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ES2136743T3 - Parche de principios activos contenedor de substancias volatiles que puede ser elaborado sin disolventes. - Google Patents

Parche de principios activos contenedor de substancias volatiles que puede ser elaborado sin disolventes.

Info

Publication number
ES2136743T3
ES2136743T3 ES94928368T ES94928368T ES2136743T3 ES 2136743 T3 ES2136743 T3 ES 2136743T3 ES 94928368 T ES94928368 T ES 94928368T ES 94928368 T ES94928368 T ES 94928368T ES 2136743 T3 ES2136743 T3 ES 2136743T3
Authority
ES
Spain
Prior art keywords
active substance
matrix
readily volatile
composite
patch
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94928368T
Other languages
English (en)
Inventor
Michael Horstmann
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
LTS Lohmann Therapie Systeme AG
Original Assignee
LTS Lohmann Therapie Systeme AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LTS Lohmann Therapie Systeme AG filed Critical LTS Lohmann Therapie Systeme AG
Application granted granted Critical
Publication of ES2136743T3 publication Critical patent/ES2136743T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

LA INVENCION SE REFIERE A EMPLASTO, QUE CONTIENE SUSTANCIA ACTIVA CON UNA DISPOSICION DE FIJACION AUTOADHESIVA, CONTENIENDO AL MENOS UN INGREDIENTE ALTAMENTE VOLATIL Y CONSISTIENDO EN UNA CAPA POSTERIOR SUSTANCIALMENTE IMPERMEABLE A LA SUSTANCIA ACTIVA, AL MENOS DOS CAPAS DE MATRIZ CONTENIENDO SUSTANCIA ACTIVA Y UNA CAPA PROTECTORA DESMONTABLE. LA CAPA MATRIZ QUE CONTIENE LA SUSTANCIA ACTIVA ALTAMENTE VOLATIL ES LAMINADA SOBRE UN COMPOSITE PRODUCIDO DE FORMA SEPARADA, ELABORADO A PARTIR DE UNA O VARIAS CAPAS MATRIZ LIBRES DE OTRAS SUSTANCIAS ACTIVAS. EL EMPLASTO SE CARACTERIZA PORQUE LA PRIMERA CAPA MATRIZ CONTENIENDO SUSTANCIA ACTIVA CONSISTE EN UNA SOLUCION MOLECULAR DISPERSA DEL MATERIAL DE BASE MATRIZ DISPERSADO EN LOS INGREDIENTES ALTAMENTE VOLATILES COMO EL UNICO DISOLVENTE. DESPUES DE QUE EL INGREDIENTE ALTAMENTE VOLATIL EMIGRA DENTRO DE LA DISPOSICION DE COMPOSITE OBTENIDO DESPUES DE LA LAMINACION, EL COMPOSITE FORMA UNA MATRIZ DE SUSTANCIA ACTIVA QUE EN SU CONJUNTO ES RESISTENTE AEFECTO DE CORTE.
ES94928368T 1993-09-22 1994-09-16 Parche de principios activos contenedor de substancias volatiles que puede ser elaborado sin disolventes. Expired - Lifetime ES2136743T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4332094A DE4332094C2 (de) 1993-09-22 1993-09-22 Lösemittelfrei herstellbares Wirkstoffpflaster und Verfahren zu seiner Herstellung

Publications (1)

Publication Number Publication Date
ES2136743T3 true ES2136743T3 (es) 1999-12-01

Family

ID=6498227

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94928368T Expired - Lifetime ES2136743T3 (es) 1993-09-22 1994-09-16 Parche de principios activos contenedor de substancias volatiles que puede ser elaborado sin disolventes.

