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ES2136090T3 - Reactivos que contienen un inhibidor de fijacion no especifico para analisis de fijacion con captura de iones. - Google Patents

Reactivos que contienen un inhibidor de fijacion no especifico para analisis de fijacion con captura de iones.

Info

Publication number
ES2136090T3
ES2136090T3 ES92913618T ES92913618T ES2136090T3 ES 2136090 T3 ES2136090 T3 ES 2136090T3 ES 92913618 T ES92913618 T ES 92913618T ES 92913618 T ES92913618 T ES 92913618T ES 2136090 T3 ES2136090 T3 ES 2136090T3
Authority
ES
Spain
Prior art keywords
solid phase
reagent
capture reagent
capture
fixing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92913618T
Other languages
English (en)
Inventor
Janina Adamczyk
Daniel S Berry
Rosario Fico
Yi-Her Jou
Stephen D Stroupe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2136090T3 publication Critical patent/ES2136090T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/537—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody
    • G01N33/538—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with separation of immune complex from unbound antigen or antibody by sorbent column, particles or resin strip, i.e. sorbent materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

LA PRESENTE INVENCION INCLUYE NUEVOS ENSAYOS Y REACTIVOS USANDO UN REACTIVO DE CAPTURA, QUE INCLUYE UN MIEMBRO DE LIGAZON ESPECIFICO UNIDO A UNA SUSTANCIA ANIONICA POLIMERA, Y UN MATERIAL DE FASE SOLIDA QUE CONTIENE UNA ZONA DE REACCION O CAPTURA QUE INCLUYE UNA SUSTANCIA CATIONICA POLIMERA. UNA MUESTRA DE ENSAYO SOSPECHOSA DE CONTENER EL ANALITICO DE INTERES PUEDE SER PUESTO EN CONTACTO CON EL REACTIVO DE CAPTURA PARA FORMAR UN COMPLEJO DE CAPTURA REACTIVO/ANALITICO CARGADO. EL COMPLEJO ES ENTONCES PUESTO EN CONTACTO CON LA FASE SOLIDA OPUESTAMENTE CARGADA PARA ATRAER, FIJAR, E INMOBILIZAR EL COMPLEJO DE CAPTURA REACTIVO/ANALITICO. CON UN REACTIVO INDICADOR APROPIADO, SE PUEDEN REALIZAR ENSAYOS INTERPOLADOS, COMPETITIVOS E INDIRECTOS. PREFERIBLEMENTE, EL REACTIVO INDICADOR INCLUYE UN INACTIVADOR DE LIGAZON NO ESPECIFICO PARA REDUCIR LA LIGAZON INESPECIFICA ENTRE EL REACTIVO INDICADOR Y LA FASE SOLIDA, SIN INTERFERIR CON LA REACCION ENTRE EL REACTIVO DE CAPTURA Y LA FASE SOLIDA. INACTIVADORES DE LIGAZON NO ESPECIFICA ADECUADOS INCLUYEN MATERIALES POLIANIONICOS LIBRES O ILIMITADOS, TALES COMO UN SULFATO DEXTRAN, HEPARINA, CARBOOXIMETILO DEXTRAN, CELULOSA CARBOOXIMETILO, POLISULFATO PENTOSAN, HEXASULFATO INOSITOL O SULFATO (BETA) - CICLODEXTRINA.
ES92913618T 1991-05-30 1992-04-10 Reactivos que contienen un inhibidor de fijacion no especifico para analisis de fijacion con captura de iones. Expired - Lifetime ES2136090T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70737291A 1991-05-30 1991-05-30

Publications (1)

Publication Number Publication Date
ES2136090T3 true ES2136090T3 (es) 1999-11-16

Family

ID=24841445

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92913618T Expired - Lifetime ES2136090T3 (es) 1991-05-30 1992-04-10 Reactivos que contienen un inhibidor de fijacion no especifico para analisis de fijacion con captura de iones.

Country Status (7)

Country Link
EP (1) EP0586590B1 (es)
JP (1) JP3267613B2 (es)
AT (1) ATE181965T1 (es)
CA (1) CA2109924A1 (es)
DE (1) DE69229551T2 (es)
ES (1) ES2136090T3 (es)
WO (1) WO1992021769A1 (es)

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US7943395B2 (en) 2003-11-21 2011-05-17 Kimberly-Clark Worldwide, Inc. Extension of the dynamic detection range of assay devices
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JP6857714B2 (ja) 2017-03-30 2021-04-14 富士フイルム株式会社 生体試料中の測定対象物質を測定するためのキット及び方法
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JP6808819B2 (ja) 2017-03-30 2021-01-06 富士フイルム株式会社 生体試料中の測定対象物質を測定するためのキット及び方法
JP7203034B2 (ja) * 2017-10-02 2023-01-12 大塚製薬株式会社 アナライトの検出方法
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Also Published As

Publication number Publication date
EP0586590A1 (en) 1994-03-16
DE69229551T2 (de) 2000-01-27
DE69229551D1 (de) 1999-08-12
EP0586590B1 (en) 1999-07-07
JP3267613B2 (ja) 2002-03-18
EP0586590A4 (en) 1996-01-17
CA2109924A1 (en) 1992-12-10
WO1992021769A1 (en) 1992-12-10
ATE181965T1 (de) 1999-07-15
JPH06508210A (ja) 1994-09-14

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