing arylpiperidine carbinol intermediates and derivatives |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4007196A (en) * | 1973-01-30 | 1977-02-08 | A/S Ferrosan | 4-Phenylpiperidine compounds |
| US4189583A (en) * | 1978-04-26 | 1980-02-19 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Synthesis of 4A-aryl-decahydroisoquinolines |
| EP0802185A1 (en) * | 1996-04-15 | 1997-10-22 | Asahi Glass Company Ltd. | Process for producing piperidinecarbinols |
-
1998
- 1998-02-06 ES ES9800225A patent/ES2137131B1/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4007196A (en) * | 1973-01-30 | 1977-02-08 | A/S Ferrosan | 4-Phenylpiperidine compounds |
| US4189583A (en) * | 1978-04-26 | 1980-02-19 | The United States Of America As Represented By The Department Of Health, Education And Welfare | Synthesis of 4A-aryl-decahydroisoquinolines |
| EP0802185A1 (en) * | 1996-04-15 | 1997-10-22 | Asahi Glass Company Ltd. | Process for producing piperidinecarbinols |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1140832A4 (en) * | 1998-12-22 | 2004-11-03 | Pentech Pharmaceuticals Inc | Process for preparing arylpiperidine carbinol intermediates and derivatives |
| WO2002076940A3 (en) * | 2001-03-22 | 2003-05-22 | Pentech Pharmaceuticals Inc | Process for preparing arylpiperidine carbinol intermediates and derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2137131B1 (en) | 2000-09-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EC2A | Search report published |
Date of ref document: 19991201 Kind code of ref document: A1 Effective date: 19991201 |
|
| PC2A | Transfer of patent |
Free format text: INKE, S.A. |
|
| FD2A | Announcement of lapse in spain |
Effective date: 20161214 |