Country Status (10)

Country Link
US (1) US5902601A (es)
EP (1) EP0720474B1 (es)
JP (1) JP3523259B2 (es)
AT (1) ATE182269T1 (es)
CA (1) CA2172402C (es)
DE (2) DE4332094C2 (es)
DK (1) DK0720474T3 (es)
ES (1) ES2136743T3 (es)
GR (1) GR3031626T3 (es)
WO (1) WO1995008324A1 (es)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4433191A1 (de) * 1994-09-17 1996-03-21 Lohmann Therapie Syst Lts Selbstklebendes Pflaster zur Abgabe von Wirkstoff an die Umgebung eines Trägers
US5688523A (en) * 1995-03-31 1997-11-18 Minnesota Mining And Manufacturing Company Method of making a pressure sensitive skin adhesive sheet material
DE19701059C2 (de) * 1997-01-15 2000-12-21 Lohmann Therapie Syst Lts Acetylsalicylsäure enthaltendes transdermales therapeutisches System mit Resorptionsverstärkung
DE19728517C2 (de) * 1997-07-04 1999-11-11 Sanol Arznei Schwarz Gmbh TTS zur Verabreichung von Sexualsteroidhormonen und Verfahren zu seiner Herstellung
DE19728516C2 (de) * 1997-07-04 1999-11-11 Sanol Arznei Schwarz Gmbh TTS zur Verabreichung von Levonorgestrel und gegebenenfalls Estradiol
DE19826592A1 (de) * 1998-06-15 1999-12-16 Lohmann Therapie Syst Lts Verfahren zur Herstellung eines aus einzelnen Schichten bestehenden Laminats
EP1137406B2 (en) † 1998-12-07 2008-01-23 J. Dev Limited Transdermal patch for delivering volatile liquid drugs
DE19913732A1 (de) * 1999-03-26 2000-09-28 Lohmann Therapie Syst Lts Nikotin-TTS mit einem Zusatz von Monoterpenketonen
DE19923427A1 (de) * 1999-05-21 2000-11-23 Lohmann Therapie Syst Lts Vorrichtung und Verfahren zur Steigerung der transdermalen Permeation von Arzneistoffen
DE19949202A1 (de) * 1999-10-13 2001-05-03 Lohmann Therapie Syst Lts Transdermales therapeutisches System zur Abgabe von Acetylsalicylsäure und/oder Salicylsäure
DE10056011A1 (de) * 2000-11-11 2002-05-16 Beiersdorf Ag Hautfreundliches Wirkstoffpflaster zur insbesondere transdermalen Verabreichung ätherischer Öle
DE10056010A1 (de) * 2000-11-11 2002-05-16 Beiersdorf Ag Pflaster mit hautpflegenden Substanzen
DE10056009A1 (de) * 2000-11-11 2002-05-16 Beiersdorf Ag Hautfreundliches Wirkstoffpflaster zur transdermalen Verabreichung hyperämisierender Wirkstoffe
DE10110391A1 (de) 2001-03-03 2002-09-26 Lohmann Therapie Syst Lts Hochflexibles Nikotin transdermales therapeutisches System mit Nikotin als Wirkstoff
DE10121471A1 (de) * 2001-05-02 2002-11-07 Beiersdorf Ag Oberflächendotierte wirkstoffhaltige Pflaster
DE10338174A1 (de) * 2003-08-20 2005-03-24 Lts Lohmann Therapie-Systeme Ag Transdermale Arzneimittelzubereitungen mit Wirkstoffkombinationen zur Behandlung der Parkinson-Krankheit
NZ546992A (en) * 2003-10-28 2009-07-31 Noven Pharma Transdermal drug delivery device
JP2006169160A (ja) * 2004-12-15 2006-06-29 Yuutoku Yakuhin Kogyo Kk 外用貼付剤およびその製造方法
DE102005033543A1 (de) * 2005-07-14 2007-01-18 Grünenthal GmbH Ein einen Duftstoff aufweisendes transdermales therapeutisches System
JP4913738B2 (ja) * 2005-08-19 2012-04-11 ダイヤ製薬株式会社 プラスターの製造方法及びその製造装置及びプラスター用ライナー
DE102006026060B4 (de) * 2006-01-12 2013-01-31 Lts Lohmann Therapie-Systeme Ag Transdermales Therapeutisches System enthaltend als Wirkstoff Nikotin und Verfahren zur Herstellung solcher Systeme
DE102006050558B4 (de) 2006-10-26 2009-03-26 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System enthaltend Norelgestromin zur Kontrazeption und Hormonsubstitution
MX2009007408A (es) * 2007-01-11 2009-07-17 Drossapharm Ag Emplasto medicamente activo.
CN107441069A (zh) 2012-02-28 2017-12-08 日绊株式会社 贴附剂
DE102014000200A1 (de) 2014-01-03 2015-07-09 Michael Horstmann Transdermales Therapeutisches System

