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ES2136018B1 - SELECTIVE INHIBITOR COMPOUNDS OF CYCLOOXYGENASE-I AND ITS USE AS ANALGESICS, ANTI-INFLAMMATORIES AND ANTIARTHRITIC. - Google Patents

SELECTIVE INHIBITOR COMPOUNDS OF CYCLOOXYGENASE-I AND ITS USE AS ANALGESICS, ANTI-INFLAMMATORIES AND ANTIARTHRITIC.

Info

Publication number
ES2136018B1
ES2136018B1 ES9701315A ES9701315A ES2136018B1 ES 2136018 B1 ES2136018 B1 ES 2136018B1 ES 9701315 A ES9701315 A ES 9701315A ES 9701315 A ES9701315 A ES 9701315A ES 2136018 B1 ES2136018 B1 ES 2136018B1
Authority
ES
Spain
Prior art keywords
analgesics
cyclooxygenase
antiarthritic
inflammatories
inhibitor compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9701315A
Other languages
Spanish (es)
Other versions
ES2136018A1 (en
Inventor
Casellas David Mauleon
Avellana Jaime Pascual
Perez M Luisa Garcia
Benet Albert Palomer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Menarini SA
Original Assignee
Laboratorios Menarini SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios Menarini SA filed Critical Laboratorios Menarini SA
Priority to ES9701315A priority Critical patent/ES2136018B1/en
Priority to AU83376/98A priority patent/AU8337698A/en
Priority to PCT/EP1998/003636 priority patent/WO1998057910A2/en
Publication of ES2136018A1 publication Critical patent/ES2136018A1/en
Application granted granted Critical
Publication of ES2136018B1 publication Critical patent/ES2136018B1/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/46—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings and other rings, e.g. cyclohexylphenylacetic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Compuestos inhibidores selectivos de la ciclooxigenasa-I y su utilización como analgésicos, antiinflamatorios y antiartríticos.La presente invención se refiere a compuestos de fórmula general I,Inhibidores selectivos del isoenzima ciclooxigenasa-I, a sussales y solvatos farmacéuticamente aceptables, y a las composiciones farmacéuticas que las contienen. Los compuestos presentan una acción analgésica, antiinflamatoria y antiartrítica a la vez que, en animales con úlceras o trastornos gastrointestinales, no producen una mayor incidencia o gravedad de los mismos, ni retrasan su curación.Selective cyclooxygenase-I inhibitor compounds and their use as analgesics, anti-inflammatory and anti-arthritic drugs. contain them. The compounds have an analgesic, anti-inflammatory and anti-arthritic action while, in animals with ulcers or gastrointestinal disorders, they do not produce a higher incidence or severity of them, nor do they delay their healing.

ES9701315A 1997-06-17 1997-06-17 SELECTIVE INHIBITOR COMPOUNDS OF CYCLOOXYGENASE-I AND ITS USE AS ANALGESICS, ANTI-INFLAMMATORIES AND ANTIARTHRITIC. Expired - Fee Related ES2136018B1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
ES9701315A ES2136018B1 (en) 1997-06-17 1997-06-17 SELECTIVE INHIBITOR COMPOUNDS OF CYCLOOXYGENASE-I AND ITS USE AS ANALGESICS, ANTI-INFLAMMATORIES AND ANTIARTHRITIC.
AU83376/98A AU8337698A (en) 1997-06-17 1998-06-17 Cyclooxygenase-i selective inhibitors and the use thereof as analgesic, antiinflammatory and antiarthritic agents
PCT/EP1998/003636 WO1998057910A2 (en) 1997-06-17 1998-06-17 Cyclooxygenase-i selective inhibitors and the use thereof as analgesic, antiinflammatory and antiarthritic agents

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9701315A ES2136018B1 (en) 1997-06-17 1997-06-17 SELECTIVE INHIBITOR COMPOUNDS OF CYCLOOXYGENASE-I AND ITS USE AS ANALGESICS, ANTI-INFLAMMATORIES AND ANTIARTHRITIC.

Publications (2)

Publication Number Publication Date
ES2136018A1 ES2136018A1 (en) 1999-11-01
ES2136018B1 true ES2136018B1 (en) 2000-07-01

Family

ID=8299706

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9701315A Expired - Fee Related ES2136018B1 (en) 1997-06-17 1997-06-17 SELECTIVE INHIBITOR COMPOUNDS OF CYCLOOXYGENASE-I AND ITS USE AS ANALGESICS, ANTI-INFLAMMATORIES AND ANTIARTHRITIC.

Country Status (3)

Country Link
AU (1) AU8337698A (en)
ES (1) ES2136018B1 (en)
WO (1) WO1998057910A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ540515A (en) 2002-12-02 2008-01-31 Astellas Pharma Inc Pyrazole derivatives useful as COX-I inhibitors

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2137211B1 (en) * 1971-05-17 1974-08-02 Bouchara Emile
DE2253466A1 (en) * 1972-10-31 1974-05-09 Diamalt Ag 4-Allyloxy-3-chlorophenylacetic acid prepn. - with anti-rheumatic activity, from 3-chloro-4-hydroxyphenylacetic acid and allyl halide
US4082707A (en) * 1973-01-08 1978-04-04 Societa Italo-Britannica L. Manetti-H. Roberts & Co. 2-(4-isobutylphenyl)-propiohydroxamic acid and a procedure for its preparation
GB1480971A (en) * 1975-04-03 1977-07-27 Prodotti Antibiotici Spa Preparation of isobutylphenyl compounds
JPS54163545A (en) * 1978-06-10 1979-12-26 Taisho Pharmaceutical Co Ltd Organic carboxylic acid derivative
JPS60155144A (en) * 1984-01-24 1985-08-15 Central Glass Co Ltd Hexafluoroisobutylbenzene derivative and anti- inflammatory and analgesic agent containing same
CS274344B1 (en) * 1989-08-14 1991-04-11 Protiva Miroslav Method of 2-/4-(2-propylthio)phenyl/propionic acid's preparation
GB2306191A (en) * 1995-10-11 1997-04-30 Delta 3 Ltd A device for securing portable equipment

Also Published As

Publication number Publication date
ES2136018A1 (en) 1999-11-01
WO1998057910A2 (en) 1998-12-23
WO1998057910A3 (en) 1999-03-11
AU8337698A (en) 1999-01-04

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