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ES2136600T3 - Empleo de acido (s)(+)-2-etoxi-4-(n-(1-(2-piperidino-fenil)-3-metil-1-butil)aminocarbonilmetil)-benzoico para la preparacion de un antidiabetico de larga duracion. - Google Patents

Empleo de acido (s)(+)-2-etoxi-4-(n-(1-(2-piperidino-fenil)-3-metil-1-butil)aminocarbonilmetil)-benzoico para la preparacion de un antidiabetico de larga duracion.

Info

Publication number
ES2136600T3
ES2136600T3 ES91911959T ES91911959T ES2136600T3 ES 2136600 T3 ES2136600 T3 ES 2136600T3 ES 91911959 T ES91911959 T ES 91911959T ES 91911959 T ES91911959 T ES 91911959T ES 2136600 T3 ES2136600 T3 ES 2136600T3
Authority
ES
Spain
Prior art keywords
methyl
piperidino
butyl
benzoic
etoxi
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91911959T
Other languages
English (en)
Inventor
Wolfgang Grell
Andreas Greischel
Gabriele Zahn
Michael Mark
Hansjorg Knorr
Eckhard Rupprecht
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Priority claimed from EP91911959A external-priority patent/EP0589874B1/de
Application granted granted Critical
Publication of ES2136600T3 publication Critical patent/ES2136600T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

LA INVENCION SE REFIERE AL NUEVO (S)(+) [N OCARBONILMETIL] EDADES FARMACOLOGICAS, VALIOSAS PRODUCIENDO UNA ACCION SOBRE EL METABOLISMO INTERMEDIO Y EN PARTICULAR SOBRE EL DESCENSO DE LOS NIVELES DE AZUCAR EN SANGRE. LA INVENCION SE REFIERE TAMBIEN A LOS NUEVOS PRODUCTOS INTERMEDIOS DE LAS FORMULAS (I), (III), (IV) Y (VI) ASI COMO A SUS SALES DE ADICION. LOS NUEVOS COMPUESTOS PUEDEN SER PREPARADOS DE ACUERDO CON LOS METODOS CONOCIDOS PARA LA PREPARACION DE COMPUESTOS ANALOGOS.
ES91911959T 1991-06-21 1991-06-21 Empleo de acido (s)(+)-2-etoxi-4-(n-(1-(2-piperidino-fenil)-3-metil-1-butil)aminocarbonilmetil)-benzoico para la preparacion de un antidiabetico de larga duracion. Expired - Lifetime ES2136600T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP91911959A EP0589874B1 (de) 1991-06-21 1991-06-21 Verwendung von (s)(+)-2-äthoxy-4-[n-[1-(2-piperidino-phenyl)-3-methyl-1-butyl]aminocarbonylmethyl]-benzoesäure zur herstellung eines langzeitantidiabetikums

Publications (1)

Publication Number Publication Date
ES2136600T3 true ES2136600T3 (es) 1999-12-01

Family

ID=8209133

Family Applications (2)

Application Number Title Priority Date Filing Date
ES99101810T Expired - Lifetime ES2179558T3 (es) 1991-06-21 1991-06-21 Procedimiento para preparar (s)-3-metil-1-(2-piperidino-fenil)-1-butilamina.
ES91911959T Expired - Lifetime ES2136600T3 (es) 1991-06-21 1991-06-21 Empleo de acido (s)(+)-2-etoxi-4-(n-(1-(2-piperidino-fenil)-3-metil-1-butil)aminocarbonilmetil)-benzoico para la preparacion de un antidiabetico de larga duracion.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES99101810T Expired - Lifetime ES2179558T3 (es) 1991-06-21 1991-06-21 Procedimiento para preparar (s)-3-metil-1-(2-piperidino-fenil)-1-butilamina.

Country Status (4)

Country Link
EP (1) EP0965591B1 (es)
AT (2) ATE223391T1 (es)
DE (1) DE59109240D1 (es)
ES (2) ES2179558T3 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004101540A2 (de) * 2003-05-14 2004-11-25 Cilag Ag Verfahren zur herstellung von phenylessigsäurederivaten
EP2177221A1 (en) 2008-10-20 2010-04-21 Krka Tovarna Zdravil, D.D., Novo Mesto Process for the preparation of substantially optically pure Repaglinide and precursors thereof
EP2364977A1 (en) 2010-01-26 2011-09-14 Reuter Chemische Apparatebau KG Process for the enantiomeric enrichment of 3-methyl-1-(2-piperidinophenyl)-1-butylamine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3320583A1 (de) * 1983-06-08 1984-12-13 Dr. Karl Thomae Gmbh, 7950 Biberach Neue galenische zubereitungsformen von oralen antidiabetika und verfahren zu ihrer herstellung
DE3347565A1 (de) * 1983-12-30 1985-07-11 Thomae Gmbh Dr K Neue phenylessigsaeurederivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
JPH01131143A (ja) * 1987-11-16 1989-05-24 Earth Chem Corp Ltd ｄ，ｌ−カルニチンニトリルクロライドの光学分割法

Also Published As

Publication number Publication date
ATE184279T1 (de) 1999-09-15
EP0965591B1 (de) 2002-09-04
EP0965591A1 (de) 1999-12-22
ATE223391T1 (de) 2002-09-15
ES2179558T3 (es) 2003-01-16
DE59109240D1 (de) 2002-10-10

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