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4379454A (en) * 1981-02-17 1983-04-12 Alza Corporation Dosage for coadministering drug and percutaneous absorption enhancer
GB2105990B (en) * 1981-08-27 1985-06-19 Nitto Electric Ind Co Adhesive skin patches
JPS61293911A (ja) * 1985-06-24 1986-12-24 Teisan Seiyaku Kk 徐放化製剤
EP0249475A3 (en) * 1986-06-13 1989-10-11 Alza Corporation Delayed percutaneous delivery
DE3629304A1 (de) * 1986-08-28 1988-03-24 Lohmann Gmbh & Co Kg Transdermales therapeutisches system, seine verwendung und verfahren zu seiner herstellung
US5538736A (en) * 1987-04-28 1996-07-23 Lts Lohmann Therapie-Systeme Gmbh Active substance-containing plaster for the controlled administration of active substances to the skin
HU197519B (en) * 1987-06-22 1989-04-28 Biogal Gyogyszergyar Process for producing medicine form capable for penetrating through epidermis and suitable for intaking the agent through epidermis by kinetics of zero-grade
DE3743945A1 (de) * 1987-09-01 1989-03-09 Lohmann Gmbh & Co Kg Vorrichtung zur abgabe von stoffen, verfahren zu ihrer herstellung sowie ihre verwendung
DE3743946A1 (de) * 1987-09-01 1989-03-09 Lohmann Gmbh & Co Kg Vorrichtung zur abgabe von nitroglycerin an die haut, verfahren zu ihrer herstellung sowie ihre verwendung
US5306502A (en) * 1987-09-01 1994-04-26 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Apparatus for delivering nitroglycerin to the skin, processes for the production thereof and the use thereof
US4943435A (en) * 1987-10-05 1990-07-24 Pharmetrix Corporation Prolonged activity nicotine patch
FR2623718B1 (fr) * 1987-11-27 1994-04-15 Fabre Medicament Pierre Dispositif therapeutique transdermique et son procede de preparation
US4915950A (en) * 1988-02-12 1990-04-10 Cygnus Research Corporation Printed transdermal drug delivery device
DE3843238C1 (es) * 1988-12-22 1990-02-22 Lohmann Therapie Syst Lts
US5164416A (en) * 1989-02-03 1992-11-17 Lintec Corporation Transdermal therapeutic formulation containing a limonene
DE69003632T2 (de) * 1989-02-28 1994-02-17 Teijin Ltd Pflaster sowie dessen herstellung.
DE4210165A1 (de) * 1991-07-30 1993-02-04 Schering Ag Transdermale therapeutische systeme
JP3182440B2 (ja) * 1991-11-08 2001-07-03 リンテック株式会社 経皮吸収型製剤の製造方法
US5323780A (en) * 1992-08-07 1994-06-28 University Of Florida Research Foundation, Inc. Artifact-free imaging contrast agent
US5462746A (en) * 1992-11-02 1995-10-31 Lts Lohmann Therapie-Systeme Gmbh & Co. Kg Patch for transdermal administration of volatile pharmaceutically active ingredients of chemically basic nature and a process for preparation

Also Published As

Publication number Publication date
DE4332094C2 (de) 1995-09-07
CA2172402C (en) 2005-08-23
JP3523259B2 (ja) 2004-04-26
DK0720474T3 (da) 2000-02-21
EP0720474A1 (de) 1996-07-10
DE4332094A1 (de) 1995-03-23
EP0720474B1 (de) 1999-07-21
CA2172402A1 (en) 1995-03-30
GR3031626T3 (en) 2000-01-31
DE59408524D1 (de) 1999-08-26
WO1995008324A1 (de) 1995-03-30
US5902601A (en) 1999-05-11
ATE182269T1 (de) 1999-08-15
JPH09503756A (ja) 1997-04-15

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